• BMB Reports
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• v.56 no.1
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• pp.43-48
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• 2023

Pre-clinical models are critical in gaining mechanistic and biological insights into disease progression. Recently, patient-derived organoid models have been developed to facilitate our understanding of disease development and to improve the discovery of therapeutic options by faithfully recapitulating in vivo tissues or organs. As technological developments of organoid models are rapidly growing, computational methods are gaining attention in organoid researchers to improve the ability to systematically analyze experimental results. In this review, we summarize the recent advances in organoid models to recapitulate human diseases and computational advancements to analyze experimental results from organoids.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1991.04a
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• pp.20-25
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• 1991

In order to predict properly the effects of ground motion associated wi th earthquakes on underground radioactive waste disposal facilities, understanding of the structural behavior of an underground opening in discontinuous rook masses subjected to dynamic loadings is essential. Therefore, this paper includes literature review on computational models for discontinuous rook masses and on mathematical models for the structural analysis of underground openings. Then, structural analyses of underground openings using the distinct element computer program written for the static and dynamic analysis of discontinuous rook masses have been performed.

• Wind and Structures
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• v.37 no.4
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• pp.255-274
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• 2023

The aim of this paper is to enhance the accuracy of predicting time-averaged external surface pressures on low-rise buildings by utilizing Computational Fluid Dynamics (CFD) simulations. To achieve this, benchmark studies of the Silsoe cube and the Texas Tech University (TTU) experimental building are employed for comparison with simulation results. The paper is structured into three main sections. In the initial part, an appropriate domain size is selected based on the precision of mean pressure coefficients on the windward face of the cube, utilizing Reynolds Averaged Navier-Stokes (RANS) turbulence models. Subsequently, recommendations regarding the optimal computational domain size for an isolated building are provided based on revised findings. Moving on to the second part, the Silsoe cube model is examined within a horizontally homogeneous computational domain using more accurate turbulence models, such as Large Eddy Simulation (LES) and hybrid RANS-LES models. For computational efficiency, transient simulation settings are employed, building upon previous studies by the authors at the Windstorm Impact, Science, and Engineering (WISE) Lab, Louisiana State University (LSU). An optimal meshing strategy is determined for LES based on a grid convergence study. Three hybrid RANS-LES cases are investigated to achieve desired enhancements in the distribution of mean pressure coefficients on the Silsoe cube. In the final part, a 1:10 scale model of the TTU building is studied, incorporating the insights gained from the second part. The generated flow characteristics, including vertical profiles of mean velocity, turbulence intensity, and velocity spectra (small and large eddies), exhibit good agreement with full-scale (TTU) measurements. The results indicate promising roof pressures achieved through the careful consideration of meshing strategy, time step, domain size, inflow turbulence, near-wall treatment, and turbulence models. Moreover, this paper demonstrates an improvement in mean roof pressures compared to other state-of-the-art studies, thus highlighting the significance of CFD simulations in building aerodynamics.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1995.04a
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• pp.73-81
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• 1995

In Korea, the pilot construction of the first high-speed railroad on the Seoul-Pusan has already started 2 years ago. In the thesis, an attempt is made to develop reliability-based integrity-assessment models for the computer-aided control and maintenance of high-speed railroad bridges. The strength limit state models for PC railroad bridges encompass the bending and shear strengths as well as the strength interaction equations which simultaneously take into the element and system reliablities of the proposed limit states and reliability models. Then, the actual load carrying capacity and the realistic safety of bridges are evaluated using the system reliability-based equivalent strength, and the results are compared with those of the element reliability-based or conventional methods. Various parametric studies are performed for the proposed reliability-based safety and integrity-assessment models using the actual PC box girder bridges used in the pilot construction. And the sensitivity analyses are performed for the basic random variables included in strength limit state models. It is concluded that proposed models may be practically applied for the rational assessment of safety and integrity of high speed railroad bridges.

• Korean Journal of Computational Design and Engineering
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• v.18 no.4
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• pp.299-307
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• 2013

Introduction of PLM in domestic shipyards is being retarded as ship PLM has yet to firm up return of investment and process integration. To implement a ship PLM system, it is required to share ship CAD model data in various design and manufacturing environments. Lightweight CAD models provide a promising solution for sharing CAD models in the product life cycle, which can expedite implementation of ship PLM in domestic shipyards in the near future. Compared to proprietary CAD models, it is easy for lightweight CAD models to be interfaced with various application systems and be connected to manufacturing information. In this paper, the reason why lightweight CAD models are necessary to implement a ship PLM system is addressed and current implementation results are introduced.

• Journal of computational fluids engineering
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• v.10 no.4 s.31
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• pp.1-11
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• 2005

A numerical study of the evaluation of turbulence models for thermal striping phenomenon is performed. The turbulence models chosen in the present study are the two-layer model, the shear stress transport (SST) model and the V2-f model. These three models are applied to the analysis of the triple-jet flow with the same velocity but different temperatures. The unsteady Reynolds-averaged Navier-Stokes (URANS) equation method is used together with the SIMPLEC algorithm. The results of the present study show that the temporal oscillation of temperature is predicted by the SST and V2-f models, and the accuracy of the mean velocity, the turbulent shear stress and the mean temperature is a little dependent on the turbulence model used. In addition, it is shown that both the two-layer and SST models have nearly the same capability predicting the thermal striping, and the amplitude of the temperature fluctuation is predicted best by the V2-f model.

• Journal of computational fluids engineering
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• v.15 no.4
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• pp.85-91
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• 2010

In this study, aerodynamic analyses based on unsteady computational fluid dynamics (CFD) have been conducted for a 2-bladed vertical-axis wind turbine (VAWT) configuration. Reynolds-averaged Navier-Stokes equations with standard $k-{\varepsilon}$ and SST $k-{\varepsilon}$ turbulence models are solved for unsteady flow problems. The experiment model of 2-bladed VAWT has been designed and tested in this study. Aerodynamic experiment of the present VAWT model are effectively conducted using the vehicle mounted testing system. The comparison result between the experiment and the computational fluid dynamics (CFD) analysis are presented in order to verify the accuracy of CFD modeling with different turbulent models.

• Journal of computational fluids engineering
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• v.18 no.2
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• pp.99-108
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• 2013

The standard drag force and virtual mass force, which exert to the primary flow direction, are generally considered in two-phase analysis computational codes. In this paper, the lift force, wall lubrication force, and turbulent dispersion force including turbulence models, which are essential for a computational multi-fluid dynamics model and play an important role in motion perpendicular to the primary flow direction, were introduced and verified with conceptual problems.

• Computational Structural Engineering
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• v.30 no.1
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• pp.29-35
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• 2017

• 한국전산유체공학회:학술대회논문집
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• 1999.11a
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• pp.7-16
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• 1999