• Tuberculosis and Respiratory Diseases
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• 제81권1호
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• pp.59-72
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• 2018

Background: It remains uncertain if $interferon-{\gamma}$ release assays (IGRAs) are superior to the tuberculin skin test (TST) for the diagnosis of active tuberculosis (TB) or latent tuberculosis infection (LTBI) in immunosuppressed populations including people with human immunodeficiency virus (HIV) infection. The purpose of this study was to systematically review the performance of IGRAs and the TST in people with HIV with active TB or LTBI in low and high prevalence TB countries. Methods: We searched the MEDLINE database from 1966 through to January 2017 for studies that compared results of the TST with either the commercial QuantiFERON-TB Gold in Tube (QFTGT) assay or previous assay versions, the T-SPOT.TB assay or in-house IGRAs. Data were summarized by TB prevalence. Tests for concordance and differences in proportions were undertaken as appropriate. The variation in study methodology was appraised. Results: Thirty-two studies including 4,856 HIV subjects met the search criteria. Fourteen studies compared the tests in subjects with LTBI in low TB prevalence settings. The QFTGT had a similar rate of reactivity to the TST, although the first-generation version of that assay was reactive more commonly. IGRAs were more frequently positive than the TST in HIV infected subjects with active TB. There was considerable study methodology and population heterogeneity, and generally low concordance between tests. Both the TST and IGRAs were affected by CD4 T-cell immunodeficiency. Conclusion: Our review of comparative data does not provide robust evidence to support the assertion that the IGRAs are superior to the TST when used in HIV infected subjects to diagnose either active TB or LTBI.

• 대한인간공학회지
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• 제32권3호
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• pp.267-271
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• 2013

Objective: The purpose of this study is to examine the test-retest reliability of paper-pencil test for investigating population stereotype of burner-control linkages of four-stove gas ranges. Background: Much of the research on gas-range stereotype strength has been performed using the paper-pencil test. While the use of the paper-pencil tests has the advantage of collecting data in a large group of subjects against reasonable costs, concerns regarding the reliability of the paper-pencil test has also been stated. Method: Three paper-pencil tests classified by intervals of test-retest were performed, in which eight types of burner-control arrangements were investigated. Sixty eight subjects were test-retested within two weeks, 85 subjects were test-retested within four weeks and 58 subjects were test-retested three times in series with interval of two and four weeks. Results: Chi-square test showed that three intervals of test-retest including two, four and two & four weeks have not statistically significant effect on subjects' responses irrespective of eight types of burner-control linkages dealt with in this study(p>0.10). Concordance rates of subjects' responses ranged between 73.5% and 100.0% for two-week test-retest, between 67.1% and 97.6% for four-week test-retest, and between 65.5% and 100.0% for two- and four-week serial test-retest. The concordance rates were linearly correlated with proportion of subjects' responses for stereotypes of burnercontrol linkages. Conclusion: It is concluded that the paper-pencil tests for investigating gas range relevant stereotypes could reproduce reliable results compared to baseline test within interval of four weeks. Application: The results of this study would be useful as an ergonomic guideline when designing the paper-pencil tests for stereotype relevant studies.

• 사상체질의학회지
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• 제27권2호
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• pp.211-221
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• 2015

Objectives The aim of this study is to develop a Korea Sasang Constitutional Diagnostic Questionnaire (KS-15) with practicality and validity. Methods The data of body shape, temperament and symptoms were collected from 11 nationwide multi-centers in Korean Medical Clinics between Nov. 2009 to Aug. 2012. KS-15 algorithm was developed through Multinomial Logistic Regression and was applied for test group to verify it's classificatory function. Results The weight value of variables of KS-15 were different between male and female. The concordance of KS-15 with the expert in training group was 58.34% (72.8% in Tae-eumin, 54.8% in Soeumin, and 44.1% in Soyangin). The concordance of KS-15 with the expert in test group was 63.1% (63% in Tae-eumin, 83.3% in Soeumin, and 51.9% in Soyangin). Conclusions KS-15 seems to have suitable implement with practicality and validity. Further study is necessary to verify it accuracy and cut-off.

• Radiation Oncology Journal
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• 제34권1호
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• pp.64-75
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• 2016

Purpose: In order to evaluate the relationship between the dose to the liver parenchyma and focal liver reaction (FLR) after stereotactic ablative body radiotherapy (SABR), we suggest a novel method using a three-dimensional dose distribution and change in signal intensity of gadoxetate disodium-gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) hepatobiliary phase images. Materials and Methods: In our method, change of the signal intensity between the pretreatment and follow-up hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was calculated and then threshold dose (TD) for developing FLR was obtained from correlation of dose with the change of the signal intensity. For validation of the method, TDs for six patients, who had been treated for liver cancer with SABR with 45-60 Gy in 3 fractions, were calculated using the method, and we evaluated concordance between volume enclosed by isodose of TD by the method and volume identified as FLR by a physician. Results: The dose to normal liver was correlated with change in signal intensity between pretreatment and follow-up MRI with a median $R^2$ of 0.935 (range, 0.748 to 0.985). The median TD by the method was 23.5 Gy (range, 18.3 to 39.4 Gy). The median value of concordance was 84.5% (range, 44.7% to 95.9%). Conclusion: Our method is capable of providing a quantitative evaluation of the relationship between dose and intensity changes on follow-up MRI, as well as determining individual TD for developing FLR. We expect our method to provide better information about the individual relationship between dose and FLR in radiotherapy for liver cancer.

• 한국문헌정보학회지
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• 제22권
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• pp.143-177
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• 1992

The main purpose of the school library is to present the various kinds of instructional media for an effective instruction including not only books, but also audiovisual materials and equipments. But unfortunately our school libraries have only books for the students and faculties at this time. But hereafter school library should house the various kinds of audiovisual media as well as printed media for the promotion of scholarstic achivemint. With a view to promoting the teaching method, and at the same time improving the scholarstic achivement of the students, instructional media were used in the class. To verify the efficiency of the instructional media, transparencies were used in the social science class of the 1st grade in the middle school and the natural science class of the 1st grade in the high school. In consequence, the academic achievement of the experimental class in which instructional media were used is superior to that of controlled class in which the textbook was only used. In < Social Science I >, the mean difference between the experimental class and the controlled class is 4.199 marks. And the difference, 0.032 is verified as a significant value in concordance to the t-test. In < Natural Science I >, the mean difference of the experimental class over the controlled class is 6.333. And the difference, 0.034 is verified as a significant value in concordance to the t-test. As shown in the above experimental research, using various kinds of the instructional media is more efficient than using textbook only. As a result of the questionaire on using the instructional media, most of the students desire to use of them continually because the use of the instructional media induce the interest, promote the comprehension, and entice the development of better memories.

• 한국산학기술학회논문지
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• 제10권3호
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• pp.634-641
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• 2009

보건복지가족부 질병관리본부의 건강관리를 위한 지역 코호트사업으로 금산군 1개읍 9개면에 거주하는 만 40세이상부터 70세까지의 주민 중 본 연구에 참여의사를 밝힌 임의 추출된 총 2,007명(남: 868명, 여: 1,139명) 중 부부가 함께 조사된 297쌍(594명)을 대상으로 배우자의 고혈압 위험요인이 상대 배우자의 고혈압에 미치는 영향을 조사한 결과는 다음과 같다. 고혈압 위험요인은 아내가 대사증후군이 있는 경우(OR=2.879), 현재 음주자(OR=1.892)에서 높았다. 아내 고혈압에 대한 남편의 고혈압 위험요인은 연령(OR=1.037), 비만(OR=1.922), 대사증후군(OR=4.100), 중성지방(OR=1.793)에서 높았다. 결론적으로 농촌지역 부부들에서 함께 공유하는 공간과 시간에서 고혈압에 영향을 주는 요인은 연령, 체질량지수, 대사 증후군이 중요하므로 이에 대한 관리가 필요하다고 본다.

• BMB Reports
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• 제54권7호
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• pp.386-391
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• 2021

Owing to rapid advancements in NGS (next generation sequencing), genomic alteration is now considered an essential predictive biomarkers that impact the treatment decision in many cases of cancer. Among the various predictive biomarkers, tumor mutation burden (TMB) was identified by NGS and was considered to be useful in predicting a clinical response in cancer cases treated by immunotherapy. In this study, we directly compared the lab-developed-test (LDT) results by target sequencing panel, K-MASTER panel v3.0 and whole-exome sequencing (WES) to evaluate the concordance of TMB. As an initial step, the reference materials (n = 3) with known TMB status were used as an exploratory test. To validate and evaluate TMB, we used one hundred samples that were acquired from surgically resected tissues of non-small cell lung cancer (NSCLC) patients. The TMB of each sample was tested by using both LDT and WES methods, which extracted the DNA from samples at the same time. In addition, we evaluated the impact of capture region, which might lead to different values of TMB; the evaluation of capture region was based on the size of NGS and target sequencing panels. In this pilot study, TMB was evaluated by LDT and WES by using duplicated reference samples; the results of TMB showed high concordance rate (R² = 0.887). This was also reflected in clinical samples (n = 100), which showed R² of 0.71. The difference between the coding sequence ratio (3.49%) and the ratio of mutations (4.8%) indicated that the LDT panel identified a relatively higher number of mutations. It was feasible to calculate TMB with LDT panel, which can be useful in clinical practice. Furthermore, a customized approach must be developed for calculating TMB, which differs according to cancer types and specific clinical settings.

• Korean Journal of Radiology
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• 제19권6호
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• pp.1077-1088
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• 2018

Objective: To correlate CT parameters on detector-based dual-energy CT enterography (DECTE) with Crohn's disease activity index (CDAI) and externally validate quantitative CT parameters. Materials and Methods: Thirty-nine patients with CD were retrospectively enrolled. Two radiologists reviewed DECTE images by consensus for qualitative and quantitative CT features. CT attenuation and iodine concentration for the diseased bowel were also measured. Univariate statistical tests were used to evaluate whether there was a significant difference in CTE features between remission and active groups, on the basis of the CDAI score. Pearson's correlation test and multiple linear regression analyses were used to assess the correlation between quantitative CT parameters and CDAI. For external validation, an additional 33 consecutive patients were recruited. The correlation and concordance rate were calculated between real and estimated CDAI. Results: There were significant differences between remission and active groups in the bowel enhancement pattern, subjective degree of enhancement, mesenteric fat infiltration, comb sign, and obstruction (p < 0.05). Significant correlations were found between CDAI and quantitative CT parameters, including number of lesions (correlation coefficient, r = 0.573), bowel wall thickness (r = 0.477), iodine concentration (r = 0.744), and relative degree of enhancement (r = 0.541; p < 0.05). Iodine concentration remained the sole independent variable associated with CDAI in multivariate analysis (p = 0.001). The linear regression equation for CDAI (y) and iodine concentration (x) was y = 53.549x + 55.111. For validation patients, a significant correlation (r = 0.925; p < 0.001) and high concordance rate (87.9%, 29/33) were observed between real and estimated CDAIs. Conclusion: Iodine concentration, measured on detector-based DECTE, represents a convenient and reproducible biomarker to monitor disease activity in CD.

• Journal of Gastric Cancer
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• 제19권2호
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• pp.173-182
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• 2019

Purpose: Intraoperative peritoneal washing cytology (PWC) is used to determine treatment strategies for gastric cancer with suspected serosal invasion. However, a standard staining method for intraoperative PWC remains to be established. We evaluated the feasibility of a rapid and simple staining method using Shorr's stain for intraoperative PWC in advanced gastric cancer. Materials and Methods: Between November 2012 and December 2014, 77 patients with clinical T3 or higher gastric cancer were enrolled. The sensitivity, specificity, and concordance between the Shorr staining method and conventional Papanicolaou (Pap) staining with carcinoembryonic antigen (CEA) immunohistochemistry (IHC) were analyzed. Results: Intraoperative PWC was performed laparoscopically in 69 patients (89.6%). The average time of the procedure was 8.3 minutes, and the average amount of aspirated fluids was 83.3 mL. The average time for Shorr staining and pathologic review was 21.0 minutes. Of the 77 patients, 16 (20.7%) had positive cytology and 7 (9.1%) showed atypical findings; sensitivity and specificity were 73.6% and 98.2% for the Shorr method, and 78.9% and 98.2% for the Pap method with CEA IHC, respectively. Concordance of diagnosis between the 2 methods was observed in 90.9% of cases (weighted ${\kappa}$ statistic=0.875) and most disagreements in diagnoses occurred in atypical findings (6/7). In overall survival, there was no significant difference in C-index between the 2 methods (0.459 in Shorr method vs. 0.458 in Pap with CEA IHC method, P=0.987). Conclusions: Shorr staining could be a rapid and reliable method for intraoperative PWC in advanced gastric cancer.

• 한국전문물리치료학회지
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• 제28권2호
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• pp.146-153
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• 2021

Background: Researchers have previously commenced examining the degree of concordance between parent proxy and child self-reports on health-related quality of life (HRQOL) of many disease and impairment populations. Objects: To explore the differences between parent proxy and child self-reports on the HRQOL using Korean version of KIDSCREEN-10 questionnaires for applying to elementary school children and their parents who participated for a school-based wellness program. Methods: The focus groups were recruited for a school-based wellness program by implementing the following wellness services: 1) referring to a screening session for detecting potential posture-related musculoskeletal problems and 2) recommending home exercise programs. Before a primary field testing for the program, two focus groups were formed with a group of 9 parents and their 9 elementary school children aged 8-10 years of age. The parent proxy and child self-report versions of KIDSCREEN-10 questionnaires were administered to both groups after completion of the wellness program. Item level Rasch rating scale analysis was applied to compute logit scales of KIDSCREEN-10 questionnaire. Intraclass correlation coefficients (ICCs) and scatterplot of item difficulty between two reports were analyzed. Results: For fit statistics of parent proxy report, all items except 4 items (i.e., psychological well-being, mood/emotions, self-perception, parent relation) were found to be acceptable. For fit statistics of child self-report, all items except 3 items (i.e., psychological well-being, autonomy and home life) were acceptable. The relationship between two reports using ICCs were ranging from weak to very strong at p = 0.05 (i.e, ICCs = 0.011 to 0.905). Scatterplot analysis between two reports showed a major disparity on self-perception item at 95% confidence intervals. Conclusion: Both item level analyses and ICC comparisons provided a disparity between parent proxy and child self-reports of the HRQOL on self-perception item after competing a school-based wellness program. Therapist should consider the item as part of the HRQOL assessment.