• Journal of Industrial and Engineering Chemistry
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• v.67
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• pp.293-300
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• 2018

Lipocalins are diverse group of small extracellular proteins found in various organisms. In this study, members of 10 non-homologous lipocalin-ligand crystal complex structures were remodeled using rigid and flexible ligand modes to validate the prediction efficiency of molecular docking simulation. The modeled ligand conformations indicated a high prediction accuracy in rigid ligand mode using cluster based analysis for most cases whereas the flexible ligand mode required further considerations such as ligand binding energy and RMSD for some cases. This in silico study is expected to serve as a platform in the screening of novel ligands against lipocalin family of proteins.

• BMB Reports
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• v.55 no.3
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• pp.125-135
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• 2022

Continuously renewing the proteome, translation is exquisitely controlled by a number of dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the DEAD box family has emerged as one of the critical regulators of translation, the failure of which is frequently observed in a wide range of proliferative, degenerative, and infectious diseases in humans. DDX3 unwinds double-stranded RNA molecules with coupled ATP hydrolysis and thereby remodels complex RNA structures present in various protein-coding and noncoding RNAs. By interacting with specific features on messenger RNAs (mRNAs) and 18S ribosomal RNA (rRNA), DDX3 facilitates translation, while repressing it under certain conditions. We review recent findings underlying these properties of DDX3 in diverse modes of translation, such as cap-dependent and cap-independent translation initiation, usage of upstream open reading frames, and stress-induced ribonucleoprotein granule formation. We further discuss how disease-associated DDX3 variants alter the translation landscape in the cell.

• The Korean Journal of Franchise Management
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• v.7 no.1
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• pp.5-11
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• 2016

Purpose - The purpose of this paper is to find the issues associated with international expansion of Korean franchisors going international and suggest lessons of proposition to reduce the failure risk in international expansion of franchise systems. Research design, data, and methodology - This is the exploratory study and structured to review (1) background to motivate the expansion of franchisors towards international market, (2) the status of Korean franchisors going international in recent years, (3) issues, (4) lessons learned from the experiences, and (5) summary. Secondary sources were reviewed to get necessary data and statistics. Results - Master franchising was the most preferred entry mode for Korean franchisors. Franchisors must understand the expenses to be incurred as well as revenues associated with international activities. Brand is the core asset of franchisor as a differentiation strategy. Conclusions - The paper indicates that even if international franchising is the unique business model for franchisors to use in little or least risk compared with other international entry modes, it needs a set of complex capabilities that much differ from those in domestic and franchisors should take a step approach to the international market with the planned and long term perspective.

• Journal of Yeungnam Medical Science
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• v.40 no.2
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• pp.123-135
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• 2023

Advances in perinatal and pediatric intensive care and recent advances in mechanical ventilation during the last two decades have resulted in an exponential increase in the number of children undergoing home mechanical ventilation (HMV) treatment. Although its efficacy in chronic respiratory failure is well established, HMV in children is more complex than that in adults, and there are more considerations. This review outlines clinical considerations for HMV in children. The goal of HMV in children is not only to correct alveolar hypoventilation but also to maximize development as much as possible. The modes of ventilation and ventilator settings, including ventilation masks, tubing, circuits, humidification, and ventilator parameters, should be tailored to the patient's individual characteristics. To ensure effective HMV, education for the parent and caregiver is important. HMV continues to change the scope of treatment for chronic respiratory failure in children in that it decreases respiratory morbidity and prolongs life spans. Further studies on this topic with larger scale and systemic approach are required to ensure the better outcomes in this population.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.44 no.3
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• pp.88-96
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• 2007

H.264 is a new international video coding standard that can achieve considerably higher coding efficiency than conventional standards. Its coding gain has been achieved by employing advanced video coding methods. Specially, the increased number of macroblock modes and the complex mode decision procedure using the Lagrangian optimization are the main factors for increasing coding efficiency. Although H.264 obtains improved coding efficiency, it is difficult to do an real-time encoding because it considers all coding parameters in the mode decision procedure. In this paper, we propose a fast mode decision algorithm which classifies the macroblock modes in order to determine the optimal mode having low complexity quickly. Simulation results show that the proposed algorithm can reduce the encoding time by 34.95% on average without significant PSNR degradation or bit-rate increment. In addition, in order to show the validity of simulation results, we set up a low boundary condition for coding efficiency and complexity and show that the proposed algorithm satisfies the low boundary condition.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.2
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• pp.206-222
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• 2015

This work uses different finite element approaches to the free vibration analysis of reinforced shell structures, and a simplified model of a typical launcher with two boosters is used as an example. The results obtained using a refined one-dimensional (1D) beam model are compared to those obtained with commercial finite element software. The 1D models that are used in the present work are based on the Carrera Unified Formulation (CUF), which assumes a variable kinematic displacement field over the cross-sections of the beam. Two different sets of polynomials that correspond to Taylor (TE) or Lagrange (LE) expansions were used. The analyses focused on three reinforced structures: a stiffened panel, a reinforced cylinder and the complete structure of the launcher. The frequencies and natural modes obtained using one-dimensional models are compared to those obtained from classical finite element analysis. The classical FE models were built using a beam-shell or solid elements, and the results indicate that the refined beam models can in fact be used to investigate the behavior of very complex reinforced structures. These models can predict the shell-like modes that are typical of thin-walled structures that cannot be detected using classical beam models. The refined 1D models used in the present work provide results that are as accurate as those from solid FE models, but the 1D models have a much lower computational cost.

• Korean Journal of Child Studies
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• v.17 no.1
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• pp.153-171
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• 1996

The purpose of this study was to examine children's social-cognitive modes of play in same-age and mixed-age kindergarten classrooms. The subjects were 45 children. in three classrooms of 4-year-olds, 69 children in three classrooms of 5-year-olds, and 60 children in three mixed-age classrooms of 4- and 5-year-olds. Observations were conducted by videotape recordings. Observation periods were of five-minutes duration. There were ten observations of each child's indoor free-play periods. Observational data were collected by the time sampling method with the social cognitive play behavioral checking list based on an adaptation of one devised by Rubin(1985). The data was analyzed by t-test with the SAS computer program. Four- and five-year-olds in mixed-age classrooms were more likely to engage in "complex" modes of play than 4- and 5-year-olds in same-age classrooms. Four-year-olds in same-age classrooms were more likely to engage in solitary-functional, parallel-functional, and group-functional play than 4-year-olds in mixed-age classrooms. However, 4-year-olds in mixed-age classrooms were more likely to engage in group-constructive, group-dramatic, solitary-game, and group-game play than 4-year-olds in same-age classrooms. Five-year-olds in same-age classes were more likely to engage in solitary-functional and parallel-functional play than 5-year-olds in mixed-age classes. Five-year-olds in mixed-age classes were more likely to engage in group-constructive, group-dramatic, and group-game play than their counterparts in same-age settings.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.5
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• pp.41-49
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• 2005

This paper discusses the test procedure, instrumentation, verification methodology and the results of the ground vibration test(GVT) performed on the KF-16D aircraft to estimate experimentally dynamic characteristics of the aircraft. The modal tests for 7 external store configurations were conducted to estimate effects of external stores on the aircraft vibration modes. To emulate free-free boundary conditions the test aircraft was mounted on its landing gear structure with deflated tires during the GVT. The airframe modal tests were done by burst random excitations with 6 to 8 shakers and about 200 accelerometers. Frequency response functions(FRFs) were measured for each test, and the FRFs were reduced and analyzed to identify the dynamic parameters interested. The analyses were carried out in two steps. To extract modal parameters such as, frequencies and damping ratios, the poly-reference least square complex exponential method was used in the time domain. The mode shape coefficients were estimated with the least squares frequency domain method to identify the vibration modes.

• Journal of Broadcast Engineering
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• v.19 no.6
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• pp.836-846
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• 2014

To expedite UHD (Ultra High Definition) video service, the HEVC (High-Efficiency Video Coding) technology has recently been standardized and it achieves two times higher compression efficiency than the conventional H.264/AVC. To obtain the improved efficiency, however, it employs many complex methods which need complicated calculation, thereby resulting in a significantly increased computational complexity when compared to that of H.264/AVC. For example, to improve the coding efficiency of intra frame coding, up to 35 intra prediction modes are defined in HEVC, but this results in an increased encoding time than the H.264/AVC. In this paper, we propose a fast intra prediction mode decision scheme which reduces computational complexity by changing the number of intra prediction mode in accordance with the percentage of PU sizes for a given video resolution, and by classifying the 35 intra prediction modes into 4 categories considering video resolution and quantization parameter. The experimental results show that the total encoding time is reduced by about 7% on average at the cost of only 2% increase in BD-rate.

• The Journal of the Acoustical Society of Korea
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• v.30 no.7
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• pp.368-376
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• 2011

Piezoelectric composites have been widely used in broadband acoustic transducers because of their lower acoustic impedance and higher electro-mechanical coupling factor. However, their complex structure has placed many limitations on the design of various transducers. This paper suggests the methodology to substitute the 1-3 piezocomposites by a single-phased material that has properties equivalent to those of the piezocomposites. The resonant method and finite element analysis (FEA) are used to derive the equivalent properties that can accurately depict resonant properties at various vibration modes of the piezocomposites. Validity of the suggested method is confirmed by comparing frequency characteristics of fabricated 1-3 piezocomposite specimens and FEA models. Further, accuracy of the derived material constants is checked by applying the equivalent properties to FEA models of the single phase material for various resonant modes.