• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2645-2651
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• 2015

Background: The phosphatidylinositol 3'-kinase/Akt (PI3K/Akt) pathway is a key regulator for HER2-overexpressing breast cancer, but data about whether activation of PI3K/Akt is associated with poor prognosis and resistance to trastuzumab therapy is controversial. In this study we investigated predictive and prognostic significance of expression of p27, Akt, PTEN and PI3K, which are components of the PI3K/Akt signaling pathway, in HER2-positive metastatic breast cancer (MBC), retrospectively. Materials and Methods: Fifty-four HER2-positive MBC patients who had received first-line trastuzumab-based therapy were recruited for the study group. All of the patient's breast tissue samples were examined for p27 and Akt expression. In addition, twenty-five patients with sufficient amount of tumor tissue were also examined for PTEN and PI3K expression. p27, Akt, PTEN and PI3K were evaluated by immunohistochemistry and their relationship with patient demographic features, tumor characteristics, response to trastuzumab-based treatment and survival outcomes were analyzed. Results: p27, Akt, PTEN and PI3K were positive in 25.9%, 70.4%, 24% and 96% of the cases, respectively. Nomne were significantly associated with response to trastuzumab and time to progression (TTP). A trend toward statistical significance for longer overall survival (OS) was found for PTEN-positive patients (p=0.058); there was no significant relationship between the other immunohistochemical variables and OS. When we analyzed groups regarding co-expression, the PTEN-negative/Akt-negative group had a significantly lower objective response rate (ORR) (20% vs 80%, p=0.023) and the PTEN-negative/p27-negative and PTEN-negative/Akt-negative groups had significantly lower median OS compared to other patients (26.4 months vs 76.1 months, p=0.005 and 25.6 months vs 52.0 months, p=0.007, respectively). Conclusions: p27, Akt, PTEN and PI3K expression is not statistically significantly associated with ORR, TTP and OS, individually. However, the combined evaluation of p27, Akt and PTEN could be helpful to predict the response to trastuzumab-based therapy and prognosis in HER2-positive MBC.

• 대한치과의사협회지
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• 제50권12호
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• pp.763-770
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• 2012

The purposes of this work were to assess the cognition of the registered nurse(RN) on oral and maxillofacial emergency treatment and to compare cognition of the RN with that of the 119 emergency medical technician(EMT). 450 RNs who were working at each of secondary hospitals in Jeju province had responded to the questionnaire. Independent sample t-test and chi-square test were used to assess the state of RN on dental emergency treatment and to compare RN with EMT. The question 'education time on dentistry in formal education' that marked '0 hour' and '1-3 hours' were 73.3% and 20.0%, respectively. The question 'refresher training class on dentistry' that marked '0 hour' and '1-3 hours' were 92.9% and 6.7%, aggregately 99.6%. The results showed low score in the question 'reduction of temporo-mandibular joint(TMJ)'($1.67{\pm}0.857$), 'fixation of dislocated TMJ'($1.70{\pm}0.853$) and 'post-avulsed tooth treatment'($1.78{\pm}0.774$) by 5-point Likert scale. Likewise, the scores were $2.02{\pm}0.806$ in the question 'treatment of maxillofacial trauma', $2.76{\pm}1.061$ in the question 'emergent care of avulsed tooth', $2.70{\pm}1.095$ in the question 'treatment time of avulsed tooth' and $2.79{\pm}1.056$ in the question 'mouth guard', respectively. Compared to EMT, results of RN showed a statistically lower figure(p<0.05) in all items compared except the question 'medicine control', and the question 'doctor care in emergency room' was borderline(p=0.069). From this study, it is necessary for RN and student of nursing science to be educated on the oral and maxillofacial emergency treatment for the initial management of injuries. Authors suggest further co-study and nation-wide research with nursing care.

• 한국소음진동공학회논문집
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• 제25권5호
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• pp.321-328
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• 2015

최근 극지 선박의 수요가 늘어나고 있고 IACS(국제선급연합)에서는 대빙 선박에 대한 새로운 기준이 적용되고 있다. 이 선박에서는 추진시스템에 대한 대빙 설계 기준으로 빙 충격 토크는 프로펠러 날개 수를 중심으로 한 조화 함수로 규정되어 있다. 그러나 실 상황에서는 이러한 주기적인 기진 토크보다는 불규칙한 빙의 충격 토크가 발생할 수 있는 확률이 오히려 크다. 이 논문에서는 비틀림진동이 비교적 큰 6개의 실린더를 갖는 디젤엔진을 주 기관으로 한 추진시스템의 안정성을 검토하고자 한다. 특히 불규칙한 빙 충격 토크와 디젤엔진에서 발생하는 진동토크를 동시에 고려하여 비틀림진동의 공진점을 통과할 과도 비틀림 진동 응답을 이론적으로 해석하였다. 여기서 빙 충격토크는 빙이 프로펠러에 부딪칠 때를 여러 유형별로 가상하여 선급에서 규정된 방법에 의해서 구하였다. 전체적인 시스템의 과도응답 해석은 직접적분방법의 하나인 뉴마크(Newmark) 법을 이용하였다.

• 한국응급구조학회지
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• 제9권2호
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• pp.147-168
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• 2005

It examined the doubt point which AED motive relates until now, the AED should have bought a life how, present address of our country site pre-hospital care, comparison it tried to observe the advanced nation instance back. Gist of this research the AED important cold region once compared to informed to how many cardiac arrest patient, against him the what kind of preparation wanted informing the necessary cold region. It soaks simultaneously but the AED motive is widely supplied distant in future and it is generality and it is feeble but it wanted doing one morning. The habit difference of an American who does of course meat diet mainly and a Korean is many and it compares in the United States and the cardiac arrest patient comparison occurs holds a point few. To become Western anger but and be caused by with thin dietary life, stanching bleeding cung, with the fact that the heart attack is increasing rapidly with the hyperextension. It is a talk which anyone it knows all. The major league most Choi huy Sub in condition will catch the ball which floats and the multi co-player and to collide when falling down, the medical device which is committed with emergency aid is AED motive. From the United States subway station and the shopping which are a public place on the baseball field outside the jar which it will drive, the museum and the school, easily there is it will be able to discover the AED from the court of justice back. The Pittsburg university the students per the individual $30 the core phyey were receiving the smallness lifestyle alcoholic beverage and a AED motive actual training with mercy of degree. From the United States distant in future the AED motive is sold even from the retail store and. From our country like this plan government offices temporary disposal education from from 119 fire fighters emergency structure company in fire fighting government employee and nursing must magnify a former enterprise rainy spell in summer multi temporary disposal education with the head which it will burn with the head. This plan in early rising will be able to become fixed in Korea it forecasts with the fact that. The research which it sees it leads and like the United States to some day become fixed even from our country to believe and suspicion it is not and in the people in approach ease one AED supply plan fire fighting government employees stand in the first and feed with the fact that must be positive at this enterprise they become.

• 호스피스학술지
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• 제7권1호
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• pp.15-28
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• 2007

This study was focused on figure out what kinds of elements are influencing on job satisfaction with approach of the educational system. It was also to figure out how work characteristics and role conflicts of employees influence on job satisfaction. Objects of study were employeeswho had been working in Hospice and Palliative medical center at least for 6 months, and they were doctors, nurses, ministers, and welfare workers. Collected materials were analyzed by Frequency Analysis, One-way ANOVA, Correlation Analysis, and SimpleRegression Analysis. Results from study can be summarized like below. The first, job satisfaction of workers in Hospice and Palliative medical center were 3.36, and this numerical value is pretty high over all. For saying from the higher to the lower satisfaction level, there were satisfaction with job itself, satisfaction with co-workers, satisfaction with seniors (superiors), and satisfaction with organizations, on the other hands, satisfaction with salaries was turned out as the lowest level among those. The second, role conflict was 2.63, and it is considered as the medium level. after inquiring into it by elements of role conflict, they felt many environmental difficulties compared to other workers in different fields such as environmental difficulty, role ambiguity, insufficient ability, process obscurity, etc. The third, work environment influencing on job satisfaction are as follows. Professional environment among characteristics of work environment was significant statistically. Job satisfaction of ministers was the highest; others were in the order of doctors, welfare workers, and nurses. For employment history, job satisfaction was higher as they have more and longer job experience including whole professional experience both in hospice and palliative medical center. In addition, participating in hospice and palliative programs, intensive training regularly was significantly. Job Motivation was also significant statistically. Especially, job satisfaction was higher when people decided to work in hospice and palliative medical center because of individual desire (self-realization). Lastly, influence of role conflict on job satisfaction is as follows. Environmental difficulty, role ambiguity, insufficient ability, process obscurity, etc showed the significant meaning statistically, and the lower role conflict was related with the higher job satisfaction. Suggestions for next study based on such results are as follows in order to improve or increase job satisfaction of employees in hospice/palliative medical centers. The first, to expand education opportunity of employees is needed to increase job satisfactionof hospice/palliatives medical centers. Participating in intensive programs and seminars by types of occupation and acquiring professional knowledge are very important since employees are motivated by those activities. For that, developing and activating intensive education/programs by professional occupations are suggested. The second, dividing roles of employees and determining each job's limit clearly in hospice/palliative medical centers are required. For that, study developing standard job regulations is suggested for each professional job. Lastly, developing and providing reasonable salaries is needed because low salaries of hospice/palliative medical centers are the absolute reason lowering job satisfaction. Therefore, this paper suggests improving the salary level of employees of hospice/palliative medical centers and developing practical plan for it.

• 동의생리병리학회지
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• 제22권5호
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• pp.1112-1118
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• 2008

Qi is in the capacity of pivotal element to describe the life, based on the principles of remedy such as Qigong, meridian pathways, acupuncture, moxibustion and herbal medicine. The purpose of this study was to identify the status of course offered Qigong and Qigong-related clubs in 11 college of oriental medicine. For survey courses offered Status of Qigong in 11 college of oriental medicine, I checked its homepage in august 2008. And about the facts that I could not verify information from the homepage, I obtained through the phone manner. For survey Qigong-related clubs in 11 college of oriental medicine, I phoned the president of union clubs and found out Qigong-related clubs. And then I phoned the presidents of Qigong-related clubs that consented before the fact, investigated the overall situation of clubs. Nine out of 11 college of oriental medicine offered course of Qigong. All of them are opened as major in a premedical course. Six universities have practical training. Six out of 11 college of oriental medicine had Qigong-related clubs. And the number of club is 12. The number of club in Daeguhaany university, 4, is the most. The number of membership of club in Daeguhaany university, 61, is the most too. Most of them are co-majoring both Jung-gong and Dong-gong. It is considered that in lecture of Qigong, It is in a need of lecturing in a regular course with clinical contents, rather than lecturing in a premedical course with basic contents. Of spontaneous club activities, after graduation so that they can get practical help for future. I think from now on we need to investigate deeply practical rate of satisfaction and the present condition of clubs.

• 한국문헌정보학회지
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• 제48권1호
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• pp.27-52
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• 2014

문헌정보학과의 교육과 졸업생의 희망직업은 사서직 취업에 집중되어 있는 경향이 있다. 사서직 취업의 향상을 위해 도서관 확충 등을 주장하기도 하지만 그 효과는 한계가 있고 신규 도서관에 사서를 채용하더라도 정규직보다는 비정규 계약직으로 채용하는 등의 직업환경 또한 밝지 않다. 본 연구는 사서직 취업률 향상을 위한 정책제안을 하는데 목적이 있다. 연구방법으로 선행연구, 통계데이터, 학생 및 사서대상의 설문조사 결과를 사용하였다. 정책개선 대상은 사서양성의 측면에서 사서자격제도, 사서양성체계의 개선방안을 살피고, 사서고용의 측면에서 도서관법, 도서관 협의체 서비스의 개선방안으로 4개의 정책적 목표를 설정하였으며, 세부적으로는 15개의 전략을 제안하였다. 그 중 도서관법 개선(안)으로는 비정규직 지원체계, 사서직 명칭 및 도서관 명칭 관련 사항, 사서배치기준의 현실화 및 강제화, 모든 관종의 도서관평가 의무화 등을, 관련 협의회 활동사항으로는 사서수상제도 확대, 사서직 취업정보시스템 구축, 사서직 외부홍보자료 구축 및 배포 등을 제안하였다.

• 한국조리학회지
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• 제18권4호
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• pp.27-46
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• 2012

호텔산업에서 직원의 성과를 예측할 수 있는 주요 변인으로 크게 조직적 차원과 개인적 특성으로 나누어 연구되어 오고 있다. 특히 개인적 특성은 고용시점에서 고려사항으로서 더 깊이 연구되어야 할 변인으로 보아진다. 이에 본 연구는 개인적 특성의 하나로서 감정을 조절하는 능력인 정서지능을 주요 변인으로 채택하였다. 본 연구의 실증적 목적은 정서지능이 구조적 모델 안에서 직무태도의 변인인 직무만족과 조직몰입에 주는 영향관계를 검증하고자 시행되었다. 연구 목적을 위해, 편의 표본추출 방식으로 한국의 특1급호텔의 근무자를 대상으로 설문조사 하였으며 데이터분석을 위해 SPSS와 AMOS 4를 이용한 구조 모형방정식을 통해 연구가설의 유의성을 측정하였다. 그 연구 결과, 정서지능의 감정 인지와 감정이해 요인이 모든 직무만족 요인에 유의한 영향을 주었다. 상대적으로 감정 인지가 직무만족 각각의 하위 변수에 더 영향을 미치는 것으로 나타났다. 아울러, 조직몰입은 동료와 호텔 내 커뮤니케이션에 대한 만족에 의해 직접적인 영향을 받는 것으로 나타났다. 이러한 연구결과 통해, 해당호텔에 적합한 심리요법 또는 이에 상응하는 호텔 교육프로그램을 직원교육 콘텐츠의 하나로 적용시킬 필요성이 제안된다. 왜냐하면 정서지능은 훈련 등을 통해 발전될 수 있기 때문이다.

• Bulletin of the Korean Chemical Society
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• 제30권5호
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• pp.1121-1126
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• 2009

This paper describes a pattern recognition method of Magnoliae flos based on a gas chromatographic/mass spectrometric (GC/MS) analysis of the essential oil components. The botanical drug is mainly comprised of the four magnolia species (M. denudata, M. biondii, M. kobus, and M. liliflora) in Korea, although some other species are also being dealt with the drug. The GC/MS separation of the volatile components, which was extracted by the simultaneous distillation and extraction (SDE), was performed on a carbowax column (supelcowax 10; 30 m{\time}0.25 mm{\time}0.25{\mu}m$) using temperature programming. Variance in the retention times for all peaks of interests was within RSD 2% for repeated analyses (n = 9). Of the 74 essential oil components identified from the magnolia species, approximately 10 major components, which is $\alpha$-pinene, $\beta$-pinene, sabinene, myrcene, d-limonene, eucarlyptol (1,8-cineol), $\gamma$-terpinene, p-cymene, linalool, $\alpha$-terpineol, were commonly present in the four species. For statistical analysis, the original dataset was reduced to the 13 variables by Fisher criterion and factor analysis (FA). The essential oil patterns were processed by means of the multivariate statistical analysis including hierarchical cluster analysis (HCA), principal component analysis (PCA) and discriminant analysis (DA). All samples were divided into four groups with three principal components by PCA and according to the plant origins by HCA. Thirty-three samples (23 training sets and 10 test samples to be assessed) were correctly classified into the four groups predicted by PCA. This method would provide a practical strategy for assessing the authenticity or quality of the well-known herbal drug, Magnoliae flos.

• 대한치과의사협회지
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• 제53권1호
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• pp.36-46
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• 2015

Objectives: The objective of this work was to investigate the hospital nursing care of oral and maxillofacial health in jeju province. Methods: 438 Registered nurses(RN) who were working at each of secondary hospitals in Jeju province had responded to the questionnaire. The data were analyzed via frequency analyses and one-way ANOVA to assess the state of RN on hospital nursing care of oral and maxillofacial health. Results: The class of education on density in formal density that marked '0 hour' and '1-3 hours' were 73.5% and 19.9%, respectively. The class of refresher training on density that marked '0 hours' and '1-3 hours' were 92.9% and 6.6%, aggregately 99.5%. The nursing education on appearance after tumor of maxillofacial area that marked 'formal education' and 'none' were 45.2% and 52.1%, respectively. The score of question 'function, effect and side effect of hexamedin gaggle' was $2.68{\pm}0.95$ by Likert 5-point scale. Likewise, the scores were $2.82{\pm}0.88$ on question 'management of removal denture', $2.83{\pm}0.95$ on question 'preventive dental treatment before anticancer therapy', $2.88{\pm}0.86$ on question 'function of saliva', $2.96{\pm}0.99$ on question 'oral management of tube feeding patient', $3.13{\pm}1.00$ on question 'bacterial endocarditis from oral microflora', $3.36{\pm}0.89$ on question 'dysphagia' and $3.62{\pm}1.03$ on question 'aspiration pneumonia'. RN replied that 'lack of knowledge' and 'delay of cooperation' formed 53.7% and 33.3% respectively, on question 'problem in dental consultation other diseased patient'. Conclusions: From this study, it is necessary for RN and student of nursing science to be educated on the oral and maxillofacial nursing. Authors suggest further co-study and nation-wide research.