• 약학회지
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• 제46권1호
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• pp.39-46
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• 2002

The water fraction exhibiting anticancer activity was prepared from 70% methanol extract of Artemisis argyi by stepwise solvent partioning. This water fraction(5 $\mu$g/ml concentration) showed a considerable cytotoxicity against leukemic L1210 cells with a maximal value of 92% for 3 days culture. Contrastingly to such substantial anticancer activities the identical fraction showed far low toxicity against normal lymphocytes than chloroform fraction of Artemisia argyi mitomycine and 5-fluorouracil at every concentration ranging 0.01$\mu$g/ml~10.00$\mu$g/ml. The cytotoxicity displayed against L1210 cells by the water fraction of Artemisia was found to be proportinal to the decrease of viability of L1210 cells. On the other hand, $O_2$ion generation in L1210 cells appeared to be elevated in accordance to cytotoxicity by the water fraction with concurrent increases of superoxide dismuatse (SOD) and glutathione peroxidase (GPx) which are responsible for the conversion of $O_2$ ion and $H_2O$$_2$ respectively These findings taken together indicate that the death of L1210 cells by the water fraction of Auemisia atgyi, may be induced at least in part by the detrimental action of reactive oxygen species (ROS) including $O_2$- in spite of substantial extorts of SOD and GPx to overcome the attack of ROS.

• Nuclear Engineering and Technology
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• 제48권4호
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• pp.1047-1057
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• 2016

Design engineering process for field programmable gate array (FPGA)-based reactor trip functions are developed in this work. The process discussed in this work is based on the systems engineering approach. The overall design process is effectively implemented by combining with design and implementation processes. It transforms its overall development process from traditional V-model to Y-model. This approach gives the benefit of concurrent engineering of design work with software implementation. As a result, it reduces development time and effort. The design engineering process consisted of five activities, which are performed and discussed: needs/systems analysis; requirement analysis; functional analysis; design synthesis; and design verification and validation. Those activities are used to develop FPGA-based reactor bistable trip functions that trigger reactor trip when the process input value exceeds the setpoint. To implement design synthesis effectively, a model-based design technique is implied. The finite-state machine with data path structural modeling technique together with very high speed integrated circuit hardware description language and the Aldec Active-HDL tool are used to design, model, and verify the reactor bistable trip functions for nuclear power plants.

• 한국임상약학회지
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• 제29권4호
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• pp.223-230
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• 2019

Background: Small-molecule tyrosine kinase inhibitors (TKIs) have had major impacts on anticancer therapy by targeting the catalytic activities of dysregulated tyrosine kinases. TKIs have not presented traditional toxicities; however, some serious adverse effects, including hepatotoxicity, have been documented in clinical trials and post-marketing surveillance. Although TKI-induced hepatotoxicity can cause severe clinical complications in patients, the underlying mechanism is still unclear. Methods: Studies on TKI-induced hepatotoxicity were identified by Pubmed search, and relevant articles were reviewed. Results: Immunoallergic reaction, cytochrome P (CYP) 450 polymorphisms, and formation of reactive metabolites are under consideration as mechanisms of TKI-induced hepatotoxicity. Host protein-drug metabolite conjugates are recognized as antigens by class II major histocompatibility complexes and are believed to cause liver injuries. Polymorphisms in CYP, which influences TKI metabolism, can slow TKI metabolism and may induce development of hepatotoxicity. The formation of reactive metabolites during drug metabolism can induce hepatotoxicity by directly causing cytotoxicity, leading to cell dysfunction, and indirect toxicity by mediating secondary immune reactions. Concurrent use of various medications with TKI can also cause hepatotoxicity by affecting drug transporter or enzyme activities. Conclusion: Periodic monitoring of patients taking TKIs and risk/benefit reassessments though post marketing surveillance are necessary to prevent hepatotoxicity.

• 통상정보연구
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• 제7권4호
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• pp.325-349
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• 2005

One aspect of the globalization of the financial market after the 1980s is represented by the concurrent monetarization of the national stock markets. As the IR activity is regarded as a new financial productivity measure, the IR activity in the stock market is being emphasized domestically and internationally. This study analyzes domestic IR activities and compares them with foreign IR activities. Specifically the "road show", a typical IR activity, which is known to resolve the information asymmetry between the firm and the investors is analyzed to see the extent of the their value increase impact on the firm. The study employs domestic and international firms that publicly announced "road shows" after April 2004. Event studies are done to see the existence of abnormal return after the public announcement of road shows. Domestic firms were found to have positive IR impacts on the stock prices, but international firms were found to have negative IR impacts on the stock prices. Also it was found that international public announcement of the road show have stronger positive impact on the stock price than domestic public announcement. The investigation of the statistically significant difference of CAR before and after the fair public announcement enforcement rule showed that the positive CAR impact is strengthened after the adoption of the rule. The conclusion is that increase of the firm value after the road show implies that the information asymmetry is reduced by the active IR actions on the firm side. The policy implication is that we have to reassure the understanding of the role of the IR activities. Specifically Korean firms may have to encourage IR activities to share the information of the firms with the investors, which may result in the trustworthy relationship between the firms and investors.

• 한국임상수의학회지
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• 제30권6호
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• pp.464-467
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• 2013

6년령의 중성화된 암컷 코카스파니엘이 전신적인 건성지루증으로 내원하였다. 간효소 활성도 증가 및 초음파 상의 stellate pattern에 근거하여 담낭점액종으로 진단되었다. 16개월 동안 담낭점액종에 대한 약물처치가 이루어졌으나 치료반응이 없었다. 호르몬 및 조직병리학 검사를 통하여 갑상선기능저하증이 확인되었다. Levothyroxine 치료 후 피부, 혈청화학 및 초음파상의 이상소견들이 빠르게 회복되었다. 본 증례보고는 담낭점액종과 갑상선기능저하증이 병발한 개에서 갑상선기능저하증에 대한 치료 후 피부병변, 혈정화학 및 초음파상의 연속적인 변화를 기술하고 있다.

• 한국시뮬레이션학회논문지
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• 제15권1호
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• pp.1-10
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• 2006

유연생산시스템은 많은 병렬적이고 동시 발생적인 기계들, 장치들, 수송 시스템들로 구성되며, 이러한 것들은 각각 버퍼들, 도구들, 라우터들로 나누어진다. 시스템에서 여러 생산품들의 병렬적인 흐름은 자원들을 이용하기 위해 서로 경쟁하게 되며, 유연생산시스템의 이러한 특징들로 인해 교착상태가 발생한다. 교착상태는 상대방이 점유하고 있는 자원을 서로 요구하는 과정에서 흐름이 멈추어진 상태를 말하므로, 이러한 교착상태의 탐지와 회피는 매우 중요한 문제이다. 이 사실에 근거하여 일반 플레이스와 자원공유플레이스 사이의 관계를 나타내는 DAPN(Deadlock Avoidance Petri Wet)을 정의하여 교착상태를 탐지하고 회피하기 위한 새로운 알고리즘을 연구하였다. 또한 제안된 알고리즘을 유연생산시스템의 특징을 가진 모델에 적용하여 그 결과를 제시한다.

• 한국통신학회논문지
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• 제17권11호
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• pp.1228-1237
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• 1992

네트워크 관리를 위한 원격 위임 모델은 관리 기능들을 관리자의 피관리자 간에 적절하게 분배함으로써 보다 신뢰성 있고 효율적인 네트워크 관리를 지원하고, 복잡하고 고속인 네트워크 내에서 네트워크 관리의 신뢰도를 높이기 위한 모델이다. 이 모델에서는 관리자는 관리 기술 언어로 미리 기술되어 있는 관리 프로그램의 실행을 피관리자에게 위임하며, 피관리자는 프로그램 내의 피리미티브들을 이용하여 관리 객체들을 효율적으로 감시, 통제할 수 있게 된다. 본 논문에서는 관리자가 피관리자에게 위임할 관리 스크립트를 작성하기 위한 포괄적인 관리 알고리즘을 제안하고, OSI 장애 관리 모델을 부분적으로 구현하였다. 그리고 제안된 관리 알고리즘은 관리 정보를 병행으로 엑세스할 수 있으며, 위임을 효율적으로 지원할 수 있음을 몇가지 예를 들어 설명한다. 특히 관리 알고리즘은 객체지향 병행 언어인 ABCL로 쉽게 표현될 수 있어 구현이 용이하고, 다양하고 명시적인 동기화 메카니즘을 제공할 수 있다.

• 품질경영학회지
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• 제18권2호
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• pp.54-68
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• 1990

Contingency response in a FMS system requires that the system be able to identify and evaluate a number of alternatives. This paper is outlined that DSS completes with a problem processor in corporating Timed Petri Nets model, and a data base system. DSS enables the FMS user to get the maximum benefit from a FMS. The structure of this DSS parallels the organizational activities involved in running the FMS. In designing a shop floor controller for FMS, interactions between the different real time, discrete event functions must be established. The specification of the machine tool and material handling system functions working as a concurrent and cooperative system is given in terms of Timed Petri Nets. In addition, the basic concepts and uses of Petri Nets are surveyed. The system to be studied is first modelled by a Timed Petri Nets and then procedure for evaluating the FMS system performance are presented. Numerical examples are studied to illustrate a session of the FMS used-DSS interaction.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1998년도 추계종합학술대회 논문집
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• pp.519-522
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• 1998

The Constructive Battle simulation Model is very important to the recent military training for the substitution of the field training. However, real battlefield systems operate under rea-time conditions, they are inherently distributed, concurrent and dynamic. In order to reflect these properties by the computer-based simulation systems which represent real world processes, we have been developing constructive simulation model for several years. The constructive simulation system is one of the famous real-time system software, nd the one common feature of all real-time systems is defined as the correctness of the system depend not only on the logical result of computation, but also on the time at which the results are produced. Conventionally, scheduling and resource allocation activities which have timing constraints are major problem of real-time computing systems. To overcome these constraints, we elaborated on these issues and developed the simulation system on commercially available hardware and operating system with lock-free resource allocation scheme and rae monotonic scheduling.

• 대한산업공학회지
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• 제24권2호
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• pp.185-197
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• 1998

Engineering design involves the specification of many variables that define a product, how it is made, and how it behaves. Before some variables can be determined, other variables must first be known or assumed. This fact implies a precedence order of the variables, and of the tasks of determining these variable consequently. Moreover, design of complex systems may involve a large number of design activities. In this paper, the activity-activity incidence matrix is considered as a representation of design activity analysis which mainly focuses on the precedence constraint. In order to analyze the activity-activity incidence matrix, a heuristic algorithm is proposed, which transforms an activity-activity, parameter-formula, and parameter-parameter incidence matrix into a lower triangular form. The analysis of the structured matrices can not only significantly reduce the overall project complexity by reorganizing few critical tasks in practice, but also aims at obtaining shorter times considering the solution structure by exploring concurrency.