• Genomics & Informatics
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• 제19권1호
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• pp.3.1-3.12
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• 2021

Functional interpretation of noncoding genetic variants associated with complex human diseases and traits remains a challenge. In an effort to enhance our understanding of common germline variants associated with lung cancer, we categorize regulatory elements based on eight major cell types of human lung tissue. Our results show that 21.68% of lung cancer-associated risk variants are linked to noncoding regulatory elements, nearly half of which are cell type-specific. Integrative analysis of high-resolution long-range chromatin interactome maps and single-cell RNA-sequencing data of lung tumors uncovers number of putative target genes of these variants and functionally relevant cell types, which display a potential biological link to cancer susceptibility. The present study greatly expands the scope of functional annotation of lung cancer-associated genetic risk factors and dictates probable cell types involved in lung carcinogenesis.

• Smart Structures and Systems
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• 제14권4호
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• pp.617-641
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• 2014

The energy constraint is still a common issue for the practical application of wireless sensors, since they are usually powered by batteries which limit their lifetime. In this paper, a practical compound energy efficiency strategy is proposed and realized in the implementation of a real time wireless sensor platform. The platform is intended for wireless structural monitoring applications and consists of three parts, wireless sensing unit, base station and data acquisition and configuration software running in a computer within the Matlab environment. The high energy efficiency of the wireless sensor platform is achieved by a proposed adaptive radio transmission power control algorithm, and some straightforward methods, including adopting low power ICs and high efficient power management circuits, low duty cycle radio polling and switching off radio between two adjacent data packets' transmission. The adaptive transmission power control algorithm is based on the statistical average of the path loss estimations using a moving average filter. The algorithm is implemented in the wireless node and relies on the received signal strength feedback piggybacked in the ACK packet from the base station node to estimate the path loss. Therefore, it does not need any control packet overheads. Several experiments are carried out to investigate the link quality of radio channels, validate and evaluate the proposed adaptive transmission power control algorithm, including static and dynamic experiments.

• Journal of Chest Surgery
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• 제45권4호
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• pp.246-250
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• 2012

Background: Although it is rare for the fracture itself to become a life threatening injury in patients suffering from rib fracture, the lives of these patients are occasionally threatened by other associated injuries. Especially, early discovery of patients with rib fracture and intra-abdominal organ injury is extremely important to the prognosis. This study analyzed the link between rib fracture and intra-abdominal injury to achieve improved treatment. Materials and Methods: Among trauma patients that had visited the hospital emergency room from January 2007 to December 2009, a retrospective study was conducted on 453 patients suffering from rib fracture due to blunt trauma. Rib fracture was classified according to location (left, right, and bilateral), and according to level (upper rib fracture [1-2nd rib], middle rib fracture [3-8th rib], and lower rib fracture [9-12th rib]). The researched data was statistically compared and analyzed to investigate the correlation between the location, level, and number of rib fracture and intra-abdominal organ injury. Results: Motor vehicle injury was found to be the most common mechanism of injury with 208 cases (46%). Associated injuries accompanied with rib fracture were generated in 276 cases (61%). Intra-abdominal organ injury was discovered in 97 cases (21%). Liver injury was the most common intra-abdominal injury associated with rib fracture with 39 cases (40%), followed by spleen injury, with 23 cases (23%). Intra-abdominal injury according to level of rib fracture was presented as upper rib fracture in 11 cases (11%), middle rib fracture in 31 cases (32%), and lower rib fracture in 55 cases (57%), thus verifying that intra-abdominal injuries were commonly accompanied in lower rib fractures (p=0.03). In particular, significant increase of intra-abdominal injury was presented in fractures below the 8th rib (p=0.03). The number of intra-abdominal injuries requiring emergency operations was significantly higher in patients with more than 6 rib fractures (p=0.04). Conclusion: Intra-abdominal organ injury is more common in patients with lower rib fracture, especially fractures below the 8th rib. Intra-abdominal organ injuries generated in multiple rib fracture patients with more than 6 fractures significantly higher severity. These cases must be thoroughly inspected and carefully observed as there is possibility of emergency operation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권10호
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• pp.2544-2560
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• 2013

As a cornerstone of the next generation air traffic management (ATM), automatic dependent surveillance-broadcast (ADS-B) system can provide continual broadcast of aircraft position, identity, velocity and other messages over unencrypted data links to generate a common situational awareness picture for ATM. However, since ADS-B messages are unauthenticated, it is easy to insert fake aircrafts into the system via spoofing or insertion of false messages. Unfortunately, the authentication for ADS-B messages has not yet been well studied. In this paper, we propose an efficient broadcast authentication scheme with batch verification for ADS-B messages which employs an identity-based signature (IBS). Security analysis indicates that our scheme can achieve integrity and authenticity of ADS-B messages, batch verification, and resilience to key leakage. Performance evaluation demonstrates that our scheme is computationally efficient for the typical avionics devices with limited resources, and it has low communication overhead well suitable for low-bandwidth ADS-B data link.

• 한국전자파학회논문지
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• 제26권11호
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• pp.978-984
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• 2015

본 논문에서는 유무인항공기에서 사용될 통달거리 200 km, 전송속도 45 Mbps급 데이터 전송장비의 RF 송수신기에 대해 다룬다. RF 송수신기는 Ku 대역에서 동작하도록 설계되었으며, 상/하향 변환모듈, 고출력 증폭 모듈, 전단 처리 모듈로 구성된다. 제안된 RF 송수신기의 성능을 만족시키기 위해 출력신호 레벨이 10 W급인 전력 증폭기가 요구되었으며, 이는 GaN 소자기반의 전력증폭기로 구현되었다. 또한, 적응형 전송속도 변환기능이 요구되었고, 이를 위해 다양한 대역폭의 신호를 수신할 때의 상호 주파수 간섭을 최소화하기 위하여 6종의 SAW 필터로 구성된 수신기 구조가 적용되었다. 시스템 요구사항의 만족 여부를 확인하기 위해 AWR 시뮬레이션 툴을 이용하였다.

• 한국도로학회논문집
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• 제15권2호
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• pp.131-138
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• 2013

PURPOSES : The intents of the study are to identify the accident factors and to demonstrate the potentials of tobit model as a tool to study the number of accidents on arterial roads segments. METHODS : This paper uses a tobit regression as a methodology to analyze the factors affecting the number of accidents. In pursuing the above goal, this study gives particular attentions to analyzing the data of 2,446 accidents (1,610 in major arterial roads and 836 in minor arterial roads) occurred on arterial roads in 2007 to 2010. RESULTS : First, 3 accident models which were classified by total arterial roads, major arterial roads and minor arterial roads, and were all statistically significant were developed. Second, the exclusive right-turn lane as common variable, and the number of accident, traffic volume, number of lanes, link length, rate of median, number of entrances, number of pedestrian crossings, number of curves, number of bus stops and exclusive left-turn as specific variables of the models were selected. Finally, the paired sample t-test could not be rejected the null hypotheses of three types of models. CONCLUSIONS : Using data from vehicle accidents on arterial roads, the estimation results show that many factors related to roadway geometrics and traffic characteristics significantly affect to the number of accidents.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2016년도 춘계학술발표대회
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• pp.124-126
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• 2016

Successful deployment of the Software Defined Network (SDN) depends on its ability to cope up with network failures. There are various types of failures that may occur in an SDN. The most common are switch and link failures. It is necessary to recover the network from failures for a continuous service availability. But for the real-time services fast recovery from the failure is required to minimize the service disruption time. In the proposed work, we focused on minimizing the recovery time after the failure is detected. Once the failure is detected, the controller involvement is needed to dynamically reroute the failure disrupted flows from the failed component to an alternate path. The aim of the proposed scheme is to provide a traffic management scheme which can react to the dynamic network events by rapidly modifying the forwarding behavior of the switches for faster in-band network adaptability. The proposed scheme (1) Considers the shared data and control path delay (2) Optimally utilize the network resources (3) Eliminates the need of constant monitoring overhead at the controller which results into faster detouring and ultimately rapid recovery.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2000년도 International Symposium on Bioinformatics
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• pp.53-55
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• 2000

Xenie is the JAVA application software that integrates and represents 'gene to function'information of human gene. Xenie extracts data from several heterogeneous molecular biology databases and provides integrated information in human readable and machine usable way. We defined 7 semantic frame classes (Gene, Transcript, Polypeptide, Protein_complex, Isotype, Functional_object, and Cell) as a common schema for storing and integrating gene to function information and relationship. Each of 7 semantic frame classes has data fields that are supposed to store biological data like gene symbol, disease information, cofactors, and inhibitors, etc. By using these semantic classes, Xenie can show how many transcripts and polypeptide has been known and what the function of gene products is in General. In detail, Xenie provides functional information of given human gene in the fields of semantic objects that are storing integrated data from several databases (Brenda, GDB, Genecards, HGMD, HUGO, LocusLink, OMIM, PIR, and SWISS-PROT). Although Xenie provide fully readable form of XML document for human researchers, the main goal of Xenie system is providing integrated data for other bioinformatic application softwares. Technically, Xenie provides two kinds of output format. One is JAVA persistent object, the other is XML document, both of them have been known as the most favorite solution for data exchange. Additionally, UML designs of Xenie and DTD for 7 semantic frame classes are available for easy data binding to other bioinformatic application systems. Hopefully, Xenie's output can provide more detailed and integrated information in several bioinformatic systems like Gene chip, 2D gel, biopathway related systems. Furthermore, through data integration, Xenie can also make a way for other bioiformatic systems to ask 'function based query'that was originally impossible to be answered because of separatly stored data in heterogeneous databases.

• 한국ITS학회 논문지
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• 제4권3호
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• pp.33-43
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• 2005

고속도로에서 수집 저장되는 이력자료의 활용도를 효과적으로 향상시키기 위해 Archived Data User Service (ADUS)/Archived Data Management System(ADMS) 구축에 대한 연구가 활발하게 진행되고 있다. 그러나, 방대한 이력교통자료의 활용도를 높이기 위해 우선 차량검지기 자료처리과정에 대한 체계적인 조사 분석을 통한 차량검지기 자료의 신뢰성 확보가 선행되어야 한다. 본 연구에서는 고속도로 차량검지기 자료처리과정에 대한 종합적인 문제점 분석을 통해 고속도로 교통관리 시스템의 개선사항에 대하여 살펴보았으며, 차로 이용률과 관련된 문제점과 개선방향에 연구의 초점을 맞추어 수행하였다. 본 연구에서는 우선 하루 동안 전체 검지기에서 수집된 자료 중 오류데이터가 차지하는 부분을 분석하였으며, 전체 수집 자료중 15%가 신뢰성에 영향을 미치는 오류데이터로 분석되었다. 또한, 고속도로 차량검지기에서 수집되는 자료의 차로 이용률(Lane Usage)을 살펴보았다. 분석결과 2차로구간에서는 1 2차로간 평균 차로이용률이 12% 정도의 차이를 나타내는 것으로, 3차로 구간에서는 1 2차로의 37%에 비해 3차로의 차로이용률이 24%로 비교적 낮게 분포하는 것으로 분석되었다. 4차로 분석구간에서는 1 4차로가 2 3차로에 비해 낮은 차로이용률을 나타내는 것으로 분석되어 실제 차로이용률이 차로별로 동일하지 않은 분포를 가짐을 확인할 수 있었다. 고속도로 차량검지기 자료처리과정에 대한 조사 분석 결과 더 신뢰성 있는 자료를 수집 저장하기 위해서는 고속도로에서 각 차로별 차로 이용률이 시간대에 따라 다르게 분포하는 점을 고려한 검지기 지점 데이터 생성 process에 대한 추가적인 연구가 필요하다.{\mu}m$ 였다. 으뜸세포의 사립체의 크기는 정상대조군, 종양대조군 및 BCG 투여군이 각각 $0.80({\pm}0.130){\mu}m,\;0.83({\pm}0.143){\mu}m$ 및 $0.72({\pm}0.078){\mu}m$ 였다. 이상의 결과를 종합해보면 BCG를 반복 투여하면 위점막으뜸세포의 분비과립이 약간 작아지는 등 분비기능이 다소 억제되나 그 정도가 경미하여 으뜸세포의 분비기능에 큰 손상을 주지 않는 것으로 생각된다.모양을 비교한 결과 꼬리핵과 줄무늬체바닥핵에서는 모두 가지돌기가시(dendritic spine)에 연접하였으나, 중격옆핵과 중격핵에서는 가지돌기 (dendrite)에 연접하는 것과 가지돌기가시에 연접하는 것이 혼재하였다. 이들 두 신경핵 무리는 이마앞겉질에서 기원하는 축삭종말의 연접차이로 볼 때 서로 다른 회로계통에 속할 것으로 생각되며, 문헌고찰을 통해서 꼬리핵과 줄무늬체바닥핵은 줄무늬체회로 (striatal circuit)에 속하고 중격옆핵과 중격핵은 변연계통회로(limbic circuit)에 속할 것으로 판정했다. 이마앞겉질은 생리적, 약리적, 신경학적 및 형태학적 근거들로 보아 바닥핵들을 통해 변연계통과 대뇌겉질 전체에 영향을 미칠 것으로 여겨지는데, 본 실험에서는 네 종류의 바닥핵들, 즉 꼬리핵, 줄무늬체바닥핵, 중격옆핵 및 중격핵과 관련된 신경연접들을 관찰하였으며, 그 결과를 문헌 고찰한 결과 변연계통과 줄무늬체계통이 앞뇌의 바닥에 있는 신경핵들에서 형태학적 교차연결을 통해 정서와 마음의 상태를 행동과 대응으로 표현하는 중요한 신경회로가 존재함을 제안하였다.腎臟組織)에서 더많이 발생되었다. 틸라피아의 신사구체(腎絲球體)는 담수(淡水)에서

• 정보과학회 논문지
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• 제44권5호
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• pp.476-485
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• 2017

미래 대공 유도무기체계 전술작전센터는 미래 공중위협, 전술정보, 통합전장 환경 생성 및 관리, 교전통제 및 지휘통제 알고리즘 연구를 위한 환경을 제공한다. 통합전장상황 생성 및 처리, 전술작전 자동화 처리 핵심 기능요소에 대한 개발을 위해서는 다역할(포대/대대) 전술작전 통제 및 재구성 설계가 가능한 소프트웨어가 필요하다. 따라서 기능 별 알고리즘 소프트웨어, 전술작전화면 소프트웨어, 장비들 간 연동을 위한 링크 소프트웨어를 데이터 중심 설계를 통해 재구성 가능하도록 개발하였다. 본 논문에서는 포대/대대 별 전술작전 운용화면에 재구성이 가능한 전술작전화면 프레임워크를 소개한다. 전술작전화면 프레임워크는 포대/대대 및 임무별 다역할 전술작전화면을 재구성 가능한 구조를 위해 공통데이터 모델설계와 MVC패턴을 이용한 화면구성도구를 개발하였다. 화면구성도구를 이용하여 화면 개발을 위한 전술작전화면 프레임워크를 제공한다. 전술작전화면 프레임워크를 이용하게 된다면 공통기반의 구조를 통해 화면 설계를 재사용 할 수 있다. 또한 쉽고 빠르게 재구성이 가능한 화면을 개발할 수 있을 것이다.