• Convergence Security Journal
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• v.10 no.1
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• pp.55-61
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• 2010

It is of great practical interest to deciding when to stop testing a software system in development phase and transfer it to the user. This decision problem called an optimal release policies. In this paper, because of the possibility of introducing new faults when correcting or modifying the software, we were researched release comparative policies which based on infinite failure NHPP model and types of interval failure times. The policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement can optimal software release times. In a numerical example, applied data which were patterns, if intensity function constant or increasing, decreasing, estimated software optimal release time.

• Archives of Pharmacal Research
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• v.10 no.2
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• pp.88-93
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• 1987

Chitosan ($\beta$-D-glucosaminan) is chemically prepared from chitin (N-acetyl-$\beta$- D-glucosaminan) which is an unutilized natural resource. We now report on the suitability of the chitosan matrix for use as vehicles for the controlled release of drugs. Salicylic acid and aspirin were used as model drugs in this study. The permeation of salicylic acid in the chitosan membranes was determined in a glass diffusion cell with two compartments of equal volume. Drug release studies on the devices were conducted in a beaker containing 5% sodium hydroxide solution. Partition coefficient (Kd) value for acetate membrane (472) is much greater than that for fluoro-perchlorate chitosan membrane (282). Higher Kd value for acetate chitosan membrane appears to be inconsisstent with the bulk salicylic acid concentration. The permeability constants of fluoro-perchlorate and acetate chisotan membranes for salicylic acid were 3.139 ${\times}10^{-7}cm^2$ min up to 60 min and that of 30% aspirin in the devices was 4.739${\times}10^{-7}cm^2$sec upto 60 min. As the loading dose of aspirin in a chitosan device increased, water up-take of chitosan device increased, but in case of salicylic acid it decreased. The release rate increased with increase in the molecular volume of the drugs. Thses result suggest that the release mechanism may be controlled mainly by diffusion through pores.

• Journal of Pharmaceutical Investigation
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• v.17 no.3
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• pp.111-126
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• 1987

Methyl methacrylate-butyl methacrylate copolymer (MMBM)-dibutyl phthalate (DBP) films were investigated as a potential topical drug delivery system for the controlled release of nitrofurazone. The kinetic analysis of release data indicated that drug release followed a diffusion-controlled granular matrix model, where the quantity released per unit area is proportional to the square root of time. DBP of several hydrophobic plasticizers selected was found to give the highest release of nitrofurazone. However, hydrophilic plasticizers such as propylene glycol and polyethylene glycol 400 had no controlled release properties and acceptable film formation. The effects of changes in film composition, drug concentration, film thickness, pH of release medium, and temperature on the in vitro release of nitrofurazone were analyzed both theoretically and experimentally. The release rate constant (k') was found to be proportional to DBP content, pH, and the temperature of release medium, but independent of film thickness, and drug concentration in a range of 0.1-0.4% by weight. The linear relationship was found to exist between the log k' and DBP content. The release of nitrofurazone from MMBM-DBP (8:2) films was found to be an energy-linked process. Two energy terms were calculated ; the activation energy for matrix diffusion was 13.45 kcal/mole, and the heat of drug crystal solvation was 27.26-29.34 kcal/mole. Observation of scanning electron micrographs and microscopic photographs showed that the incorporation of DBP in films increased markedly the particle size of nitrofurazone dispersed in the film matrix, comparing with the fine dispersion of nitrofurazone in pure MMBM film alone.

• Korean Journal of Environmental Agriculture
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• v.30 no.2
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• pp.144-152
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• 2011

BACKGROUND: Eutrophication occurs occasionally in flood control reservoirs around Juam lake in summer and early autumn. Lakeside macrophyte which is one of internal pollutants effects on water quality when it is submerged during water surface is rising after rainy season. METHODS AND RESULTS: To improve water the quality of water from water supply source and to establish the management plan of submerged plants in flood control reservoirs around Juam Lake, the removal and release velocities of nutrients by submerged plants in site 1 and 2 were investigated. Removal or release velocity constant (K) of COD by Carex dimorpholepis Steud in column was 0.07~0.18 $day^{-1}$ at 0~4 days after flooding, -0.23~-0.17 $day^{-1}$ at 5~19 days after flooding and -0.28~0.03 $day^{-1}$ at 20~33 days after flooding. Removal or release velocity constant (K) of T-N by Carex dimorpholepis Steud was 0.02 $day^{-1}$ at 0~4(8) days after flooding, -0.13~-0.10 $day^{-1}$ at 5(9)~33 days after flooding in column. Removal or release velocity constant (K) of T-P by Carex dimorpholepis Steud was 0.05~0.06 $day^{-1}$ at 0~4 days after flooding, -0.14~-0.09 $day^{-1}$ at 5~33 days after flooding. Release velocity constant (K) of nutrients by Miscanthus sacchariflorus Benth was lower than that by Carex dimorpholepis Steud. In site 1, the amount of nutrients release by Carex dimorpholepis Steud was 6,719 kg/month/area for COD, 2,397 kg/month/area for T-N and 466 kg/month/area for T-P. The amounts of nutrients release by Carex dimorpholepis Steud were higher than those by Miscanthus sacchariflorus Benth in both sites. CONCLUSION(s): The results of this study suggest that COD, T-N and T-P in water quality of Juam lake were strongly influenced by submerged plants in flood control reservoirs.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.1
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• pp.24-31
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• 2015

A differential codebook using M-ary phase shift keying (M-PSK) constellation as its codeword elements, is proposed for Long term evolution (LTE), LTE-Advanced (LTE-A), and/or WiMAX systems. Due to the temporal correlation of the adjacent channel, the consecutive precoding matrices are likely to be similar. This approach quantize only the differential information of the channel instead of the whole channel subspace, which virtually increase the codebook size to realize more accurate quantization of the channel. Especially, the proposed codebook has the same properties of LTE release-8 codebook that is, constant modulus, complexity reduction, and nested property. The mobile station can be designed by using a less expensive non-linear amplifier utilizing the constant modulus property. Computer simulations show that the capacity of the proposed codebook performs better than LTE release-8 codebook with the same amount of feedback information.

• Archives of Pharmacal Research
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• v.13 no.2
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• pp.151-160
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• 1990

In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.

• Transactions of the Korean Society of Automotive Engineers
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• v.1 no.1
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• pp.50-58
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• 1993

The ignition delay of diesel oil and fish oil blended with diesel oils was investigated at various pressure and temperature conditions in a constant volume combustion bomb. The evaporation and combustion duration of diesel oil and fish oil blended with diesel oils were respectively different in high and low temperature. The dependence of ignition delay on the temperature was different in high and low temperature ranges which were divided at the 773K. The dependence of ignition delay on the pressure was almost linear, regardless of the test fuels at the constant temperature(863K). The ignition delay became longer as the blending rate of fish oil increased at the constant temperature and pressure, but it was especially short with 20% fish oil blended with diesel oils.

• Clinics in Shoulder and Elbow
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• v.21 no.3
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• pp.127-133
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• 2018

Background: This study was undertaken to evaluate the outcome of the arthroscopic capsular release for adhesive capsulitis of the shoulder. Methods: This study retrospectively investigated thirty shoulders in 29 patients who presented with recalcitrant adhesive capsulitis and underwent arthroscopic treatments. Other than typical findings of adhesive capsulitis, combined pathologies in the glenohumeral joint and subacromial space were evaluated by arthroscopy. Clinical evaluations were performed using the Constant's score and ranges of motion (ROM) at preoperative, 6 months postoperatively and at the final follow-up. Results: Our study included 17 women and 12 men with a mean age of 53.8 years (range, 34-74). Mean follow-up duration was 24 months (range, 12-40 months). Assessment of combined pathologies revealed that partial rotator cuff tear of less than 25% thickness, was most common (overall 83.3%; with bursal 57% and articular 23%). Subacromial synovitis and adhesion were also frequent (53.3%). The Constant score and ranges of motion significantly improved at the final follow-up, compared with preoperative levels. However, clinical results at 6 months postoperatively were found to be significantly inferior to those observed at the final follow-up ($p{\leq}0.001$ for all factors). Functional impairment was the major complaint in 59.3% patients at the 6 months follow-up. Conclusions: Although arthroscopic capsular release yielded favorable outcome at the mean 24 months follow-up, pain and motion limitations at 6-month postoperatively persisted in more than 50% of our patients. While combined pathologies were commonly encountered during arthroscopy, although their effects on surgical outcome in adhesive capsulitis remains unclear in this study.

• KSBB Journal
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• v.11 no.6
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• pp.676-680
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• 1996

The characteristics of controlled drug release were studied for a biodegradable drug delivery system. A biodegradable chitosan matrix was prepared after swelling chitosan with 10%-acetic acid and adding sulfadiazine. The release behavior of sulfadiazine from the chitosan matrix was studied using the Higuchi's diffusion controlled model in phosphate buffer solutions of pH 7.4 and pH 1.2. The drug release time was delayed by increasing the content of sulfadiazine. The drug release at pH 7.4 was more delayed than that at pH 1.2. The reason is that chitosan has greater swelling abilities at low pH than at high pH. The apparent release rate constant(K) increased as the concentration of drug increased. In shoat, the formulation the biodegradable chitosan matrix to suppress the burst effect of drug release mechanism, which led to a sustained release pattern.

• Archives of Pharmacal Research
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• v.8 no.1
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• pp.7-14
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• 1985

Membrane-coated tablet of isonicotinic acid hydrazide (INAH) which releases INAH at the zero-order kinetics was deveoped. It consisted of a soluble tablet core surrounded by a porous membrane which controls the diffusion rate. Tablet cores were prepared by compressing granules of INAH and polyvinyl chloride (PVC) dissolved in methyl ethyl ketone in which micronized sucrose were suspended. Diffusion rate of INAH from the tablet through the membrane was constant until the loaded INAH in the core was almost released. The rate was independent of pH of the dissolution medium. Water-soluble sucrose particles behaved as a poreproducing material in the water-insoluble PVC film coat. The pH independency of the rate was probably due to the high solubility of INAH in the water of wide pH range. The diffusion rate of INAH could be controlled by chnaging the composition of the membrane or the coat weight. This membrane-coated INAH tablet seemed to be a powerful candidate for the controlled release drug delivery system (DDS) of INAH or other highly watersoluble drugs.