• 한국학교보건학회지
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• 제23권2호
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• pp.276-285
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• 2010

Purpose: This study is descriptive research that confirms breakfast eating habit of woman's college students and related factors. Methods: This investigation took place in August 2010 and was participated 142 students of one woman's college which located in a large city. The contents of the questionnaire consists of general trait, diet trait, life patterns and health states. Results: According to the results of uni-variate analysis, the significant variables of breakfast eating habit are: Recognition of importance of breakfast, spare time before attendance, her parents's breakfast eating habit, times of snack, times of eating out and index of food life style. But, according to the results of multi-variate analysis, the number of the significant variables became narrow and they were: Recognition of importance of breakfast, spare time before attendance and her father's breakfast eating habit. Conclusion: Finally, it can be said that the breakfast eating habit of woman's college student is related to recognition of importance of breakfast, spare time before attendance and her father's breakfast habit strongly. It is necessary to emphasis on the recognition of the importance of breakfast and concerns of parents for breakfast eating habit to improve the regularity of breakfast eating habit for woman's college students' health.

• 동의생리병리학회지
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• 제26권3호
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• pp.386-391
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• 2012

The purposes of this study were to investigate the difference on activities of daily living(ADL), instrumental activities daily of living(IADL) and quality of life of aged woman with dementia reported by aged woman with dementia and caregivers. From December 2009 to February 2010, 64 subjects in the institutionalized aged woman with dementia, 22 caregivers were surveyed through structured questionnaires. There was no difference ADL and quality of life of aged woman with dementia reported by aged woman with dementia and caregivers. But, there was significant differences in IADL. Also, ADL was positively related to IADL in aged woman with dementia and caregivers. ADL and IADL were negatively related to quality of life in aged woman with dementia and caregivers. In daily activity and life quality, there is no difference recognized by aged woman with dementia and caregivers. So it's not matter for the nursery to recognize the demand of the aged woman with dementia and to care them. It is necessary to study the elderly with dementia at home, and to compare the patients in accordance with severity.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2001년도 추계학술대회 및 정기총회
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• pp.86-86
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• 2001

Based on the potential inhibitors of cyclooxygenase-2 (COX-2) as anti-inflammatory or cancer chemopreventive agents, we have evaluated the active principles of COX-2 inhibition from natural products. The methanol extract of the cortex of Eugenia caryoplyllata (Myrtaceae) showed the potent inhibition of prostaglandin E$_2$(PGE$_2$) production in lipopolysaccharide (LPS)-activated RAW 264.7 cells (98.3% inhibition at the test concentration of 10 $\mu\textrm{g}$/$m\ell$) Further, hexane-soluble layer was the most active partition compared to ethyl acetate, n-butanol, and water -soluble parts. By bioassay-guided fractionation of hexane-soluble layer, eugenol was isolated and exhibited a significant suppression of PGE$_2$ production (IC$\_$50/=0.06$\mu\textrm{g}$/$m\ell$). In addition, eugenol suppressed the COX-2 gene expression in LPS-stimulated mouse macrop-hage cells. Therfore, eugenol might be a plausible lead candidate for further developing the COX-2 inhibitor as an anti-inflammatory or cancer chemopreventive agent.

• 대한방사선협회지
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• 제28권1호
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• pp.67-73
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• 2002

Purpose : For the woman, compression of breast during mammogram introduce pain that woman used to have fear for mammogram. Therefore, the purpose of this study was to determine the adequate and minimized compression power for mammogram with maintaining th

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.86-86
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• 2003

In a continuous effort to develop novel anticancer agents we newly synthesized and evaluated the antitumor activity of nucleoside analogues. One analogue, 4 - ［2-Chlor-6- (3-iodo- benzy lamino) -purin -9-yl］- 2,3-dihydroxy-cyclopentanecarbo xylic acid methylamide (LJ-331), has been shown to exert a potent inhibition of human cancer cell growth in vitro including human lung (A549), stomach (SNU-638) and leukemia (HL-60) cancer cells. Following mechanism of action study revealed that LJ - 331induces cell cycle arrest at the G1 phase in HL-60 cells and evokes apoptotic phenomena such as an increase in DNA ladder intensity and chromatin condensation by a dose- and time-dependent manner. LJ-331 also activated the caspase-3 activity in HL-60. This result suggests that the growth inhibition of human cancer cells by LJ-331 might be related to the cell cycle arrest and induction of apoptosis.

• 여성건강간호학회지
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• 제3권2호
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• pp.238-249
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• 1997

For the purpose of improving the nursing research on the woman's health the nursing papers form Korea were analyzed by subject and content. This work was anticipated to suggest the direction of the research on the filed of woman's health. A total of 420 papers form journals, TaeHan KanHo, Journal of Academy of Nursing, and Journal of Korean Woman's Health Nursing Academic Society published from 1992 to 1996 were analyzed by Dubar and Patterson's criteria. The Number of papers on the woman's health was 66(15.7%), and those of mother's role and other clinical studies were 36(8.6%) and 318(75.7%) each. Special fields of the 66 papers on the woman's health and its number were health management 27(40.9%), psychiatric health 15(22.7%), postmenopausal period 5(7.6%), sex 5(7.6%), menstruation 4(6.1%), abortion 3(4.5%), nursing need 2(3.0%), violence 1(1.5%) respectively. Considering the subjects according to the life cycle, the subject on pregnant and middle aged period were more frequent than that on juvenile, peripartum, married or aged periods. According to above results, the proposals for promoting the nursing research were followings : Woman should be included as a subjects more frequently in general nursing research. The methodology for comparison study on the sex difference should be developed to understand the multifaced phenomena of woman's health. The factor analysis affecting the woman's health inadequately should be done.

• 여성건강간호학회지
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• 제1권2호
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• pp.260-274
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• 1995

In order to help the theory development for "women health", and to apply to the women client care, the concept analysis of "women health" was done. According to the concept analysis method by Walker & Avant, the characters of concept "women health" were analyzed from literature. The results were as followings : first, it emphasizes reproductive focused health care(childbirth-oriented) and normal development process regarded as abnormal. Second, it is affected by cultual environment. Third, it is related with sex. Forth, it considers the human, feminine and maternal aspects. Fifth, it need woman-centered nursing approach to promote woman's quality of life. Sixth, it stresses not only wholistic human health promotion but also the harmony between human and environment. Seventh, it is needed to be considered woman's various experiences as important and it approaches phenomenogically and interdisciplinary. Eighth, it needed to understands person-situation interactional aspect. Ninth, it can promote the adaptation power to surrounding environment. Above results can elucidate the concept of "women health", and will be a basis of theory development of "women health" In practical nursing, these results will be a basis for the promotion of women health and for the increase of life quality.

• Clinical and Experimental Reproductive Medicine
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• 제31권1호
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• pp.51-57
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• 2004

Objective: To investigate whether polymorphism of gene encoding COMT is associated with the risk of endometriosis in Korean women. Methods: We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's COMT genotype. Results: The distribution according to NIaIII genetic polymorphisms of COMT were as follows. $COMT^{HH}$, $COMT^{HL}$, and $COMT^{LL}$ genotypes were 56.6% (77 women), 34.6% (47 women) and 8.8% (12 women) in the study group and 50.6% (127 women), 39.4% (99 women) and 10.0% (25 women) in the control group. There was no significant difference between the study group and the control group. Conclusion: The results suggest that COMT genetic polymorphism may not be associated with the development of endometriosis in Korean women.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.90-90
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• 2003

The acetylation of histone is one of the mechanisms involved in the regulation of gene expression and is tightly controlled by two core enzymes, histone acetyltransferase (HAT) and deacetylase (HDAC). There are several reports that imbalance of HAT and HDAC activity is associated with abnormal behavior of the cells in morphology, cell cycle, differentiation, and carcinogenesis. Recently, an increasing number of structurally diverse HDAC inhibitors have been identified that inhibit proliferation and induce differentiation and/or apoptosis of tumor cells in vivo and in vitro. In this study, we have investigated the effects of novel HDAC inhibitors, IN2001 on ER positive and ER negative human breast cancer cell lines. The growth inhibition, cell cycle arrest and apoptosis of cells by HDAC inhibitors were determined using SRB assay, DNA fragmentation, and flow cytometry. We found that IN 2001 as well as Trichostatin A inhibited cell growth dose-dependently in both ER positive and ER negative human breast cancer cell lines. The growth inhibition with HDAC inhibitors was associated with profound morphological change. The result of cell cycle analysis after 24 h exposure of IN2001 showed G2-M cell cycle arrest in MCF-7 cell and apoptosis in T47D and MDA-MB-231 cell. In summary, IN2001 has antiproliferative effect on human breast cancer cells regardless of the expression of estrogen receptor. These findings heights the possibility of developing HDAC inhibitors as potential anticancer therapeutic agents for the treatment of breast cancer.

• 한국생활과학회지
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• 제4권1호
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• pp.75-83
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• 1995

A pregnant woman usually brings on a great change of her body line after the six month pregnant time. In particular, the abdomen is the biggest of all body parts, in the latter of her pregnance, compared with the fact of the bosom is as such for the common body line. Accordingly, we have the 10 main item to design a pregnant woman's proper pattern by the Body Volume Pre-Outline. The pregnent woman's bodice basic pattern of this study is designed loosely for hiding the change of body as the progress of pregnance, in order to be applied to a pregnant woman's pattern design variously.