• 한국환경보건학회지
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• 제18권2호
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• pp.125-134
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• 1992

The purpose of this study is to investigate the effects of Ginseng saponin on the cadmium which is widely distributed in the environment, results in immune system alteration. For the experiments, 125 mice of ICR strain were used. The experimental groups were divided into 5 groups a control, a cadmium alone treatment group, three Cd and saponin (10, 50, 100 mg/kg) combined treatment groups. The mice were allocated 25 to each group and observed for 8 weeks. The results of experiment are as follows: 1. Body weight growth rates during 8 weeks were as this control group 36.47%, Cd alone group 32.48%, saponin combined treatment group (10, 50, 100 mg/kg) 32.49%, 39.17%, 24.27% respectively. 2. In all groups, the relative weights of liver and kidney were increased, compared with control group. In the case of spleen, saponin combined treatment group (50, 100 mg/kg) was high to the significant level compared with a control group (p<0.05). Thymus was not. 3. On blood lymphocyte count observation, Cd alone treament group has 25.6% less than control group, and saponin combined treatment group have increasing trends. but in thymus and spleen, there was no trends like blood. 4. On antibody titer, there was no difference among groups. 5. On total serum protein, saponin (100 mg/kg) combined treatment group was high to significant level compared with control group (p<0.05), and other treatment groups have increasing trends. 6. Cd accumulation in kidney was higher than in liver, and all treatment groups were high to the very significant level compared with the control group (p<0.05), but there was no difference among groups. From the results of this study, it can be concluded that the oral administration of Cd results in alteration of immune system and Ginseng saponin prevents this effect. But, Cd accumulation was not affected by saponin.

• 동의생리병리학회지
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• 제27권5호
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• pp.509-519
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• 2013

Through the study on judgment of Body form and settle Energy flow(立形定氣) before diagnose the patients, the results are as follows. The observation of the body form is to determine prosperity and deficiency of each internal organ. It is necessary to distinguish Body form loss(形脫) and Body form fullness(形充). Fat man(肥人), Thin man(瘦人), Creamy man(膏人), Muscular man(肉人), Small Fat man(脂人) are discriminated by fat distribution, fat content, and muscle mass. The observation of the body form means the observation of structure disorder, color change, develop part at body, head and face. The observation of the body form that is to determine prosperity and deficiency of each internal organ is from the limited knowledge of the anatomy. The observation of face color is considered by blood perfusion, blood oxygenation and accumulation of carotinoid, bilirubin and change of melanin in the facial skin. The prosperity and the deficiency of energy flow is considered by symptom combined with growth (<40 years) and aging (>40 years). The prosperity of energy flow includes the anger, anxious emotion and the deficiency of energy flow includes the fear, depressive emotion. The breathing type is expiratory exhalation like asthma patients in the prosperity of energy flow. The deficiency of energy flow is weakness to overcome the disease. The prosperity and the deficiency of energy flow are considered by body metabolic ratios (Basal metabolic Rate: BMR, Resting metabolic rate: RMR, Physical activity ratios: PASs). Development of subcutaneous fat is good in the person of prosperous energy flow. The person of prosperous energy flow is hard to overcome to heat weather than cold weather. The person of deficiency of energy flow has tendencies of low blood pressure, insufficiency of blood flow in the peripheral and being shocked. The person of deficiency of energy flow has tendencies of chronic fatigue syndrome or automatic nerve disorder. If the patient who has deficiency of energy flow has severe weight loss should be checked for the presence of disease. The observation of small and large of bone is to check the development and disorder of bone growth and aging. The observation of thickness and weakness of muscle is to check the development of muscle, particularly biceps, gastrocnemius, and rectus abdominal muscle. The observation of thickness and weakness of skin is to check the ability of regulating body temperature by sweating.

• 한국지구과학회지
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• 제25권7호
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• pp.586-594
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• 2004

이 연구는 야외 지질 학습에 대한 관찰 및 가설을 분석하여 야외 지질 학습에 대한 방향을 찾아보고자 하는 기초 연구의 성격을 가진 질적 연구이다. 야외 지질 학습장에서의 학습 내용을 분석함으로써 관찰, 가설의 관련성을 연구하는데 그 목적이 있다. 이 연구를 통해 얻은 결론은 다음과 같다. 첫째, 지질학습의 특성상 초등학생들은 대부분 시각에 의존하여 관찰하며, 퇴적 지층 지역의 관찰은 암석 관찰에, 가설은 지질 구조에 관한 가설을 많이 생성하였다. 둘째, 관찰 분류들로 분석 한 결과, 이 연구에서 추가한 관찰 행동 영역인 비교 관찰의 빈도가 높게 나타났으며, 2가지 관찰 행동의 조합으로 나타난 사례의 빈도도 높았다. 셋째, 관찰 유형을 기준으로 보면 해석적 관찰 및 비교 관찰과 조합된 과학적 설명 가설의 비율이 가장 높게 나타났다. 이것은 암석과 지질 구조를 해석하고 다른 것과 비교하여 자신의 사고를 합리화 하려는 경향으로 볼 수 있다. 가설 유형을 기준으로 분석한 결과 과학적 설명 가설이 가장 많은 비율을 차지하였고, 사전 지식이나 선개념을 적용하여 해석하고 설명하려는 경향이 있다고 판단된다.

• 대한약리학회지
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• 제17권1호
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• pp.41-46
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• 1981

Eighty of Sarcoma 180 bearing mice, averaging 30 gm of body weight, were divided into eight groups of animals receiving Saline as the control, Corynebacterium parvum, Tubercin-3 and Cyclophosphamide alone and Cyclophosphamide combined with C. parvum, with Tubercin-3 and with both C. parvum and Tubercin-3 and Tubercin-3 combined with C. parvum respectively. Treatment was initiated 4.8 hours after tumor implantation and repeated three times once a day. Doses were suspended or dissolved in 0.2 ml of Saline: 1.4 mg of C. parvum: 0.5 micrograms of Tubercin-3; and 2.7 mg of Cyclophosphamide either in alone or in combination. All the agents given were administered subcutaneously but Cyclophosphamide was given intraperitoneally. The observation on the general conditions of animal took place twice a day following the treatment until the time of death after tumor implantation was determined. Average survival days in each group were as follows: In Control, Saline (11.2 days), C. parvum (14.8 days), Tubercin-3 (16.7 days), Cyclophosphamide(18.7 days). In combination therapy, Cyclophosphamide with C. parvum(22.8 days) with Tubercin-3 (26.9 days). Cyclophosphamide with both C. parvum an Tubercin-3, however, was somewhat longer than in Cyclophosphamide alone but shorter than in combined with either one of C. parvum or Tubercin-3. Finally, in combination with immunotherapeutic agents, Tubercin-3 and C. parvum each other it (8.2 days) was shorter even than Control. Life span of host is, in generally, inversely related to the number of malignant cells and conclusively, the therapeutic potentiation was reflected to be extended survival in combined treatment of a chemotherapeutic Cyclophosphamide with either one of immunotherapeutics, Tubercin-3 or C. parvum. Tubercin-3 and C. parvum in combination, however, appeared to be antagonistic each other.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6565-6570
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• 2014

Objective: To observe the curative effects of rh-endostatin combined with DP regimen in treating patients with advanced esophageal cancer and analyze the correlation of CT perfusion (CTP) parameters and the expression of vascular endothelial growth factor (VEGF). Methods: Twenty patients with esophageal cancer confirmed pathologically were randomly divided into combined treatment (rh-endostatin+DP regimen) group and single chemotherapy group, 10 patients in each group, respectively. All patients were given conventional CT examination and CTP imaging for primary tumor. The level of VEGF, the size of tumor and CTP parameters (BF, BV, PS and MTT) before treatment and after 2 cycles of treatment were determined for the comparison and the correlation between CTP parameters and VEGF expression was analyzed. Results: the therapeutic effect of rh-endostatin+DP regimen group was superior to single chemotherapy group. VEGF level after treatment in rh-endostatin+DP regimen group was obviously lower than single chemotherapy group (P<0.01). The expression of VEGF had positive correlation with BF and BV but negative correlation with MTT. Compared with treatment before for rh-endostatin+DP regimen group, BF, BV and PS decreased while MTT increased after treatment (P<0.05). However, there were no significant differences between treatment before and after treatment in single chemotherapy (P>0.05). Conclusions: Rh-endostatin can down-regulate the expression of VEGF in esophageal cancer, change the state of hypertransfusion and high permeability of tumor vessels and had the better curative effect and slighter adverse reactions when combined with chemotherapy.

• Journal of Preventive Medicine and Public Health
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• 제16권1호
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• pp.19-24
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• 1983

In order to study the effects of iron and zinc on the lead poisoning of rats, lead with iron and zinc, or lead alone were administered orally to a total of 98 adult rats of Sprague-Dawley Species. The concentrations of lead, zinc, and iron were measured by atomic absorption spectrophotometer at every 20 days intervals of 20th, 40th, 60th, 80th and 120th day as a final measurement. Those datas were analysed and compared with those of control groups. The results were summarized as follows; 1. The concentration of lead in blood, bone. and liver tissues kept increasing in case of lead exposure group whereas it started decreasing at 60-80th day when concentration of zinc started increasing in case of combined exposure group. However, in kidney tissue, the concentration of lead in combined exposure group kept increasing up to the end of observation showing special high concentration at the final measurement at 120th day. 2. Concentration of zinc in blood and liver tissues had increased from 60-80th day in case of combined exposure group. 3. Concentration of iron in blood showed decreasing from $44.15{\pm}9.67\;to\;32.44{\pm}2.69{\mu}g/ml$ in case of lead exposure group, whereas it showed constant level of $47.50{\sim}45.65{\mu}g/ml$. However, in liver tissue it kept constant as control did from 40th to 60th days, but from 100th day on it started increasing to show much higher concentration than control.

• 한국산학기술학회논문지
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• 제19권1호
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• pp.654-659
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• 2018

본 연구에서는 연안 환경에 대한 대표적인 지상 원격 관측 기기인 Ocean Radar를 이용하여 장기파랑관측을 수행하였다. 지상에 설치한 기기로부터 이루어지는 원격 관측은 소수의 현장 기기 개수로는 관측할 수 없는 넓은 범위의 해역을 통시에 관측할 수 있고 또한 높은 빈도의 지속적인 관측이 가능한 장점이 있다. 장기관측을 위한 Ocean Radar는 과거 지진해일에 의한 피해가 발생하고, 원자력 발전소가 위치한 한국 동해안의 삼척지역에 대해 장기관측을 수행하였으며, 원격관측의 적용성을 검토하기 위해 수압식 파고계를 설치하여 각각의 조사자료를 비교하였다. 원격파랑관측은 연구대상해역 전면에 독일 Helzel사에서 개발된 Array type의 HF-RADAR인 WERA (WavE RAdar)를 2개소에 설치하여 자료를 취득하였으며, 장기간 연속된 관측된 자료의 취득률을 분석해본 결과, Ocean Radar 가 설치된 두 Site의 중심에서 약 24km이며, 약 27km의 범위 내에서는 Wave 자료가 90% 이상 취득되었으며, 시계열로 분석한 결과, 결측된 시간이 전체 계측기간의 1% 미만이다. 직접관측방식인 수압식 파고계와 관측자료를 비교한 결과, RMS 편차는 20cm 이내이며, 상관계수가 0.84 ~ 0.87로 높은 상관관계를 가지는 것으로 분석되었다. 따라서, 금회적용한 Ocean Radar는 기존의 파랑 계측 장비를 대체하여 장기간 면적 파랑관측이 가능할 것으로 생각된다.

• 복식문화연구
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• 제28권4호
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• pp.508-526
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• 2020

This study has established a fashion illustration education plan using the contour drawing that fosters observational ability and enables creative drawing. This study developed two illustration curriculum proposals consisting of 15 weeks, combining literature and case studies. The researchers organized a step-by-step teaching plan that utilizes contour drawing according to the three stages of fashion illustration classes: foundation courses, general courses, and intensive courses. When the contour drawing is used at the beginning stage of the foundation courses of fashion illustration, it can be used as a technique to reduce the fear of students about practical skills, induce interest in illustration, and cultivate observation ability about objects. In general process, it is combined with various tools and coloring materials to strengthen expression power, and it is possible to produce detailed expressions and illustrations about human body and clothing. In intensive courses, it is expanded to the production of creative works with new aesthetics through digital techniques and mixed materials. As such, the contour drawing is expanded in various ways according to the learning contents and goals of each step, and is flexibly adjusted according to the learning content. Contour drawing has the effect of acquiring observation and expression ability, and it is analyzed as a technique that enables the production of creative illustration of students.

• 수산해양기술연구
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• 제40권1호
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• pp.17-22
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• 2004

This study was carried out at the CWC of Chosun university for the purpose of resistance performance improvement of planing hull, and the results of the tests were confirmed cooperatively with WJFEL. G/T 100 ton class planing hull form was selected, and the improvement of hull form including appendages were performed by using some model test techniques. The model test scope comprises resistance relative tests including wave profile observation, trim and sinkage measurement and flow visualization tests at full load and trial conditions for one bare hull and for two appended hulls. The final wedge and spray strip combined with improved hull form showed about 1.0 knot speed improvement at both of full and trial conditions, and outstanding improvement for fore wave phenomena.

• Applied Microscopy
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• 제29권4호
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• pp.493-498
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• 1999

기억저장매체로서 광디스크의 개발이 활발히 진행되고 있으며 최근의 레이저 기술의 발전, 제조기술의 발전에 따른 기억밀도의 증가로서 기존의 자기기록매체와 경쟁을 하고 있다. 기록밀도의 증대와 신뢰성의 향상을 위하여 다층박막 구조를 가지는 광디스크의 미세구조는 더욱 복잡하며 소형화되고 있다. 이종의 물질로 구성된 다층박막형 광디스크의 미세구조 관찰 및 분석을 위해서는 투과전자현미경과 같은 미소영역 분석법이 필수적이며 비교적 간단하고 신뢰성 높은 시편준비법의 확립이 선행되어야 한다. 본 연구에서는 투과전자현미경 분석을 위한 광디스크의 평면 및 단면시료 제작법을 제시하고 제조된 시편으로부터 얻어진 광디스크의 미세구조 분석결과를 보고한다.