• 대한간호학회지
• /
• 제37권2호
• /
• pp.249-256
• /
• 2007

Purpose. Tai Chi exercise, an ancient Chinese martial art, has drawn more and more attention for its health benefits. The purpose of the study was to identify the effects of a Sun-style Tai Chi exercise on arthritic symptoms (joint pain and stiffness), motivation for performing health behaviors, and the performance of health behaviors among older women with osteoarthritis. Methods. Total of 72 women with the mean age of 63 years old were recruited from outpatients clinic or public health centers according to the inclusion criteria and assigned randomly to either the Tai Chi exercise group or the control. A Sun-style Tai Chi exercise has been provided three times a week for the first two weeks, and then once a week for another 10 weeks. In 12 weeks of study period, 22 subjects in the Tai Chi exercise group and 21 subjects in the control group completed the posttest measure with the dropout rate of 41 %. Outcome variables included arthritic symptoms measured by K-WOMAC, motivation for health behavior, and health behaviors. Results. At the completion of the 12 week Tai Chi exercise, the Tai Chi group perceived significantly less joint pain (t = -2.19, P = 0.03) and stiffness (t = -2.24, P = 0.03), perceived more health benefits (t = 2.67, P = 0.01), and performed better health behaviors (t = 2.35, P = 0.02), specifically for diet behavior (t = 2.06, P = 0.04) and stress management (t = 2.97, P = 0.005). Conclusion. A Sun-style Tai Chi exercise was found as beneficial for women with osteoarthritis to reduce their perceived arthritic symptoms, improve their perception of health benefits to perform better health behaviors.

• 대한치과교정학회지
• /
• 제50권2호
• /
• pp.136-144
• /
• 2020

Hemifacial microsomia (HFM) patients may experience emotional withdrawal during their growth period due to their abnormal facial appearance. Distraction osteogenesis at an early age to improve their appearance can encourage these patients. Some abnormalities of the affected side can be overcome by distraction osteogenesis at an early age. However, differences in the growth rate between the affected and unaffected sides during the rest of the growth period are inevitable due to the characteristics of HFM. Therefore, re-evaluation should be performed after completion of growth in order to achieve stable occlusion through either orthognathic surgery or camouflage orthodontic treatment. An eight-year-old patient visited the clinic exhibiting features of HFM with slight mandibular involvement. He received phase I treatment with distraction osteogenesis and a functional appliance. Distraction osteogenesis was performed at the right ramus, which resulted in an open bite at the right posterior dentition. After distraction osteogenesis, a functional appliance and partial fixed appliance were used to achieve extrusion of the affected posterior dentition and settlement of the occlusion adjustment on the unaffected posterior dentition. The patient visited the clinic regularly for follow-up assessments, and at the age of 20 years, he showed facial asymmetry of the mandible, which had deviated to the right side. He received orthodontic treatment to improve the occlusion of his posterior dentition after the growth period. Without orthognathic surgery, stable occlusion and a satisfactory facial appearance were obtained through camouflage orthodontic treatment.

• 한국실천공학교육학회논문지
• /
• 제4권2호
• /
• pp.116-121
• /
• 2012

청년 취업아카데미 사업은 산업계 주도로 대학 졸업예정자 및 졸업생을 대상으로 맞춤형 취업역량향상 프로그램을 지원함으로써, 산업현장에 맞는 인재를 양성하고 청년실업의 구조적 수급불일치 해소를 목적으로 한다. 본 사업의 핵심은 운영기관과 참여기업, 참여대학 및 교육생으로 이루어진 사업 네트웍의 구성에 있으며, 이 중에서 운영기관이 가장 큰 역할을 담당한다. 청년 취업아카데미 사업의 운영기관은 사업종료 후 6개월이 지난 시점에서의 최종취업률로 평가하게 되어 있으나 차년도 사업의 운영기관 선정 시 활용할, 중간평가의 의미를 가지는 운영기관 성과평가가 필요하다. 본 논문에서는 청년취업아카데미 운영기관의 성과지표 개발에 관련된 개념 및 원리를 소개하고 주요 성과지표를 제시하였다.

• 한국정보과학회논문지:소프트웨어및응용
• /
• 제35권1호
• /
• pp.33-40
• /
• 2008

인간은 다른 사람과 대화할 때, 시행착오 과정을 거치면서 상대방에 관한 학습이 일어난다. 본 논문에서는 이런 과정의 강화학습법(Reinforcement Learning)을 이용하여 대화시스템에 적응형 능력의 부여 방법을 제안한다. 적응형 대화 전략이란 대화시스템이 사용자의 대화 처리 습성을 학습하고, 사용자 만족도와 효율성을 높이는 것을 말한다. 강화 학습법을 효율적으로 대화처리 시스템에 적용하기 위하여 대화를 주 대화와 부대화로 나누어 정의하고 사용하였다. 주 대화에서는 전체적인 만족도를, 부 대화에서는 완료 여부, 완료시간, 에러 횟수를 이용해서 시스템의 효율성을 측정하였다. 또한 학습 과정에서의 사용자 편의성을 위하여 시스템 사용 역량에 따라 사용자를 두 그룹으로 분류한 후 해당 그룹의 강화 학습 훈련 정책을 적용하였다. 실험에서는 개인별, 그룹별 강화 학습에 따라 제안한 방법의 성능을 평가하였다.

• Journal of Microbiology and Biotechnology
• /
• 제9권3호
• /
• pp.235-242
• /
• 1999

We investigated the growth-inhibitory mechanism of Helicobacter pylori by omeprazole (OMP) and its activated sulfenamide (OAS). Using dithiothreitol (DTT) and 5,5'-dithio-bis[2-nitrobenzoic acid] (DTNB; Ellman's reagent), we first determined the relationship between the binding capacity of these compounds to H. pylori membrane and its significance to membrane P-type ATPase activity. After incubation of the intact H. pylori cells with either OMP or OAS, the residual quantity of free SH-groups on the cell membrane was measured, and, the resulting values were plotted as a function of time. From this experiment, we found that there was a considerable difference in the membrane-binding rates between OMP and OAS. At neutral pH, the disulfide bond formation on H. pylori membrane was completed within 2 min of incubation of the intact cells with OAS. By OMP, however, it was gradually formed, exceeding 10 min of incubation for completion, whereby, the extent of P-type ATPase inhibition appeared to be proportional to the disulfide forming rate. From this data, it was suggested that the disulfide formation might directly affect enzyme activity. Since OMP per se cannot yield a disulfide bond with cysteine, it is predicted that the enzyme inactivation must be caused by the OAS form. Accordingly, we postulated that, under the neutral pH, OMP could be converted to OAS in the course of transport. By extrapolating the inhibitory slopes, we could evaluate K₁ values, relating to their minimal inhibitory concentrations (MICs) for H. pylori growth. In these MIC ranges, H. pylori uptake or vesicular export of nutrients such as peptides were totally prohibited, but their effect in Escherichia coli were negligible. From these observations, we strongly suggest that the P-type ATPase activity is essential for the survival of H. pylori cells in particular.

• 터널과지하공간
• /
• 제23권6호
• /
• pp.572-580
• /
• 2013

이 사례연구에서는 스위스 바젤에서 진행되었던 인공지열발전(EGS) 프로젝트인 Deep Heat Mining Basel(DHMB)의 미소진동 관리시스템을 살펴보았다. 인공지열발전 프로젝트에 꼭 필요한 인공지열저류층 생성을 위한 수리자극으로 인해 발생하는 유도진동은 안전관리시스템을 수립하여 수리자극의 압력과 유량을 관리하여야 한다. DHMB프로젝트에서는 수리자극 기간 동안 지속적인 관측활동을 통해 미소진동 발생 진도에 따라 단계별로 대응하는 경보시스템과 커뮤니케이션 대응 절차가 사전에 수립되어 관리되었다. 그러나 수리자극을 위한 주입 완료 후에도 지열저류층에서 발생한 주입이후 진동현상으로 인해 예상보다 큰 지진이 발생하자 프로젝트가 중단되었다. 사후분석 결과 실시간 경보시스템은 주입이후 진동 현상을 감안한 새로운 미소진동 안전관리시스템을 수립하는 것이 필요하다고 확인되었다.

• Radiation Oncology Journal
• /
• 제35권1호
• /
• pp.32-38
• /
• 2017

Purpose: Several accelerated partial breast radiation (APBR) techniques have been investigated in patients with early-stage breast cancer (BC); however, the optimal treatment delivery techniques remain unclear. We evaluated the feasibility and toxicity of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I BC, using a novel fractionation schedule. Materials and Methods: Forty-two patients aged ${\geq}65$ years, with stage I BC who underwent breast conserving surgery were enrolled in a phase I/II study evaluating APBR using IMRT. Forty eligible patients received 40 Gy in 4 Gy daily fractions. Patients were assessed for treatment related toxicities, and cosmesis, before APBR, during, and after completion of the treatment. Results: The median age was 73 years, median tumor size 0.8 cm and the median follow-up was 54 months. The 5-year locoregional control was 97.5% and overall survival 90%. Erythema and skin pigmentation was the most common acute adverse event, reported by 27 patients (69%). Twenty-six patients (65%) reported mild pain, rated 1-4/10. This improved at last follow-up to only 2 (15%). Overall the patient and physician reported worst late toxicities were lower than the baseline and at last follow-up, patients and physicians rated cosmesis as excellent/good in 93% and 86 %, respectively. Conclusion: In this prospective trial, we observed an excellent rate of tumor control with daily APBR. The acceptable toxicity profile and cosmetic results of this study support the use of IMRT planned APBR with daily schedule in elderly patients with early stage BC.

• 한국임상수의학회지
• /
• 제19권2호
• /
• pp.165-173
• /
• 2002

The purpose of this study was to evaluate the effect of chitosan-calcium sulfate mixture on early bony consolidation in osteodistracted dogs. The experimental group was divided into 3 groups: saline group(Control), chitosan group(Group CH) and chitosan-calcium sulfate mixture group(Group CH+CS). Four dogs were allocated to each group and classified into B week observation subgroups and 5 week observation subgroups, respectively. Two dogs were allocated to each subgroup. The lateral surface of the left mandibular body was exposed in the subperiosteal plane and vertical osteotomy was carried out on the mandibular body. An external distraction device was applied to the mandibular body. Mandibular distraction was started 5 days after the osteotomy at a rate of 1 m per day for a total of 10 w distraction for 10 days. After completion of distraction, chitosan, chitosan-calcium sulfate and saline were injected into the distracted zone of the group CH, group CH+CS and control. The external device was left in place for 3 or 5 weeks to allow for bony consolidation. Serial radiographs were carried out every week. Two dogs of each group, six dogs in total, were sacrificed at 3 weeks, and the other six dogs at 5 week after distraction. Bone specimens of the distracted mandibles were taken for histologic examination. New bone was not noted in the distracted zone of 3 week observation subgroups in the control and group CH. However, new bone was developed in the group CH+CS with a narrow fibrous interzone in the area of the distracted zone. While osteogenesis was mild in the margin of the distracted Bone of 5 week observation subgroup in the control, new bone was noted much in the group CH and group CH+CS. However, osteogenesis was noted more significantly in the group CH+CS than that of group CH. In conclusion, chitosan-calcium sulfate mixture was more effective on early bony consolidation in distraction osteogenesis

• Radiation Oncology Journal
• /
• 제5권2호
• /
• pp.119-129
• /
• 1987

With the introduction of X-rays of higher energy that have higher penetrability, it has become possible to treat the deep-seated tumor with increased local control rate. But at the same time it has incrased the damage to the deep seated organs, especially to the lung which is known to be the less radiotolerable tissue in the body. This study analyses the 66 patients who were exposed to the irradiation of the lung, and examines the development of radiation pneumonitis and its related factors. The results of the study are summarized as follows: 1, The 66 patients were consisted of 40 cases of lung cancer, 15 cases of breast cancer and 11 cases of mediastinal tumors. There were 37 males and 29 females with the male to female ratio 1.3: 1. A male to female ratio in the lung cancer was 3: 1. 2. Among 66 patients, 26 patients $(39\%)$ developed the radiographical changes of acute radiation pneumonitis and 13 out of 26 patients $(50\%)$ showed the clinical features of acute radiation pneumonitis. 3. The onest of acute radiation pneumonitis ranged from 10 days to 6 months after the completion of radiotherapy. 4. There was a statistically significant close relationship between the development of radiation pneumonitis and the radiation dose. 5. As the irradiated lung volume increased, the development of radiation pneumonitis increased. But the statistical significance was not strong. 6. The increased incidence of radiation pneumonitis was observed when the chemotherapy was given before or concomittantly with radiotherapy. 7 There was no significant correlation between the development of radiation pneumonitis and the age, smoking and the presence of underlying lung disease.

• 한국습지학회지
• /
• 제12권3호
• /
• pp.39-47
• /
• 2010

최근 우리나라 농경지 면적은 해마다 감소하고 있는 추세이나 이러한 농업지역으로부터 발생되는 오염부하량은 오히려 증가하고 있는 실정이다. 농업지역으로부터 발생되는 오염물질 중 대부분은 비점오염원에 의해 배출되며 이는 주로 저농도이면서 넓은 지역에서 대량으로 배출되는 특성을 보인다. 본 연구의 목적은 농업지역 내 비점오염원을 관리하기 위한 방안으로 인공습지를 적용하여 수질정화효율을 분석함으로써 인공습지 적용가능성과 오염물질 제거기작, 설계인자 등을 제공함에 있다. 모니터링 결과를 토대로 수질분석을 실시하였으며 분석 결과, 유입수의 평균 농도 제거율은 TSS가 26 %, BOD가 28 %, TN이 16 %, TP가 39 %로 나타났다. 또한 국내 하천수질기준에 준하여 인공습지 유입수과 유출수의 수질을 비교해 본 결과 대부분의 항목에서 수질등급이 향상되었다.