• Nutrition Research and Practice
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• v.18 no.1
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• pp.98-109
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• 2024

BACKGROUND/OBJECTIVES: The efficacy of Lab4 probiotic and vitamin C combination on the prevention of upper respiratory tract infections (URTIs) was investigated in two studies with children. Our objective was to pool dataset of 57 preschool children from the PROCHILD study (ISRCTN28722693) and the dataset of 50 preschool matched cohort from the PROCHILD-2 study (ISRCTN26587549) to evaluate the impact of probiotic/vitamin C combination on the prevention of upper respiratory tract symptoms and provide a more robust assessment of effect using detailed individual level data. SUBJECTS/METHODS: The children were supplemented daily for 6 months with either the multistrain probiotic (1.25×10¹⁰ cfu/tablet consisting of two strains of Lactobacillus acidophilus CUL21 and CUL60, Bifidobacterium bifidum CUL20 and Bifidobacterium animalis subsp. lactis CUL34) plus 50 mg vitamin C or a placebo. RESULTS: In the pooled analysis of the individual participant data (per protocol population), significant reductions were observed for the incidence (-25%; 95% confidence interval [CI], 0.66, 0.85; P < 0.0001) and duration (-14.9 days; 95% CI, -24.8, -5.1; P = 0.0030) of typical URTI symptoms in the active group compared with the placebo. The incidence rates of absenteeism from preschool (IR ratio, 0.75; 95% CI, 0.66, 0.86; P < 0.0001), paediatric visits (IR ratio, 0.56; 95% CI, 0.47; 0.68; P < 0.0001) and antibiotic usage (IR ratio, 0.53; 95% CI, 0.39, 0.71; P < 0.0001) were also significantly reduced. CONCLUSION: The pooled analysis findings of comparable preschool cohorts from two studies indicate that the supplementation with probiotic and vitamin C combination is beneficial in the prevention and management of URTI symptoms.

• Korea journal of population studies
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• v.18 no.2
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• pp.115-168
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• 1995

It is a common wisdom that the long-term economic development of Korea chiefly depends not only on the steady increase of the capital formation but also on the stable increase of the national saving. And also it is a widely accepted opinion that household saving plays a significant role for the smooth supply of investment funds. For the empirical analysis on the determining factors of household saving, consumption function of the household of Korea was utilized indirectly. The reason is that consumption function is regarded as a stable function whereas saving function is considered to be an unstable function of the relevant independent variables. In order to carry out the regression process of the consumption functions, data on the family income and expenditure survey and the farm household economy survey was used. The regression result could be summarized as follows : Firstly, household income and the number of the employed in the household have the negative effect in determining the consumption ratio of the Korean households. On the other hand, ages and the educational attainment of the household heads as well as the number of the household members have the positive effect. During the early part of 21st century, the consumption ratio of the Korean households is expected to be decreased because of the increasing trend of household income, and the ever increasing number of the employed member of the household based on the increasing trend of the labor force participation rate of women and the decrease of the average size of the number of household members owing to widespread nuclear family system. On the other hand, the consumption ratio of the household of Korea is expected to be increased because of the continuous increase of the average ages of the household heads caused by the population aging phenomena and improvement of the educational attainment of the household heads. But on the whole, household saving ratio is expected to be increased owing to the secular downward trend of the consumption and therefore no significant difficulties are anticipated for the smooth provision of investment resources needed to have long-term economic progress of Korea.

• Korean Journal of Weed Science
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• v.9 no.1
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• pp.39-45
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• 1989

An experiment was conducted at the Yeongnam Crop Experiment Station for 4 years from 1985 to understand the effect of repeated use of same herbicide on weed growth. For this, the most common 6 herbicides, butachlor, bifenox, butachlor/pyrazolate, piperophos/dimethametryne, bentazon and propanil were used as single treatment or combination treatment. For non chemical plots, weed occurrence was rapidly increased with time in terms of number and weight. However no rice plot recorded the least increasing ratio. Similar trend was obtained at the herbicide plot even though the increasing ratio varied by herbicide properties. The least increasing ratio (1200 was recorded at the plot of butachlor/pyrazolate (5 days after transplanting, 5 DAT) followed by bentazon+propanil(25 DAT) while the greatest ratio (28%) was obtained from the plot of bifenox (5 DAT). In general, Scirpus hotarui, Eleocharis kuroguwai and Cyperus serotinus was gradually inereased with time by herbicide application, particularly at the butachlor/pyrazolate treatment. The community dominance and simpson index increased at the plot of bentazon and propanil due to increased of particular species while other herbicide plots exhibited reverse trend. Grain yield was curvilinearly decreased with weed weight for both times, 40 DAT and heading time eventhough the correlation coefficient of heading time was higher than 40 DAT.

• Health Policy and Management
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• v.32 no.1
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• pp.63-72
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• 2022

Background: Depression is a common disease around the world. Many studies are showing that mental health can be improved through physical activity, and daily regular exercise can reduce the negative effects of depression or depressive symptoms. In order to promote individual physical activity, a physical activity-friendly environment must precede. Therefore, this study attempted to confirm whether the number of sports facilities for all affects individual depression. Methods: Among the respondents to the 2018 Community Health Survey, data from 181,086 people excluding missing value were used. Descriptive and chi-square tests were performed to understanding the general characteristics of individual level variables. A multilevel logistic regression was conducted to confirm the effect of individual and regional level variables on depressive symptoms. Results: As a result of confirming the effect of individual characteristics on depressive symptoms, it was confirmed that both socioeconomic and health behavior factors had an effect. Similar results were shown in a model that considered regional level variables, and in the case of the number of sports facilities per population, people who belongs to smaller areas were more likely to have depressive symptoms (odds ratio, 0.98; 95% confidence interval, 0.97-0.99). Conclusion: As a result of the analysis, it was confirmed that both individual level and regional level variables had a significant effect on depressive symptoms. This suggests that not only individual level approaches but also regional level approaches are needed to improve individual depressive symptoms In particular, it may be possible to consider to increase the number of sports facilities in areas where the prevalence of depressive symptoms is high and the number of sports facilities is insufficient.

• Journal of Korean Neurosurgical Society
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• v.66 no.4
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• pp.409-417
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• 2023

Objective : The association between boule (BOLL) and endothelin receptor type A (EDNRA) loci and intracranial aneurysm (IA) formation has been reported via genome-wide association studies. We sought to identify genome-wide interactions involving BOLL and EDNRA loci for IA in a Korean adult cohort. Methods : Genome-wide pairwise interaction analyses of BOLL and EDNRA involving 250 patients with IA and 296 controls were performed using the additive effect model after adjusting for confounding factors. Results : Among 512575 single-nucleotide polymorphisms (SNPs), 23 and 11 common SNPs suggested a genome-wide interaction threshold (p<1.25×10^-8) involving rs700651 (BOLL) and rs6841581 (EDNRA). Rather than singe SNP effect of BOLL or EDNRA on IA development, they showed a synergistic effect on IA formation via multifactorial pair-wise interactions. The rs1105980 of PTCH1 gene showed the most significant interaction with rs700651 (natural log-transformed odds ratio [lnOR], 1.53; p=6.41×10^-11). The rs74585958 of RYK gene interacted strongly with rs6841581 (lnOR, -19.91; p=1.64×10^-9). Although, there was no direct interaction between BOLL and EDNRA variants, two EDNRA-interacting gene variants of TNIK (rs11925024 and rs1231) and FTO (rs9302654), and one BOLL-interacting METTL4 gene variant (rs549315) exhibited marginal interaction with BOLL gene. Conclusion : BOLL or EDNRA may have a synergistic effect on IA formation via multifactorial pair-wise interactions.

• Korean journal of applied entomology
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• v.7
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• pp.15-20
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• 1969

This experiment was planned to study the mating behavior of the fall webworm. Hyphantria cunea Drury. In this experiment. observations on mating behavior of the fall webworm were based on the time of moth emergence, time of mating activity, copulation period, mating frequency, and effect of moth ages on the mating ratio. Mating frequency was determined by visual observation and the number of spermatophores. The results obtained were as follows; 1) The moths started emerging at about 3 P. M. and ended at about 12 P. M. The peak of moth emergence was between 7 and 8 P. M. Total ratio or the moths emerged between 7 and 8 P. M. was 42. 1 for female and 41.8 for male. 2) Mating activity was mostly confined to the period between 5 and 6 A. M. The average complation period was 12 hours (ranges between 7 and 17 hours). 3) The average ratio of single mating was $66.0\%$ for both sexes, and that of double. matings were $4.1\%$ for females and $5.4\%$ for males in laboratory test. The mating ratio of female moths collected from the field was $62.1\%$ for single mating. and 15.5" for doubles matings. These data indicated that single mating seemed to be most common. 4) Mating usually occured within four days after the emergence from the pupae. Mating ratio was greatly varied with the moth ages. The highest mating ratio was observed within 6 to 15 hours after moth emergence. Both sexes usually mated with the moths of the same ages.

• The Korean Journal of Pain
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• v.29 no.3
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• pp.153-157
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• 2016

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

• Progress in Medical Physics
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• v.13 no.3
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• pp.156-162
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• 2002

In this study, we attempted in preparing high precision EEG measuring equipment. To measure EEG in high efficiency, pre-amplifier should get high performance common mode rejection ratio. Also, separation amplifier is essential to eliminate common line noise. So, our study were pointed at elevating the efficiency of eliminating noise, user safety and low noise characteristics. Prepared high precision pre-amplifier for EEG was A/D converted to automatically classify $\alpha$ wave, $\beta$ wave and $\theta$ wave. And converted data were Fast Fourier Transformed with real time DSP (Digital Signal Processing). Clinical demonstrations were carried out with healthy students, aged between 20 to 26 who has no histories of illness. To recognize the efficiency of the EEG, prepared EEG were used with MS equipment in low stimulated state and high stimulated state. Then, we studied at the effect of sensitivity on brain wave. From this study, it is known that our EEG equipment is efficient in sensitivity evaluation and suitable stimulations for each psychological state are required.

• Journal of Genetic Medicine
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• v.3 no.1
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• pp.29-32
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• 1999

The Apolipoprotein E type 4 allele (ApoE ${\varepsilon}4$) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease. The BchE-k variant, which is the common variant of the BchE gene, has been reported to show allelic association with AD in subjects who are also carriers of the ${\varepsilon}4$ allele of the ApoE, especially in subjects over the age of 75. This study was performed to evaluate the distribution of the ApoE and the BchE genotypes in the healthy and AD groups and to evaluate the synergy between the BchE-k variant and the ApoE ${\varepsilon}4$ in AD. The ApoE and the BchE genotypes were determined in DNA samples from 610 healthy people and 60 LOAD patients by using ARMS by standard agarose gel electrophoresis. The effect of the ApoE ${\varepsilon}4$ was closely related to AD(p<0.05). A comparison between the AD patients and the healthy individuals, both with the ${\varepsilon}4$ allele, indicated an interaction between the BchE-k and the ApoE ${\varepsilon}4$(p<0.05). The association of the BchE-k with AD was limited to carriers of the ApoE ${\varepsilon}4$ allele, among whom the presence of the BchE-k gave an odds ratio of AD 3.48 (95% C.I. 1.3-9.2). Therefore, these results suggested that further evidence of an association between the ApoE ${\varepsilon}4$ and LOAD, and the BchE-k acts in synergy with the ApoE ${\varepsilon}4$ as a susceptibility gene for AD.

• Journal of the Korea Organic Resources Recycling Association
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• v.20 no.3
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• pp.71-82
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• 2012

Common bulking agents in composting system include woody materials such as sawdust and woodchips. These bulking agents are mainly used for the purpose of the proper control of C/N ratio and moisture content in the composting. The topic for the effect on air permeability of bulking agents has far received relatively little attention in the composting field. This study investigated the effect of bulk density, moisture content, air-filled porosity, particle size and air flow rate on air permeability of several mixture ratios of sawdust and woodchip bulking agent. Increasing the moisture contents, the air-filled porosity was decreased and the particle size was increased for all kinds of bulking agent mixtures. Especially, with the increasing of mixing ratio of woodchip, these effects were sharply magnified. The air permeability respond to air-filled porosity was very similar to that for moisture content which was anticipated the linear relationship between air-filled porosity and moisture content. Above the region of moisture content 0.25 or 0.43(d.b.)(20 or 30% w.b.), the pressure drop decreased even though air-filled pore spaces were filling with water. Especially, to the particle size of 5 mm the pressure drop was decreased exponentially, so the air permeability was dramatically improved. By the water had the role of binding of the small particles, the macropores less resistances to air flow were created in the matrix. The effect of particle size on air permeability was much stronger than that of air-filled porosity or moisture content. And it is needed the preparing of initial particle size above 5 mm for efficient composting.