• The Korean Journal of Physiology and Pharmacology
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• 제17권6호
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• pp.511-516
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• 2013

Bladder cancer is the seventh most common cancer in men that smoke, and the incidence of disease increases with age. The mechanism of occurrence has not yet been established. Potassium channels have been linked with cell proliferation. Some two-pore domain $K^+$ channels (K2P), such as TASK3 and TREK1, have recently been shown to be overexpressed in cancer cells. Here we focused on the relationship between cell growth and the mechanosensitive K2P channel, TREK2, in the human bladder cancer cell line, 253J. We confirmed that TREK2 was expressed in bladder cancer cell lines by Western blot and quantitative real-time PCR. Using the patch-clamp technique, the mechanosensitive TREK2 channel was recorded in the presence of symmetrical 150 mM KCl solutions. In 253J cells, the TREK2 channel was activated by polyunsaturated fatty acids, intracellular acidosis at -60 mV and mechanical stretch at -40 mV or 40 mV. Furthermore, small interfering RNA (siRNA)-mediated TREK2 knockdown resulted in a slight depolarization from $-19.9mV{\pm}0.8$ (n=116) to $-8.5mV{\pm}1.4$ (n=74) and decreased proliferation of 253J cells, compared to negative control siRNA. 253J cells treated with TREK2 siRNA showed a significant increase in the expression of cell cycle boundary proteins p21 and p53 and also a remarkable decrease in protein expression of cyclins D1 and D3. Taken together, the TREK2 channel is present in bladder cancer cell lines and may, at least in part, contribute to cell cycle-dependent growth.

• Progress in Superconductivity
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• 제4권1호
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• pp.42-47
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• 2002

Measuring magnetic fields with a SQUID sensor always requires preliminary adjustments such as optimum bas current determination and flux-locking point search. A conventional magnetoencephalography (MEG) system consists of several dozens of sensors and we should condition each sensor one by one for an experiment. This timeconsuming job is not only cumbersome but also impractical for the common use in hospital. We had developed a serial port communication protocol between SQUID sensor controllers and a personal computer in order to control the sensors. However, theserial-bus-based control is too slow for adjusting all the sensors with a sufficient accuracy in a reasonable time. In this work, we introduce programmatic control sequence that saves the number of the control pulse arrays. The sequence separates into two stages. The first stage is a function for searching flux-locking points of the sensors and the other stage is for determining the optimum bias current that operates a sensor in a minimum noise level Generally, the optimum bias current for a SQUID sensor depends on the manufactured structure, so that it will not easily change about. Therefore, we can reduce the time for the optimum bias current determination by using the saved values that have been measured once by the second stage sequence. Applying the first stage sequence to a practical use, it has taken about 2-3 minutes to perform the flux-locking for our 37-channel SQUID magnetometer system.

• 한국ITS학회 논문지
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• 제9권1호
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• pp.91-100
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• 2010

최근 항공교통량의 증가에 따라 보다 효율적인 항공교통흐름제어가 요구되고 있다. 이에 본 논문에서는 효율적인 항공교통흐름제어를 위한 알고리즘을 제안하였다. 항공통신 환경은 일반 통신 환경과는 다르게 스테이션(항공기) 사이에 직접적인 통신 기능이 필요하며, 안전성을 위한 메시지의 우선순위가 매우 엄격하게 요구된다. 게다가 넓은 서비스 지역은 높은 전파지연을 발생시킨다. 본 논문에서는 기존의 CSMA/CA 매체접속제어(MAC) 프로토콜을 사용하여 항공교통상황(혼잡 공항 지역, 접근관제구역, En route구역, 대양 항행)에 따라 메시지 우선순위를 설정하고, 이러한 우선순위가 높은 메시지가 보다 더 높은 접속 확률을 갖고 데이터를 전송하도록 하였다. 항공기 대수에 따른 시뮬레이션 결과, 교통량이 증가할수록 기존 방식보다 더 높은 채널 사용 효율 및 전송확률을 가짐을 확인하였다.

• 대한전자공학회논문지TC
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• 제38권12호
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• pp.10-19
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• 2001

본 논문에서는 IMT(international mobile telecommunications)-2000 3GPP(3rd generation partnership project) 규격에 따른 전송률이 서로 다른 다수의 사용자 신호들을 효과적으로 처리할 수 있는 간단한 병렬형 간섭제거기를 제안한다. 제안한 방식은 다중 전송률 처리를 위하여 모든 사용자들에 공통적이며 전송률이 가장 낮은 제어채널의 한 심벌을 기준블록으로 설정하여 기준블록 단위마다 병렬로 간섭제거를 수행한다. 또한, 사용자간 비동기 환경에서 자신보다 짧은 지연을 갖는 간섭 사용자의 다음 기준블록에 의하여 발생하는 간섭을 미리 판정하고 재생하여 제거함으로써 간섭제거 성능을 개선할 수 있는 효과적인 사전 제거 기법을 제안한다. 제안된 사전 제거 기법을 사용한 다중 전송률 처리 병렬형 간섭제거기의 효율적인 구현을 위하여 샘플단위의 파이프라인을 도입하여 기준블록 주기로 판정하고, 이어서 샘플단위로 재생성하고 샘플단위로 간섭제거를 수행함으로써 최소의 하드웨어를 필요로 하는 파이프라인 구조를 제안한다. 모의실험을 통하여 저l안한 간섭제거기의 신호 대 잡음비 및 사용자 수에 따른 비트 오류율 성능을 분석한다.

• 세라미스트
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• 제21권2호
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• pp.4-18
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• 2018

Lastly, neuromorphic computing chip has been extensively studied as the technology that directly mimics efficient calculation algorithm of human brain, enabling a next-generation intelligent hardware system with high speed and low power consumption. Three-terminal based synaptic transistor has relatively low integration density compared to the two-terminal type memristor, while its power consumption can be realized as being so low and its spike plasticity from synapse can be reliably implemented. Also, the strong electrical interaction between two or more synaptic spikes offers the advantage of more precise control of synaptic weights. In this review paper, the results of synaptic transistor mimicking synaptic behavior of the brain are classified according to the channel material, in order of silicon, organic semiconductor, oxide semiconductor, 1D CNT(carbon nanotube) and 2D van der Waals atomic layer present. At the same time, key technologies related to dielectrics and electrolytes introduced to express hysteresis and plasticity are discussed. In addition, we compared the essential electrical characteristics (EPSC, IPSC, PPF, STM, LTM, and STDP) required to implement synaptic transistors in common and the power consumption required for unit synapse operation. Generally, synaptic devices should be integrated with other peripheral circuits such as neurons. Demonstration of this neuromorphic system level needs the linearity of synapse resistance change, the symmetry between potentiation and depression, and multi-level resistance states. Finally, in order to be used as a practical neuromorphic applications, the long-term stability and reliability of the synapse device have to be essentially secured through the retention and the endurance cycling test related to the long-term memory characteristics.

• 대한의용생체공학회:의공학회지
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• 제29권1호
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• pp.32-39
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• 2008

This paper reports on a realtime OS based master-slave configuration robot control system for laparoscopic surgery robot which enables telesurgery and overcomes shortcomings with conventional laparoscopic surgery. Surgery robot system requires control system that can process large volume information such as medical image data and video signal from endoscope in real-time manner, as well as precisely control the robot with high reliability. To meet the complex requirements, the use of high-level real-time OS (Operating System) in surgery robot controller is a must, which is as common as in many of modem robot controllers that adopt real-time OS as a base system software on which specific functional modules are implemened for more reliable and stable system. The control system consists of joint controllers, host controllers, and user interface units. The robot features a compact slave robot with 5 DOF (Degree-Of-Freedom) expanding the workspace of each tool and increasing the number of tools operating simultaneously. Each master, slave and Gill (Graphical User Interface) host runs a dedicated RTOS (Real-time OS), RTLinux-Pro (FSMLabs Inc., U.S.A.) on which functional modules such as motion control, communication, video signal integration and etc, are implemented, and all the hosts are in a gigabit Ethernet network for inter-host communication. Each master and slave controller set has a dedicated CAN (Controller Area Network) channel for control and monitoring signal communication with the joint controllers. Total 4 pairs of the master/slave manipulators as current are controlled by one host controller. The system showed satisfactory performance in both position control precision and master-slave motion synchronization in both bench test and animal experiment, and is now under further development for better safety and control fidelity for clinically applicable prototype.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제55권8호
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• pp.498-507
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• 2012

Background and Objectives We aimed to develop a Korean version of the velopharyngeal insufficiency (VPI) speech corpus system. Subjects and Method After developing a 3-channel simultaneous speech recording device capable of recording nasal/oral and normal compound speech separately, voice data were collected from VPI patients aged more than 10 years with/without the history of operation or prior speech therapy. This was compared to a control group for which VPI was simulated by using a french-3 nelaton tube inserted via both nostril through nasopharynx and pulling the soft palate anteriorly in varying degrees. The study consisted of three transcriptors: a speech therapist transcribed the voice file into text, a second transcriptor graded speech intelligibility and severity and the third tagged the types and onset times of misarticulation. The database were composed of three main tables regarding (1) speaker's demographics, (2) condition of the recording system and (3) transcripts. All of these were interfaced with the Praat voice analysis program, which enables the user to extract exact transcribed phrases for analysis. Results In the simulated VPI group, the higher the severity of VPI, the higher the nasalance score was obtained. In addition, we could verify the vocal energy that characterizes hypernasality and compensation in nasal/oral and compound sounds spoken by VPI patients as opposed to that characgerizes the normal control group. Conclusion With the Korean version of VPI speech corpus system, patients' common difficulties and speech tendencies in articulation can be objectively evaluated. Comparing these data with those of the normal voice, mispronunciation and dysarticulation of patients with VPI can be corrected.

• 대한전자공학회논문지TC
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• 제43권5호
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• pp.84-93
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• 2006

이더넷 PON은 현재 광가입자망의 기술 수준, 경제성을 고려할 때 가입자망의 고속화 실현을 위한 가장 현실성 있는 구현 방안으로 주목받고 있다. 이더넷 PON은 하향 및 상향 전송을 위하여 점대다점(point-to-multipoint), 다점대점(multipoint-to-point) 구조를 갖는다. 따라서 하향 전송을 위하여 이더넷 프레임은 수동분배기를 거쳐 모든 ONU에게 방송되는 반면, 상향 구조는 다수의 ONU가 단일의 상향 채널을 공유하는 형태이므로 각 ONU에게 공평하고 효율적인 채널 할당을 위한 MAC 프로토콜이 요구된다. 따라서 종래의 연구는 ONU간 충돌을 해결하고 망 자원을 효율적으로 사용하기 위한 다양한 MAC 프로토콜과 대역 할당 알고리즘에 초점을 맞추었다. 그러나 서비스를 제공하는 망 사업자 입장에서 볼 때, 망 사업자는 각 ONU에게 사전에 협약한 대역폭을 보장하는 동시에 IP 트래픽에 유연한 효율적인 망 자원 관리 책임이 요구된다. 이러한 관점에서 하향 트래픽 제어는 매우 중요하다. 본 논문에서는 이더넷 PON 환경에서 하향 트래픽의 협약 대역을 보장함으로써 각 ONU에게 공평성을 제공하고 망 자원의 효율적 사용을 위한 하향 트래픽 제어 기법을 제안한다. 제안한 기법은 하나의 토큰 버킷과 과거 트래픽 정보를 이용한 서비스제공 확률을 기반으로 구현의 단순성, 공평성, 융통성을 제공한다. 제안한 기법의 성능 평가를 위해 AWESIM을 이용하여 IEEE 802.3ah 기반의 이더넷 PON 시스템을 설계하고 시뮬레이션을 수행하였으며, 다양한 시나리오를 기반으로 공평성, 지연, 폐기율 관점에서 성능을 평가하고 분석하였다.

• 수산해양기술연구
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• 제52권1호
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• pp.56-64
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• 2016

This study analyzed characteristics of officers' watch-keeping during fishing operation at the fisheries training ship KAYA (GT: 1,737 tons, Pukyong National University). It observed fishing works of three officers in wheel house of KAYA. The observations were carried out at the fishing ground 45 miles away from east of Jeju from 7 to 8 January 2010. The works and movements of the officers were recorded with three common video cameras and a 4-channel MPEG-4 Triplex DVR. Recorded data of the working circulation was analyzed by using the post-processing method. As a result of the traffic lines, the average (${\pm}S.D$) of working hour (min) and moving frequency (times), distance (m) and speed (m/min) during setting the net was 11.8 (0.9), 43.7 (8.1), 133.9 (35.8) and 10.5 (0.6), respectively. During trawling the net, it was 100, 241 (39.8), 615.7 (194.6) and 5.2 (1.6), respectively. During hauling the net, it was 17.6 (1.4), 41.0 (7.2), 196.9 (37.6) and 10.7 (0.8), respectively. In addition, it has a different tendency of the instrument usage frequency by the fishing works. During setting, the usage priority was CCTV, ECDIS, RPM and pitch controller, net monitor, GPS plotter, chart room, X-band radar, fish finder and public addressor. During trawling, it was CCTV, ECDIS, fish finder, X-band radar, net monitor, chart room, GPS plotter, RPM and pitch controller, auto pilot and steering, interphone, wind speed and direction indicator, No.1. VHF, navigation light control panel and public addressor. During hauling, it was CCTV, RPM and pitch controller, GPS plotter, public addressor, chart room, net monitor, X-band radar, auto pilot and steering and fish finder.

• 생물정신의학
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• 제12권2호
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• pp.123-135
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• 2005

Objectives:EEG coherence could imply the connectivity between two different areas of the brain, which is known to be important in the pathophysiology of bipolar I disorder(BPD I) and schizophrenia. The authors investigated EEG coherence in patients with BPD I and schizophrenia to examine the connectivity of the neural circuit. Methods:EEGs were recorded in 15 schizophrenia and 14 bipolar disorder patients, and 14 age-matched normal control subjects from 16 electrodes with linked-ear reference. Spectral parameters and coherence were calculated for the alpha bandwidth(8-13Hz) by a multi-channel autoregressive model using 20 artifact-free 2-seconds epochs and the differences were compared among three groups by two different statistical methods;F-test and Kruskal-Wallis test. Furthermore, when there were significant differences among three groups, Scheffe's multiple comparison tests were provided and Jonckheere-Terpstra tests for the ordered alternative were given. Results:In the intra-hemispheric comparison, left frontal coherence was increased in order of control, BPD I and schizophrenia. In the inter-hemispheric comparison, 1) inter-prefrontal coherence in BPD I was signifi- cantly higher than in normal controls, and 2) inter-prefrontal coherence in schizophrenia was significantly lower than in controls. Conclusion:These results suggest that 1) both schizophrenia and BPD I are diseases having the abnormality of neural circuit connectivity in both frontal and prefrontal lobes, and 2) the abnormality is more severe in schizophrenia than in BPD I. Furthermore, the data support that a common pathogenetic process may reside in both schizophrenia and BPD I.