• Korean Journal of Clinical Pharmacy
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• v.24 no.4
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• pp.255-264
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• 2014

Objective: The aims of this study are to investigate the total volume of prescribed medicines against Alzheimer's disease (AD) and the trends of usage by analyzing the claims-data from the Korea National Health Insurance Service. Method: The demographic and claims-data were included the major AD treating medicines such as donepezil, galantamine, rivastigmine and memantine, and analyzed during the period of 2010~2012. The assessing criteria were gender, age, habitation, types of medical institution, code of ingredients, outcomes of treatment, volume and amount of claims, and the numbers of patients with dementias. After trimming the data, it were analyzed by the market size, demographic traits, characteristics of medical service, characteristics of each anti-AD medicine, etc. Results: Among the chosen 4 medicines, donepezil had the top prescription volumes. Most prevalent prescribing preparations of donepezil were conventional types. However, among the non-conventional types, oro-dispersible formulation is the fast increasing one in both volume and growth rate. This specialized preparations to improve both toleration and adherence, tend to being prescribed generally at the tertiary medical institutions. While the younger patients with mild-to-moderate AD mostly treated by expensive medicines in resident at the tertiary hospitals, the rest older patients with severe AD have been treated non-expensive one at long-term care facilities. Conclusion: AD is a chronic illness therefore, long-term use of therapeutic medications are highly important. If an anti-AD treatment was applied steadily in the earlier stages, it would be achieved not only improving the quality of life of patient but also reducing the expenses in the medical and nursing cares. As the socioeconomical impacts of AD is expanding, healthcare professionals need to aware the importance of pharmacotherapy and to improve sociopolitical fundamentals.

• International Journal of Fluid Machinery and Systems
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• v.3 no.1
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• pp.11-19
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• 2010

The performance of the crossover system of a centrifugal compressor stage consisting of static components of $180^{\circ}$ U-bend, return channel vanes and exit ducting with a $90^{\circ}$ bend is investigated. This study is confined to the assessment of performance of the crossover system by varying the shape of the return channel vanes. For this purpose two different types of Return Channel Vanes (RCV1 and RCV2) were experimentally investigated. The performance of the crossover system is discussed in terms of total pressure loss coefficient, static pressure recovery coefficient and vane surface pressure distribution. The experimentation was carried out on a test setup in which static swirl vanes were used to simulate the flow at the exit of an actual centrifugal compressor impeller with a design flow coefficient of 0.053. The swirl vanes are connected to a mechanism with which the flow angle at the inlet of U-bend could be altered. The measurements were taken at five different operating conditions varying from 70% to 120% of design flow rate. On an overall assessment RCV1 is found to give better performance in comparison to RCV2 for different U-bend inlet flow angles. The performance of RCV2 was verified using numerical studies with the help of a CFD Code. Three dimensional sector models were used for simulating the flow through the crossover system. The turbulence was predicted with standard k-$\varepsilon$, 2-equation model. The iso-Mach contour plots on different planes and development of secondary flows were visualized through this study.

• KIEAE Journal
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• v.16 no.4
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• pp.71-77
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• 2016

Purpose : The energy saving in a residential building (apartment) sector is known as one of the effective solution of energy reduction. In South Korea, the government has recently reinforced regulations associated with the energy performance of buildings. However, there is a lack of research on the methods for the energy performance diagnosis that is used to analyze the wall thermal performance of the existing apartments. Because a reliable diagnosis is necessary to save the building energy, this study analyzed wall thermal performance of an existing apartment in Seoul. Method : This paper applied two methods for analysis of the thermal insulation performance; HFM(Heat Flow Meter) method and ASTR(Air-Surface Temperature Ratio) method. The HFM method is suggested by ISO9869-1 code to measure the thermal performance. The ASTR method is proposed by this study for the simplified In-situ measurement and it uses three temperature data (interior wall surface, interior and exterior air) and the overall heat transfer coefficient. This study conducted the experiment of an existing apartment in Seoul using these methods and analyzed the results. Furthermore, the energy simulation tool of the building was used to suggest retrofit of the building based on the results of measurements. Result : The error rate of HFM method and ASTR method was analyzed in about 17 to 20%. As the results of comparison between the initial design values of the wall and the measured values, the 26% degradation of insulation thermal performance was measured. Lastly, the energy simulation tool of the building shows 10.8% energy savings in accordance with the construction of suggested retrofit.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.6C
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• pp.625-631
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• 2002

This paper presents a MSB-first digit-serial systolic array for computing modular multiplication of A(x)B(x) mod G(x) in finite fields $GF(2^m)$. From the MSB-first multiplication algorithm in $GF(2^m)$, we obtain a new data dependence graph and design an efficient digit-serial systolic multiplier. For circuit synthesis, we obtain VHDL code for multiplier, If input data come in continuously, the implemented multiplier can produce multiplication results at a rate of one every [m/L] clock cycles, where L is the selected digit size. The analysis results show that the proposed architecture leads to a reduction of computational delay time and it has much more simple structure than existing digit-serial systolic multiplier. Furthermore, since the propose architecture has the features of unidirectional data flow and regularity, it shows good extension characteristics with respect to m and L.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.10C
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• pp.936-941
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• 2003

Density evolution was developed as a method for computing the capacity of low-density parity-check(LDPC) codes under the sum-product algorithm [1]. Based on the assumption that the passed messages on the belief propagation model can be approximated well by Gaussian random variables, a modified and simplified version of density evolution technique was introduced in [2]. Recently, the min-sum algorithm was applied to the density evolution of LDPC codes as an alternative decoding algorithm in [3]. Next question is how the min-sum algorithm is combined with a Gaussian approximation. In this paper, the capacity of various rate LDPC codes is obtained using the min-sum algorithm combined with the Gaussian approximation, which gives a simplest way of LDPC code analysis. Unlike the sum-product algorithm, the symmetry condition [4] is not maintained in the min-sum algorithm. Therefore, the variance as well as the mean of Gaussian distribution are recursively computed in this analysis. It is also shown that the min-sum threshold under a gaussian approximation is well matched to the simulation results.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.1C
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• pp.131-137
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• 2009

Binary offset carrier (BOC) signal synchronization is one of the most important steps to recover the transmitted information in global navigation satellite systems (GNSS) including Galileo and global positioning system (GPS). Generally, BOC signal synchronization is based on the correlation between the received and locally generated BOC signals. Thus, the multiple side-peaks in BOC autocorrelation are one of the main error sources in synchronizing BOC signals. Recently, a novel correlation function with reduced side-peaks was proposed for BOC signal synchronization by Julien [8]; however, Julien's correlation function not only still has the side-peaks, but also is only applicable to sine phased BOC(n, n), where n is the ratio of the pseudo random noise (PRN) code rate to 1.023 MHz. In this paper, we propose a new correlation function for BOC signal synchronization, which does not have any side-peaks and is applicable to general types of BOC signals, sine/cosine phased BOC(kn, n), where k is the ratio of a PRN chip duration to the period of a square wave sub-carrier used in BOC modulation. In addition, an efficient correlator structure is presented for generating the proposed correlation function.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.6A
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• pp.608-616
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• 2007

OFDM Systems for multi-user use adaptive modulation and ending (AMC) which is a method that selects suitable modulation order and code rate depending on channel state of each user. Using AMC, OFDM system can provide high quality and reliable communication. Base station using AMC scheme requires downlink channel information of each terminal to operate optimality. However, under practical system environment, it is unsuitable to transmit all channel information because uplink bandwidth of the system is limited. In this paper, we propose a flexible block-wise loading (FBL) algorithm combined with a novel CQI feedback scheme with reduced number of required bits to optimize the performance of AMC system. Proposed algorithm allocates sub-carrier groups dynamically to improve the sector throughput and outage probability performance.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.15 no.10 s.89
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• pp.1011-1017
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• 2004

Ultra Wideband(UWB) technologies have been developed to exploit a new spectrum resource in substances and to realize ultra-high-speed communication, high precision geolocation, and other applications. The energy of UWB signal is extremely spread from near DC to a few GHz. This means that the interference between conventional narrowband systems and UWB systems is inevitable. However, the interference effects had not previously been studied from UWB wireless systems to conventional mobile wireless systems sharing the frequency bands such as Korean Cellular CDMA and WCDMA. This paper experimentally evaluates the interference from two kinds of UWB sources, namely a direct-sequence spread-spectrum CDMA(DS-CDMA) UWB source and an impulse radio UWB source, to a Cellular CDMA and WCDMA digital transmission system. The average frame error rate degradation of each system are presented. From these experimental results, the interference effects of DS-CDMA UWB source is not severe compared to the Impulse UWB.

• Preventive Nutrition and Food Science
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• v.18 no.4
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• pp.263-268
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• 2013

In this study, the quick HPLC-MS/MS method for the simultaneous separation of 2-acetyl-4(5)-tetrahydroxybuthylimidazole (THI) and 4-(5)-methylimidazole (4-MI) in alkaline medium was used for caramel color and processed foods in Korea. After a simple sample pretreatment, 51 4-MI-labeled samples were positive for 4-MI and 2 also contained THI. The concentration of 4-MI was 260.5~24, $499.3{\mu}g/kg$ in caramel color, less than $LOD{\sim}1,712.5{\mu}g/kg$ in sauce, 1,242.3, $5,972.2{\mu}g/kg$ in balsamic vinegar, $2,118.3{\sim}5,802.4{\mu}g/kg$ in complex seasoning, $82.7{\sim}5,110.6{\mu}g/kg$ in curry, and $29.9{\sim}464.4{\mu}g/kg$ in soft drinks. The recovery rate of 4-MI was 97.1~111.0% in sauce and 81.9~110.0% in powder and that of THI was 83.6{\sim}106.4% in sauce and 61.2{\sim}99.4% in powder. Our results concluded a safe amount of 4-MI and THI compared to the limit of Korea additive code but the processed foods do not have a limit of caramel color and 4-MI in Korea. Therefore, research and monitoring of 4-MI and THI is needed for processed foods in Korea.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.4 no.4
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• pp.286-294
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• 2011

Cable modems typically are implemented by a forward error correction(FEC) scheme. The ITU-T Recommendation J-38 Annex B specifies using 64- and 256- quadrature amplitude modulation (QAM) and extended RS coding scheme. In implementing the cable modem, there are some problems to fabricate and fitting on FPGA chip. First, many clocks are needed in implementing cable modem because of different code rate and different modulation types. To reduce the number of clocks, we use the two memories, which are different clock speed for reading and writing data. Second, this system lost the bit-synchronization and frame-synchronization in decoder, the system recognize that all data is error. This paper solves the problems by using simple 5-stage registers and unique sync-word. Based on solutions for about problems, the cable modem is fabricated on FPGA chip name as Vertex II pro xc2vp30-5 by Xilinx, and we confirmed the effectiveness of the results.