• 대한간호학회지
• /
• 제33권4호
• /
• pp.503-509
• /
• 2003

Purpose. The purpose of this study was to survey the prevalence rate of cognitive impairments and to identify the factors influencing cognitive impairment in the elderly in rural communities of Jeju Province. Methods. 590 elderly in 6 rural communities of Jeju Province were interviewed, using a questionnaire consisting of sociodemographic characteristics, health behavior, quality of life, and MMSE-K Results. Prevalence of cognitive impairment was 33.1 % (39.1 % of females, 16.76% of males). Prevalence of dementia was 12.4% (16.3% of females, 2.87% of males). Factors related to cognitive impairment were age, sex, education, standard of living, employment status, and subjective health state. Conclusions. In community health care for the elderly, factors relating to cognitive impairment have to be considered. When planning community health care, priority should be given to the elderly; who need care but live alone; who lack social support; who have a low standard of living; who experience discomfort in the activities of daily living; who believe they are not in a good state of health; or whose life satisfaction is low.

• Journal of Audiology & Otology
• /
• 제23권1호
• /
• pp.1-7
• /
• 2019

Self-reported difficulties in speech-in-noise (SiN) recognition are common among tinnitus patients. Whereas hearing impairment that usually co-occurs with tinnitus can explain such difficulties, recent studies suggest that tinnitus patients with normal hearing sensitivity still show decreased SiN understanding, indicating that SiN difficulties cannot be solely attributed to changes in hearing sensitivity. In fact, cognitive control, which refers to a variety of top-down processes that human beings use to complete their daily tasks, has been shown to be critical for SiN recognition, as well as the key to understand cognitive inefficiencies caused by tinnitus. In this article, we review studies investigating the association between tinnitus and cognitive control using behavioral and brain imaging assessments, as well as those examining the effect of tinnitus on SiN recognition. In addition, three factors that can affect cognitive control in tinnitus patients, including hearing sensitivity, age, and severity of tinnitus, are discussed to elucidate the association among tinnitus, cognitive control, and SiN recognition. Although a possible central or cognitive involvement has always been postulated in the observed SiN impairments in tinnitus patients, there is as yet no direct evidence to underpin this assumption, as few studies have addressed both SiN performance and cognitive control in one tinnitus cohort. Future studies should aim at incorporating SiN tests with various subjective and objective methods that evaluate cognitive performance to better understand the relationship between SiN difficulties and cognitive control in tinnitus patients.

• 성인간호학회지
• /
• 제26권1호
• /
• pp.34-45
• /
• 2014

Purpose: The purpose of this study was to investigate the effect of laughter therapy and cognitive reinforcement program on self-efficacy, depression and cognitive functions of the elderly with mild cognitive impairments (MCI). Methods: The study design was a non-equivalent control group pre and posttest design. Thirty-six subjects over the age of 65 with a diagnosis of mild cognitive impairment were assigned either to a treatment or a comparison group. Data were collected from February 7 to March 27, 2012 in the dementia supporting center. An eight week treatment program that included laughter therapy coupled with a cognitive reinforcing program including hand exercise, laughter dance routine, laughter technic and cognitive training for attention, memory, orientation and execution skill. Results: MoCA-K (t=-6.86, p<.001) and Stroop test CW correct (t=-2.54, p=.008), self-efficacy (t=-3.62, p=.001) in the treatment group were significantly higher than those of the comparison group. Reported depression (t=2.29, p=.014), Stroop test CW error (U=53.50, p<.001) in the treatment group was significantly less than the comparison group. Conclusion: In this study, the treatment was effective in improving self-efficacy, cognitive function and reducing depression in the elderly with MCI.

• 재활복지
• /
• 제20권4호
• /
• pp.1-29
• /
• 2016

피고용인의 직업만족에 대한 연구는 그들의 직업 적응과 결과를 가늠하는 매우 중요한 연구 주제이다. 본 연구의 목적은 우리나라 시각장애인 안마사들의 직업만족 정도와 그 예측 변인들을 사회인지진로발달이론의 통합직업만족모델을 근거하여 탐구한 것이다. 현재 안마사로 종사하는 221 명의 우리나라 시각장애인 안마사들이 본 연구에 참여 하였다. 다중회귀분석을 통해 얻은 결과는 다음과 같다. 자신들의 직업을 통해 얻어지는 수익이 자신이 원하는 정도와 부합하고, 안마사로서 효율적이라고 생각하며, 긍정적 정서를 경험하고, 습득한 직업 훈련 내용이 현 직업에서 수행하는 실제 내용과 잘 맞아 응답자들의 직업만족도는 높게 나타났다. 그러나 개인적 가치와 직장이 추구하는 가치가 부합하는가와 가족, 친구, 그리고 중요한 사람들로부터 얼마나 많은 사회적 지지를 받는가 하는 요인들은 현재 연구에 참여한 우리나라 시각장애인 안마사들의 직업만족 정도에 기여하지 않는 것으로 나타났다. 또한 위계적 회귀분석을 통해 두 가지 중재효과의 존재를 확인하였다. 즉, 우리나라 시각장애인 안마사들의 긍정적인 정서는 안마사들의 직업에 대한 주관적 부합과 직업만족 간의 관계에서 그리고 사회적 지지는 안마사들의 안마 효율성과 직업만족간의 관계에서 중재효과를 드러내었다. 이러한 연구결과를 근거로 정책입안자와 연구자, 장애인 재활 전문가를 위한 함의를 도출하였다.

• Journal of Ginseng Research
• /
• 제48권1호
• /
• pp.59-67
• /
• 2024

Background: Alzheimer's disease (AD) has memory impairment associated with aggregation of amyloid plaques and neurofibrillary tangles in the brain. Although anti-amyloid β (Aβ) protein antibody and chemical drugs can be prescribed in the clinic, they show adverse effects or low effectiveness. Therefore, the development of a new drug is necessarily needed. We focused on the cognitive function of Panax ginseng and tried to find active ingredient(s). We isolated panaxcerol D, a kind of glycosyl glyceride, from the non-saponin fraction of P. ginseng extract. Methods: We explored effects of acute or sub-chronic administration of panaxcerol D on cognitive function in scopolamine- or Aβ_25-35 peptide-treated mice measured by several behavioral tests. After behavioral tests, we tried to unveil the underlying mechanism of panaxcerol D on its cognitive function by Western blotting. Results: We found that pananxcerol D reversed short-term, long-term and object recognition memory impairments. The decreased extracellular signal-regulated kinases (ERK) or Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) in scopolamine-treated mice was normalized by acute administration of panaxcerol D. Glial fibrillary acidic protein (GFAP), caspase 3, NF-kB p65, synaptophysin and brainderived neurotrophic factor (BDNF) expression levels in Aβ_25-35 peptide-treated mice were modulated by sub-chronic administration of panaxcerol D. Conclusion: Pananxcerol D could improve memory impairments caused by cholinergic blockade or Aβ accumulation through increased phosphorylation level of ERK or its anti-inflammatory effect. Thus, panaxcerol D as one of non-saponin compounds could be used as an active ingredient of P. ginseng for improving cognitive function.

• 성인간호학회지
• /
• 제19권1호
• /
• pp.78-88
• /
• 2007

Purpose: The purpose of this study was to find out the degree of cognitive function among the elderly and to confirm its correlated factors. Methods: The subjects consisted of 392 elderly people over the age 65 who were living in Busan. Data were collected by the interview method, using a structured questionnaire and the K-MMSE scale. Results: The average points of the elderly's cognitive functions measured by K-MMSE were 23.76(${\pm}4.02$). With the cut-off point for cognitive impairment set as 24 points below using K-MMSE scale, 38.8% of the subjects have cognitive impairments. Among the variables related to cognitive functions, literacy showed the highest correlation with cognitive function(${\beta}=.330$, t=7.249, p<.001), followed in order by educational level, age, depression level, attendance of elderly's college, and religious activity. The total explanatory power of these variables is 36%. Conclusion: In order to prevent cognitive impairment among the elderly, elderly people have to maintain social relationships continuously, and expand the social network by participating in the related programs. Some efforts to prevent the occurrence of depression and to stimulate patients' brain activity need to be recommended.

• 한국응용과학기술학회지
• /
• 제37권3호
• /
• pp.448-462
• /
• 2020

식이 영양에 의한 충분한 영양분 섭취는 치매에 의한 뇌 인지 기능의 저하의 위험성을 줄일 수 있는 중요한 수단이다. 설포라판은 뇌 인지 기능 개선효과가 있는 것으로 알려져 있는 영양 성분으로, 설포라판이 다량으로 포함된 브로콜리 추출물은 인지 기능 개선 효과가 좋을 것으로 기대된다. 본 연구에서는 제주도 탈염 용암해수 재배로 제조한 브로콜리 추출물이 뇌 인지 기능 개선 효과를 가지고 있는지 시험하였다. 제주도 용암해수는 유용 미네랄 (아연, 바나듐, 게르마늄)이 풍부해서, 용암 해수에서 재배한 작물은 유용미네랄 함량이 높은 것으로 알려 져 있다. 제주도 탈염 용암 해수를 사용해서 재배한 브로콜리 추출물의 화학 조성 중 설포라판과 글루코라판 성분을 분석하기 위해 LC-Q-orbitrap 질량 분석기를 사용하였고, 설포라판의 정량 분석을 위해 HPLC 를 사용하였다. 브로콜리 추출물의 신경 세포 사멸 억제 효과와 항 염증 효과를 시험하기 위해 SH-SY5Y 세포를 사용한 실험을 수행하였고, 시냅스 가소성 촉진 효과를 시험하기 위해 SH-SY5Y 세포에서 시냅스 가소성 관련 단백질의 발현 변화와 아세틸콜린 분해 효소의 활성 변화를 측정하였다. 이러한 실험들을 수행한 결과 탈염 염지하수로 재배한 브로콜리 추출물은 신경 세포 사멸 억제 효과와 항염증 효과가 있음을 확인 하였고, 시냅스 가소성 관련 단백질 발현을 증가 시키고 아세틸콜린 분해 효소의 활성을 억제해서 시냅스 가소성을 증가 시키는 효과가 있는 것을 확인 하였다. 이상의 결과들은 제주도 탈염 용암해수로 재배한 브로콜리 추출물이 치매에 의한 뇌 인지 기능 저하를 억제하는 좋은 식이 영양분으로 사용될 수 있는 가능성을 제시하였다.

• 디지털융복합연구
• /
• 제18권12호
• /
• pp.343-351
• /
• 2020

본 연구는 노인을 대상으로 인지기능에 관한 교육과 함께 주의, 기억, 실행기능, 기억책략 등을 다루는 인지과제를 수행하는 인지훈련을 실시하여 훈련 이전의 인지기능 수준은 어떤 개인적 특성과 관련이 있는지, 주관적 인지감퇴는 실제적인 인지감퇴를 반영하는지, 인지훈련의 효과는 어떤 개인 특성과 관련이 있는지를 알아보기 위해 수행되었다. 연구 참가자는 건강한 노인 20명으로 14회기의 인지훈련을 주 1회, 회기당 2시간씩 진행하였으며 사전 및 사후로 검사를 실시하였다. 연구 결과, 인지기능은 연령과 자아존중감, 성격 특질 중 외향성과 개방성이 관련이 있는 것으로 나타났으며, 주관적인 인지감퇴는 객관적인 인지기능보다는 우울, 불안, 성격, 자기효능감, 자아존중감, 주관적 연령과의 상관이 유의하였다. 또한 인지훈련을 통해 전반적인 인지기능을 측정하는 정신상태, 기억, 전두엽기능 검사 점수가 향상되었으며 인지훈련의 효과는 연령, 주관적 인지감퇴, 불안, 자기효능감, 자아존중감, 주관적 연령, 성격과 관련이 있는 것으로 나타났다. 이러한 결과는 어떤 특성의 노인이 인지노화에 취약한지 알려주며, 인지훈련의 효과를 높이기 위해 교육 참가자의 특성을 고려해야 한다는 것을 시사한다.

• Journal of Microbiology and Biotechnology
• /
• 제23권12호
• /
• pp.1779-1784
• /
• 2013

Although enzyme-hydrolyzed silk fibroin has been reported to enhance cognitive function before, it has been still unknown which peptides can improve memory. Here we report that amino acid sequences of three novel peptides were identified from fibroin hydrolysate. Fibroin hydrolysate was obtained by hydrolysis with protease after partial hydrolysis with 5M $CaCl_2$. Synthesized peptides derived from these sequences improved scopolamine-induced memory impairments in mice. We confirmed this hydrolysate had effects that improved learning and memory abilities by performing the Rey-Kim test. From this hydrolysate of silk fibroin, amino acid sequences of eight peptides were identified by LC-MS/MS. Three peptides (GAGAGTGSSGFGPY, GAGAGSGAGSGAGAGSGAGAGY, and SGAGSGAGAGSGAGAGSGA) were synthesized to investigate whether they could improve memory. Passive avoidance test and Morris water maze test were performed, and all peptides showed memory-enhancing abilities on scopolamine-induced memory impairments in mice. In this study, we identified three novel peptides that could improve memory, and that silk fibroin hydrolysate was a mixture of various active peptides that could enhance memory.

• 지역사회간호학회지
• /
• 제22권4호
• /
• pp.377-388
• /
• 2011

Purpose: This study was to examine the relation between diabetes and cognitive function in older adults. Methods: Eighty community-dwelling patients with diabetes and 506 subjects without diabetes were studied with cognitive function test. Cognitive function was measured by Full-scale IQ, Basic IQ, Executive IQ, Attention Function Index, Working Memory Index, Language Function Index, Visuospatial Function Index, Memory Function Index, and MMSE-K1. Results: In model controlling for education, the diabetic group showed significantly lower scores than the non-diabetic group in in Full-scale IQ (p=.012), Basic IQ (p=.034), Executive IQ (p=.014), Attention Function Index (p=.002), Working Memory Index (p=.037), and Memory Function Index (p=.043). The diabetic and non-diabetic groups that were matched for gender, age, and education showed similar differences in 7 out of 9 cognitive measures. The impairments of Full-scale IQ and Memory Function Index in the diabetic group were, respectively, 2.7 and 2.8 times greater than that in the diabetic group. Conclusion: These results showed that diabetes should be considered to a factor of cognitive impairment in older adults.