• 한국수자원학회논문집
• /
• 제42권6호
• /
• pp.457-464
• /
• 2009

본 논문에서는 상수관로의 파손자료를 이용하여 관로의 위험률을 산정하기 위해 사용되는 비례위험모형의 관로의 순차적 파손시간 예측정확도를 분석하고 이를 이용하여 관로의 경제적 교체 시간구간을 산정할 수 있는 방법론을 제시하였다. 비례위험모형에 기초한 생존함수를 이용하여 연구대상 관로들의 순차적 파손시간을 예측하고 이들을 기록된 파손시간과의 차이를 분석하였다. 이를 통하여 비례위험모형의 파손시간 예측 오차를 최소화하는 생존확률은 0.70인 것으로 결정되었으며, 세 번째 파손으로부터 일곱 번째 파손에 대한 모형만이 관로의 파손시간을 예측하는데 적합한 것으로 분석되었다. 생존확률 0.70과 순차적 파손사건에 대한 생존함수의 하한 및 상한을 이용하여 예제로 사용된 관로에 대해 예측된 파손시간의 95% 신뢰구간의 하한 및 상한을 추정하였다. 예측된 파손시간의 95% 신뢰 구간의 하한과 상한을 이용하여 관로 파손 경향모형인 General Pipe Break Prediction Models(GPBM)을 구축하고 이들을 관로의 한계파괴율과 결합하여 시간에 대한 해를 구하므로써 경제적 교체 시간구간을 산정하였다.

• 한국임상약학회지
• /
• 제22권4호
• /
• pp.340-346
• /
• 2012

Background: Amphotericin B is a mainstay in the treatment of many systemic fungal infections due to its wide antifungal spectrum and low incidence of resistance. However, the use of amphotericin B is limited by its nephrotoxicity. Objectives: The objective of this study was to evaluate the incidence and risk factors of renal adverse drug reactions (ADRs) of conventional amphotericin B (Fungizone$^{(R)}$). In addition, we compared the changes of serum creatinine (SCr) between patients who remained conventional amphotericin B and patients who were switched to liposomal amphotericin B after occurrence of renal adverse reactions. Methods: Adult hospitalized patients who reported renal adverse reactions caused by conventional amphotericin B from January 2011 to July 2012 at pharmacovigilance center in Yonsei University Healthcare System included in this study. ADRs scored as 'doubtful' in Naranjo probability ADR scale were excluded. We retrospectively analyzed patients' basic clinical characteristics, concurrent diseases or nephrotoxic drugs in order to find variables that can correlate with occurrence of renal ADRs. Changes in SCr were compared between conventional amphotericin B group and liposomal amphotericin B group. Results: A total of 231 ADRs after administration of conventional amphotericin B in 75 patients were reported to pharmacovigilance center and assessed their severities as 'possible', 'probable', or 'definite'. Renal adverse reaction was the most common ADR with incidence rate of 42% (96 of 231 ADRs). Mean change in SCr from baseline was 0.26 mg/dL (change % 37.8) and statistically significant (p=0.000). Simple correlations analysis revealed that the number of concurrent diseases and number of nephrotoxic drugs were positively correlated with changes in SCr, but these results were not statistically significant. Among 43 patients who remained amphotericin B after occurrence of renal ADRs, 27 patients was administered conventional amphotericin B and 16 patients changed to liposomal amphotericin B. Mean change in SCr in amphotericin B group was 0.23 mg/dL (32.75%), whereas mean change in SCr in liposomal amphotericin B group were -0.28 mg/dL (19.38%) and difference between two groups was statistically significant (p=0.003). The numbers of patient with SCr elevation more than 30% were 9 (33.3%) in amphotericin B group and 2 (12.5%) in liposomal amphotericin B group (Odd Ratio=3.50, 95% Confidence Interval 0.65-18.85; p=0.130). Conclusion: An analysis of ADRs due to amphotericin B administration revealed significant mean changes in SCr from baseline. Switching to liposomal amphotericin B showed significant decrease in SCr compared with conventional amphotericin B.

• Journal of Chest Surgery
• /
• 제53권3호
• /
• pp.104-113
• /
• 2020

Background: Accurate intraoperative assessment of mediastinal lymph nodes is a critical aspect of lung cancer surgery. The efficacy and potential for upstaging implicit in these dissections must therefore be revisited in the current era of uniportal video-assisted thoracoscopic surgery (VATS). Methods: A retrospective study was conducted in which 544 patients with stage I (T1abc-T2a, N0, M0) primary lung cancer were analyzed. To assess risk factors for nodal upstaging and to limit any imbalance imposed by surgical choices, we constructed an inverse probability of treatment-weighted (IPTW) logistic regression model (in addition to non-weighted logistic models). We also evaluated risk factors for early locoregional recurrence using IPTW logistic regression analysis. Results: In the comparison of uniportal and multiportal VATS, the resected lymph node count (14.03±8.02 vs. 14.41±7.41, respectively; p=0.48) and rate of nodal upstaging (6.5% vs. 8.7%, respectively; p=0.51) appeared similar. Predictors of nodal upstaging included tumor size (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.12-2.70), carcinoembryonic antigen level (OR, 1.11; 95% CI, 1.04-1.18), and histologically confirmed pleural invasion (OR, 3.97; 95% CI, 1.89-8.34). The risk factors for locoregional recurrence within 1 year were found to be number of resected N2 nodes, age, and nodal upstaging. Conclusion: Uniportal and multiportal VATS appear similar with regard to accuracy and thoroughness, showing no significant difference in the extent of nodal dissection.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권10호
• /
• pp.4339-4345
• /
• 2015

Occupational exposure to wood dust is one cause of nasopharyngeal cancer (NPC); however, assessing this exposure remains problematic. Therefore, the objective of this study was to develop a semi-quantitative exposure assessment method and then utilize it to evaluate the association between occupational exposure to wood dust and the development of NPC. In addition, variations in risk by histology were examined. A case-control study was conducted with 327 newly diagnosed cases of NPC at the National Cancer Institute and regional cancer centers in Thailand with 1:1 controls matched for age, gender and geographical residence. Occupational information was obtained through personal interviews. The potential probability, frequency and intensity of exposure to wood dust were assessed on a job-by-job basis by experienced experts. Analysis was performed by conditional logistic regression and presented in odds ratio (ORs) estimates and 95% confidence intervals (CI). Overall, a non significant relationship between occupational wood dust exposure and NPC risk for all subjects was observed (ORs=1.61, 95%CI 0.99-2.59); however, the risk became significant when analyses focused on types 2 and 3 of NPC (ORs=1.62, 95%CI 1.03-2.74). The significant association was stronger for those exposed to wood dust for > 10 year (ORs=2.26, 95%CI 1.10-4.63), for those with first-time exposure at age > 25 year (ORs=2.07, 95%CI 1.08-3.94), and for those who had a high cumulative exposure (ORs=2.17, 95%CI 1.03-4.58) when compared with those considered unexposed. In conclusion, wood dust is likely to be associated with an increased risk of type 2 or 3 NPC in the Thai population. The results of this study show that semi-quantitative exposure assessment is suitable for occupational exposure assessment in a case control study and complements the information from self-reporting.

• Asian-Australasian Journal of Animal Sciences
• /
• 제26권10호
• /
• pp.1474-1483
• /
• 2013

The objective was to evaluate the use of prediction equations based on the chemical composition of feedstuffs to estimate the values of apparent metabolisable energy corrected for nitrogen balance (AMEn) of corn and soybean meal for broilers. For performance and carcass characteristics, 1,200 one-d-old birds (male and female) were allotted to a completely randomised factorial $2{\times}8$ (two genders and eight experimental diets) with three replicates of each sex with 25 birds. In the metabolism trial, 240 eight-d-old birds were distributed in the same design, but with a split plot in time (age of evaluation) with five, four and three birds per plot, respectively, in stages 8 to 21, 22 to 35, and 36 to 42 d of age. The treatments consisted of the use of six equations systems to predict the AMEn content of feedstuffs, tables of food composition and AMEn values obtained by in vivo assay, totalling eight treatments. Means were compared by Scott-Knott test at 5% probability and a confidence interval of 95% was used to check the fit of the energy values of the diets to the requirements of the birds. As a result of this study, the use of prediction equations resulted in better adjustment to the broiler requirements, resulting in better performance and carcass characteristics compared to the use of tables, however, the use of energy values of feedstuffs obtained by in vivo assay is still the most effective. The best equations were: AMEn = 4,021.8-227.55 Ash (for corn) combined with AMEn = -822.33+69.54 CP-45.26 ADF+90.81 EE (for soybean meal); AMEn = 36.21 CP+85.44 EE+37.26 NFE (nitrogen-free extract) (for corn) combined with AMEn = 37.5 CP+46.39 EE+14.9 NFE (for soybean); and AMEn = 4,164.187+51.006 EE-197.663 Ash-35.689 CF-20.593 NDF (for corn and soybean meal).

• 한국임상수의학회지
• /
• 제30권4호
• /
• pp.258-263
• /
• 2013

The primary goal of this study was to compute sample sizes required to achieve the each aim of a variety of foot-and-mouth disease (FMD) surveillance programs, using a statistically valid technique that takes the following factors into account: sensitivity (Se) and specificity (Sp) of diagnostic test system, desired minimum detectable prevalence, precision, population size, and desired power of the survey. In addition, sample sizes to detect FMD if the disease is present and also as proof of freedom were computed. The current FMD active surveillance programs consist of clinical, virological, and serological surveillance. For the 2012 serological surveillance, annual sample sizes (n = 265,065) are planned at four separate levels: statistical (n = 60,884) and targeted (n = 115,232) at breeding pig farms and slaughter house, in together with the detection of structural proteins (SP) antibodies against FMD (n = 88,949). Overall, the sample size was not designed taking the specific aims of each surveillance stream into account. The sample sizes for statistical surveillance, assuming stratified two-stage sampling technique, was based to detect at least one FMD-infected case in the general population. The resulting sample size can be used to obtain evidence of freedom from FMD infection, not for detecting animals that have antibodies against FMD virus non-structural proteins (NSP). Additionally, sample sizes for targeted surveillance were not aimed for the population at risk, and also without consideration of statistical point of view. To at least the author's knowledge, sampling plan for targeted, breeding pig farms and slaughter house is not necessary and need to be included in the part of statistical surveillance. Assuming design prevalence of 10% in an infinite population, a total of 29 animals are required to detect at least one positive with probability of 95%, using perfect diagnostic test system (Se = Sp = 100%). A total of 57,211 animals needed to be sampled to give 95% confidence of estimating SP prevalence of 80% at the individual animal-level with a precision of ${\pm}5%$, assuming 800 herds with an average 200 heads per farm, within-farm variance of 0.2, between-farm variance of 0.05, cost ratio of 100:1 of farm against animals. Furthermore, 779,736 animals were required to demonstrate FMD freedom, and the sample size can further be reduced depending on the parameters assumed.

• 한국구조물진단유지관리공학회 논문집
• /
• 제17권6호
• /
• pp.130-137
• /
• 2013

본 연구는 실험계획법을 통하여 과산화수소로 발포된 석고 혼입 경량기포콘크리트로 통계적 분석을 실시하였다. 본 실험에서는 경량기포콘크리트를 구성하는 각 재료의 혼합비율을 실험인자로 설정하고, 실험을 통해 얻어진 반응변수에 대한 통계적 분석으로 역학적 특성을 평가 하였다. 실험인자는 석고혼입율, 물결합재비 및 발포제첨가비 이며, 반응변수는 겉보기밀도, 압축강도, 휨강도이다. 경량기포콘크리트의 배합은 반응표면설계의 Box-Behnken (B-B)계획법에 의해 총 15회의 실험점을 설정하였다. 본 연구결과 다음과 같은 결론을 얻었다. 반응변수에 대한 각 설명인자 (석고혼입율, 물결합재비, 발포제첨가비)의 유의확률값은 유의수준 ${\alpha}$=0.05에서 유의한 것으로 추정되었다. 경량기포콘크리트의 겉보기밀도에 대한 반응표면 분석 결과, 물결합재비 와 발포제첨가비만 유의 (${\alpha}$=0.05)한 것으로 추정되었으며, 겉보기밀도와 기포량 및 함수율과의 관계는 반비례함을 확인 알 수 있었다. 경량기포콘크리트의 압축강도에 대한 반응표면 분석 결과, 물결합재비, 발포제첨가비 및 발포제첨가비의 제곱항이 유의 (${\alpha}$=0.05)한 것으로 추정되었다. 경량기포콘크리트의 휨강도에 대한 반응표면 분석 결과, 물결합재비 와 발포제첨가비만 유의 (${\alpha}$=0.05)한 것으로 추정되었다. 다중 반응 최적법을 통해 반응변수들의 목표값을 만족하는 최적조건 영역을 확인할 수 있었다.

• 한국항해항만학회지
• /
• 제33권3호
• /
• pp.181-191
• /
• 2009

일반적으로 상선에서 해상운송 사고의 주된 원인은 원의 인적과실로 고려되고 있다. 본 논문에서는 선박에 승선 중인 선장, 1항사, 2항사 및 3항사를 포함하는 갑판사관들이 야기할 수 있는 사고 위기를 평가하기 위한 인적과실 모델(HEM)의 구축기법에 관해서 기술했다. 연구범위는 130척의 선박을 관리하는 회사에 소속된 542명의 갑판사관들을 대상으로 했다. 우선, 갑판사관들의 인적 데이터에 대한 통계적 분석과 전문가에 의한 브레인스토밍 과정을 통해서 KEM을 구축하고, 인적과실을 평가하기 위한 인적요소들의 변수 $\upsilon$와 $\upsilon$에 대한 평가등급 EP($\upsilon$) 및 가중치 $\alpha$, 갑판사관의 직책별 가중치 $\beta$ 등을 결정했다. 그리고 선박의 사고기록에 대한 통계분석 결과, 인적과실에 의한 사고원인 비율 ${\gamma}_H$와 외적과실에 의한 사고원인 비율 ${\gamma}_B$은 0.517(51.7%)과 0.483(48.3%)로 나타났다. $\upsilon$의 상관계수는 95%(p < 0.05) 신뢰구간에서 유의함을 확인하였고, 각 갑판사관의 위기수준 RL의 정규 확률분포 분석으로부터 HEM의 타당성을 검토했다.

• Journal of Preventive Medicine and Public Health
• /
• 제39권2호
• /
• pp.115-122
• /
• 2006

Objectives : This study was conducted to examine the relationships of the several socioeconomic position indicators with the mortality risk in a representative longitudinal study of South Korea. Methods : The 1998 National Health and Nutrition Examination Survey was conducted on a cross-sectional probability sample of South Korean households, and it contained unique 13-digit personal identification numbers that were linked to the data on mortality from the National Statistical Office of Korea. Of 5,607 males and females, 264 died between 1999 and 2003. Cox's regression was used to estimate the relative risks (RR) and their 95% confidence intervals (CI) of mortality. Results: Socioeconomic differences in mortality were observed after adjustments were made for gender and age. Compared with those people having college or higher education, those people without any formal education had a greater mortality risk (RR=2.21, 95% CI=1.12-4.40). The mortality risk among manual workers was significantly greater than that for the non-manual workers (RR=2.73, 95% CI=1.47-5.06). A non-standard employment status was also associated with an increase in mortality: temporary or daily workers had a greater mortality risk than did the full-time workers (RR=3.01, 95% CI=1.50-6.03). The mortality risk for the low occupational class was 3.06 times greater than that of the high and middle occupational classes (95% CI=1.75-5.36). In addition, graded mortality differences according to equivalized monthly household income were found. A reduction of monthly household income by 500 thousand Korean Won (about 400 US dollars) was related with a 20% excess risk of mortality. Self-reported poor living standards were also associated with an increased risk of mortality. Those without health insurance had a 3.63 times greater risk of mortality than the insured (95% CI=1.61-8.19). Conclusions: This study showed the socioeconomic differentials in mortality in a national longitudinal study of South Korea. The existence of socioeconomic mortality inequalities requires increased social discussion on social policies in Korean society. Furthermore, the mechanisms for the socioeconomic inequalities of mortality need to be explored in future studies.

• 한국산학기술학회논문지
• /
• 제18권6호
• /
• pp.585-595
• /
• 2017

본 연구는 정서기반 학습동기향상 프로그램이 전문대학생의 학습동기와 사회적 지지에 어떠한 영향을 미치는지를 알아보는데 목적이 있다. 개발된 최종 프로그램은 학습동기 I, 학습코칭, 학습동기 II로 총 12회기로 구성되어 있으며, 각 회기마다 자기평가 및 성찰일지를 작성하여 성찰 시간을 갖도록 진행하였다. 연구대상은 G시 소재 K전문대학 재학생들 중 2016학년도 1학기 심리학 관련 교양 교과목을 수강한 공학계열 재학생 38명으로, 실험집단 19명과 통제집단 19명을 비확률 표본 추출에 의거 배치하였다. 실험집단에는 정서기반 학습동기향상 프로그램을 주 강사 1명과 보조 강사 1명 총 2명의 강사로 한 주에 1회기씩 총 12회기가 실시되었고, 자료 분석을 위하여 독립표본 t-검증, 대응표본 t-검증, 회기별 소감문 분석이 실시되었다. 연구결과는 첫째, 정서기반 학습동기 향상 프로그램에 참여한 실험집단은 통제집단에 비하여 학습동기와 하위요인 자신감, 만족감에 유의미한 차이가 있었다. 둘째, 정서기반 학습동기 향상 프로그램에 참여한 실험집단은 통제집단에 비하여 사회적 지지에서는 통계적으로 유의미한 차이가 나타나지 않았다. 참여 학생들의 소감문 분석에서는 본 프로그램이 학습동기와 사회적 지지에 영향을 미치는 것으로 나타났다. 마지막으로 본 연구결과에 대한 논의 및 함의를 기술하였다.