• Mass Spectrometry Letters
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• v.5 no.4
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• pp.104-109
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• 2014

Nonmedical use of prescription stimulants such as methylphenidate (MPH) and amphetamine (AP) by normal persons has been increased to improve cognitive functions. Due to high potential for their abuse, reliable analytical methods were required to detect these prescription stimulants in biological samples. A direct injection liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and implemented for simultaneous determination of MPH, AP and their metabolites ritalinic acid (RA) and 4-hydroxyamphetamine (HAP) in human urine. Urine sample was centrifuged and the upper layer ($100{\mu}L$) was mixed with $800{\mu}L$ of distilled water and $100{\mu}L$ of internal standards ($0.2{\mu}g/mL$ in methanol). The mixture was then directly injected into the LC-MS/MS system. The mobile phase was composed of 0.2% formic acid in distilled water (A) and acetonitrile (B). Chromatographic separation was performed by using a Capcell Pak MG-II C18 ($150mm{\times}2.0mm$ i.d., $5{\mu}m$, Shiseido) column and all analytes were eluted within 5 min. Linear least-squares regression with a 1/x weighting factor was used to generate a calibration curve and the assay was linear from 20 to 1500 ng/mL (HAP), 40-3000 ng/mL (AP and RA) and 2-150 ng/mL (MPH). The intra- and inter-day precisions were within 16.4%. The intra- and inter-day accuracies ranged from -15.6% to 10.8%. The limits of detection for all the analytes were less than 4.7 ng/mL. The suitability of the method was examined by analyzing urine samples from drug abusers.

• Science of Emotion and Sensibility
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• v.8 no.3
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• pp.277-290
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• 2005

The purpose of this study is to develope a design prototype of 'Smart Battle Jacket' for the future soldier system. Future battle field is supposed to be the place where the information is the most important. Future soldiers are also supposed to get digital devices to have more possibility of survival in the battle field. To design the smart battle jacket that has digital devices inside, it's needed to forecast the body sizes and shape of the future soldiers, to research the human bodies and movements, and to study the functions of the digital devices and the relationship between the bodies and the devices. The usability of the 1st model for the Smart battle jacket had been tested, and the model had been corrected by the results from the test. After all, a smart battle jacket design prototype for the future soldier system has been developed.

• Journal of Gastric Cancer
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• v.14 no.1
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• pp.47-53
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• 2014

Purpose: Electrogastrography is a method of measuring action potentials of the stomach. The purpose of this study was to investigate early postoperative changes in the electrogastrography and determine the correlation between electrogastrography and quality of life of patients with stomach cancer who underwent distal gastrectomy. Materials and Methods: This study analyzed 20 patients with stomach cancer who underwent electrogastrography and quality of life was measured 1, 12, and 24 weeks after the operation. Quality of life-C30 version 3.0 and quality of life-STO22, were used. Results: Fasting and postprandial mean dominant frequency at 1 week after the operation was 2.7 and 2.7 cycles per minute, and 2.8 and 2.7 cycles per minute at 12 weeks, 2.6 and 2.8 cycles per minute at 24 weeks. Fasting and postprandial mean dominant power at 1 week was 36.5 and 36.4 dB, 36.3 and 40.1 dB at 12 weeks and 40.9 and 42.3 dB at 24 weeks. The percentage of tachygastria was increased whereas the percentage of bradygradia was decreased during the postoperative periods (P<0.05). Global health, physical, emotional and social functioning scales were improved, but role and cognitive functioning were not changed. Pain, insomnia, diarrhea and financial difficulties were significantly improved according to the postoperative periods (P<0.05). The correlation between the STO22 and electrogastrography parameters was not significant (P>0.05). Conclusions: These may suggest that electrogastrography is a simple and noninvasive method and may be applicated for evaluating motility and autonomic functions of the remnant stomach.

• Sleep Medicine and Psychophysiology
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• v.8 no.2
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• pp.138-143
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• 2001

Sleepiness is associated with many different conditions and, as a neglected topic, it can be the cause of serious psychological and social disadvantages. In the aspect of learning, additional problems may arise from poor progress in school caused by the effect of sleepiness on concentration, memory, and other cognitive functions. Narcolepsy is by no means the most common cause of excessive sleepiness. Nonetheless, it is not a rarity, especially in young people. The non-specific nature of early features of narcolepsy, combined with very limited awareness that the condition can start in various ways, leads to many misinterpretations. Misinterpretation of narcolepsy symptoms is not confined to the medical profession. Teachers may well be critical of a student with narcolepsy because of their perception of narcolepsy symptoms as laziness, poor motivation, or difficult behavior and dull learning ability. Inappropriate reactions by parents, teachers, and peers, based on misinterpretation of narcolepsy symptoms or the patient's reactions to them, make a difficult situation worse. Especially in Korea, where schooling is focused on college entrance examinations, the problem is very serious and intensified by inappropriate or delayed diagnosis and treatment. Therefore, psychiatrists should be aware that narcolepsy in young adolescents is not rare and that they need to be familiar with its clinical features in both its classic and less obvious forms. Narcolepsy should be suspected if a adolescent's excessive sleepiness can not be explained in other ways. Therefore, we report on two patients who portray the tendency of dull learning ability and are mistaken as idle students. We diagnosed narcolepsy through polysomnography and multiple sleep latency testing. We treated the students with methylphenidate and pemolin. The students showed improvement in learning ability and were able to adapt better to school.

• Journal of the Korean Institute of Intelligent Systems
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• v.27 no.2
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• pp.157-163
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• 2017

Due to economic development and advancement of medical science, an aging society where the proportion of the elderly population increases is coming. Korea's aging speed is growing rapidly compared to that of other developed countries. The physical and mental abilities of elderly people with aging are getting worse more and more. They want a kind of auxiliary system in order to mitigate and prevent their weakness. The supplementary system can greatly contribute to improving the quality of life for elderly people. In particular, some devices that include muscle strengthening and cognitive and balance ability enhancement are useful for the most older people. In this paper, we introduce a development of human care contents based rehabilitation equipment to enhance these functions, and present its usability evaluation. The evaluation is conducted for rehabilitation specialists as well as expected users and their results are analyzed.

• Journal of the Korea Society of Computer and Information
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• v.12 no.5
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• pp.303-311
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• 2007

The instruction based on mass production system has contributed to the materialistic abundance, but it caused the innate target of education, development of 'holistic human beings' to be lost. Accordingly, the mentoring has been highlighted as an alternative instructional method because it can support learners in the aspect of cognitive and affective domain. On the other hand, as an effort of overcoming time and place constraints of face-to-face mentoring, e-mentoring is being required. This research aims to propose the e-mentoring system design plan for guiding learning after school, which may support face-to-face mentoring. Based on literature reviews, the direction of design was set and the necessary functions were drawn. e-Mentoring system design plan proposed in this article may be helpful to practitioners who are interested in the enhancement of effectiveness and efficiency of mentoring programs. Also it is required that more practical study should be performed for developing the system and testing its effectiveness.

• Journal of the Ergonomics Society of Korea
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• v.28 no.4
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• pp.51-59
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• 2009

These days mobile phone which were used mainly by grown-up persons are now widely used among children as well due to new social demands. Despite this trend, existing mobile phones are still being designed and produced according to the taste of people in their 20s and 30s, even the elderly, not satisfying physical, emotional and cognitive characteristics raised by children. This study aimed to extract the design factors of mobile phones for children by reflecting functional factors requested by children and parents in QFD's customer demands. First, functional and design factors requested in mobile phones for children were extracted from existing products and documentary records and some functional factors were selected through a process of integration and omission. The survey research was conducted on children and parents, based on the selected functional factors. Based on the survey research, functional factors were analyzed using AHP, and key functional factors considered by children and parents in mobile phones for children were investigated. Finally, in order to reflect the results in QFD, the correlation between functional factors and design factors was constructed as HOQ through experts' evaluation. The results showed that both children and parents recognized the basic functions such as telephoning, text messaging and phone directory as high priority functional factors, even though the relative importance was different between children and parents. Therefore, it is likely to satisfy the desires of both children and parents by designing mobile phones for children in consideration of design factors such as menu depth, button independence and button arrangement. It is expected that this study will promote experiments on design factors and propose basic data for and guidelines to mobile phone design for children.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2003.11a
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• pp.239-250
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• 2003

In this research, we propose a hybrid group decision support mechanism (H-GDSM) based on Fuzzy AHP (Analytic Hierarchy Process) and FCM (Fuzzy Cognitive Map). The AHP elicits a corresponding priority vector interpreting the preferred information among the decision makers. Corresponding vector was composed of the pairwise comparison values of a set of objects. Since pairwise comparison values are the judgments obtained from an appropriate semantic scale. However, AHP couldn't represent the causal relationship among information, which were used by decision makers. In contrast to AHP, FCM could represent the causal relationship among variables or information. Therefore, FCMs were successfully developed and used in several ill-structured domains, such as strategic decision-making, policy making, and simulations. Nonetheless, many researchers used subjective and voluntary inputs to simulate the FCM. As a result of subjective inputs, it couldn't avoid the rebukes of businessman. To overcome these limitations, we incorporated the Fuzzy membership functions, AHP and FCM into a H-GDSM. In contrast to current AHP methods and FCMs, the H-GDSM method developed herein could concurrently tackle the pairwise comparison involving causal relationships under a group decision-making environment. The strengths and contributions of our mechanism were 1) handling of qualitative knowledge and causal relationships, 2) extraction of objective input value to simulate the FCM, 3) multi-phase group decision support based on H-GDSM. To validate our proposed mechanism we developed a simple prototype system to support negotiation-based decisions in electronic commerce (EC).

• Science of Emotion and Sensibility
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• v.20 no.4
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• pp.113-126
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• 2017

The purpose of the study was to find grey matter (GM) and white matter (WM) volume reduction in the brain reward system among patients with alcohol dependency. This study investigated regional GM and WM in chronic alcoholic patients, focusing primarily on the reward system, including principal components of the mesocorticolimbic reward circuit as well as cortical areas with modulating and oversight functions. Sixteen abstinent long-term chronic alcoholic men and demographically matched 16 healthy control men participated in the study. Morphometric analysis was performed on magnetic resonance brain scans using voxel-based morphometry (VBM)-diffeomorphic Anatomical Registration through Exponentiated Liealgebra (DARTEL). We derived GM and WM volumes from total brain and cortical and subcortical reward-related structures. Morphometric analyses that revealed the total volume of GM and WM was reduced and cerebrospinal fluid (CSF) was increased in the alcohol group compared to control group. The pronounced volume reduction in the reward system was observed in the GM and WM of the nucleus accumbens (NAc), GM of the amygdala, GM and WM of the hippocampus, WM of the thalamus, GM and WM of the insula, GM of the dorsolateral prefrontal cortex (DLPFC), GM of the orbitofrontal cortex (OFC), GM of the cingulate cortex (CC), GM and WM of the parahippocampal gyrus in the alcohol group. We identified volume reductions in WM as well as GM of reward system in the patients with alcohol dependency. These structural deficits in the reward system elucidate underlying impairment in the emotional and cognitive processing in alcoholism.

• Journal of the Korean Society of Clothing and Textiles
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• v.35 no.11
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• pp.1309-1321
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• 2011

Clothes for a 3 to 6 year-old toddler should be made in consideration of their behavioral characteristics since it is when the physical ability of toddlers has rapidly developed and their social, emotional, and cognitive development are increasingly active. Indoor clothes are the item that consumers prefer because they provide the function of outside underwear when functioning as outerwear when indoors that is used frequently for toddlers. We analyzed the wearing condition and the uncomfortable aspects of toddler's clothes worn indoors through consumer surveys of toddler wear. This study gathers data for the development of indoor clothing that is useful for 3-6 year old toddlers. Consumer surveys indicate that the clothes most worn indoors were underwear (69.4%). The most important aspect in the selection of indoor clothes was the suitability for activities (29%). The preferred colors for indoor clothes were found to be pastel-tone colors (66%). Regarding the uncomfortable aspects of indoor clothes, knees of the clothes (36.8%) have the most naps and the breast of the clothes (37.8%) dirty quickly. Knee parts (35.4%) become worn easily; in addition, the material for the knee area is likely to have naps and require special functions. In conclusion, designing toddler clothing requires elaborated design techniques that consider the characteristics of the subject group and reduce inconveniences. This study will serve as preliminary data to develop ultimate products that have the functionality to meet gender behavior characteristics and the aesthetics for toddlers 3 to 6 years of age.