• Title/Summary/Keyword: complex degradation

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A Study on the Insulation Reliablity of Form-Wound Stator Windings by Complex Degradation (복합열화에 의한 형권 고정자권선의 절연신뢰성에 관한 연구)

  • 이헌돈;김상걸;오현석;왕종배;김기준;이준웅
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2000.07a
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    • pp.152-155
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    • 2000
  • PWM inverter-fed traction motor is able to occur problems by additive transient surge stress and harmonic loss in contrast with motor driven by 60Hz sine wave alternating source. Therefore in this paper, test method and standard of existed already were investigate, "thermal + electric" complex degradation test that considered additive degradation occurred by inverter drive carried out in order to obtain insulation reliability of traction motor driven by inverter. It seems that this test method confers large value of application at reliability estimation which the subject of complete motor not windings sample from now on.

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CHIP promotes the degradation of mutant SOD1 by reducing its interaction with VCP and S6/S6' subunits of 26S proteasome

  • Choi, Jin-Sun;Lee, Do-Hee
    • Animal cells and systems
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    • v.14 no.1
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    • pp.1-10
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    • 2010
  • Previously we showed that CHIP, a co-chaperone of Hsp70 and E3 ubiquitin ligase, can promote the degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis (fALS) via a mechanism not involving SOD1 ubiquitylation. Here we present evidence that CHIP functions in the interaction of mutant SOD1 with 26S proteasomes. Bag-1, a coupling factor between molecular chaperones and the proteasomes, formed a complex with SOD1 in an hsp70-dependent manner but had no direct effect on the degradation of mutant SOD1. Instead, Bag-1 stimulated interaction between CHIP and the proteasome-associated protein VCP (p97), which do not associate normally. Over-expressed CHIP interfered with the association between mutant SOD1 and VCP. Conversely, the binding of CHIP to mutant SOD1 was inhibited by VCP, implying that the chaperone complex and proteolytic machinery are competing for the common substrates. Finally we observed that mutant SOD1 strongly associated with the 19S complex of proteasomes and CHIP over-expression specifically reduced the interaction between S6/S6' ATPase subunits and mutant SOD1. These results suggest that CHIP, together with ubiquitin-binding proteins such as Bag-1 and VCP, promotes the degradation of mutant SOD1 by facilitating its translocation from ATPase subunits of 19S complex to the 20S core particle.

Catechin Degradation by Several Fungal Strains Isolated from Mexican Desert

  • Aguilar Cristobal Noe;Mario Cruz;Raul Rodriguez;Gerardo Gutierrez-Sanchez;Ascencion Ramirez-Coronel;Christopher Augur
    • Journal of Microbiology and Biotechnology
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    • v.14 no.2
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    • pp.426-429
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    • 2004
  • Eleven fungal strains previously isolated from the Mexican desert were evaluated for their capacity to use catechin as carbon source in submerged cultures. At 2 g/l of catechin, all strains grew better than the control strains, Aspergillus niger Aa-20. Aspergillus niger PSH and Penicillium commune EH2 degraded 79.33% and 76.35% with degradation rates of 0.0065 and 0.0074 g/l/h, respectively, when an initial catechin concentration of 3 g/l was used. Obtained results demonstrated the potential biotechnological capacity of these fungal strains to use condensed tannins as carbon source.

Degradation of Chlorothalonil by Zerovalent Iron-Montmorillonite Complex (Zerovalent iron-montmorillonite 복합체에 의한 chlorothalonil의 분해)

  • Choi, Choong-Lyeal;Park, Man;Lee, Dong-Hoon;Rhee, In-Koo;Song, Kyung-Sik;Kang, Sang-Jae;Kim, Jang-Eok
    • Korean Journal of Environmental Agriculture
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    • v.25 no.3
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    • pp.257-261
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    • 2006
  • Zerovalent iron (ZVI) has been recently used for environmental remediation of soils and groundwaters contaminated by chlorinated organic compounds. As a new approach to improve its reductive activity and stability, zerovalent iron-montmorillonites (ZVI-Mt) complex are synthesized by simple process. Therefore, this study was carried out to elucidate the characteristics of ZVI-Mt complex and to investigate degradation effects of fungicide chlorothalonil. The XRD patterns of ZVI-Mt complex showed distinctive peaks of ZVI and montmorillonite. In ZVI-Mt complex, the oval particles of ZVI were partly surrounded by montmorillonite layers that could prevent ZVI surface oxidation by air. The degradation ratio of chlorothalonil after 60 min exhibited 71% by ZVI and 100% by ZVI-Mt complex. ZVI-Mt21 complex exhibited much higher and faster degradation ratio of chlorothalonil compare to that of ZVI or ZVI-Mt11 complex. Also, degradation rate of chlorothalonil was increased with increasing ZVI or ZVI-Mt complex content and with decreasing initial solution pH.

Aeroengine performance degradation prediction method considering operating conditions

  • Bangcheng Zhang;Shuo Gao;Zhong Zheng;Guanyu Hu
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.17 no.9
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    • pp.2314-2333
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    • 2023
  • It is significant to predict the performance degradation of complex electromechanical systems. Among the existing performance degradation prediction models, belief rule base (BRB) is a model that deal with quantitative data and qualitative information with uncertainty. However, when analyzing dynamic systems where observable indicators change frequently over time and working conditions, the traditional belief rule base (BRB) can not adapt to frequent changes in working conditions, such as the prediction of aeroengine performance degradation considering working condition. For the sake of settling this problem, this paper puts forward a new hidden belief rule base (HBRB) prediction method, in which the performance of aeroengines is regarded as hidden behavior, and operating conditions are used as observable indicators of the HBRB model to describe the hidden behavior to solve the problem of performance degradation prediction under different times and operating conditions. The performance degradation prediction case study of turbofan aeroengine simulation experiments proves the advantages of HBRB model, and the results testify the effectiveness and practicability of this method. Furthermore, it is compared with other advanced forecasting methods. The results testify this model can generate better predictions in aspects of accuracy and interpretability.

A Viscoelastic Study of Glass Transition and Degradation Processes of Phenolic Resin/Carbon Fiber Composites (페놀수지/탄소섬유 열경화성 복합재료의 유리전이와 고온 분해과정에서 관찰되는 점탄성 특성 연구)

  • ;J. C. Seferis
    • The Korean Journal of Rheology
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    • v.11 no.1
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    • pp.9-17
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    • 1999
  • Viscoelastic characteristics of cured phenolic resin/carbon fiber composite materials were investigated through glass transition and degradation reaction processes in the high temperature region up to $400^{\circ}C$. A typical glass transition of the cross-linked thermoset polymer was followed by irreversible degradation reactions, which were exhibited by the increasing storage modulus and loss modulus peak. A degradation master curve was constructed by using the vertical and horizontal shift factors, both of which complied well with the Arrhenius equation in light of the kinetic expression of degradation rate constants. Using an analogy to the Havriliak-Negami equation in dielectric relaxation phenomena, a viscoelastic modeling methodology was developed to characterize the frequency- and temperature-dependent complex moduli of the degrading thermoset polymer composite systems. The temperature-dependent relaxation time of the degrading composites was determined in a continuous fashion and showed a minimum relaxation time between the glass transition and degradation reaction regions. The capability of the developed modeling methodology was demonstrated by describing the complex behavior of the viscoelastic complex moduli of reacting phenolic resin composite systems.

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A Study on the Complex Accelerating Degradation and Condition Diagnosis of Traction Motor for Electric Railway (전기철도용 견인전동기의 복합가속열화 상태진단에 관한 연구)

  • 왕종배
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.15 no.1
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    • pp.93-101
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    • 2002
  • In this study, the stator form-winding sample coils based on silicone resin and polyimide were made for fault prediction and reliability estimation on the C-Class(200$\^{C}$ ) insulation system of traction motors. The complex accelerative degradation was periodically performed during 10 cycles, which was composed of thermal stress, fast rising surge voltage, vibration, water immersion and overvoltage applying. After aging of 10 cycles, the condition diagnosis test such as insulation resistance '||'&'||' polarization index, capacitance '||'&'||' dielectric loss and partial discharge properties were investigated in the temperature range of 20 ∼ 160$\^{C}$. Relationship among condition diagnosis tests was analyzed to find a dominative degradation factor and an insulation state at end-life point.

Fault Prediction & Reliability Estimation of the Traction Motor by the Complex Accelerating Degradation and Condition Diagnosis (견인전동기의 복합가속열화 상태진단에 의한 고장예측 및 신뢰성 평가)

  • 왕종배;김명룡
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2000.07a
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    • pp.763-766
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    • 2000
  • In this paper, stator form-winding sample coils based on silicone resin and polyimide were made for fault prediction and reliability estimation on the 200 Class insulation system of traction motors. The complex accelerative degradation was performed by periods during 10 cycles, which was composed of thermal stress, fast rising surge voltage, vibration, water immersion and overvoltage applying. After aging of 10 cycles, condition diagnosis test such as insulation resistance & polarization index, capacitance & dielectric loss and partial discharge properties were investigated in the temperature range of 20∼160$^{\circ}C$. Relationship among condition diagnosis test was analyzed to find an dominative degradation factor and an insulation state at end-life point.

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Studies on the Formation of Inclusion Complex between Omeprazole and $\beta$-cyclodextrin (오메프라졸과 베타-시클로덱스트린과의 포접화합물 형성에 따른 특성)

  • 소재일;이창현;이계주
    • YAKHAK HOEJI
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    • v.35 no.5
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    • pp.372-378
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    • 1991
  • To increase the stability and bioavailability of Omeprazole(OMP), which is used newly as a proton-pump inhibitor, inclusion complex of OMP with $\beta$-cyclodextrin($\beta$-CD) was prepared by coprecipitation method and its characteristics were ascertained by means of solubility test, DSC, IR, and the accelerated stability analysis. The type of OMP inclusion complex is classified as Bs-type on phase solubility diagram, and the stoichiometric ratio of OMP: $\beta$-CD complex is 1:2 and formation constant is 80.82/mole. The solubility of the complex could be increased remarkably by complexation compare with OMP. Degradation process of both OMP and OMP complex followed apparent first-order kinetics, of which degradation rate constants and activation energies are k$_{25}$=8.1$\times$10$^{-4}$/day, E$_{a}$=22 Kcal/mole (OMP), and k$_{25}$=4.65$\times$10$^{-6}$/day, E$_{a}$=35 Kcal/mole (complex), respectively. These results show the increase of the stability and solubility of OMP markedly, therefore it is believed that the improvement of stabilization for OMP by inclusion complexation might be practically available.

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Interaction of pharmaceuticals with betacyclodextrin III Influence of Betacyclodextrin on Phenobarbital Hydrolysis

  • Min, Shin-Hong
    • YAKHAK HOEJI
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    • v.16 no.4
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    • pp.155-161
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    • 1972
  • The hydrolysis of phenobarbital is decelerated in alkaline solution by betacyclodextrin. The betacyclodextrin inhibits the degradation of phenobarbital up to 1.5 fold in the system containing 1% betacyclodextrin. The degradation mechanism in systems containing betacyclodextrin is the same that in system without complexing agent, although the rate constants are different. The pH dependence of the hydrolysis rate deceleration is compared with the ionization percent of betacyclodextrin. The results indicate that a direct relationship does not exist between the ionization of betacyclodextrin. It seems reasonable therefore that the phenobarbital undergoes a stable complex with betacyclodextrin and complex formation would provide a better shield for the phenobarbital from hydroxyl ion attack.

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