• Nuclear Engineering and Technology
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• 제21권1호
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• pp.1-11
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• 1989

원자로 정지동안에도, 잔열제거계통은 그 기능이 계속 유지되어야 하나, 실제로 가압 경수로에서 냉각상실고가 많이 발생되어 있다. 본 논문은 원자로 정지중의 냉각기능상실을 예방하고, 또한 냉각기능상실로 인한 노심손상의 중대성을 완화시키기 위한 대책을 강구하기 위한 시도로서, 전형적인 가압경수로에 대한 사고/고장 수목과 운전원실수 확률을 위한 HCR 모델, 초기 사상의 빈도를 위한 2단계 bayesian 방법 및 고장난 계통의 회복 활률을 위한 계단함수 모델 등을 이용한 원자로 정지 위해도 모델을 개발하여, 잔열제거계통의 신뢰도를 분석하였다. 그 결과는 원자로가 정지 중일 때의 위해도가 운전중일 때 이것에 비해 별로 낮지 않은 것으로 나타났으며, 몇 가지의 설계개선을 통하여 냉각기능상실로 인한 노심 손상확률을 상당히 낮출 수 있는 것으로 나타났다.

• Journal of Korean Medical Science
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• 제33권46호
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• pp.289.1-289.10
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• 2018

Background: Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated. Methods: We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. PD patients were classified according to their motor subtypes: tremor-dominant, intermediate, and postural instability-gait disturbance (PIGD). Other cerebrovascular risk factors and small vessel disease (SVD) burdens were also evaluated. Results: Two-hundred and five patients with PD and 205 control subjects were included. The prevalence of CMBs was higher in PD patients than in controls (16.1% vs. 8.8%; odds ratio [OR], 2.126; P = 0.019); CMBs in the lobar area showed a significant difference between PD patients and controls (11.7% vs. 5.9%; OR, 2.234; P = 0.032). According to the motor subtype, CMBs in those with PIGD type showed significant difference from controls with respect to the overall brain area (21.1% vs. 8.9%; OR, 2.759; P = 0.010) and lobar area (14.6% vs. 4.9%; OR, 3.336; P = 0.016). Among PD patients, those with CMBs had higher age and more evidence of SVDs than those without CMBs. Conclusion: We found that CMBs are more frequent in PD patients than in controls, especially in those with the PIGD subtype and CMBs on the lobar area. Further study investigating the pathogenetic significance of CMBs is required.

• 대한한의학회지
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• 제40권1호
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• pp.46-62
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• 2019

Objectives: This study was made by Chung Yeon Korean Medicine Hospital in order to perform appropriate East-West integrative medicine. The purpose of this manual is to support decision-making and communication in the implementation of the East-West cooperative treatment of vascular dementia. Methods: In order to carry out this study, it is based on search terms such as 'vascular dementia', 'acupuncture', 'herbal medicine', 'integrative medicine', 'chinese traditional medicine', and 'cognitive function' in databases such as MEDLINE, EMBASE, OASIS and CNKI We collected references. The drafting proceeded with the collaboration of two specialists of the Korean medicine, and the disagreement on the basis of the quotation was determined through a two person agreement. After, The draft was reviewed by a western medical doctor(rehabilitation specialist). Then, The opinions of the entire medical staff of the committee were reflected in the draft and finalized the agreement. Results: Through this study, manuals for diagnosis, treatment, and other considerations in the process of applying East-West integrative medicine to vascular dementia were derived. Conclusions: This study has significance in that it provides manual information about the decision structure, treatment contents, role distribution, etc. of East-West integrative medicine within the medical institution that conducts the vascular dementia consultation. In order for this study to function as a generalized medical guideline, it is necessary to improve the research methodology and carry out professional consensus procedures.

• 동의생리병리학회지
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• 제35권5호
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• pp.139-150
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• 2021

This paper examines whether the conceptual metaphor theory, which has been recently treated as important research topic in the field of cognitive linguistics, can be a new method that can promote the modernization of basic Korean medicine (KM) theory. In addition, the significance and potential of this study are reviewed by looking at Chinese research cases that applied this theory to Traditional Chinese Medicine theories and terminologies. The results are summarized as follows. From the viewpoint of metaphoric cognition, KM is a medicine that attempts to understand the human body (microcosm) through nature (great universe) by metaphorically projecting human experiences of nature on the human body based on the thought of correspondence between nature and human (天人相應). The language system of KM is based on a metaphor that extends our experience of nature to the human body, and an abundance of metaphors can be seen throughout the language of KM. Understanding and interpreting KM theories and terminologies from a metaphorical point of view allow us to understand the nature of KM theoretical key terms more deeply than now. And this understanding can help define and describe KM theoretical key terms and promote the modernization of KM theory research. In addition, various image schema that plays an important role in the metaphorical expansion of physical experience can be used for modeling KM theory. Research of KM theories and terminologies from a metaphorical point of view can serve as a bridge between traditional KM theory and modernization research, opening a new path to the modernization of basic KM theory in difficult situations.

• Biomolecules & Therapeutics
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• 제30권4호
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• pp.320-327
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• 2022

Neurodevelopmental disorders are complex conditions that pose difficulty in the modulation of proper motor, sensory and cognitive function due to dysregulated neuronal development. Previous studies have reported that an imbalance in the excitation/inhibition (E/I) in the brain regulated by glutamatergic and/or GABAergic neurotransmission can cause neurodevelopmental and neuropsychiatric behavioral deficits such as autism spectrum disorder (ASD). NMDA acts as an agonist at the NMDA receptor and imitates the action of the glutamate on that receptor. NMDA however, unlike glutamate, only binds to and regulates the NMDA receptor subtypes and not the other glutamate receptors. This study seeks to determine whether NMDA administration in mice i.e., over-activation of the NMDA system would result in long-lasting behavioral deficits in the adolescent mice. Both gender mice were treated with NMDA or saline at early postnatal developmental period with significant synaptogenesis and synaptic maturation. On postnatal day 28, various behavioral experiments were conducted to assess and identify behavioral characteristics. NMDA-treated mice show social deficits, and repetitive behavior in both gender mice at adolescent periods. However, only the male mice but not female mice showed increased locomotor activity. This study implies that neonatal exposure to NMDA may illicit behavioral features similar to ASD. This study also confirms the validity of the E/I imbalance theory of ASD and that NMDA injection can be used as a pharmacologic model for ASD. Future studies may explore the mechanism behind the gender difference in locomotor activity as well as the human relevance and therapeutic significance of the present findings.

• 산업융합연구
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• 제20권9호
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• pp.1-10
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• 2022

본 연구는 비인지적 영역인 개인특성과 직무특성이 자기개발의도에 미치는 영향을 파악하여 금융회사의 인력개발에 활용할 수 있도록 전략적 시사점을 제공하는데 있다. 연구대상은 금융업에 종사하는 직장인 219명이며, 이들을 대상으로 자기주도성, 친밀감, 직무중요성, 직무자율성, 직무스트레스 및 자기개발의도를 조사하였다. 연구결과는 첫째, 개인특성 중 자기주도성은 자기개발의도에 유의미한 영향을 미치지 않았으나. 친밀감은 자기개발의도에 정(+)의 영향을 미치는 것으로 분석되었다. 둘째, 직무특성 중 직무자율성은 자기개발의도에 유의미한 영향을 미치지 않았으나, 직무중요성은 자기개발의도에 정(+)의 영향을 미치는 것으로 나타났다. 셋째, 조절변수인 직무스트레스는 친밀감과 자기개발의도에 유의미한 부(-)의 조절효과가 있었다. 본 연구는 금융회사에서 인적자원개발의 실효성을 높이기 위해 개인특성과 직무특성을 활용하는 방안을 제시했다는 점에서 의의가 있다.

• 한국의상디자인학회지
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• 제25권2호
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• pp.1-16
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• 2023

Due to the current seriousness of environmental pollution and the eco-friendly movement of the fashion industry, research on sustainable fashion design is being actively conducted. In this study, consumer perception of upcycling products, are divided into image, function, and meaning; and image is further divided into shape, color, and material. It was redefined as pattern, and image recognition was evaluated among men and women in their 20s and 30s, and men and women in their 40s and 50s used as subjects. First, factors that determine each image were extracted based on qualitative analysis of the precedent cases of upcycling bags, and quantitative analysis of the subjects was induced through a questionnaire. As a result of the analysis of evaluation items related to image association, the average frequency analysis of all subjects for each stimuli and the cognitive variance of the frequency analysis by generation by gender were found to be similar. However, awareness of some stimuli by generation showed a significant difference. Overall, in the three stimuli with high overall preference, common features, such as the basic box-shaped symmetrical structure, the monochromatic color of the Munsell system, solid and practical texture, and appropriate use of patterns were identified. In addition, it was confirmed that there was a difference with factors such as femininity, simplicity, touch, and splendor in the measurement factors. In conclusion, it is considered that the main significance of this study is that it excluded the recognition and meaning of upcycling products and explored the original design and image elements of products. Therefore, it is expected that this study will be used as a basic data for responding to the gender image of each generation as an alternative method of sustainable fashion design, and it will be an opportunity to expand the scope of the study to a detailed study beyond the biased topic.

• 대한통합의학회지
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• 제11권4호
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• pp.17-25
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• 2023

Purpose: This study aimed to examine the effectiveness of a suicide prevention education program called "Life Talk Talk" among middle and high school students in D City. Methods: The educational content of the "Life Talk Talk" program was compiled through nine rounds of consultations and meetings with suicide prevention experts. Prior to the implementation of the program, consent was obtained from all research participants and their guardians. First , a pilot study was conducted with 100 middle and high school students located in D city, following which the present study was conducted from May to July 2023 with 1,400 middle and high school students in D city. The effects of the program were evaluated by assessing the changes in suicidal ideation, help-providing abilities, and suicide prevention knowledge in the data collected both before and after the education. Statistical analysis included frequency analysis and a paired-sample t-test. Results: The final analysis included 1,380 participants. In the general characteristics,, 1,079 people (78 %) answered "yes" to the question about suicide prevention education experience . The study found a significant decrease in suicidal attitudes (t=-8.92, p<.001) and significant improvements in emotional and cognitive attitudes of participants after the "Life Talk Talk" program . Additionally, all five items related to help-providing abilities (t=-23.83, p<.001) and suicide prevention knowledge (p<.001) showed significant improvement from before the program. Conclusion: The significance of this study lies in demonstrating the effectiveness of the "Life Talk Talk" suicide prevention education program in reducing suicidal attitudes as well as improving help-providing abilities and suicide prevention knowledge. Therefore, to enhance the effectiveness of suicide prevention education, it is essential to regularly implement concise and engaging educational programs that capture the attention of adolescents.

• 실천공학교육논문지
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• 제15권3호
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• pp.571-580
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• 2023

4차 산업혁명 시대가 도래함에 따라 대학 교육 영역에서도 융합학문에 대한 요구가 증가하고 있다. 따라서 본 연구는 기대이론을 적용하여 융합 관련 학과의 교육과정 개정의 주요 전략 중 하나인 모듈형 교육과정에 대한 학습자의 인식된 기대 요인을 탐색하였다. 2022년도 2학기 동안 학습자의 인식을 사전-사후로 측정하였고, 결과적으로 기대 요인 중 선택 요인은 수강 전과 비교하여 수강 후에 유의미한 수준으로 낮아진 것을 확인하였다. 과목 내 도구 활용에 대한 이해 및 어려움 수준에 대한 인식 변화가 위 결과에 영향을 미쳤을 가능성이 있다. 본 연구의 결과는 모듈형 교육과정에 대한 학습자들의 인식을 분석함으로써 융합 관련 학과의 교육과정 개정에 방향을 제시한다는 점에서 의미가 있다. 구체적으로, 교육 도구 활용에 대한 어려움이나 인지적 부담을 줄이는 방향으로 교육과정을 설계해야 한다. 또한, 교육 도구에 대한 학생들의 사전 경험과 이해 수준이 교육 성과에 영향을 미칠 수 있다는 점을 감안하여 모듈형 교육과정을 설계해야 한다.

• 대한불안의학회지
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• 제19권2호
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• pp.37-47
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• 2023

This review article explores the psychological characteristics, comorbid mental disorders, and psychosocial assessments throughout the solid organ transplant journey, spanning the pre-transplant, peri-transplant, and post-transplant phases for transplant recipients. The psychological burden and anxiety in the pre-transplant phase are high for organ failure patients with complex physical difficulties who are deciding to undergo transplantation and are on the waiting list. The pre-transplant psychosocial evaluation covers various aspects, including the patient's readiness, awareness of, and commitment to transplant treatment, medical compliance, psychopathological conditions such as cognitive function and personality disorders, lifestyle factors, including substance abuse, as well as various psychosocial factors like social support. During the peri-transplant phase, mental health problems such as postoperative delirium should be carefully recognized and addressed. After transplantation, it is essential to assist patients in coping with the various stressful experiences they encounter, manage psychiatric symptoms such as depression, anxiety, and insomnia, and improve treatment adherence and quality of life during long-term care for the transplanted organ. Managing psychiatric problems in post-transplant patients requires a deep understanding of immunosuppressant medications and a keen awareness of associated risks, including adverse effects and potential drug interactions. This comprehensive review emphasizes the significance of proactive mental health care and psychosocial evaluation, highlighting the necessity of a multidisciplinary approach to enhance the quality of life and overall success of transplant patients throughout all phases of transplantation.