• 한국소음진동공학회논문집
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• 제19권9호
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• pp.960-966
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• 2009

The World Health Organization(WHO) has reported the sleep disturbance as one of the adverse effects of noise. And the effect of combined noise sources on human have been investigated because community noises are seldom heard and are concurrent. Therefore, the effects of combined noise source and its S/N ratio on sleep disturbance were investigated; as a single noise source, road traffic noise was selected, and construction and movie noise were combined with road traffic noise. Tests for sleep disturbance were conducted in bedrooms and the effect on each subjects' sleep was evaluated by questionnaire. The results showed that the rate of awakening increased slightly only when the SPL of construction noise was 10 dB higher than that of road traffic noise. It was also found that the sleep disturbance was affected by the type of combined noise sources and its S/N ratio.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6061-6066
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• 2015

Methotrexate (Mtx), used for its anticancer and immunsuppresive properties, is known to be a nephrotoxic agent. We aimed to investigate the effects of lycopene (Lyc) alone or combined with melatonin (Mel) on Mtxinduced nephrotoxicity since both of these agents have antioxidant and anti-inflammatory effects. Nephrotoxicity was induced by intraperitoneal administration of methotrexate at a dose of 20 mg/kg. Treatment both with Lyc alone and Lyc combined with Mel provided significant reduction in tumor necrosis factor-alpha, interleukin 1-beta and ceruloplasmin levels in Mtx administered rats. Hovewer, Lyc combined with Mel provided a significant reduction also in NO levels. Hstopathological examination showed that there was an obvious improvement in the degenerative changes compared to Mtx administrated group with the Lyc combined Mel group giving best protection. In conclusion Lyc alone and combined with Mel provided significant improvement against renal damage caused by Mtx, preseumably via antioxidant and anti-inflammatory activities.

• 부모자녀건강학회지
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• 제10권1호
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• pp.65-76
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• 2007

Purpose: This study was to determine the effects of a combined obesity management program in obese women. The study also attempted to measure the effects of the program on blood lipid, body mass index, dietary calory and dietary habit. Method: This research employed a one group pretest-posttest design. A total of 251 obese women(BMI: over 25) were selected for this research. The subjects in a combined obesity management program (combined exercise therapy and dietary therapy) for 8weeks. Results: After performing the program for 8 weeks, the result were follows. 1) There were significant reduction in total cholesterol(t=4.10, p= .00), triglyceride(t=5.09, p= .00) but no significant reduction BMI. 2) There were reduction in dietary calory, but no significantly. 3) There were significant increase in dietary habit. Conclusion: From these findings, it was confirmed that a combined obesity management program for obese women can decrease TC, TG, BMI and increase dietary habit. Therefore, this program can be utilized for various population groups including women, and further researches are required on program for men, elderly.

• 생물정신의학
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• 제5권2호
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• pp.155-161
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• 1998

Mood disorder is a medical illness resulting from the disorder of CNS neurotransmission and its principal therapeutic tool is pharmacotherapy. Psychotherapeutic drugs for mood disorder have some clinical limitations which are due to no or partial response, decreased compliance for drug by the side effects, and delayed therapeutic effects. So, general hope of all clinicians that mood diorder will respond to a single psychotherapeutic agent may be the exception rather than the rule. Recently, combined drug treatments have become increasingly popular to overcome the clinical limitations of individual agent in mood disorder. Combined treatments are usually used for augmenting or initiating rapidly the effect of drug, and for treating different target symptoms or drug side effects. When combined treatments being tried, knowledge of the action mechanism, pharmacokinetics, and pharmacodynamics is crucial to cope with the possible adverse reactions of drugs.

• 전기학회논문지
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• 제58권10호
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• pp.1881-1887
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• 2009

This paper discusses the effects of ECC (Earth Continuity Conductor) for reducing the level of induced sheath overvoltages at the single point bonded section of combined transmission lines which are mixed underground power cable with overhead line in one T/L. In previous papers, the characteristics of ECC on only underground power cable systems were sufficiently analyzed. However, the result of only underground power cable systems are totally different from that of combined transmission lines because ECC is commonly grounded with overhead grounding wire at mesh of cable head. Therefore, in this paper, the installation effects of ECC have been variously analyzed considering the three kinds of fault positions, cable formation of duct and trefoil, spacing between phase conductor and ECC, and the change of overhead transmission line section length on 154kV combined transmission line. Finally, simulation results show that ECC can effectively reduce the induced sheath voltage.

• Biomolecules & Therapeutics
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• 제2권2호
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• pp.185-189
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• 1994

The eight combined products composed of ranitidine.HCI, tripotassium dicitrato bismuthate and sucralfate were prepared with various ratios and studied in therapeutic effects of them on various gastrointestinal diseases. These were induced in rats with the porous ligation, ethanol-HCI, acetic acid and cysteamine method, etc. In all experimental setting, the effect of the combined treating was more pronounced than the effect of each drug alone. Specially, the combined treatment consisted of ranitidine : tripotassium dicitrato bismuthate sucralfate ratio of 1.5 : 2 : 6 showed the most powerful therapeutic effect on acute gastric ulcer model and revealed a significant acceleration of the healing on chronic gastroduodenal ulcer model. And that, therapeutic doses of ranitidine, tripotassium dicitrato bismuthate arid sucralfate given in combination had an additive or, in some case, synergistic effect. From the above results, this combined treatment may useful to heal the gastrointestinal diseases that aren't cured well by treatment of each them alone.

• 대한물리치료과학회지
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• 제26권3호
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• pp.1-7
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• 2019

Purpose: The purpose of this study was to investigate the effects of the Otago exercise combined with action observation training on changes of the brain activity of the elderly. Design: Randomized controlled trial. Methods: Thirty elderly women in the experiment were included. Participants were randomly assigned to the Otago combined with action observation training group, the Otago exercise group, and the control group (10 in each group). The Otago combined with action observation training group and the Otago exercise group performed the strength and balance exercises of the Otago exercise program for 50 minutes three times a week for 12 weeks. The Otago combined with action observation training group underwent additional action observation training for the Otago movement for 20 minutes three times a week. No intervention was performed in the control group. PolyG-1 (LAXTHA Inc., Daejeon, Korea) was used to measure the changes in the brain activity following intervention. One-way analysis of variance was used to compare the effects among the groups and a post-hoc test was performed. Results: The relative mu rhythms in the F3, C3, and C4 regions were significantly increased in the Otago combined with action observation training group. Relative beta wave activity in the Fp1, F3, F3, and C3 regions was significantly increased in the Otago combined with action observation training group (p<0.05). Conclusion: The results indicated that the Otago exercise combined with action observation training was effective for promoting the brain activity of the elderly.

• PNF and Movement
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• 제18권2호
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• pp.297-303
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• 2020

Purpose: The purpose of this study was to examine the effects of inhalation and exhalation exercise combined with upper extremity proprioceptive neuromuscular facilitation pattern on two spirometry values: forced volume vital (FVC) and peak expiratory flow (PEF). Methods: Thirty-two healthy adults were divided into two groups: 1) a combined group, which performed upper extremity D2 flexion pattern (shoulder flexed/abducted/external rotated, forearm supinated, wrist radial deviated, and finger extended) during exhalation and D2 extension pattern (shoulder extended/adducted/internal rotated, forearm pronated, wrist ulnar deviated, and finger flexed) during inhalation; and 2) reverse combined group, which performed the D2 flexion pattern during inhalation and the D2 extension pattern during exhalation. The inverse application of upper extremity movements during inhalation and exhalation induced selective resistance or assistance on respiration. FVC and PEF were measured at two time points, before and after four weeks. Results: In both groups, the pre-post intervention comparison showed significant increases in FVC and PEF (p < .05). In the between-groups comparison, the reverse combined group showed a significantly higher PEF than the combined group at four weeks post intervention (p < 0.05). Conclusion: The combined respiration exercise with reverse PNF upper extremity patterns using selective resistance showed an effective increase in PEF in healthy adults. Clinicians and researchers might consider using selective resistance as a widely applicable and cost-effective option for respiratory rehabilitation planning.

• Nutrition Research and Practice
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• 제12권3호
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• pp.208-214
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• 2018

BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the biological and sleep-promoting effects of combined ${\gamma}$-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) using caffeine-induced sleepless fruit flies, ICR mice, and Sprague-Dawley rats. MATERIALS/METHODS: Video-tracking analysis was applied to investigate behavioral changes of Drosophila melanogaster. Pentobarbital-induced sleep test and electroencephalogram (EEG) patterns were used for analysis of sleep latency, duration, and quantity and quality of sleep in vertebrate models. RESULTS: Administration of combined GABA/5-HTP could significantly reverse the caffeine induced total distance of flies (P < 0.001). Also, individually administered and combined GABA/5-HTP significantly increased the total sleeping time in the caffeine-induced sleepless ICR mice (P < 0.001). In the caffeine-induced sleepless SD-rats, combined GABA/5-HTP showed significant differences in sleep quality between individual amino acid administrations (P < 0.05). CONCLUSIONS: Taken together, we identified inhibitory effects of combined GABA/5-HTP in locomotor activity, sleep quantity and quality in caffeine-induced sleepless models, indicating that combined GABA/5-HTP may be effective in patients with insomnia by providing sufficient sleep.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2001년도 봄 학술발표회 논문집
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• pp.665-670
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• 2001

The studies on chloride diffusion of concrete have been done so far by many researchers. However, there are few studies that present the effects of other attacks on chloride diffusion properties. Therefore, in this study the experiments are carried out to show the effects of combined attacks, such as carbonation, sulfate attacks, on chloride diffusivity in concrete. The specimens are made by varying cement type and replacement ratio of fly ash. The results show that cement type and replacement of fly ash do not affect greatly chloride diffusion properties. And concrete treated by combined attacks show a little higher chloride content than those treated by chloride solution only. Therefore, the effects of these factors should be taken into account in predicting the penetration of chloride ion in concrete.