• 한국지능시스템학회논문지
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• 제8권2호
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• pp.70-81
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• 1998

본 논문은 저비용이면서 정확한 비퍼지화 연산을 수행하는 새로운 COA(Center of Area) 비퍼지화기를 제안한다. 제안한 COA 비퍼지화기의 정확성은 비퍼지화 연산시 소속값뿐 아니라 소속 함수의 폭을 고려함으로서 얻어진다. 제안한 COA 비퍼지화기의 저비용성은 비퍼지화 연산시 요구되는 나눗셈 연산을 좌.우측 모멘트의 균형점을 찾는 것으로 대신함으로서 얻어진다. 제안한 COA 비퍼지화기는 승산기가 부가적으로 필요하고 모멘트의 균형점을 찾는데 많은 시간이 걸리는 단점이 있다. 첫번째 단점은 승산기를 확률적 AND 연사으로 대치함으로서 극복되고, 두번째 단점은 모멘트의 균형점을 빠르게 탐색하는 coarse-to-fine 탐색 알고리즘에 의해 해결된다. VHDL 시뮬레이션을 통해 제안한 COA 비퍼지화기를 트럭 후진 주차 문제에 적용한 결과 기존의 COA 비퍼지화기보다 향상된 평균 주행 거리 특성을 보임을 확인하였다.

• 전자공학회논문지B
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• 제33B권10호
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• pp.80-89
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• 1996

This paper proposes a new COA (center of area) defuzzifier that is working in the accurate and fast manner. The proposed COA defuzzifier involves both membership values and the spans of membership functions in clauclating a crisp value. In additon, it avoid division by replacing the COA calculation with the searching of the momentum equilibrium point. The moment equilibrium point is searched in the coarse-to-fine manner such that the moment computing points during the coarse searching are moved in the interval of fuzzy terms until they are reached at two adjacent fuzzy terms searching method accerlates the finding of the moment equilibrium point by O(M) mazimally when compared iwth the equal interval searching method of ruitz. In order to verify the accuracy of the proposed COA defuzzifier, the crisp values obtained form the proposed coarse-to-fine searching are compared with the precise crisp values from the arithmetic calculation. Application to the truck backer-upper control problem of the proposed COA defuzzifier is presented. The control performance is compared with that of the conventional COA defuzzifier in tems of the average tracing distance.

• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 2003년도 추계학술대회 및 정기총회
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• pp.3-10
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• 2003

Developments in science and technology based on computer technology influenced military fields and created up-to-date weapons and equipment, and as a result, which is changing the war accomplishing methods of the future warfare. Due to these changes in the war accomplishing methods, the army command centers are requested to make changes in their decision-making process. In other words, they need to apply more scientific methods rather than just build a scheme by the mere analysis of commanders and the staffs as in the past. Consequently, we propose a model, Vision 21 we developed as a war game model for division-size unit analysis use, in the COA development process, which is the most important part in establishing the OPLAN for mission accomplishment. Vision 21, with a comparative analysis of the other COA built in the COA development process, can be applied to making the best COA. Model employment concept can let us choose the best COA, operating war games on condition that the COA of the opposite forces is fixed and ours sequentially opposed against, and with a comparative analysis also. Moreover, if the time available is limited, before establishing several courses, we can apply the COA to the process for making the best decision, analysing in stages or by main phases and not establishing several courses for a special purpose.

• 한국지능시스템학회논문지
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• 제6권4호
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• pp.81-91
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• 1996

본 논문은 퍼지 논리 제어기의 제어 성능을 향상시키는 최적의 COA(Center Of Area) 비퍼지화 방법을 제안한다. 제안한 비퍼지화 방법은 플랜트의 제어를 위해 필요한 확정치(Crisp Value)를 얻기 위해 소속 함수값과 소속함수의 폭을 동시에 이용한다. 주어진 문제에 가장 최적인 소속 함수의 폭은 유전자 알고리즘에 의해 자동적으로 결정된다. 제안한 비퍼지화 방법을 트럭 후진(Truck backer-upper) 제어 문제에 적용하여 얻어진 시뮬레이션 결과로부터 소속 함수만을 고려한 기존의 COA 비퍼지화 방법보다 평균 주행거리 면에서 20% 이상 짧아짐을 확인하였다.

• 가정과삶의질연구
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• 제25권2호
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• pp.1-12
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• 2007

This is an investigative study to consider children's COA by parent's problem drinking and their psychological-social character by the COA. According to the results of this study, almost half of the children's COA, among those who have problem drinking parents, demonstrated high dangerous lever in the lower factors, such as emotional character, personnel relative character, and co-dependent character. Results of the inspection into the differences between the psyrhological-social characters, according to the danger lever of the children's COA, suggested the children's danger lever is higher, the self-efficiency and adaptable flexibility, which are the psychological-social characters, are lower, and there are no special differences in the social-support.

• Journal of Microbiology and Biotechnology
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• 제24권9호
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• pp.1238-1244
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• 2014

Dephosphocoenzyme A (CoaE) catalyzes the last step in the biosynthesis of the cofactor coenzyme A. In this study, we report the identification and application of CoaE from Stretomyces peucetius ATCC27952. After expression of coaE, the protein was found to have a molecular mass of 28.6 kDa. Purification of the His-tagged fused CoaE protein was done by immobilized metal-affinity chromatography, and then in vitro enzymatic coupling assay was performed. The increasing NADH consumption with time shed light on the phosphorylating activity of CoaE. Furthermore, the overexpression of coaA and coaE independently under the $ermE^*$ promoter in the doxorubicin -producing wild type strain, resulted in 1.4- and 1.5-fold enhancements in doxorubicin production, respectively. In addition, the overexpression of both genes together showed a 2.1-fold increase in doxorubicin production. These results established a positive role for secondary metabolite production from Streptomyces peucetius.

• 한국정보시스템학회지:정보시스템연구
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• 제18권1호
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• pp.25-46
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• 2009

According to adaptive structuration theory, faithfulness of appropriation(FOA), and consensus on appropriation(COA) are variables for measuring appropriation in use of IT. FOA is the level of interpreting and using the intentions of the IT designers objectively and COA is the level of agreement on ways of using IT among or with user group independently of designers' intention. In traditional theories of IT adoption, computer self-efficacy(CSE), self evaluation on abilities of using computer, has been considered as one of the important individual differences. which would influence on beliefs of using IT. Therefore, considering the relationship among CSE, FOA, COA and attitude, we can hypothesize that CSE would play a moderation varaible among appropriation related variables relationships, FOA-attitude and COA-attitude. The objective of this study is an analysis of CSE's moderation effects in causality relationship among appropriation measuring variables. For this purpose, we propose a research model where there are four hypotheses for moderation effects of CSE on the relationships between appropriation variables. We test these hypotheses by sampling ERP and groupware users. In result, our proposed hypotheses except moderation effect of COA-usefulness are accepted. Main contribution of this study is to identify the relationship between CSE and AST. This study implies that very careful consideration of users' CSE is necessary in order to perform managerial activities based on FOA and COA in IT management department.

• 미생물학회지
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• 제41권1호
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• pp.24-37
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• 2005

국내 사육 하우 염소, 돼지, 개, 닭 및 마우스 등을 포함한 각종 동물과 사람환자에서 분리한 총 116주의 S. aureus 분리주에 대해서 5종의 PCR 기법을 적용하여 분자역학적 특성을 분석하였다. 먼저 종특이 유전자(SSG: aroA, coa, nuc 및 spa-gene)의 다양성을 PCR 기법으로 조사하였고, 또한 약제내성의 MRSA 균주의 분포양상과 내독소(Enterotoxin)산생유전자(SE)의 분포양상에 대해서도 조사하였다. 그리고 이 연궁선 수행한 5종의 PCR 기법 들이 생산한 개별성적을 객관적으로 비교하여, 가장 신뢰도 높고 효율적 PCR기법을 선발하였다. 먼저 PCR기법을 적용한 SSG의 분포양상 조사에서는 $nuc-gene\;(100\%)$, $spa-gene\;(91.4\%)$, $coa-gene\;(87.9\%)$, 및 $aroA-gene\;(26.7\%)$의 빈도로 조사되었다. 그리고 aroA와 coa-gene PCR 증폭산물에 대한 RsaI과 AluI 효소로 소화시킨 RELP 성적에서 coa-Bene PCR-RFLP에서는 모두 10 type의 con-type이 동정되었고, 그중 coa-3 type (809 bp)이 닭, 마우스, MRSA 및 사람유래 균주를 포함한 총 36주 $(33.0\%)$로서 가장 대표적인 genotype으로 결정되었다. 반면에 aroA-gene PCR-RELP에서는 단지 7 type의 genotype만이 산생되어 대조를 보였고, 17주 $(73.9\%)$가 대표적인 그룹으로 분류되었다. 한편 spa-gene PCR에서는 총 11 type의 spa-type이 확인되었고, 그중 spa-7 type (9 repeats; 263 bp)이 한우, 닭, 개, 염소, 마우스 및 MRSA 균주 등을 포함한 총 39주 $(34.8\%)$로서 가장 대표적인 genotype으로 결정되었다. 또한 총 116주에 대해 MRSA 균주의신속한 검출을 위해서 mecA-gene PCR을 적용하였던 바, 단지 사람유래의 14주 $(12.1\%)$에서만 양성의 증폭산물 (533 bp)이 검출되었고, 이들 증폭된 PCR산물의 유전학적 검증을 위해 HhaI으로 소화시켰던바 14주 모두 $(100\%)$가 알려진 2개의 DNA band (332 & 201 bp)로 양분되어 유전자수준에서 MRSA 양성균주로 검증되었다. 한편 내독소 산생유전자 (SE-gene)는 multiplex-PCR기법으로 조사하였으며 sea-gene $(63.7\%)$이 가장 지배적이었고, 이어서 seb-gene $(10.0\%)$ 및 sec-gene $(7.2\%)$의 순서였다. 특히 sea+sec의 2종의 SE genes를 보유한 균주도 11주로서 가장 많았으며 그 외에도 sea+seb (2주)및 seb+see (1주) genes를 보유한 균주도 함께 검출되었다. 최종적으로 5종의 PCR기법들이 생산한 성적들을 수치 (SID)로 변환하여 객관적으로 감별능력 (DA)을 비교하였던바, aroA-gene PCR-RFLP는 가장 저조한 DA [SID=0.462]을 나타내었고, 반면에 coa-gene PCR-RELP는 5종의 분석기법 중에서 가장 신뢰도 높은 DA [SID=0.894]을 발현하였다. 따라서 현재의 연구결과con-gene PCR-RELP기법이 사람을 포함한 다양한 동물종유래 S. aureus 균주들의 유전학적 분석목적에 가장 신뢰도 높고 감별능력이 뛰어난 분석기법으로 선발되었다.

• Journal of Microbiology and Biotechnology
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• 제31권10호
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• pp.1350-1357
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• 2021

Staphylococcus aureus (S. aureus) is a major pathogen that causes human pneumonia, leading to significant morbidity and mortality. S. aureus coagulase (Coa) triggers the polymerization of fibrin by activating host prothrombin, which then converts fibrinogen to fibrin and contributes to S. aureus pathogenesis and persistent infection. In our research, we demonstrate that isovitexin, an active traditional Chinese medicine component, can inhibit the coagulase activity of Coa but does not interfere with the growth of S. aureus. Furthermore, we show through thermal shift and fluorescence quenching assays that isovitexin directly binds to Coa. Dynamic simulation and structure-activity relationship analyses suggest that V191 and P268 are key amino acid residues responsible for the binding of isovitexin to Coa. Taken together, these data indicate that isovitexin is a direct Coa inhibitor and a promising candidate for drug development against S. aureus infection.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권10호
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• pp.2601-2619
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• 2012

A differencing multiuser detection (MUD) method is proposed for multiple-input multiple-output (MIMO) direct sequence (DS) ultra-wideband (UWB) system to cope with the multiple access interference (MAI) and the computational efficiency in Nakagami fading channel. The method, which combines a multiuser-interference-cancellation-based decision feedback equalizer using error feedback filter (MIC DFE-EFF), a coefficient optimization algorithm (COA) and a differencing algorithm (DA), is termed as MIC DFE-EFF (COA) with DA for short. In the paper, the proposed MUD method is illuminated from the rudimental MIC DFE-EFF to the advanced MIC DFE-EFF (COA) with DA step by step. Firstly, the MIC DFE-EFF system performance is analyzed by minimum mean square error criterion. Secondly, the COA is investigated for optimization of each filter coefficient. Finally, the DA is introduced to reduce the computational complexity while sacrificing little performance. Simulations show a significant performance gain can be achieved by using the MIC DFE-EFF (COA) with DA detector. The proposed MIC DFE-EFF (COA) with DA improves both bit error rate performance and computational efficiency relative to DFE, DFE-EFF, parallel interference cancellation (PIC), MIC DFE-EFF and MIC DFE-EFF with DA, though it sacrifices little system performance, compared with MIC DFE-EFF (COA) without DA.