• Journal of the Society of Cosmetic Scientists of Korea
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• v.17 no.1
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• pp.64-80
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• 1991

The SKINTEX Method is based on a two-compartment physico-chemical model which includes a Biomembrane Barrier in compartment one and an organized macromolecular matrix in compartment two. Test samples absorb onto or permeate through the keratin/collagen Biomembrane Barrier and then can interact with the organized macromolecular matrix. Changes in the integrity of the barrier release a dye indicator: Changes in the matrix can alter its transparency. The sum of these two responses is read spectrophotometrically at 470nm. An early investigation of 950 chemicals and formulations in the SKINTEX System produced results which were 89% concordance to in vivo Draize dermal irritation results obtained with 24-hour occluded application of test samples with-out abrasion and standard scoring. Alkaline materials were analyzed in a specialized SKINTEX AMA Protocol. In this early study, the model did not distinguish nonirritant test materials and formulation with PDII(Primary Dermal Irritation Index)in the range from 0 to 1.2, A High Sensitivity Assay Protocol(HSA)was developed to amplify the changes in both compartments of this model and provide more accurate calibration of these changes. A study of 60 low irritation test samples including cosmetics, household products, chemicals and petro-chemicals distinguished nonirritants with PDII $\leq$ 0.7 for 26 of 30 nonirritants. A second protocol was developed to evaluate the SKINTEX model predictability with respect to human irritation. The Human Response Assay (HRA )has been optimized based on differences in penetration and irritation responses in humans and rabbits. An additional 32 test materials with different mechanisms and degrees of dermal toxicity were evaluated by the HRA. These in vitro results were 86% concordant to human patch test results. In order to further evaluate this model, a Standard Chemical Labelling (SCL) Protocol was developed to optimize this system to predict Draize dermal irritation results after a 4-hour application of the test material. In a study of 52 chemicals including acids, bases, solvents, salts, surfactants and preservatives, the SCL results demonstrated 85% concordance to Draize results for a 4-hour application of test samples on non-abraded rabbit skin. The SKINTEX System, including three specialized protocols, provided results which demonstrated good correlation to the endpoint of dermal irritation in man and rabbits at different application times.

• Journal of Oriental Neuropsychiatry
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• v.31 no.1
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• pp.1-12
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• 2020

Objectives: The purpose of this study was to evaluate the reliability and validity of the instrument on pattern identification for insomnia (PIT-Insomnia) and verify the correlation between PIT-Insomnia and psychological tests. Methods: Two evaluators examined the pattern identification of the participants who met insomnia disorder diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-5) and took the Insomnia Severity Index (ISI) score over 15 once manually and twice using the PIT-Insomnia to measure the inter-rater and test-retest reliability. We also conducted the following surveys: the Pittsburgh Sleep Quality Index (PSQI), the Korean version of Beck's depression inventory (K-BDI), the Korean version of the State-Trait Anxiety Inventory (STAI-K), the Korean Symptom checklist-95 (KSCL-95), and the EuroQol-5 dimension (EQ-5D), to measure concurrent validity and correlation between the PTI-Insomnia and psychological tests. Results: 1. The test-retest reliability analysis of the pattern identification results showed moderate agreement, and test-retest reliability analysis of each pattern identification score showed agreements from poor to moderate. 2. The inter-rater reliability analysis of the pattern identification results via manual showed slight agreement, when analysis was performed with calibration, the inter-rater reliability analysis of the pattern identification results via manual showed fair agreement. 3. The concordance analysis between results via manual and the PIT-Insomnia showed poor agreement, when the analysis was performed with calibration, concordance analysis showed fair agreement. 4. The concordance analysis between the PIT-Insomnia and the PSQI showed positive linear correlation. 5. The concordance analysis between the PIT-Insomnia and the PSQI, K-BDI, STAI-K, KSCL-95, and EQ-5D showed that non-interaction between the heart and kidney have positive linear correlation with the K-BDI, anxiety item of KSCL-95, dual deficiency of the heart-spleen have positive linear correlation with somatization item of KSCL-95, paranoia item of KSCL-95, heart deficiency with timidity have positive linear correlation with stress vulnerability item of KSCL-95, parania item of KSCL-95, phlegm-fire harassing the heart have positive linear correlation with K-BDI, paranoia item of KSCL-95, depressed liver qi transforming into fire have positive linear correlation with the anxiety item of KSCL-95, parania item of KSCL-95, all pattern identification have negative linear correlation with EQ-5D. Conclusions: The PIT-Insomnia has moderate agreement of reliability and reflects the severity of insomnia since it has some concurrent validity with the PSQI. There are some correlations between the PTI-Insomnia with specific psychological tests, so we could suggest it can be used appropriately in the clinical situation.

• Tuberculosis and Respiratory Diseases
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• v.50 no.1
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• pp.42-51
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• 2001

Background : Recently, cardiopulmonary exercise testing (CPX) has become a popular diagnostic method for differentiating the main cause of exertional dyspnea or exercise limitation. We evaluated the difference in the CPX results according to interpretative algorithms and the methals of exercise in Korea. Method : Sixty-six patients with chronic lung disease and 48 adults with dyspneic symptoms, but with no abnormalities in a spirometry performed symptom limited CPX, were included in this study. The results were interpreted using both Wasserman's(WA) and Eschenbacher's algorithm (EA), and a comparison between both algorithms was made. Thirty-three healthy medical students performed the CPX with a cycle ergometer and treadmill. The results were interpreted with EA and the concurrence in interpretations was evaluated accord ing to the methods of exercise. Results : 1. In patients with chronic lung disease, the overall concordance rate between the two algorithms was 63.6%. The concordance rates waw 69.8% in patients with obstructive, 25.0% in those with restrictive, and 66.7% in those with mixed pulmonary insufficiency. In patients with dyspneic symptoms but normal findings in resting spirometry, the concordance rate was 60.4%. 2. In healthy medical students, in results inter preted with EA, the concordance rate between the cycle ergometer and treadmill exercise was 25.0%. Conclusion : Both interpretative algorithms and methods of exercise may affect the CPX results. In using CPX as a diagnostic test for the causes of dyspnea in the Korean population. the interpretative algorithms and method of exercise need to be standardized, and a predictive $VO_2$max equation needs to be established.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.22 no.1
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• pp.67-75
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• 1992

Transcranial radiograph is widely used in the diagnosis of craniomandibular disorder because it can be used by the dentist with relative ease in spite of image distortion. But correct information can be obtained only when one know the image change by projection angulation. The author compared the condyle position in the 3 groups of transcranial radiographs (horizontal angulation - 0°, 5°, individualized) with that in the individualized corrected lateral tomogram by objective and subjective evaluation methods. The results were as follows: 1. Among 3 transcranial groups, the condyle position in individualized group showed the highest concordance rate with that in the tomogram group in objective and subjective evaluation methods. 2. Correlation coefficient between individualized transcranial group and tomogram group in objective evaluation method was highest (P≤0.01). 3. Image clarity in individualized transcranial group was worse than that of the other two transcranial groups.

• The Korean Journal of Cytopathology
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• v.1 no.1
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• pp.27-35
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• 1990

The authors report series of 360 cases of transthoracic fine-needle aspiration cytology (TFNA) from Oct. 1982, through Aug. 1986 at the Seoul National University Hospital. A diagnosis of neoplastic lesion was established in 50.3% of the cases. A non-neoplastic diagnosis was made in 38.5%, nondiagnostic one in 6.5% and inadequate one in 4.7% of the total. Statistical findings on cytological diagnoses were as follows. Specificity was 100% ; sensitivity, 92% ; predictive value for positive, 1.0 ; predictive value for negative, 0.9 ; concordance rate, 84.2% ; diagnostic accuracy in non-neoplastic lesion, 65.4%, and typing accuracy in malignant tumor, 0.77.

• Journal of Korea Multimedia Society
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• v.21 no.2
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• pp.138-146
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• 2018

In this paper, we describe an algorithm for extracting depth information from a single image based on CNN. When acquiring three-dimensional information from a single two-dimensional image using a deep-learning technique, it is difficult to accurately predict the edge portion of the depth image because it is a part where the depth changes abruptly. in this paper, we introduce the concept of pixel-wise confidence to take advantage of these characteristics. We propose an algorithm that estimates depth information from a highly reliable flat part and propagates it to the edge part to improve the accuracy of depth estimation.

• Annual Conference on Human and Language Technology
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• 2017.10a
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• pp.175-178
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• 2017

본 연구는 거시적 빅데이터 인문학과 미시적 언어 텍스트 검색 시스템을 구축하고, 이를 통해서 언어를 통한 문화의 역동적 변화를 시간적 순서에 따라 살펴보고자 한다. 연구의 최종적인 목표는 문화도 생물체처럼 변화하는 존재라 여기고 그 구성요소들을 연구한다는 뜻인 '문화체학(文化體學; Culturomics)'과 같은 '인문학 + 정보과학 + 사회과학' 등등의 다학문간의 융합적 연구에 있다. 이 시스템을 통해서 인류 역사의 기록인 텍스트 빅데이터를 통한 인문학적 성찰을 시각화하고 있다. 이러한 구글의 업적은 인문학과 정보기술의 융합을 통해서 인문학 자체의 지평을 넓히고, 사회과학을 변형시키고, 산업과 상아탑 사이의 관계를 재조정하는데 있다.

• Genomics & Informatics
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• v.8 no.4
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• pp.212-218
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• 2010

An accurate system for predicting the survival of patients with oral squamous cell carcinoma (OSCC) will be useful for selecting appropriate therapies. A nomogram for predicting survival was constructed from 96 patients with primary OSCC who underwent surgical resection between January 1994 and June 2003 at the Yonsei Dental Hospital in Seoul, Korea. We performed univariate and multivariate Cox regression to identify survival prognostic factors. For the early stage patients group, the nomogram was able to predict the 5 and 10 year survival from OSCC with a concordance index of 0.72. The total point assigned by the nomogram was a significant factor for predicting survival. This nomogram was able to accurately predict the survival after treatment of an individual patient with OSCC and may have practical utility for deciding adjuvant treatment.

• Journal of The Korean Astronomical Society
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• v.43 no.4
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• pp.135-139
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• 2010

We present the result of our investigation on the impact of the low Solar abundance of Asplund and collaborators (2004) on the derived ages for the oldest star clusters based on isochrone fittings. We have constructed new stellar models and corresponding isochrones using this new solar mixture with a proper Solar calibration. We have found that the use of the Asplund et al. (2004) metallicity causes the typical ages for old globular clusters in the Milky Way to be increased roughly by 10%. Although this may appear small, it has a significant impact on the interpretation for the formation epoch of Milky Way globular clusters. The Asplund et al. (2004) abundance may not necessarily threaten the current concordance cosmology but would suggest that Milky Way globular clusters formed before the reionization epoch and before the main galaxy body starts to build up. This is in contrast to the current understanding on the galaxy formation.

• Korean Journal of Veterinary Service
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• v.33 no.4
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• pp.335-340
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• 2010

On the basis of the 2009 business plan, 20,394 Korean native cattle and beef cattle were carried examination of bovine tuberculosis by using ELISA technique from March to December. As a result, 66 cattle tested positive for tuberculosis and showed 0.32% positive ratio. Intradermal tuberculin test about 66 cases of ELISA positive cattle was carried out, and all of 66 cattle were confirmed as negative. However, when 7 PPD-positive cattle derived from slaughterhouse were tested by 20k ELISA kit and MS ELISA kit, 3 (2 suspect) cattle and 5 cattle showed positive results, respectively. As compared to the results of PPD test, the concordance rates were 43% (71% included suspect) with 20k ELISA kit and 71% with MS ELISA kit.