• Animal Bioscience
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• v.36 no.6
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• pp.861-868
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• 2023

Objective: Loin muscle area (LMA) is an important target trait of pig breeding. This study aimed to identify single nucleotide polymorphisms (SNPs) and genes associated with LMA in the Duroc×(Landrace×Yorkshire) crossbred pigs (DLY). Methods: A genome-wide association study was performed using the Illumina 50K chip to map the genetic marker and genes associated with LMA in 511 DLY pigs (255 boars and 256 sows). Results: After quality control, we detected 35,426 SNPs, including six SNPs significantly associated with LMA in pigs, with MARC0094338 and ASGA0072817 being the two key SNPs responsible for 1.77% and 2.48% of the phenotypic variance of LMA, respectively. Based on previous research, we determined two candidate genes (growth hormone receptor [GHR] and 3-oxoacid Co A-transferase 1 [OXCT1]) that are associated with fat deposition and muscle growth and found further additional genes (MYOCD, ARHGAP44, ELAC2, MAP2K4, FBXO4, FBLL1, RARS1, SLIT3, and RANK3) that are presumed to have an effect on LMA. Conclusion: This study contributes to the identification of the mutation that underlies quantitative trait loci associated with LMA and to future pig breeding programs based on marker-assisted selection. Further studies are needed to elucidate the role of the identified candidate genes in the physiological processes involved in LMA regulation.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.126.1-126.1
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• 2008

• JSTS:Journal of Semiconductor Technology and Science
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• v.15 no.1
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• pp.131-144
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• 2015

An extensive investigation of the influence of gate engineering on the CNTFET switching, high frequency and circuit level performance has been carried out. At device level, the effects of gate engineering on the switching and high frequency characteristics for CNTFET have been theoretically investigated by using a quantum kinetic model. It is revealed that hetero - material - gate CNTFET(HMG - CNTFET) structure can significantly reduce leakage current, enhance control ability of the gate on channel, and is more suitable for use in low power and high frequency circuits. At circuit level, using the HSPICE with look - up table(LUT) based Verilog - A models, the performance parameters of circuits have been calculated and the optimum combinations of ${\Phi}_{M1}/{\Phi}_{M2}/{\Phi}_{M3}$ have been concluded in terms of power consumption, average delay, stability, energy consumption and power - delay product(PDP). We show that, compared to a traditional CNTFET - based circuit, the one based on HMG - CNTFET has a significantly better performance (SNM, energy, PDP). In addition, results also illustrate that HMG - CNTFET circuits have a consistent trend in delay, power, and PDP with respect to the transistor size, indicating that gate engineering of CNTFETs is a promising technology. Our results may be useful for designing and optimizing CNTFET devices and circuits.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.68.2-68.2
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• 2008

• Nuclear Engineering and Technology
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• v.54 no.12
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• pp.4798-4808
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• 2022

The porous corrosion deposits (known as CRUD) adhered to the cladding have an important effect on the heat transfer from fuel rods to coolant in PWRs. The vapor film is the main constituent in the two-phase film boiling model. This paper presents a vapor film thickness correlation, associated with CRUD porosity, CRUD chimney density, CRUD particle size, CRUD thickness and heat flux. The dependences of the vapor film thickness on the various influential factors can be intuitively reflected from this vapor film thickness correlation. The temperature, pressure, and boric acid concentration distributions in CRUD can be well predicted using the two-phase film boiling model coupled with the vapor film thickness correlation. It suggests that the vapor thickness correlation can estimate the vapor film thickness more conveniently than the previously reported vapor thickness calculation methods.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.177.1-177.1
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• 2008

• Journal of Ginseng Research
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• v.47 no.5
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• pp.645-653
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• 2023

Background: Changes to work-life balance has increased the incidence of cervical cancer among younger people. A minor ginseng saponin known as ginsenoside Rk1 can inhibit the growth and survival of human cancer cells; however, whether ginsenoside Rk1 inhibits HeLa cell proliferation is unknown. Methods and results: Ginsenoside Rk1 blocked HeLa cells in the G0/G1 phase in a dose-dependent manner and inhibited cell division and proliferation. Ginsenoside Rk1 markedly also activated the apoptotic signaling pathway via caspase 3, PARP, and caspase 6. In addition, ginsenoside Rk1 increased LC3B protein expression, indicating the promotion of the autophagy signaling pathway. Protein processing in the endoplasmic reticulum signaling pathway was downregulated in Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, consistent with teal-time quantitative PCR and western blotting that showed YOD1, HSPA4L, DNAJC3, and HSP90AA1 expression levels were dramatically decreased in HeLa cells treated with ginsenoside Rk1, with YOD1 was the most significantly inhibited by ginsenoside Rk1 treatment. Conclusion: These findings indicate that the toxicity of ginsenoside Rk1 in HeLa cells can be explained by the inhibition of protein synthesis in the endoplasmic reticulum and enhanced apoptosis, with YOD1 acting as a potential target for cervical cancer treatment.

• Proceedings of the Korean Society of Computer Information Conference
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• 2019.01a
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• pp.285-286
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• 2019

최근 자유 여행을 즐기는 사람이 늘어남에 따라, 그에 맞춰 여행 애플리케이션은 빅데이터를 기반으로 관광지 추천 서비스를 제공하고 있다. 그렇지만 이 경우 전형적인 관광지만을 추천하여 독특한 여행 경험을 원하는 여행자들을 만족시키지 못하고 있다. 이러한 문제를 해결하기 위해, 본 논문은 현지인 가이드가 자신만의 경험이 담긴 투어 상품을 구상하고 직접 안내까지 함으로써 여행자에게 특별한 현지 경험을 선사해 주는 것을 목표로 한 여행 가이드 애플리케이션을 개발하였다. 가이드와 여행자 입장에서 각각의 편리성 제공을 위해 두 개의 애플리케이션으로 개발하였으며, 웹서버 연동을 통해 상호간의 실시간 정보 업데이트가 가능하게 하였다. 또한 네이티브 애플리케이션을 기반으로 여행지 어디에서나 투어 상품을 구매할 수 있어 여행자에게 편리성을 제공한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.5
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• pp.2381-2399
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• 2019

Traditional recommendation algorithms on Collaborative Filtering (CF) mainly focus on the rating prediction with explicit ratings, and cannot be applied to the top-N recommendation with implicit feedbacks. To tackle this problem, we propose a new collaborative filtering approach namely Maximize MAP with Matrix Factorization (MFMAP). In addition, in order to solve the problem of non-smoothing loss function in learning to rank (LTR) algorithm based on pairwise, we also propose a smooth MAP measure which can be easily implemented by standard optimization approaches. We perform experiments on three different datasets, and the experimental results show that the performance of MFMAP is significantly better than other recommendation approaches.

• Journal of Magnetics
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• v.21 no.1
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• pp.25-28
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• 2016

In the present study, bulk anisotropic nanocrystalline $SmCo_5$ magnets were prepared by hot deformation. The effect of deformation temperature on the texture and magnetic properties are presented, based on which the mechanism of plastic deformation and texture formation during the hot deformation process is discussed. Our analyses reveal that deformation temperature is one of the most important parameters that determine the texture of $SmCo_5$ grains. We suggest that diffusion creep plastic deformation occurs during hot deformation, which is very sensitive to the energy gain provided by an increase in temperature.