• 약학회지
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• 제44권3호
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• pp.237-244
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• 2000

Liver isolated from 18 hours fasted rats was subjected to $N_2$hypoxia (for 45 min) followed by reoxygenation (for 30 min). The perfusion medium used was Krebs-Henseleit bicarbonate buffer (pH 7.4, $37^{\circ}C$). Vitamin C (0.5 mM) and trolox C (0.5 mM), soluble vitamin E analog, were added to perfusate. Lactate dehydrogenase (LDH), total glutathione, oxidized glutathione, lipid peroxide and drug-metabolizing enzymes were measured. After hypoxia LDH significantly increased but this increase was attenuated by vitamin C and combination of vitamin C and E. Total glutathione and oxidized glutathione in perfusate markedly increased during hypoxia and this increase was inhibited by vitamins C, E and its combination. Similarly; oxidized glutathione and lipid peroxide in liver tissue increased after hypoxia and reoxygenation and this increase was inhibited by vitamin I and combination of vitamin C and E. Hepatic drug metabolizing function (phase I, II) were suppressed during hypoxia but improved during reoxygenation. While vitamins C and E only increased glucuronidation, the combination of vitamin C and E increased the oxidation, glucuronidation and sulfation. Our findings suggest that vitamins C and E synergistically ameliorates hepatocellular damage as indicated by abnormalities in drug metabolizing function during hypoxia/reoxygenation and that this protection is in major part, caused by decreased oxidative stress.

• Physical Therapy Rehabilitation Science
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• 제9권3호
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• pp.171-177
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• 2020

Objective: This study aimed to investigate the upper limb strength, active joint range of motion (AROM), and upper limb function in persons with chronic stroke using virtual reality training in combination with upper limb sensory stimulation. Design: Two-group pretest-posttest design. Methods: 20 subjects were divided into two groups of 10, the sensory motor stimulation and virtual reality training (SMVR) and virtual reality training (VR) groups. The training was conducted for 30 minutes per session, three times a week for 8 weeks.The participants' upper limb strength was measured via the hand-held dynamometer, joint angle AROM was measured via dual inclinometer, function was measured using the Jebson-Taylor hand function test and the manual function test. Results: Significant differences were observed in all groups before and after the training for upper extremity strength, AROM, and function (p<0.05). Between the two groups, the SMVR group showed significant improvement in muscle strength, AROM, and Jebsen-Taylor hand function test scores compared with the VR groups (p<0.05). Conclusions: In this study, we confirmed that sensory stimulation and VR had positive effects on upper extremity strength, AROM, and function of persons with chronic stroke. The results suggest that in the future, VR in combination with sensory stimulation of the upper limb is likely to become an effective method (a rehabilitation training program) to improve the upper limb function of persons with chronic stroke.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제3권2호
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• pp.99-106
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• 1999

In this paper, the spline hazard rate model to the randomly censored data is introduced. The unknown hazard rate function is expressed as a linear combination of B-splines which is constrained to be linear(or constant) in tails. We determine the coefficients of the linear combination by maximizing the likelihood function. The number of knots are determined by Bayesian Information Criterion. Examples using simulated data are used to illustrate the performance of this method under presenting the random censoring.

• Kyungpook Mathematical Journal
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• 제50권2호
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• pp.281-288
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• 2010

By introducing some parameters and using the way of weight function and the technic of real analysis and complex analysis, a new Hilbert-type integral inequality with a best constant factor and a combination kernel involving two mean values is given, which is an extension of Hilbert's integral inequality. As applications, the equivalent form and the reverse forms are considered.

• 전기학회논문지
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• 제62권1호
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• pp.133-139
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• 2013

Convex combination of two adaptive filters is an efficient method to improve adaptive filter performances. In this paper, a subband convex combination method of two adaptive filters for fast convergence rate in the transient state and low steady state error is presented. The cost function of mixing parameter for a subband convex combination is defined, and from this, the coefficient update equation is derived. Steady state analysis is used to prove the stability of the subband convex combination. Some simulation examples in system identification scenario show the validity of the subband convex combination schemes.

• 호남수학학술지
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• 제43권2호
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• pp.183-197
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• 2021

Recently several authors have extended the Beta function by using its integral representation. However, in many cases no expression of these extended functions in terms of classic special functions is known. In the present paper, we introduce a further extension by defining a family of functions G_r,s : ℝ^*₊ → ℂ, with r, s ∈ ℂ and ℜ(r) > 0. For given r, s, we prove that this function satisfies a second-order linear differential equation with rational coefficients. Solving this ODE, we express G_r,s as a combination of confluent hypergeometric functions. From this we deduce a new integral relation satisfied by Tricomi's function. We then investigate additional specific properties of G_r,1 which take the form of new non trivial integral relations involving exponential and error functions. We discuss the connection between G_r,1 and Stokes' first problem (or Rayleigh problem) in fluid mechanics which consists in determining the flow created by the movement of an infinitely long plate. For $r{\in}{\frac{1}{2}}{\mathbb{N}}^*$, we find additional relations between G_r,1 and Hermite polynomials. In view of these results, we believe the family of extended beta functions G_r,s will find further applications in two directions: (i) for improving our knowledge of confluent hypergeometric functions and Tricomi's function, (ii) and for engineering and physics problems.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제15권5호
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• pp.375-379
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• 2009

도메인은 단백질의 진화와 삼차구조 및 분자 기능의 기본 단위체이다. 단백질은 한 개 이상의 도메인들로 구정 되며, 단백질의 기능 또한 각 도메인이 가진 기능의 집합으로 구현된다. 단백질은 특정 기능을 담당하기 위해 진화되어 왔으므로, 도메인 또한 단백질 내에서 기능을 위한 특정 조합 패턴, 즉 보존도메인 조합을 가진다. 본 논문은 각 도메인 조합의 진화상 보존 정도를 측정할 수 있는 연관성 규칙 기반 계산 기법을 제안한다. 제안된 기법은 기존 기법에서 주로 고려되었던 도메인 조합의 빈도뿐 아니라, 조합 내 소속 도메인간의 상호 의존도를 측정하여 주어진 조합의 보존 정도를 산출한다. 이를 기반으로 S.cerevisiae의 단백질을 대상으로 보존 도메인 조합을 추출하였으며, Gene Ontology를 이용하여 그 생물학적 의미를 분석하였다. 그 결과 제안된 기법으로 추출된 보존 도메인 조합은 기존의 것에 비해 조합 내 기능의 유사도가 높았으며, 따라서 제안된 기법이 생물학적 기능의 협업 위해 보존된 도메인 조합의 추출에 우수하다 할 것이다. 또한 S.cerevisiae 단백질체에는 서로 의존도가 높고 자주 나타나는 보존 도메인 조합이 존재하며, 그러한 조합들은 molecular function의 협업과 관련 있음을 밝혀냈다.

• Communications for Statistical Applications and Methods
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• 제23권6호
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• pp.563-574
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• 2016

In this study, we propose several simultaneous tests to detect the difference between means and variances for the two-sample problem when the underlying distribution is normal. For this, we apply the likelihood ratio principle and propose a likelihood ratio test. We then consider a union-intersection test after identifying the likelihood statistic, a product of two individual likelihood statistics, to test the individual sub-null hypotheses. By noting that the union-intersection test can be considered a simultaneous test with combination function, also we propose simultaneous tests with combination functions to combine individual tests for each sub-null hypothesis. We apply the permutation principle to obtain the null distributions. We then provide an example to illustrate our proposed procedure and compare the efficiency among the proposed tests through a simulation study. We discuss some interesting features related to the simultaneous test as concluding remarks. Finally we show the expression of the likelihood ratio statistic with a product of two individual likelihood ratio statistics.

• 대한예방한의학회지
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• 제14권1호
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• pp.49-58
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• 2010

Objective : The purpose of this study is to examine safety of herbal medicine on liver function and compare with western medicine. Method : 303 subjects of skin disease(vitiligo and psoriasis) were chosen at a local oriental medical clinic, and tested with a spot liver function test from Sept 1, 2006 to Dec 31, 2006. Subjects were grouped into untreated, herbal medicine, western medicine, and combination group by treatment record. Total bilirubin, AST, ALT and LDH was compared in each group, odds ratio and regression coefficient was calculated. Results : Subjects comprised of 116 individuals receiving western medication(38.28%), 54 receiving herbal medication(17.82%), 107 receiving combined forms of medication(35.31%), and 26 individuals without any types of medication(8.58%). With the mean age of 37.0 yr. 204 were male(67.3%), 99 were female(32.7%). Comparing variables of liver functions, there was no significant difference between the control and experiment groups. After adjusting potential confounders, monthly $\beta$(SE) of multiple regression -0.009~0.000 for the herbal group, -0.005~0.000 for the western group, and -0.001~0.001 for the combination group. No significant difference between the groups. OR of T-bilirubin were 1.02, 1.05, and 1.04. AST were 0.92, 0.94, and 0.98. ALT were 0.85, 0.99, and 0.97. LDH were 0.96, 1.06, 1.00 for the herbal, western, and combination group, respectively. Conclusion : Comparing with western medication, herbal medication did not cause special ill-effect on the liver function based on liver function tests.

• 응용통계연구
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• 제15권1호
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• pp.107-117
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• 2002

본 논문에서는 혼합보증기간이 있는 수리 가능한 시스템에 대하여 보증기간이 종료된 이후의 교체정책을 고려한다. 이러한 교체정책은 보증기간이 재생되는 재생혼합보증과 재생되지 않는 비재생혼합보증에 대하여 고려되며, 최적의 교체정책을 설정하기 위 해서 단위 시간당 기대비용을 사용한다. 재생혼합보증과 비재생혼합보증이 있는 시스템에 대하여 소비자 관점에서의 단위 시간당 기대비용을 구하고, 이를 최소화하는 최적의 보전기간을 결정한다 그리고, 시스템의 고장시간이 와이블분포일 때 수치적 예를 통해서 제안된 최적의 교체정책을 설명한다.