• 대한지역사회영양학회지
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• 제12권2호
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• pp.133-141
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• 2007

Minerals play important roles in biological processes. Hair mineral analysis has the advantages of conveniences in sampling and observing the profiles of multiple minerals simultaneously. The purpose of this study was to compare hair mineral contents between urban and local middle school students, and to find out the relation with nutrient intakes and clinical symptoms. Ten nutritional minerals and 7 environmental mineral contents were analyzed in the hair samples of 44 and 37 male students who resided in urban and local area, respectively. And their nutrient intake and clinical symptom score were estimated from questionnaire. The average age, height, and weight were 15.1 years, 168.4 cm, 56.8 kg in urban subjects and 15.4 years, 169.1 cm, 61.9 kg in local subjects, respectively. The residence types were apartment (63.6%) and small-sized apartment (22.7%) in urban subjects and apartment (51.4%) and house (37.8%) in local subjects. The primary water sources were purified water (38.3%), running water (18.2%) in urban subjects and purified water (32.4%), underground water (27.0%) in local subjects, respectively. Daily energy and nutrient intakes were not significantly different between two groups. Among the surveyed 17 clinical symptoms, the scores of constipation, cold, anxieties and total score of clinical symptoms in urban subjects were significantly love. than those in local subjects. Hair contents of Na, Mg, Ca, Cu, V Al, As were significantly higher, while U was lower in urban subjects compared to those in rural subjects. Hair contents of Ni and U were significantly correlated with food intake, and Cr, V, Al, Sb, As, U showed a correlation with energy intake. Hair Mg level showed significantly negative correlation with total clinical symptom score. In conclusion, hair mineral profile between urban and local students was significantly different. And some of these minerals were significantly correlated with food and nutrient intakes. Especially hair magnesium was significantly correlated with total clinical symptom score. Therefore, hair mineral levels would be needed for more systematic study elucidating potentiality as a useful clinical tool.

• Journal of Hospice and Palliative Care
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• 제11권2호
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• pp.99-105
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• 2008

목적: 본 연구에서는 호스피스 병동에 입원한 말기 암 환자들을 대상으로 임상적으로 보다 정확한 잔여 수명을 예측하고자 임종의 시기에 객관적으로 임상적 증상 및 징후들의 변화를 관찰하였다. 방법: 강남성모병원 호스피스센터를 방분한 말기 암 환자를 대상으로 입원 시부터 임종까지 말기에 흔히 나타나는 증상과 신체적 징후의 변화를 관찰하였다. 증상의 정도는 $0{\sim}3$점수화하였으며 신체적 징후는 있다 또는 없다로 구분하였다. 이밖에 활력증후와 통증 정도, 진통제 사용을 관찰하였다. 결과: 호흡곤란, 혼수의 증상은 입원 시와 비교해서 임종 $1{\sim}2$일 전에 악화되었다. 대상자의 활동 수행 능력은 임종 시간이 가까워질수록 점진적으로 감소하였고, 섭취량과 소변 배설량도 줄어들었다. 특히 임종 $1{\sim}2$2일 전부터 현저하게 혈압이 감소하였다. 임종 시점을 기준으로 시기에 따라 증상의 변화가 유의하게 나타난 임상 지표는 활동수행 능력, 수축기 혈압, 구강건조증, 식욕저하, 쇠약감, 변비, 황달, 부종, 욕창, 호흡곤란, 진정, 혼수, 청색증, 호흡이상, 가래 끓는 소리, 눈을 뒤로 젖힘 등이었다. 결론: 말기 암 환자에서 수축기 혈압의 감소, 호흡곤란, 진정, 혼수, 청색증, 호흡이상, 가래 끓는 소리, 눈을 뒤로 젖힘 등의 증상이 나타나면 임종이 임박했음을 예상하여 가족들과 환자가 준비할 수 있도록 해야 하며, 의료진도 임종에 관한 돌봄을 시행하도록 해야 한다.

• 한국식품조리과학회지
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• 제29권2호
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• pp.185-192
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• 2013

구멍쇠 미역의 변비 개선 효능을 검정한 결과, 흰쥐의 사료섭취량과 체중 변화는 정상군에 비해 구멍쇠 미역 투여군이 유의적으로 식욕억제와 비만예방에 효과가 있을 것으로 사료된다. 장통과시간은 대조구 853.1분이었고, 구멍쇠 미역 5% 급이군에서 789.7분으로 감소하였다. 변비를 유발시키면서 식이섬유를 급이한 흰쥐의 체중 대비 간의 무게는 모든 실험군에서 정상군과 차이가 없었으며, 신장의 무게도 각 실험군에서 차이가 나타나지 않았다. 또한, 소장 및 대장의 길이는 변비의 유무와 식이섬유 급원에 따른 군간 유의적인 차이가 없었다. 분변량을 측정한 결과 정상군의 1일 평균 분변량은 2.84 g, 대조군은 1.34 g, 구멍쇠 미역 5% 급이군은 1.57 g, 구멍쇠 미역 10% 급이군은 2.02 g으로 구멍쇠 미역의 섭취가 변비 증상 호전 효과가 있을 것으로 판단된다. 분변의 수분함량 측정 결과, loperamide를 단독 투여한 대조군 분변의 수분함량이 정상군에 비해 유의적으로 감소하여 loperamide 투여로 인해 변비가 유발된 것을 확인하였으며, 구멍쇠미역 5% 및 10%가 함유된 사료를 급이한 군은 정상군에 비해 분변의 수분함량이 각각 1.6배 및 2.1배 증가하였다. 구멍쇠 미역을 급이한 흰쥐의 혈청 중 cholesterol 및 triglyceride 함량 변화측정 결과, 혈청 중 total cholesterol 함량은 구멍쇠 미역 5% 급이군에서 loperamide로 변비를 유발한 대조군에 비해 3.5% 감소하였으나 유의적인 차이는 없었으며, 구멍쇠 미역 10% 급이군은 40.21 mg/dL로 33.5% 감소하여 구멍쇠 미역의 섭취량이 높아질수록 흰쥐의 혈중 cholesterol 함량이 감소하였다. GOT 및 GPT는 각 실험군에서 차이가 나타나지 않았으나, BUN 농도는 대조군에 비해 구멍쇠 미역 10% 급이군에서 낮게 나타났으며, 혈중 포도당 농도는 각 실험군 간에 유의적인 차이가 없었다. 간 조직 내의 총콜레스테롤 분석 결과, 구멍 쇠 미역 급이군 모두 정상군 및 대조군에 비해 총콜레스테롤 함량이 감소하였으며, loperamide 투여에 의해 감소되었던 HDL-콜레스테롤은 구멍쇠 미역 급이 시 대조군에 비해 증가하였으나 유의적인 차이는 없었다. 또한, 중성지방 함량은 총 콜레스테롤과 마찬가지로 구멍쇠 미역 급이군이 정상군과 대조군에 비해 감소하였다. 이와 같은 결과로 보아 구멍쇠 미역은 장 이동률을 증가시켜 장운동을 촉진하리라 생각되며, 변비 해소 작용도 나타내어 장 기능 개선에 효과가 있을 것으로 판단된다.

• Advances in pediatric surgery
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• 제17권1호
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• pp.65-71
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• 2011

Currarino syndrome is a hereditary syndrome characterized by the triad of a sacral bony defect, presacral mass and anorectal malformation. We retrospectively reviewed 13 Currarino syndrome patients who were treated in our center between 1997 and 2010. Demographic data, initial symptoms, initial diagnosis. pathologic diagnosis of presacral mass, associated anomalies and managements were analyzed. There were 8 boys and 5 girls. Four patients were diagnosed as Currarino syndrome immediately after birth with failure of passage of meconium and abdominal distension. Four patients underwent surgery for imperforate anus immediately after birth and W8re diagnosed as Currarino syndrome later and underwent reoperation. Three patients were diagnosed during work-up and management with of the tentative diagnosis of Hirschsprung's disease. Diagnosis of the remaining two patients was at the age of 26 months and 9 years and anorectal malformation was not associated. Twelve patients showed hemi-sacrum and one patient showed bilateral sacral subtotal agenesis. Two patients without anorectal malformation underwent presacral mass excision, untethering of spinal cord and repair of myelomeningocele. Six out of 8 patients, excluding 3 that expired or were lost to follow up, with anorectal malformation underwent colostomy, presacral mass excision, untethering of spinal cord, repair of myelomeningocele, posterior sagittal anorectoplasty and colostomy repair. One patient underwent only posterior sagittal anorectoplasty after colostomy. One waits the scheduled operation only with Hegar dilatation. Pathologic examation of presacral masses showed myelomeningoceles in 4 patients, lipomyelomeningoceles in 3 patients and dermoid Cyst in one patient. Teratoma was combined in 2 patients. Eight patients needed neurosurgical operation for spinal cord problems. Seven patients had urologic anomalies and two of them underwent operation. Currarino syndrome should be considered as a differential diagnosis in pediatric patients with abdominal distension, constipation and anorectal malforlnation. For proper evaluation and treatment, a multi-disciplinary approach is recommended.

• 대한한방부인과학회지
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• 제26권3호
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• pp.93-102
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• 2013

Objectives: This study aims to research character of the patients with leukorrhea including Digital Infrared Thermal Imaging (DITI) and symptoms associated with leukorrhea in view of Korean medicine theory. Methods: We studied 71 patients visiting ${\bigcirc}{\bigcirc}$ Korean Hospital from April, 2012 to March, 2013. The subjects were categorized in two groups, leukorrhea group (n=40) and control group (n=31). We investigated the difference of DITI and other physical symptoms between two groups. Results: The average temperature of CV4 in leukorrhea group ($29.56{\pm}0.80^{\circ}C$) were significantly lower than that of control group ($30.12{\pm}0.54^{\circ}C$)(p<0.01). And there is no statistical difference of temperature of CV17 located in chest area between two groups. But temperature difference between CV17 and CV4 (${\Delt}T$) in leukorrhea group ($1.18{\pm}0.55^{\circ}C$) is significantly higher than control group ($0.68{\pm}0.43^{\circ}C$)(p<0.01). There is no correlation between leukorrhea and some sypmtoms, like menorrhea, irregular menstruation, fatigue, constipation and loss of appetite. But leukorrhea group is more likely to suffer from dyspepsia and insomnia than control group. Conclusions: Leukorrhea group is related to lower temperature in lower abdomen than control group. And patients with leukorrhea are more likely to appear dyspepsia and insomnia than no leukorrhea group.

• 동의생리병리학회지
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• 제18권2호
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• pp.376-380
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• 2004

The purpose of this study is the develop a questionnaire for measuring Yin-Deficiency and examine the reliability and validity for its' value as a barometer for evaluating Yin-Deficiency. Questionnaire was developed according to the symptoms of Yin-Deficiency suggested in the 'Standardization of diagnostic terms and requirements of Korean Medicine', With and as a reference, each symptom has been worked on to be put on the questionnaire. Visual analogue scales(VAS) was used as a barometer for measuring frequency of manifestation of symptoms. A study was performed to measure validity and reliability of the final questionnaire for analysis. reliability of YinDQ was measured by Cronbach's alpha coefficient and test-retest method. This study utilized factor analysis and clinical validity for evaluation of validity. For the purpose of decreasing the amount of data-the number of factors, and at the same time minimize the loss of information factor analysis was performed Component factors were extracted using Principal Component Analysis. This study evaluated the clinical validity for examination of difference between the normal group and the patient group. Evaluation on the's internal consistency showed strong internal consistency with value of 0.8615. reliability from test-rest with three-week interval, followed by comparisons of the correlation coefficient and mean values of each item between the two. The Spearman correlation coefficient was 0.54-0.79. By factor analyse two factors with Eigen value of greater than 2.2 were selected. Factor 1 consists of items of 'irritable fever on the five Hearts', 'flushing of the zygomatic region in the afternoon', 'tidal fever', 'night sweats', and 'dryness on the mouth or the throat'. Factor two consists of items of 'emaciation', 'dizziness', 'insomnia', 'decreased amount of urine with yellowish color', and 'constipation'. The comparison between the patient group and the normal group showed significant differences for every ten questions. The results implies that YinDQ is a barometer with sufficient reliability and validity. The questionnaire for Yin-Deficiency may not be enough to replace the specific differential diagnosis by a doctor of Oriental medicine. Nevertheless, it can be effectively utilized as an assisting method in consultation or a method of measuring the degree of Yin-Deficiency in a group.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.435-440
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• 2013

Background: Breast cancer is the leading cause of cancer-related death among women in Malaysia. A diagnosis is very stressful for women, affecting all aspects of their being and quality of life. As such, there is little information on quality of life of women with breast cancer across the different ethnic groups in Malaysia. The purpose of this study was to examine the quality of life in Malay and Chinese women newly diagnosed with breast cancer in Kelantan. Materials and Methods: A descriptive study involved 58 Malays and 15 Chinese women newly diagnosed with breast cancer prior to treatment. Quality of life was measured using the Malay version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and its breast-specific module (QLQ-BR23). Socio-demographic and clinical data were also collected. All the data were analyzed using SPSS version 20.0. Results: Most of the women were married with at least a secondary education and were in late stages of breast cancer. The Malay women had lower incomes (p=0.046) and more children (p=0.001) when compared to the Chinese women. Generally, both the Malay and Chinese women had good functioning quality-of-life scores [mean score range: 60.3-84.8 (Malays); 65.0-91.1 (Chinese)] and global quality of life [mean score 60.3, SD 22.2 (Malays); mean score 65.0, SD 26.6 (Chinese)]. The Malay women experienced more symptoms such as nausea and vomiting (p=0.002), dyspnoea (p=0.004), constipation (p<0.001) and breast-specific symptoms (p=0.041) when compared to the Chinese. Conclusions: Quality of life was satisfactory in both Malays and Chinese women newly diagnosed with breast cancer in Kelantan. However, Malay women had a lower quality of life due to high general as well as breast-specific symptoms. This study finding underlined the importance of measuring quality of life in the newly diagnosed breast cancer patient, as it will provide a broader picture on how a cancer diagnosis impacts multi-ethnic patients. Once health care professionals understand this, they might then be able to determine how to best support and improve the quality of life of these women during the difficult times of their disease and on-going cancer treatments.

• 대한한의학방제학회지
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• 제20권2호
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• pp.177-186
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• 2012

In this study, we selected some herbal formulation about a series of Chijasi-tang in Dongeuibogam by using web-based open program;Prescription Lineage Graph (http://164.125.206.43/PrescriptionLineageGraph.aspx). And we compared and analyzed the changes of efficacy, major target symptoms of each herbal formulation according to compositional variation of each herbal formulation. Chijasi-tang, first appeared in Sanghanlun, consists of Capejasmine and Fermented soybean, and it is mainly used to treat insomnia due to vexation, heartburn and yellow greasy tongue fur. Capejasmine can clear away irritable feverish sensation in chest by flowing downward the heat, and Fermented soybean can disperse stagnated heat throughout the chest by expelling stagnated heat from the exterior In the case of the heat stagnation caused by relapsing of disease due to overstain, Chisijisil-tang can be used. And if symptom appear more on the upper or exterior than a case of Chisijisil-tang, Seosisi-tang could be more suitable, if half exterior and half interior, Omae-tang could be for it. In addition, if symptom caused by relapsing due to improper diet, Chisijihwang-tang could be proper formulation. In the case of the heat stagnation body inside and jaundice, if it is caused by alcohol, Chijadaehwang-tang could be used for the purpose of urgent purgation, Galchul-tang would be suitable for helping the function of the spleen and the stomach and for treatment of damp-heat of the spleen and the stomach. And if it is caused by pandemic infection, Jangdal-hwan would be good formulation for it. Samhwangseokgo-tang and Yangdokchija-tang could be appropriate formulation for the raging of noxious heat and pathogenic fire caused by febrile disease with toxic yang. Daehwangeum-ja is for severe constipation due to heat-dryness with stagnated fever, Haebaek-tang is appropriate for severe diarrhea due to heat type change of Soeum. According to the result of our investigation, although there are various target causes and symptoms of each herbal formulations, whatever pathogenetic cause is, the stagnated heat in interior side is the basis of symptoms. Therefore, the purpose of including Chijasi-tang in composition of each herbal formulation is treatment of the stagnated heat. For such reason, on the fundamental or ancillary basis of Chijasi-tang plus some herbs for each therapeutic purpose.

• 대한한방내과학회지
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• 제21권3호
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• pp.369-376
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• 2000

Purpose : Cerebrovascular disease is the most frequent cause of death in Korea and it remains severe disabilities disturbing normal life, According to the previous studies, mortality of the stroke in the first one week is up to the 20% and 95% of stroke patients in the acute stage are accompanied by more than one complications. These complications affect not only the acute stage mortality but also the late stage rehabilitations. In Korea the oriental medicine is preformed in the treatment of stroke. Therefore it is important to recognize thoroughly the complications in the acute stage of stroke and to prevent them. But studies about complications of acute stage stroke is rarely presented in the fields of oriental medicine. So this study is prepared for investigating the characteristics and frequency of complications in the acute stage of stroke. And we are to assess the importance of theses acute complications by systemic reviewing the previous studies. Methods : Fifty one patients are included who had been admitted to ICU(intensive care unit) of Chenju Hospital of Wonkwang Oriental Medicine. Twenty nine patients are diagnosed as ischemic stroke and twenty one patients are diagnosed hemorrhagic stroke. Medical and neurological complications were investigated retrospectively based on medical notes excluding primary symptoms of stroke Le. motor weakness, sensory disturbance and speech disorder. And risk factors of stroke such as D.M. or hypertension are excluded. Results : Medical complications are more frequent than neurological ones. Most frequent medical complication is dysuria(61%) and constipation(45%), fever(30%) and aspiration pneumonia(22%) are followed in order of frequency. In Neurological complication dysphagia(56%), the exacerbation of infarction due to increased intracranial pressure(24%), irritability or insomnia(21%) is most frequently complicated in order of frequency. Conclusions : These complications are mostly caused by bed rest state in acute stage stroke. It is supposed that more aggressive management can prevent theses ones. And it is possible to improve the medical and neurological conditions by sticking theses study results.

• 동의신경정신과학회지
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• 제12권2호
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• pp.37-51
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• 2001

The clinical study was carried out the 43 patients with Depression who were treated in Department of Neuropsychiatry, College of Oriental Medicine, Dae Jeon University from 22 February 2000 to 14 November 2001. The results were summarized as follows. 1. The ratio of male and female was 10:33, 60's(32.6%) was frequent, no inducing factor(38.3%) was seen in a lot of cases and many patients came to our hospital by way of west-neuropsychiatry(56.8%). 2. The period of clinical history was frequent from 3 to 10 years(23.2%), the most frequent preceding disease was cardiovascular systemic disease(18.4%). 3. The main clinical symptoms were apprehension alpitation(13.4%), anorexia(9.8%), headache nuchal region stiffness(9.8%), general body weakness(6.5%), chest discomfort(6.5%), dizziness(5.7%), febris(5.3%) and constipation(5.3%). 4. The patient's tongue aspect had pink tongue and empty fur(32.6%) and pulse type had thin and deficient pulse(39.5%). The prescription drugs were Chunggansoyo-san(30.0%), purging liver and alleviating depression to regulate qi, and Guibiondam-tang(15.8%) eliminating phlegm, cooling pericardium and warming gallbladder. 5. The curve was within normal range at Psychoneural system(81.4%), and Visceral system(90.1%). 6. The regulation was Normal(48.1%), RL(27.9%), RR(20.2%) at Psychoneural system and Normal(45.9%), RL(28.5%), RR(20.3%) at Visceral system. 7. Activity and Reactivity had much lower response at 1th, 2th, 3th, 4th, 7th SANGHAN, Polalization had much higher response at 1th, 4th, SANGHAN and much lower response at 2th, 3th, 7th SANGHAN.