• International Journal of Oral Biology
• /
• 제42권4호
• /
• pp.169-174
• /
• 2017

Transient receptor potential melastatin 8 (TRPM8) plays a crucial role in innocuous cool sensation, acute cold pain and cold-induced hyperalgesia during pathologic conditions. To help understand TRPM8-mediated cold perception in the dental pulp and periodontal tissues, we examined the distribution of TRPM8-immunopositive (+) axons in molar and incisor pulp and periodontal tissues using transgenic mice expressing a genetically encoded axonal tracer in TRPM8+ neurons. In the radicular pulp of the molar teeth, a small number of TRPM8+ axons were observed. TRPM8+ axons branched frequently and extensively in the core of coronal pulp, forming a network in the peripheral pulp. Some TRPM8+ axons ascended between odontoblasts and were observed in the dentinal tubule. TRPM8+ axons were linear-shaped in the radicular pulp, whereas many TRPM8+ axons showed portions shaped like beads connected with thin axonal stands at the peripheral pulp. TRPM8 was densely expressed in the bead portions. In the incisor pulp, TRPM8+ axons were occasionally observed in the core of the coronal pulp and rarely observed at the peripheral pulp. TRPM8+ axons were occasionally observed and showed a linear shape rather than a bead-like appearance in the periodontal ligament and lamina propria of the gingival tissue. These findings, showing differential distribution of TRPM8+ axons between radicular and coronal portions of the molar pulp, between incisor and molar pulp, and between dental pulp and periodontal tissues, may reflect differential cold sensitivity in these regions.

• 한국생활과학회지
• /
• 제12권5호
• /
• pp.747-754
• /
• 2003

The actual clothing conditions were surveyed to diagnose clothing condition of Korean female in the view point of the adaptation to the thermal environment according to seasonal changes. Then, clothing microclimate, physiological responses, and subjective sensation were investigated through wearing trials on human body in climatic chamber based on the results from the survey. Factors to evaluate validity of clothing condition were clothing weight, clothing microclimate, physiological response of human body, and subjective sensation. The results were as follows: 1. Clothing weight per body surface area of the season was $856g/m^{2}$, $439g/m^{2}$ in summer, $630g/m^{2}$ in fall, and $1184g/m^{2}$ in winter. Cold - resistance of Korean female in office was superior to Japanese, inferior to residents of rural areas of Korea, and similar to male in office. However, in heat - resistance, female in office was inferior to residents of rural areas of Korea. 2. In spring, fall, winter, clothing microclimate temperature was a little higher than that in summer. Therefore, it was not a desirable wearing condition even though the clothing microclimate was comfortable zone. 3. Mean skin temperature of female in office was including within the range of Winslow's comfortable zone, but the range of comfortable zone in mean skin temperature of female was more narrow than Winslow's. Thus, it has problem for female to adaptation to thermal environment.

• 한국의류학회지
• /
• 제24권1호
• /
• pp.77-86
• /
• 2000

Purposes of this study were firstly to refine the measurement technique of tactile sensation and sensibility induced by touching the fabrics and secondly to investigate the differences of tactile sensibility depending on environmental conditions and the type of polyester fabrics. The environmental conditions were controlled at 20$\pm$1$^{\circ}C$, 65$\pm$3%RH(standard) and at 29$\pm$1$^{\circ}C$, 75$\pm$3%RH(warm & humid). As results, three factors were extracted from factor analysis of sensory assessment scale. The first factor was thickness and weight, the second one was surface-related property and the third one was stiffness in both environments. Depending on the environmental conditions, heat and moisture-related sensations such as [cold], [damp] and [dry & drapable] were affected significantly. Regression equations with the sensation descriptors were developed for the prediction of tactile sensibility(R2>.89). While the most efficient descriptor was [thin & flexible] in the standard environmental conditions, that was [dry & drapable] in the warm & humid environmental condition.

• Journal of Chest Surgery
• /
• 제33권10호
• /
• pp.792-797
• /
• 2000

Background : Even though there were developments in various treatment techniques for acute arterial occlusion this disease still has high rate of mortalities and limb amputations. We investigated the combined diseases symptoms location of occlusion type of treatment complication and prognosis in our patients. Meterial and methods: This study recruited 48 patients(42 men, 6 women, mean age 57.7 years) who received the operation from January 1995 toDecember 1998. We investigated the post-operation course via medical record review or telephone interview with patients or their family members. Result: The most common combined diseases were atherosclerosis in 30 patients. other diseases were 17 diabetes mellitus 16 hypertension and 12 atrial firillation. Pain and clod sensation were noticed in all patients paresthesia in 5 patients fibrillation. Pain and cold sensation were noticed in all patients paresthesia in 5 patients and lower extremity paralysis in 11 patients. In 29 patients the time interval from the onset of symptom to admission was over 72 hours and 15 patients were admitted within 24 hours. The distribution of arterial occlusion location was at 28 femoral arteries 14 popliteal arteries and 6 iliac arteries. All the patients were received embolectomy and 5 patients were received additional bypass grafting. Postoperative complications were 12 reocclusions. 6 compartment syndromes 6 skin necrosis and 2 acute renal failure. The mortality rate was 16.7%(8/48) and the amputation rate was 25% Conclusion : This study revealed 25% reocclusion 25% limb amputation and 16.7% mortaliyt. To improve the prognosis of acute lower extrements arterial occlusion early diagnosis and understand the underlying diseases prompt treatment and operation additional operation including interventional radiologic examination and thorough postoperative care would be appreciated.

• 한국의류학회지
• /
• 제18권2호
• /
• pp.273-282
• /
• 1994

The physiological significances of the upper and lower body on thermoregulation and sensation were studied in this paper. Experiments were carried out on 4 females in a climatic chamber conditioned at 1) $25^{\circ}C\rightarrow35^{\circ}C\rightarrow25^{\circ}C$, 2) $25^{\circ}C\rightarrow15^{\circ}C\rightarrow25^{\circ}C$, both with 50% R.H., covering the upper body (U) or lower body (L) with garments. 1. When the upper or lower body is covered or exposured respectively, the mean skin tempterature of upper body is higher than that of lower body. And upper body is more easily influenced by the environmental temperature than lower body. It means the skin temperatures of the upper body change faster than those of the lower body following the environmental changes. 2. In U and L, the skin temperatures of the upper limbs (thighs, upper arms) are lower than those of the peripherals (hands, feet). 3. Warm sensations and skin temperatures of the upper body showed high correlation and it was the case with cold sensations and skin temperatures of the lower body. 4. In high temperature condition $(25^{\circ}C\rightarrow35^{\circ}C\rightarrow25^{\circ}C)$, mean skill temperature and rectal temperature in L were lower than in U. This lower rectal temperature in L is probably due to the insulation of the lower body with garments that promotes the heat radiation only in the high temperature environment.

• The Korean Journal of Pain
• /
• 제6권1호
• /
• pp.129-132
• /
• 1993

Paraplegia complicating a block of the celiac plexus with alcohol for recurrent stomach cancer is described. A 33 year old male patient was admitted to control for severe epigastric pain. With the patient in prone position, the needle was advanced further than 2 cm on the anterior margin of $L_1$ vertebral body under fluoroscopy. 3 ml of 1% lidocaine and 5 ml of conray were injected through each needle, and the diffusion of the contrast medium was checked, This was followed by 7 ml of pure alcohol and 8 ml of 50% alcohol for each needle. At that time, the patient was very satisfied with loss of abdominal pain. About 30 minutes after injection of alcohol, suddenly patient complained of severe burning pain on back and both extremities. Thereafter, loss of sensation and paralysis in both extremities were developed slowly. The senstivity to cold recovered 3 days after block. By the 33rd day after the block, sensation had recovered in both extremities, the bladder and rectum. Movement of the right ankle joint and left great toe was also possible.

• Archives of Reconstructive Microsurgery
• /
• 제10권2호
• /
• pp.169-174
• /
• 2001

Purpose : The problems of late deterioration of sensation and a double sensibility phenomenon are a known deficiency of the original neurovascular island flap. To eliminate this problems, the authors was performed to assess the results of Thumb-pulp loss reconstruction with a heterodigital neurovascular island Flap Using a Nerve Disconnecting-Reconnecting Technique Material and Methods : Between July. 1987 and November. 2000, we have used a disconnecting-reconnecting technique for heterodigital island flaps in which divided nerve of the transferred island flap is sutured to original nerve of the thumb in 9 patients. 9 patients with a mean follow-up period of 3.6 years were examined, while 7 patients were follow-up for 2years or more. Evaluation of results was based on flap quality, donor site quality, classic two-point sensory discrimination(2PD), and location of sensation(double sensibility), donor site cold intolerance, neuroma formation, scar contractures, total active movement(TAM) of the thumb and donor digit and subjective results and objective results. Results : The two-point discrimination was average 6.7 mm. Donor site paresthesia was observed more frequently in a short postoperative period. Sensation was referred to the thumb in all cases and the recovery occurred over a period of a two months. There were no flap complication or failures and the length of the thumb tip was preserved in all cases. Conclusion : This technique was found to provide well-vascularized pulp of the thumb with proper cortical representation in one operative stage.

• 대한설비공학회지:설비저널
• /
• 제16권6호
• /
• pp.590-605
• /
• 1987

The purpose of this study was to investigate thermal environmental factors, thermal clothing properties, and thermal sensation of the office workers in four selected office buildings in Seoul, and to determine the effect of thermal environmental factors and clothing insulation to the thermal sensation of the subjects. The subjects selected from each office were 5 males and 5 females at a time. Thermal environmental factors(DBT, GT, RH, MRT, $ET^{\ast}$) and clothing variables such as clothing weight per body surface $area(g/m^2)$ and estimated clothing insulation values(clo) were significantly different among each seasons(p<0,001). Means of $ET^{\ast}$ and estimated clothing insulation values of each season were as follows; Winter; $20.84^{\circ}C$ $ET^{\ast}$ with 0.72 clo for male and 0.79 clo for female Spring and fall; $23.65^{\circ}C$ $ET^{\ast}$ with 0.59 clo for male and 0.68 clo for female Summer; $26.00^{\circ}C$ $ET^{\ast}$ with 0.47 clo for male and 0.53 clo for female. In comparison these data with ASHRAE Standard, the subjects were predicted to feel comfort-able in spring and fall, and slightly hot in summer and slightly cold in winter because of high and low clo respectively. But the result of this survey showed more than $80\%$ of the occupants were thermally comfortable at a given environmental temperature and clo.

• 대한인간공학회지
• /
• 제36권3호
• /
• pp.169-181
• /
• 2017

Objective: The aim of this study was to explore the influence of outdoor weather conditions on subjective responses during physical activity. Background: The largest difference between indoor and outdoor conditions is the existence of the sun. The heat load from the sun has an influence on the heat gain of the human body and the intense degree of solar radiation affected thermal comfort. Method: Thirty eight people were exposed to a range of climatic conditions in the UK. Weather in England does not have extremely hot and cold temperature, and the current study was conducted under warm (summer and autumn) and cool (spring and summer) climates. Measurements of the climate included air temperature, radiant temperature (including solar load), humidity and wind around the subjects. Subjective responses were taken and physiological measurements included internal body temperature, heart rate and sweat loss. Results: This study was conducted under four kinds of environmental conditions and the environmental measurement was performed in September, December, March, and June. The values for sensation, comfort, preference, and pleasantness about four conditions were from 'neutral' to 'warm', from 'not uncomfortable' to 'slightly comfortable', from 'slightly cooler' to 'slightly warmer', and from 'neither pleasant nor unpleasant' and 'slightly unpleasant', respectively. All subjective responses showed differences depending on air temperature and wind speed, and had correlations with air temperature and wind speed (p<0.05). However, subjective responses showed no differences depending on the radiant temperature. The combined effects of environmental parameters were showed on some subjective responses. The combined effects of air temperature and radiant temperature on thermal sensation and pleasantness were significant. The combined effects of metabolic rate with air temperature, wind speed and solar radiation respectively have influences on some subjective responses. In the case of the relationships among subjective responses, thermal sensation had significant correlations with all subjective responses. The largest relationship was shown between preference and thermal sensation but acceptance showed the lowest relationship with the other subjective responses. Conclusion: The ranges of air temperature, radiant temperature, wind speed and solar radiation were $6.7^{\circ}C$ to $24.7^{\circ}C$, $17.9^{\circ}C$ to $56.6^{\circ}C$, $0.84ms^{-1}$ to $2.4ms^{-1}$, and $123Wm^{-2}$ to $876Wm^{-2}$ respectively. Each of air temperature and wind speed had significant relationships with subjective responses. The combined effects of environmental parameters on subjective responses were shown. Each radiant temperature and solar radiation did not show any relationships with subjective responses but the combinations of each radiant temperature and solar radiation with other environmental parameters had influences on subjective responses. The combinations of metabolic rate with air temperature, wind speed and solar radiation respectively have influences on subjective responses although metabolic rate alone hardly made influences on them. There were also significant relationships among subjective responses, and pleasantness generally showed relatively high relationships with comfort, preference, acceptance and satisfaction. Application: Subjective responses might be utilized to predict thermal stress of human and the application products reflecting human subjective responses might apply to the different fields such as fashion technology, wearable devices, and environmental design considering human's response etc.

• Fibers and Polymers
• /
• 제6권4호
• /
• pp.343-347
• /
• 2005

The purpose of this study was to investigate the appropriate amounts of phase change materials to give objective and subjective wear sensations. Vapor-permeable water-repellent fabrics with (WR-PCM) and without (WR) octadecane containing microcapsules were obtained by wet-porous coating process. Then, calculating the area of the WR-PCM treated clothes, we estimated the total calories of the clothing by multiplying the heat of fusion and heat of crystallization of PCM to the calculated area. Wear tests were conducted in both warm environment $(30^{\circ}C,\;65\%\;RH)$ and cold environment $(5^{\circ}C,\;65\%\;RH)$ with sports warm up style experimental garments made with WR and WR-PCM fabrics. Rectal, skin, and clothing microclimate temperatures, saliva and subjective evaluation measurements were done during the wear test. There was no difference of rectal and mean skin temperatures between WR and WR-PCM, but the clothing microclimate temperature of WR-PCM under warm environment was slightly lower than that of WR. In cold environment, WR-PCM showed much higher temperature than in WR. Saliva change did not appear between clothes, but did between two environments. Although subjective sensation between WR and WR-PCM was not significantly different, WR-PCM was rated as cooler than WR in warm environment and as warmer than WR in cold environment. The results of this study indicated that octadecane containing microcapsules in water-repellent fabric provide cooling effect.