• 사상체질의학회지
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• 제9권2호
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• pp.245-261
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• 1997

The investigation were carried out the 37 patient with cerebrovascular accidents who had been treated in Oriental Medical Hospital in Kyung Hee University and in KangNam Uy Lim, and the 10 examinees who had been worked in Medical Hospital in Kyung Hee University. The consitution which had discriminated by survey, which had discriminated by study on the morphological diagrammings, which had discriminated by the result of the impatient of hospital on a dosage of constitutial prescription. The Prostaglandin E2 in blood for 47 persons (37 patients & 10 examinees) was measured. The following results were obtained. 1.In the constitution which had discriminated by survey, in the value of Prostaglandin E2 in bood of ammong four constitutiens didn,t showed significant differance. 2.In the constitution which had discriminated by study on the morphological diagrammings, in the value of Prostaglandin E2 in bood of ammong four constitutiens didn,t showed significant differance. 3.In the constitution which had discriminated by the result of patient of hospital on a dosage of constitutial prescription, the value of Prostaglandin E2 in blood of among four constitutions didn,nt showed signicant differance. 4.In the constitution which had discriminated by colligated three methods(survey, morphological diagrammings,the result of patient of hospital on a dosage of constitutial prescription), the value of Prostaglandin E2 in blood of ammong four constituion didn,t showed significant differnce. 5.In the constitution which had discriminated by survey, a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the TAE-EUM-IN(太陰人) and the others of female showed significant differance. 6.In the constitution which had discriminated by study on the morphological diagrammings,a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the SO-EUM-IN(少陰人) and the others of male showed significant differance. 7.In the constitution whichhad discriminated by the result of patient of hospital on a dosage of constitutial prescription,a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others was conducted. Only the value of Prostaglandin E2 in blood between in the TAE-EUM-IN(太陰人) and the others of male showed significant differance. 8.In the constitution which had discriminated was the colligated three methods(survey,morphological diagrammings,the result of patient of hospital on a dosage of constitutial prescription),a test of significance between the value of Prostaglandin E2 in blood of each constitution and the value of Prostaglandin E2 in blood of the others didn,t showed significant differnce. In this connected study is inadequete at present. But if the study is done persistently,the analysis of various ingredient in the body enables objectification in differentiation of four types of physical constitution as the supplemental method.

• 혜화의학회지
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• 제16권1호
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• pp.199-206
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• 2007

Objective : The purpose of this study is to report treated case about patient with diplopia caused by stroke. Methods : The improvement of diplopia was observed as he was treated with acupuncture therapy and herb medicine named Bo-gan-san(保肝散). Results : Diplopia improved and disappeared gradually with acupuncture therapy and herb medicine named Bo-gan-san(保肝散). The patient was discharged with favorable recovery. Conclusion : In traditional Korean medicine, diplopia is caused by disorder of JungKi(精氣), intrusion of PoongSa(風邪) into Neoi(腦), and hollowness of Gan(肝), Shin(腎). Treating it is by expelling PoongSa(風邪) or strengthening Gan(肝), Shin(腎). The patient was diagnosed as cerebral infarction according to Brain MRI. Diplopia was improved after acupunctural therapy and intaking Bo-gan-san(保肝散), herbal prescription selected from DongYiBoGam(東醫寶鑑).

• 사상체질의학회지
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• 제31권4호
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• pp.28-40
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• 2019

Objectives The purpose of this study is to analyze how obesity of Taeeumin have been treated. Methods We searched clinical studies from the databases including Koreanstudies Information Service System(KISS), Oriental medicine Advanced Searching Integrated System(OASIS), Research Information Sharing Service(RISS), National Discovery for Science Leader(NDSL), Korea Citation Index(KCI) and pubmed with the keywords relevant to treatment of Taeeumin obesity. Results A total of 14 studies were analyzed. Herbal medicines were mostly used, and the most frequently used prescription was Taeeumjowi-tang. And concurrent therapies such as diet therapy, exercise therapy, electroacupuncture were performed. Several evaluation methods were used, and patient's body weight was the most used. Conclusion Through this literature review, we could find out tendencies of Korean medicine treatments of obesity of taeeumin up to date and some points that may have clinical significance.

• 사상체질의학회지
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• 제28권3호
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• pp.225-232
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• 2016

Objectives This study was implemented to investigate the distribution of Sasang constitution and prescription of the patients with coldness in hands and feet.Methods Sixteen patients with coldness were analyzed in terms of age, Sasang constitution, season and prescriptions.Results The distribution of Sasang constitution of the patients with coldness in hands and feet was like Taeeumin 50%, Soeumin 43.8% and Soyangin 6.2%. And the date of consultation of the patients is different seasonally, 50% of the patients visited in winter, 18.8% in spring and fall respectively and 6.3% in summer. The frequency by age group is different was like 31.3% of the patients visited in 20s, 18.8% in 10s, 30s and 50s, 12.5% in 40s. In terms of Exterior and Interior diseases, Soyanging and Soeumin patients were categorized in Interior diseases while Taeeumin patients were categorized in Exterior disease.Conclusions Patients with coldness in hands and feet were mostly classified into Taeeumin and Soeumin and the prevalence of its symptom was high in their 20s. Patients were willing to visit clinics in winter. The Exterior/Interior diseases and mild/severe diseases were different according to Sasang constitution.

• Journal of Applied Biological Chemistry
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• 제61권4호
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• pp.341-349
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• 2018

The aim of this study was to evaluate autophagy-enhancing and neuroprotective effects of Wonji-Gobon mixture (WGM), a traditional Chinese prescription medication, in Parkinson's disease (PD) mouse models. Our investigation found that WGM increased the expression of both Beclin1 and LC3b-II proteins as measured with western blot in the BV2 cell line; both proteins play a role in autophagy. WGM also increased the autophagy expression as measured by fluorescence-activated cell-sorting analysis in the BV2 cell line. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD models, WGM significantly increased the amount of dopamine in a striatum-substantia nigra suspension, produced notable results in the forced swim test, and increased serotonin as measured by high-performance liquid chromatography analysis; these results are indicative of neuroprotective effects. In summary, our findings indicate that WGM treatment has neuroprotective effects that are partially mediated by autophagy enhancement.

• 대한한의학회지
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• 제41권4호
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• pp.112-119
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• 2020

Objectives: The present study reports a case of chronic anemia patient who was significantly improved after taking Nokyongdaebo-tang (NYDBT) Methods: A 48-year-old male patient diagnosed with iron deficiency anemia (IDA) visited the Daejeon Korean medicine Hospital of Daejeon University on June 2018. The patient was treated with Korean medicine for 23 months including acupuncture, herbal medicine and Sasang constitutional medicine prescription. Improvement of anemia was assessed by changes of Hemoglobin value. Laboratory analysis was used to evaluate the safety of treatment. Results: Chronic anemia has significantly improved since taking NYDBT on 9 days (2019.12.09-2019.12.17). The Hb value has been maintained in the normal range since it first entered the normal range on January 18, 2020. The patient had become transfusion-free and this condition persisted for 6 months after stopping the transfusion. Conclusion: This case demonstrates the therapeutic potential of Sasang constitutional medicine for chronic anemia as a personalized medicine.

• 사상체질의학회지
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• 제25권4호
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• pp.359-372
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• 2013

Objectives The object of this study was to observe the effects of Hyeongbangjihwhang-tang (HB; Soyangin prescription) on the 5/6 NTX induced CRF rats. Methods Each of Hyeongbangjihwhang-tang aqueous extracts 200mg/kg were orally administered once a day for 35 days from 4 weeks after 5/6 NTX surgery. Four groups, each of 8 rats per group were used in this study, were sham group, CRF group, ${\alpha}$-Tocoperol group and HB group. Changes on the left remnant kidney weights, serum BUN, creatinine levels, caspase-3, PARP immunoreactivities were observed to nephroprotective effects, and relative immunomodulatory effects were monitored based on the changes of lymphatic organ weights and splenic cytokine contents. In addition, the changes on the kidney MDA, GSH contents and SOD, CAT activities were also calculated for antioxidant effects, and the effects on the CRF related cachexia were demonstrated based on the changes of body and epididymal fat pad weights, serum TG, TC, LDL and HDL levels. Results and Conclusions 1) HB was significantly decreased the left remnant kidney weights, serum BUN, creatinine levels and caspase-3, PARP immunoreactivities. 2) HB was significantly increased lymphatic organ weights and splenic cytokine contents. 3) HB was significantly increased body and epididymal fat pad weights, and was significantly decreased serum TG, TC, LDL and HDL levels. 4) HB was significantly decreased MDA contents, and was significantly increased GSH contents and SOD, CAT activities. The results obtained in this study suggest that HB significantly retarded immunosuppressions and cachexia related to the 5/6 NTX induced CRF through modulations of oxidative defense systems. Especially HB showed the highest favorable effects more than those of ${\alpha}$-tocoperol.

• 사상체질의학회지
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• 제26권2호
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• pp.165-179
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• 2014

Objectives To evaluate the neuroprotective effects of Hyangsayangwi-tang (HY), a Korean traditional medicinal prescription in a Parkinson's disease mouse model. Methods Four groups(each of 10 mouse per group) were used in this study. The neuroprotective effect of HY was examined in a Parkinson's disease mouse model. C57BL/6 mouse treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30mg/kg/day), intraperitoneal (i.p.) for 5 days. Slow behavioral responses and memory disorder is the major clinical symptoms of PD. In order to investigate the effect of HY on recovery of behavioral deficits and memory, we examined the motor function and memory by using Morris water maze and Forced swimming test. Ischemic mouse brain stained with TTC(2,3,5 triphenyl tetrazolium chloride) in the MPTP-induced Parkinson's disease to find out ischemia and tissue damage in mouse. The convenient, simple, and accurate high-performance liquid chromatography (HPLC) method was established for simultaneous determination of neurotransmitters in MPTP-HY group. To measure the amount of dopamine in mice brain, striatum-substantia nigra, was examined by Bradford assay. Immunohistochemistry was examined in the MPTP-induced Parkinson's disease (PD) mouse to evaluate the neuroprotective effects of Hyangsayangwi-tang on hippocampal lesion, ST and SNpc. Results and Conclusions Hyangsayangwi-tang (HY) prevents MPTP-induced loss of serotonin, hippocampus and TH-ir cell.

• 사상체질의학회지
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• 제10권2호
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• pp.1-14
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• 1998

1. 연구목적 사상의학(四象醫學) 임상은 무엇보다 정확한 체질진단(體質診斷)과 적합한 용약(用藥)이 필요하다. 동무(東武)는 "동의기세보원(東醫器世保元)"을 통해 체질진단(體質診斷)의 단서(端緖)로 체형기상(體形氣像), 용모동기(容貌洞氣), 성질재간(性質材幹) 등을 제시하고 있으나 무엇보다 병증(病症)을 관찰하여 용약(用藥)할 것을 강조하였다. 이 글에서는 체질병증(體質病證)의 특징(特徵)을 개괄적으로 살피고, 사상인(四象人) 고유의 처방(處方)이 나오게 되는 배경과 처방(處方)의 임상예(臨床例)를 사상의학(四象醫學)의 임상(臨床) 활용(活用)의 정확성을 기하는 것이 연구의 목적이다. 2. 연구 방법 "동의세기보원(東醫器世保元)"의 "사상인병증론(四象人病證論)"과 "동의사상신편(東醫四象新編)"의 사상처방(四象處方) 운용(運用)의 임상예(臨床例)를 중심으로 체질(體質) 병증(病症)의 특징을 파악하고 처방의 사용 정신을 살펴 보고자 하였다. 3. 연구 결과 사상인(四象人) 각 병증약리(病症藥理)를 살펴 보아 아래와 같은 결과를 얻었다. 1. 사상의학(四象醫學)의 병증(病證)은 심신(心身)을 중시한 형상의학(形象醫學)에서 나왔고 온열양한(溫熱凉寒)의 사상적(四象的) 요약(要約) 정신(精神)으로 설명되고 있다. 2. 소음인(少陰人)과 소양인(少陽人) 병증(病症)은 수곡지기(水穀之氣)의 한열병증(寒熱病證)으로 치료(治療) 정신(精神)은 상하승강(上下升降)의 조절(調節) 정신(精神)에서 찾을 수 있고, 태양인(太陽人) 병증(病證)은 기액지기(氣液之氣)의 온량병증(溫凉病證)으로 치료(治療) 정신(精神)은 내외완속(內外緩束)의 조절(調節) 정신(精神)에서 찾을 수 있다. 3. 사상인(四象人)의 병증(病證)을 개괄하면, 태양인(太陽人病證)은 하허상실병증(下虛上實病證)이며 혈액구모병증(血液俱耗病證)이고, 소음인병증(少陰人病證)은 하함병증(下陷病證)이며 위한병증(胃寒病證)이고, 태음인병증(太陰人病證)은 조열병증(燥熱病證)이며 이열병증(裏熱病證)이고, 소양인병증(少陽人病證)은 화열병증(火熱病證)이며 이열병증(裏熱病泣)이다. 4. 사상의학(四象醫學) 체질병증(體質病證)의 특징은 성정(性情)과 한열(寒熱)의 표리병증(表裏病證) 구분(區分) 정신(精神), 보명지주(保命之主)를 통한 표리병증(表裏病證)의 포괄(包括) 정신(精神), 수곡지기(水穀之氣)와 기액지기(氣液之氣) 병증(病證)의 구분(區分) 정신(精神)으로 설명하고 있다. 5. 병증(病證)의 운영정신(運營精神)은 경중완급(輕重緩急) 및 순역(順逆)의 구분(區分) 정신(精神), 체질속성(體質屬性)에 따른 약물(藥物) 조절(調節) 정신(精神), 동출일속(同出一屬)의 포괄적 치료(治療) 정신(精神)으로 요약할 수 있다.

• 사상체질의학회지
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• 제13권2호
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• pp.8-27
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• 2001

1. Purpose This paper was written in order to understand the concept of ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$ (東武遣稿 藥性歌) which was descending as the material of Sasang pharmacology. So we are planning to make use of the fundamental material of the study on the Sasang Medications and Prescriptions. 2. Methods Through comparing each clause of ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$ on all the sasang -records, we understood that concept. 3 Result 1) ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$ of a literary work of DongMu(東武) which contain special elucidative-method of herb-nature has 18 type of YakSungGa which explain each 27 herbs for the Taeeumin, Soyangin and Soeumin. The period of authoship is supposed to the time just before ${\ulcorner}$DongyiSuseBowon Gabobon${\lrcorner}$ (東醫壽世保元 甲午本)(1894, DongMu 58 years old) or middle of fifties(53-57 years old). 2) YakSungGa of ${\ulcorner}$DongMuYooGo${\lrcorner}$ which is published by the BoGunsung(保健省) of North Korea is supposed to close to original type. The main meaning of that is the herb-nature which works on the weakst point of each Sasangin. And then the herbs were classfied by the diseases and symptoms possessing Bomyungjiju(保命之主), the herb's efficacy is explained at the each constitution. 3) The meaning of ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$ is exposure of the opinion of DongMu's early stage that proposed herb-nature which is applied to the principle of Jang(臟) of Sasangin, reason and purpose to enact newly created prescriptios by the constitutional diseases and symptoms, and the compositional principle of newly created prescription. 4) The selection of herbs or cogution of herb-nature of DongMu's pharmacological opinion of his early stage was changed by accumulating clinical experience. So all the newly created prescriptios of ${\ulcorner}$DongyiSuseBowon${\lrcorner}$ could not be explained by only the herb and the herd-nature on ${\ulcorner}$DongMuYooGo YakSungGa${\lrcorner}$. Therefore the purpose of DongMu's YaksungGa is not explaining the symptoms in charge of each herb or classifying the herb by constitution, but offering the principle of composition of prescription of Sasang, from the necessary herb which possess and expand Bomyungjiju to nature of herb which is applied to the constitution for treating all the diseases and sypmtoms by the heavy or light and slow or speedy.