• 대한임상독성학회지
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• 제3권2호
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• pp.126-129
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• 2005

Valproic acid (VPA) is used in the management of a variety of conditions including simple and complex absence seizure disorder. bipolar disorder, and migraine prophylaxis. Clinical manifestation of VPA overdose vary in severity from mild confusion and lethargy to severe coma and death. The treatment of VPA toxicity is mainly supportive. There is no specific antidote, nor are there specific guidelines for the management of VPA intoxication. Anecdotal reports describe the efficacy of naloxone and L-carnitine, but the data are insufficient to make strong conclusions. Various techniques of extracoporeal therapy for the management of VPA toxicity have been described, but none has prevailed as standard therapy. We report a patient with VPA overdose who was successfully treated with hemoperfusion with activated charcoal and L-carnitine. VPA levels of the patient was more than 1,000 ${\mu}g$/ml and was normalized after 3 times hemoperfusion. The patient was injected with L-carnitine by maximum 600 mg/kg/day for 5days without complications.

• 임상간호연구
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• 제19권2호
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• pp.265-274
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• 2013

Purpose: The aim of this study was to determine the risk factors contributed to unplanned readmission to intensive care unit (ICU) and to investigate the prediction model of unplanned readmission. Methods: We retrospectively reviewed the electronic medical records which included the data of 3,903 patients who had discharged from ICUs in a university hospital in Seoul from January 2011 to April 2012. Results: The unplanned readmission rate was 4.8% (n=186). The nine variables were significantly different between the unplanned readmission and no readmission groups: age, clinical department, length of stay at 1st ICU, operation, use of ventilator during 24 hours a day, APACHE II score at ICU admission and discharge, direct nursing care hours and Glasgow coma scale total score at 1st ICU discharge. The clinical department, length of stay at 1st ICU, operation and APACHE II score at ICU admission were the significant predictors of unplanned ICU readmission. The predictive model's area under the curve was .802 (p<.001). Conclusion: We identified the risk factors and the prediction model associated with unplanned ICU readmission. Better patient assessment tools and knowledge about risk factors could contribute to reduce unplanned ICU readmission rate and mortality.

• 대한임상독성학회지
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• 제7권1호
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• pp.26-31
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• 2009

Hydrogen sulfide is a by-product of decayed organic material and is ubiquitously found as an ingredient of manufacturing reagents or as an undesirable by-product of the manufacturing or industrial processing. Hydrogen sulfide is a chemical asphyxiant and interferes with cytochrome oxidase and aerobic metabolism. It has thus been deemed an important cause of work-related sudden death. This gas is particularly insidious due to the unpredictability of its presence and concentration and its neurotoxicity at relatively low concentrations, causing olfactory nerve paralysis and loss of the warning odor. Here, we report two cases of comatose patients presenting after accidental exposure to hydrogen sulfide gas.

• Journal of Communications and Networks
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• 제8권3호
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• pp.290-296
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• 2006

In this paper, a generalized blind adaptive algorithm is introduced for multi-user detection of direct sequence code division multiple access (OS-COMA) wireless communication systems. The main property of the proposed algorithm is its ability to resolve the multipath fading channel resulting in inter symbol interference (ISI) as well as multiple access interference (MAI). Other remarkable properties are its low complexity and mitigation to the near-far problem as well as its insensitivity to asynchronous transmission. The proposed system is based on the minimization of the output energy and convergence to the minimum mean square error (MMSE) detector. It is blind in the sense that it needs no knowledge of the other users' signatures, only the intended user signature and timing are required. Furthermore, the convergence of the minimum output energy (MOE) detector to the MMSE detector is analytically proven in case of M-ary PSK. Depicted results show that the performance of the generalized system dominates those previously considered. Further improvements are obtained when multiple input multiple output (MIMO) technique is employed.

• 한국통신학회논문지
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• 제25권6A호
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• pp.885-892
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• 2000

MC-COMA 시스템에서 RBF 네트워크를 이용한 다중사용자 수신기를 제안하고자 한다. 제안된 수신기에서는 주파수 다양성을 효과적으로 이용할 수 있도록 RBF 네트워크가 주파수축에 연결된 구조를 갖는다. 본 논문에서는 주파수 선택적 다중 경로 페이딩 채널에 대한 모의 실험을 수행하였다. 이러한 모의 실험을 통해, 제안된 수신기가 near-far 효과에 대한 대응성과 사용자 용량증가를 통한 성능향상을 얻고자 하는데 사용될 수 있음을 확인되었다. 그리고 제안된 수신기가 도플러 주파수는 10Hz이고 경로수가 5일 경우 $10^{-3}$의 BER에서 병렬 간섭제거 기법을 이용한 다중사용자 수신기보다 약 1.8배의 사용자를 수용할 수 있음을 확인하였다.

• 정보저장시스템학회논문집
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• 제3권4호
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• pp.191-195
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• 2007

The optical disc drive has used a high NA objective lens and a shorter wavelength laser diode for high recording density. But high NA and shorter wavelength cause several margins to become short. Focusing and tracking servo has to be more accurate and active tilt compensation mechanism is also needed for coma aberration compensation. In this paper, we proposed 3-axis moving magnet type actuator. For 3-DOF motion, moving coil actuator has to be equipped with 6 wires for supplying 3 independent signals. However, moving magnet type actuator doesn't need to change the configuration of wires because coils are in stator. So, we added a tilt mechanism to the 2-axis moving magnet actuator which is designed in previous research. Addition of the tilt mechanism cuts down the focus sensitivity. So, maximization the tilting sensitivity and securing the focusing sensitivity are objectivities of this research. DOE (design of experiments) procedures of electromagnetic circuit are performed for parameter study and the optimization is also performed to maximize the tilt sensitivity. And then the final design is suggested and its performance is verified by FE simulation.

• 한국광학회지
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• 제4권3호
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• pp.252-259
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• 1993

극자외선 과장을 사용하는 micro-lithography를 위해 등배율을 갖는 4-반사경 holosymmetric system을 설계하였다. Holosymmetric system에서는 모든 차수의 코마와 왜곡수차가 영이 된다. 이 원리를 4-구명경계에 적용하여 등배율을 갖고 5개의 3차 수차가 모두 제거된 4-구면 반사경 holosymmetric system에 대해 유일한 해를 완전히 해석적인 표현으로 구하였다. 이 4-구면경계에 남아있는 고차 수차들을 보정하기 위해 holosymmetric 성질을 유지하면서 비구면을 채용하였고 그결과 개구수 0.33과 image field diameter 7.6mm 이내에서 극자외선 파장 $0.248{\mu}m$(KrF 엑시머 레이저 빔)에 대해 거의 회절한계의 수차성능을 갖는 비구면 4-반사경 holosymmetric system를 얻었다.

• Biomolecules & Therapeutics
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• 제8권3호
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• pp.255-261
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• 2000

WooHwangChungSimWon is a traditional prescription for treating with hypertension, arteriosclerosis, coma, and stroke in China, Korea, and Japan. In the new presciption of WooHwangChungSimWon, the covet is substituted for the musk, the major component of WooHwangChungSimwon, because of the prohibition law about the musk. We have made a comparative study of the effects on the ischemic damage between the musk containing and civet containing WooHwangChungSimWon. In order to investigate the effects of WooHwangChungSimWon on the ischemic damage, each samples were administrated for 12 days, ischemia was induced for 10 minutes at 7th day, and immunohistochemistry was performed in the region of hippocampus of mongolian gerbils. According to the result of immunohistochemistry, the survival rates of neuroal cells in the hippocampal CA1 region are 37.8% in the high dose of musk containing WooHwangChungSimWon (HM-WHCSW) administrated group, 27.8% in low dose of civet containing WooHwangChungSimWon (LC-WHCSW), and 35.5% in high dose of civet containing WooHwangChungSimWon (HC-WHCSW) administrated group. These survial rates were significantly different from the survival rate of sham control group (14.4%). The results suggest that all the samples except the low dose of musk containing WooHwangChungSimWon (LM-WHCSW) have protective or preventive effects on cerebral ischemia.

• 생약학회지
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• 제31권4호
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• pp.373-382
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• 2000

This study was performed to investigate the antithrombotic activity and protective effect of hexane fraction of Kamihyulbuchukeotang (KHCTH) on brain injury by KCN and MCA occlusion a prescription of HCT added with Lumbricus and Notoginseng Radix. Experiemental parameters are brain ischemia by MCA occlusion assay, KCN-induced brain injury, pulmonary thrombosis and platelet aggregation assay. The results were summarized as follows; 1. KHCTH extracts significantly inhibited the duration of KCN-induced coma (67%) and mortality (80%). 2. KHCTH extracts significantly suppressed brain ischemic area and edema following MCA occlusion and protected neuron cells as compared with control data. 3. KHCTH extracts inhibited pulmonary thrombosis induced by collagen and epinephrine. 4. KHCTH extracts inhibited platelet aggregation induced by collagen, ADP as agonist up to 76.9% and 32.3% respectivey at 1 mg/ml more effective than water extract of KHCT These data suggested that KHCTH could be applied as the protector of brain ischemia and injury and antithrombotic agent.

• 대한지역사회영양학회지
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• 제3권3호
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• pp.430-439
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• 1998

This study was performed to investigate the nutritional status of neurosurgical tube-fed patients. The objective of this study was to improve the nutrition management of tube-fed patients. The current practices of tube feeding and enteral nutrition formula as for 95 patients in the hospital were examined by reviewing patients charts, and interviewing patients, nurses and their family members. The results are summarized as follows ; 57.9% of patients that received the formula showed a decrease in mental status. Among the subjects, 55.7% had nervous system diseases due to old age. Most of the tube-fed patients were hospitalized in the emergency room and while hospitalized, the status of their respiratory organ was abnormal. The method of tube-feeding was by Bolus injection and the type of the tube was a 16Fr size silicone tube. The amount of the injection per day while tube-feeding was on average 1424kcal for men and 1322kcal for women and the calories per day ranged from 1000-1500kcal(50.5%). The injection volume averaged 332.7ml and 45% of patients received more than 300ml per injection. The tube feeding intake rate was 127.9ml/min with 50% of subjects in the range of 50-100ml/min and 10% at 20ml/min. The longer the hospitalization, the older age, coma status, and the higher tube feeding rate, the more decreased were the biochemical parameters.