• 제목/요약/키워드: complete blood cell count

검색결과 120건 처리시간 0.029초

Nodal tumor response according to the count of peripheral blood lymphocyte subpopulations during preoperative chemoradiotherapy in locally advanced rectal cancer

  • Heo, Jaesung;Oh, Young-Taek;Noh, O Kyu;Chun, Mison;Park, Jun-Eun;Cho, Sung-Ran
    • Radiation Oncology Journal
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    • 제34권4호
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    • pp.305-312
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    • 2016
  • Purpose: The objective of this prospective study was to evaluate the relationship between the circulating lymphocyte subpopulation counts during preoperative chemoradiotherapy (CRT) and tumor response in locally advanced rectal cancer. Materials and Methods: From August 2015 to June 2016, 10 patients treated with preoperative CRT followed by surgery were enrolled. Patients received conventional fractionated radiotherapy (50.4 Gy) with fluorouracil-based chemotherapy. Surgical resection was performed at 4 to 8 weeks after the completion of preoperative CRT. The absolute blood lymphocyte subpopulation was obtained prior to and after 4 weeks of CRT. We analyzed the association between a tumor response and change in the lymphocyte subpopulation during CRT. Results: Among 10 patients, 2 (20%) had evidence of pathologic complete response. In 8 patients with clinically node positive, 4 (50%) had nodal tumor response. All lymphocyte subpopulation counts at 4 weeks after CRT were significantly lower than those observed during pretreatment (p < 0.01). A high decrease in natural killer (NK) cell, count during CRT (baseline cell count - cell count at 4 weeks) was associated with node down staging (p = 0.034). Conclusion: Our results suggest that the change of lymphocyte subset to preoperative CRT may be a predictive factor for tumor response in rectal cancer.

Test turnaround Time for Complete Blood Cell Count using Delta and Panic Value Checks and the Q-flag Limit

  • Koo, Bon-Kyung;Ryu, Kwang-Hyun;Lim, Dae-Jin;Cho, Young-Kuk;Kim, Hee-Jin
    • 대한임상검사과학회지
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    • 제44권2호
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    • pp.66-74
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    • 2012
  • Test turnaround time (TAT) is the lead time from reception to reporting. In the complete blood cell count (CBC), 4 units of the XE-2100 (Sysmex Corp., Japan) processed around 80% of quantity, 1 unit of the LH-780 (Beckman-Coulter Incorp., USA) processed around 10% and 1 unit of ADVIA-2120 (Siemens AG, Munich, Germany) processed around 10%. We analyzed the change in the TAT for the CBC for over 7 years, from January of 2005 to December of 2011. The delta check made alterations of delta to WBC, hemoglobin, hematocrit, platelet and metamyelocyte, however, did not made them to band neutrophil, eosinophil, basophil and monocyte. The panic value check made alterations of panic value to hemoglobin, hematocrit, platelet and monocyte. In the criteria of currently slide review, LH-780 and ADVI-2120 analyzers prepared suspect flags of "Blast, Imm NE2, Immature granulocyte, Imm NE1, Left shift, Variant lymphocyte, Atypical lymphocyte, Platelet clumps and NRBC". The New slide review in the XE-2100 analyzer altered the preparations of a smear slide more than a "Platelet clumps flag(${\geq}200unit$), a single flag excluding the "Platelet clumps flag (${\geq}250unit$) and a multiple flag (${\geq}200unit$)". Also, below the 240 unit, medical technologists prepared manual slides selectively according to their evaluations. The automatic reporting rate was 33.4% without alterations, whereas it was 41.0% without alterations, and was thus improved by 7.6%. The slide review rate was 15.2% before using the Q-flag limit, whereas it was 12.1% for a reduce 3.1%. TAT was 45 minutes without the creation alterations of the delta and panic value checks, whereas it was 35 minutes after making alterations of the delta and panic value checks and thus was shortened by 10 minutes. We came to the conclusion that the establishment and operation of delta and panic value checks and slide review criteria suitable for laboratory environment can reduce unnecessary smear slides, re-checking, re-sampling, re-testing, telephone inquiries and concentrated workloads during specific times of the day.

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대학생의 체성분분석과 혈구산정검사의 관계연구 (A Study on the Relationship between Body Composition Analysis and CBC in University Students)

  • 조윤경;윤준;조영국;성현호
    • 대한임상검사과학회지
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    • 제48권3호
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    • pp.269-274
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    • 2016
  • 국가의 공중 보건 정책을 개선하고 사회 경제적 발전을 결정하기 위하여 미래에 성인이 될 학생의 경향 연구는 매우 중요한 일이다. 본 논문은 남녀 대학생의 체중과 체질량지수 그리고 신체조성과 CBC 결과와 관계를 분석하는데 목적이 있다. 연구 결과, 신체조성 중에서 신장과 체중, 체질량지수 그리고 골격근 양, 기초대사량과 적혈구 수와 혈색소 그리고 적혈구용적률 등에서 양에 상관관계를 나타내었고 모두 통계적인 유의성이 있었다(p<0.01). 특히, 혈소판은 체지방량과 체지방률 그리고 허리와 엉덩이 비율에서 양의 상관관계로 나타났다(p<0.01). 이러한 연구결과는 대학생들의 건강관리에 필요한 기초자료로 의미가 있다. 따라서 대학생의 건강관리와 관련된 다량의 연구는 전략적으로 반드시 필요하다. 따라서 대학생들의 건강관리는 국가적으로 매우 중요한 부분을 차지할 수 있으며, 지속적인 관리체계 구축과 그에 따른 제도적 마련이 필요하다고 사료된다.

뇌졸중환자에서 한약과 양약의 병용투여가 간장 및 신장에 미치는 영향 (The effects of Constant Use of Herbal Medicine with Western Medicine On Liver and Kidney Functions)

  • 박성욱;이형철;고창남;윤성우;한지영;이상욱
    • 대한한방내과학회지
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    • 제24권1호
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    • pp.68-74
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    • 2003
  • Objectives : The purpose of this study was to evaluate whether herbal medication may injure the liver function and kidney function. We clinically studied the changes of biochemistry and complete blood cell count in patients who were hospitalized in Korean hospital. Methods : The subjects were 160 patients admitted in Kangnam Korean hospital, Kyung Hee, whose mean duration of medication was 70 days(min 30, max 252). All patients had been checked biochemistry and complete blood cell count for 30 days since their hospitalization. Results : Aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP), blood urea nitrogen(BUN) and Creatinine(Cr) decreased significantly on discharge, compared with the values of admissoin(P<0.05). Total protein significantly elevated on dischrge compared with the values of admisson(P<0.05). Conclusions : This study suggests that even though there are few toxic herbal medicines, in general, herbal medications which are prescribed by oriental medicine doctors should be carefully administered not to hurt liver and kidney function.

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Effects on hematology and blood biochemistry profile of intramuscular meloxicam injection in Brahminy kite and Barn owl

  • Ratiwan Sitdhibutr;Raveewan Ploypan;Sirawit Subaneg;Chaiyan Kasorndorkbua
    • Journal of Veterinary Science
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    • 제24권3호
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    • pp.43.1-43.8
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    • 2023
  • Background: Meloxicam is used widely for exotic animal analgesia, but its toxicity in common raptor species in Thailand is unclear. Objectives: This study evaluated the single-dose effect of intramuscular meloxicam in common raptor species in Thailand for short-term and long-term periods. Methods: Twenty-two raptors were administered a single 1 mg/kg dose of meloxicam individually via intramuscular injection. The following were evaluated: clinical appearance, body weight, body condition score, body temperature, fecal appearance, complete blood cell count, and biochemistry panel before (day 0) and after the injection (1, 7, and 30 days). The collected samples were categorized into three groups: Brahminy kite (Haliastur indus) (n = 10), adult Barn owl (Tyto javanica) (n = 4), and juvenile Barn owl (n = 8). Results: None of the raptors in the study groups showed any abnormalities. The hematological profiles were significantly different in the short-term period (day 1 and day 7). The creatinine, aspartate aminotransferase, and creatinine kinase increased in several groups. On the other hand, the packed cell volume decreased in the Brahminy kite and juvenile Barn owl groups. According to the findings, an intramuscular injection of 1 mg/kg meloxicam affected the blood biochemistry panel of the muscle, but the affected raptors recovered within one week. Conclusions: An intramuscular injection of meloxicam at a single 1 mg/kg dose in Brahminy kites and Barn owls was not associated with the morbidity, hepatotoxicity, gastrointestinal toxicity, and nephrotoxicity in the short- and long-term periods.

Reference Values of Whole Blood Viscosity and Its Correlation with Hematology and Serum Chemistry in Beagle Dogs

  • Koh, Jun;Lee, Dong-bin;Lee, Dong Han;Kim, Nam Soo
    • 한국임상수의학회지
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    • 제35권3호
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    • pp.77-82
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    • 2018
  • The aim of this study was to measure whole blood viscosity (WBV) and then to establish its reference values and identify correlation between WBV and hematology or serum chemistry in beagle. The experiment was made up of 82 healthy beagle dogs. Jugular vein blood samples (10 ml) were collected. WBV (cP) measured within 4 hours after collection by U-shaped scanning capillary-tube viscometer ($BVD-PRO1^{(R)}$) which is capable of measuring yield stress and viscosity of whole blood continuously over a wide range of shear rates from $1s^{-1}$ to $1000s^{-1}$ is new type of capillary tube viscometer and calculates viscosity using Casson fluid model. Measured values of WBV, Complete blood cell count, serum chemistry were analyzed by RM-ANOVA test. Mean diastolic and systolic WBV (cP) were $29.032{\pm}6.137$ and $4.528{\pm}0.865$. Bodyweight (BW), Red blood cell count (RBC), Hemoglobin (HGB), Hematocrit (HCT), Alkaline phosphatase (ALP), Cholestetol (CHOL), Total protein (TP), Globulin, Chloride (Cl), Fibrinogen, were statistically correlated with WBV over whole range of shear rates (p < 0.05). This study newly evaluated reference values of WBV by U-shaped viscometer in beagle. Correlation between WBV and BW, RBC, HGB, HCT, ALP, CHOL, TP, Globulin, Cl, Fibrinogen was presented.

Stem cell therapy for dogs with immune-mediated hemolytic anemia

  • Yeonmi Lee;Eunju Kang;Junguk Ju
    • 한국동물생명공학회지
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    • 제39권1호
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    • pp.58-61
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    • 2024
  • Three different dogs who had immune-mediated hemolytic anemia (IMHA) were treated for more than two weeks with blood transfusion in an animal clinic. Despite this treatment and hospitalization, there was no clinical improvement in clinical signs as well as complete blood cell count (CBC) including hematocrit (HCT) and C-reactive protein (CRP). All cases were then injected two or three times with allogeneic stem cells through an intravenous route for treatment. Upon administrating stem cells to the IMHA dogs, clinical conditions and the indexes of HCT and CRP were clinically improved within or close to normal ranges.

뇌전증 EEG결과와 CBC결과의 관계연구 (A Study on the Relationship between CBC and EEG for Epilepsy Patients)

  • 조윤경;성현호;채경민
    • 대한임상검사과학회지
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    • 제47권4호
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    • pp.225-229
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    • 2015
  • 뇌전증은 반복적으로 발작이 발생하는 질환으로, 뇌파검사가 가장 객관적이고 유용한 검사이다. 본 연구의 대상자는 2014년 서울대학교 병원에서 뇌전증 확진판정을 받고 뇌파 검사를 받은 환자를 대상으로 연구목적에 동의한 244명을 대상으로 하였다. 이 중 뇌파 검사결과에 따라 성별과 연령에 상관없이 정상그룹 122명, 비정상그룹 122명을 대상으로 뇌파소견과 혈구산정검사와의 상관관계를 알아보고자 하였다. 이번 연구에서 분석된 뇌파 측정결과와 혈구산정검사 결과와의 유의한 상관관계는 WBC, RBC, neutrophil, lymphocyte로 4항목이었다. WBC (p<0.05)와 neutrophil (p<0.01)은 양의 관계였으며, RBC (p<0.05)와 Lymphocyte (p<0.01)는 음의 관계로 나타났다. 이 논문의 한계점은 항뇌전증 치료제의 종류에 따른 혈구산정 검사결과를 분석하지 못한 것이다. 하지만 동일한 질환에 따른 뇌파결과를 중심으로 분석한 결과는 의미가 있다. 그러므로 이러한 부분은 향후 더욱 많은 데이터를 통계적으로 분석해야 할 필요성이 있다고 생각된다.

생간건비탕가삼칠근(生肝健脾湯加三七根)이 흰쥐의 간섬유화 억제에 미치는 영향 (Inhibitory Effect of Saengangeonbitang-gasamchilgn on Liver Fibrosis in Rat)

  • 이은;김영철;고흥
    • 대한한방내과학회지
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    • 제29권2호
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    • pp.500-511
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    • 2008
  • The aim of this study was to investigate the inhibitory effect of Saengangeonbitang-gasamchilgn(SGGBTGSCG) on collagen production in rat hepatic stellate cells(HSC) and on the TAA-induced chronic liver injury model in rats. Methods : 1) HSCs were treated with SGGBTGSCG extract powder(50% EtOH SGGBTGSCG, dw SGGBTGSCG). After the treatment, MTT assay, BrdU assay and procollagen assay were done. In addition, gene expressions of collagen type $1{\alpha}2$, ASMA, TIMP1, and TIMP2, all of which are known to be associated with liver fibrosis, were analyzed by RT-PCR. 2) Liver fibrosis was developed in rats by injection of TAA 3 times a week for 5 weeks. After the SGGBTGSCG-treatment, body weight, liver & spleen weight, liver function test, the complete blood cell count and the change of portal pressure were studied. Results : In MTT assay, SGGBTGSCG significantly decreased the viability of HSCs in a dose-dependent manner. In BrdU assay, SGGBTGSCG significantly inhibited the HSC proliferation in a dose-dependant manner. In procollagen assay, SGGBTGSCG decreased procollagen production by HSC. In the change of rats' liver and spleen weight, TAA+SGGBTGSCG groups showed little difference compared with TAA-only group. In the liver function test, SGGBTGSCG decreased the serum level of ALT, AST, and Alp elevated by TAA. In the complete blood cell count, SGGBTGSCG significantly decreased WBC elevated by TAA and increased RBC and Hct lowered by TAA. In the change of portal pressure, SGGBTGSCG decreased portal pressure elevated by TAA. Conclusions : These results suggest that SGGBTGSCG is beneficial in the treatment of cirrhotic patients as well as for patients with chronic hepatitis.

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Non-B, Non-T Acute Lymphoblastic Leukemia in a Cat

  • Sumin Cha;Hyunwoo Kim;Hyeona Bae;Minjeong Kang;Rankyung Jung;Minji Kim;DoHyeon Yu
    • 한국임상수의학회지
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    • 제40권4호
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    • pp.298-302
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    • 2023
  • A 7-year-old neutered male, domestic shorthair cat presented anorexia and lethargy. The complete blood cell count revealed severe non-regenerative anemia, lymphocytic leukocytosis, neutropenia, and thrombocytopenia. On the peripheral blood smear examination, medium to large lymphoblastic cells with moderate amounts of basophilic cytoplasm were observed in up to 70% of peripheral leukocytes. Feline leukemia and immunodeficiency viruses were not detected using a commercial diagnostic kit. While splenomegaly and blunt margins of the caudoventral liver were observed in abdominal radiography, changes in the intra-abdominal lymph nodes were not remarkable. Ultimately, flow cytometric immunophenotyping from the peripheral blood revealed a negative for B-cell markers (CD21-/CD79a-) and T-cell markers (CD3-/CD4-/CD5-/CD8-). Based on the hematological examination and the immunophenotyping assay, the cat was diagnosed with non-B, non-T acute lymphoblastic leukemia. Here, we report a rare case of non-B, non-T acute lymphoblastic leukemia to raise awareness and provide information on clinical symptoms and laboratory test and immunophenotyping analysis results.