• Journal of Genetic Medicine
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• 제1권1호
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• pp.5-10
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• 1997

The amino acids formed by degradation of proteins ingested produce ammonia. The ammonia which is broken down and excreted as urea through a process known as the Klebs-Hensleit cycle or the urea cycle (Rezvani, 1995). The urea cycle consists of five enzymes necessary for the synthesis of carbamyl phosphate, citrulline, argininosuccinate, arginine, and urea: carbamyl phosphate synthetase (CPS), ornithine transcarbamylase (OTC), argininosuccinate synthetase (AS), argininosuccinate lyase (AL), and arginase (ARG) (Lloyd, 1992). Congenital deficiencies of the enzymes involved in the urea cycle are diseases that are almost fatal without treatment, showing symptoms like vomiting, lethargy, dyspnea, and coma due to hyperammonemia coming from the accumulation of ammonia and metabolic precursors resulting from the deficiency of one of these enzymes (Batshaw and Brusilow, 1983). Among these, the disease manifested by the congenital deficiency of argininosuccinate synthetase (AS) which is associated with the formation of argininosuccinate in citrulline is called argininosuccinate synthetase deficiency or citrullinemia. There have been two reports on this so far in Korea; one in July 1987 by Kim et al. and the other by Park et al. in 1995. We are to report a case of successful treatment of a child with citrullinemia who was transferred to our hospital due to dyspnea, lethargy, feeding difficulties, convulsions and cyanosis together with some document studies related to this case.

• 대한임상독성학회지
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• 제3권1호
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• pp.48-51
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• 2005

Diagostic imaging can help in management of toxicologic emergencies. We report a patient who presented to the emergency department with coma and suppressed respiration after ingestion of unknown substance. We documented chloroform with radiopaque material in bowel on abdominal radiograph. We used activated charcoal and laxative to decontaminate bowel. Hepatotoxicity occurred on 3rd admission day and elevation of liver enzyme reached peak level on 5th admission day. The patient received hemoperfusion, N-acetylsystein and supportive cares. The patient was improved from hepatic dysfunction and discharged without complication on 11th admission day. Radiograph in toxicology may confirm a diagnosis and assist in therapeutic intervention.

• 대한임상독성학회지
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• 제4권1호
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• pp.52-54
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• 2006

Datura stramonium is a wild growing plant, consumption of which can result in severe toxicity. It contains a variety alkaloids include atropine, hyoscamine, and scopolamine that can all cause anticholonergic poisoning. It has been use of herb medicine in Korea. Side effects from ingesting Datura stramonium include dry mouth, blurred vision, photophobia, and may be followed by hyperthermia, confusion, agitation, hallucination, and aggressive behavior. In severe toxicity, it can cause seizure, coma, life-threatening arrhythmia, and death. We experienced one patient who developed stupor mentality caused by Datura stramonium. Severe presentation, especially mental change of Datura stramonium should draw attention. Poisoning associated with Datura stramonium can be prevented through educational public health program.

• 대한한방내과학회지
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• 제37권5호
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• pp.885-892
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• 2016

Few studies have reported the effects of traditional Korean medical (TKM) therapy in patients with traumatic brain hemorrhage. The patient was a 93-year-old female who was unconscious after a traumatic intracerebral hemorrhage (ICH) and was not a candidate for any surgical treatment because of her age. We treated her with acupuncture and herbal medicine. After 28 days of treatment, we observed an improvement in consciousness on the Glasgow Coma Scale (GCS) and in other symptoms (aphasia, weakness in both legs, and headache).

• Journal of Trauma and Injury
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• 제30권4호
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• pp.120-125
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• 2017

Purpose: The aim of this study was to identify clinical outcome and characteristics of trauma patients via emergency medical services (EMS). Methods: Medical records of the trauma patients visiting the emergency department were retrospectively collected and analyzed from January 2015 to June 2016 in the single institution. Of 529 registered patients, 371 patients were transported by - were enrolled. The parameters including age, gender, injury mechanism, Glasgow coma scale on arrival, presence of shock (systemic blood pressure <90 mmHg) on arrival, time to arrival from accident to emergency room (ER), need for emergency procedures such as operation or angioembolization, need for intensive care unit (ICU) admission, injury severity score (ISS), the trauma and injury severity score, revised trauma score (RTS), length of stay, and mortality rate were collected. The SAS version 9.4 (SAS Institute, Cary, NC, USA) was used for the data analysis. Results: Arrival time from the field to the ER was significantly shorter in EMS group. However, overall outcomes including mortalities, length of stay in the ICU and hospital were same between both groups. Age, ISS, RTS, and injury mechanisms were significantly different in both groups. ISS, RTS, and age showed significant influence on mortality statistically (p<0.05). Conclusions: The time to arrival of EMS was fast but had no effect on length of hospital stay, mortality rate. Further research that incorporates pre-hospital factors influence clinical outcomes should be conducted to evaluate the effectiveness of such a system in trauma care of Korea.

• 대한수의학회지
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• 제38권3호
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• pp.629-641
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• 1998

This study was performed to evaluate the ultrasonographic findings of ethylene glycol intoxication. Ten healthy mongrel dogs which was administered with ethylene glycol, were evaluated in terms of clinical findings, hematological findings, blood chemistry, and ultrasonographic and histopathological findings of kidney. The results obtained through these experiment could be summarized as follows : 1. Typical clinical symptoms such as vomiting, initial apprehension, depression, thirst, dehydration, tremor, anorexia, hematuria, anuria, weakness, weight loss, flaccid paralysis, tachypnea, coma, and death, were revealed after administration of ethylene glycol. 2. Special symptom of bloody diarrhea was occurred by administration of ethylene glycol. 3. After administration of ethylene glycol, PCV was decreased continuously(p<0.01), and total leukocyte count was increased gradually, revealed the highest value at day 5 and thereafter decreased. 4. Remarkable changes of ultrasonographic findings such as high echo intensity of renal parenchyma and emergence of halo in corticomedullary junction, were revealed after administration of ethylene glycol. Early(hour 8) enlargement and late(day 3) enlargement were observed in kidney(p<0.01). Especially, late enlargement was observed concurrently with the elevation of BUN and creatinine values. 5. Calcium oxalate crystals, metabolites of ethylene glycol, were observed in histopathologic findings of kidney. Also, degeneration and necrotic exfoliation of epithelial cells were recognized in addtion to swelling of renal tubules.

• Neonatal Medicine
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• 제18권1호
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• pp.143-147
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• 2011

ASAuria는 요소회로이상증 중의 하나로 드물게 나타나는 상염색체 열성으로 유전되는 대사 질환이다. 체내에 ASA가 축적됨으로서 신생아 시기에 구토, 기면, 수유 곤란, 의식 장애를 보이며 적절한 조치를 하지 않으면 사망에 이르게 되는 치명적인 대사 질환이다. 이 질환은 혈중과 소변에 ASA가 증가하는 것으로 진단할 수 있다. 국내에서는 고전적 형태의 ASAuria가 아직 보고된 사례는 없으며, 이에 본 저자들은 고전적 ASAuria로 진단된 환아에서 유전자 검사를 통해 보인자 부모로부터 출생하였음을 진단한 신생아 환자 1예를 경험하였기에 보고하는 바이다.

• Journal of Yeungnam Medical Science
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• 제32권1호
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• pp.8-12
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• 2015

Background: Enlargement of subdural hematomas is relatively rapid in subacute stage of hematoma with clinical deterioration, which eventually necessitates surgery. The purpose of this study is to investigate the feasibility and safety of burr hole drainage using urokinase for management of patients with subacute subdural hematoma (SASDH). Methods: Nine patients with SASDH were treated by burr hole drainage using urokinase. Under local anesthesia a catheter was inserted into the hematoma through a burr hole. Burr hole drainage was followed by hematoma thrombolysis with instillation of urokinase (10,000 units) every 12 hours. Drainage was discontinued when a significant decrease of hematoma was observed on cranial computed tomography. Results: The patients' median age was 70 years (range, 62-87). The median Glasgow Coma Scale score before surgery was 15 (range, 11-15). Drainage was successfully performed in all patients. All patients had Glasgow Outcome Scale scores of 5 at discharge. There was no surgery-related morbidity or mortality. Conclusion: A burr hole drainage using urokinase could be a safe, feasible and effective minimally invasive method with low morbidity in treatment of selected patients with SASDHs.

• 동의생리병리학회지
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• 제17권2호
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• pp.467-475
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• 2003

This studt was investigated to prove the effect of GMYM on the brain damage. The results were as follows; 1. GMYM showed significantly inhibitory effect on LDH release by NMDA. AMPA and Kinate. 2. GMYM showed significantly inhibitory effect on LDH release by BSO and Fe2+. 3. GMYM decreased coma duration time in a infatal dose of KCN and showed 30% of survival rate in a fatal dose. 4. GMYM showed improvement of forelimb and hindlimb test after MCA occulusion in neurological exemination. 5. GMYM decreased ischemic area and edema incited by the MCA blood flow block. These results indicate that GMYM can be used in the brain damage sujected to brain ischemia. Further study will be needed about the functional mechanism and etc.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2002년도 춘계학술대회논문집
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• pp.373-377
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• 2002

In this study, we suggested a slim-type actuator that can be controlled in radial direction for compensating coma aberration in high-capacity optical storage devices. To deal successfully with narrow space in slim-type optical pick-up for notebook pc device, additional yokes for tilting motion are integrated into main yoke of the actuator. And the location of tilting coils is determined for mass-b3lancing effect to achieve optimal configuration for high driving sensitivity. We also suggested new concept of lens holder to guarantee excellent stability of control system by enhancing the gain margin at secondary resonant frequency. The concept was realized by forming damping sections in the lens holder, which prevent vibrational energy from transferring to lens. An exclusive measurement system was newly developed for fast and precise measurement of dynamic characteristics of actuators and utilized for the practical use. We hope to make good use of this system also in time to come.