Predictive and Prognostic Significance of p27, Akt, PTEN and PI3K Expression in HER2-Positive Metastatic Breast Cancer |
Okutur, Kerem
(Department of Medical Oncology, Acibadem University School of Medicine)
Bassulu, Nuray (Department of Pathology, Istanbul Bilim University School of Medicine) Dalar, Levent (Department of Chest Disease, Istanbul Bilim University School of Medicine) Aydin, Kubra (Ankara Oncology Training and Research Hospital) Bozkurt, Mustafa (Department of Medical Oncology, Acibadem University School of Medicine) Pilanci, Kezban Nur (Istanbul Bilim University School of Medicine) Dogusoy, Gulen Bulbul (Department of Pathology, Istanbul Bilim University School of Medicine) Tecimer, Coskun (Istanbul Bilim University School of Medicine) Mandel, Nil Molinas (Department of Medical Oncology, Koc University School of Medicine) Demir, Gokhan (Department of Medical Oncology, Acibadem University School of Medicine) |
1 | Berns K, Horlings HM, Hennessy BT, et al (2007). A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell, 12, 395-402. DOI |
2 | Chen W, Yang H, Tang WR, Feng SJ, Wei YL (2014). Updated meta-analysis on HER2 polymorphisms and risk of breast cancer: evidence from 32 studies. Asian Pac J Cancer Prev, 15, 9643-7. DOI |
3 | Dave B, Migliaccio I, Gutierrez MC, et al (2011). Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers. J Clin Oncol, 29, 166-73. DOI |
4 | Depowski PL, Rosenthal SI, Ross JS (2001). Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer. Mod Pathol, 14, 672-6. DOI |
5 | Di Leo A, Gancberg D, Larsimont D, et al (2002). HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin Cancer Res, 8, 1107-16. |
6 | Engin H, Baltali E, Guler N, et al (2006). Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters. Bull Cancer, 93, 21-6. |
7 | Esteva FJ, Guo H, Zhang S, et al (2010). PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol, 177, 1647-56. DOI |
8 | Fabi A, Metro G, Di Benedetto A, et al (2010). Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies. Oncology, 78, 141-9. DOI |
9 | Fiszman GL, Jasnis MA (2011). Molecular mechanisms of trastuzumab resistance in HER2 overexpressing breast cancer. Int J Breast Cancer, 2011, 352182. |
10 | Gori S, Sidoni A, Colozza M, et al (2009). EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. Ann Oncol, 20, 648-54. DOI |
11 | Hayes DF, Thor AD, Dressler LG, et al (2007). HER2 and response to paclitaxel in node-positive breast cancer. N Engl J Med, 357, 1496-506. DOI |
12 | Jonason JH, Gavrilova N, Wu M, Zhang H, Sun H (2007). Regulation of SCF(SKP2) ubiquitin E3 ligase assembly and p27(KIP1) proteolysis by the PTEN pathway and cyclin D1. Cell Cycle, 6, 951-61. DOI |
13 | Li SY, Rong M, Grieu F, Iacopetta B (2006). PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat, 96, 91-5. DOI |
14 | Liu P, Cheng H, Roberts TM, Zhao JJ (2009). Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov, 8, 627-44. DOI |
15 | Liu AN, Sun P, Liu JN, et al (2012). Clinicopathologic characteristics and prognostic factors in patients with operable HER-2 overexpressing breast cancer. Asian Pac J Cancer Prev, 13, 1197-201. DOI ScienceOn |
16 | Nahta R, Esteva FJ (2006). HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res, 8, 215. DOI |
17 | Marty M, Cognetti F, Maraninchi D, et al (2005). Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol, 23, 4265-74. DOI |
18 | Nagata Y, Lan KH, Zhou X, et al (2004). PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell, 6, 117-27. DOI |
19 | Nahta R, Takahashi T, Ueno NT, Hung MC, Esteva FJ (2004). P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells. Cancer Res, 64, 3981-6. DOI |
20 | Newman L, Xia W, Yang HY, et al (2001). Correlation of p27 protein expression with HER-2/neu expression in breast cancer. Mol Carcinog, 30, 169-75. DOI |
21 | Perez EA, Dueck AC, McCullough AE, et al (2103). Impact of PTEN protein expression on benefit from adjuvant trastuzumab in early-stage human epidermal growth factor receptor 2-positive breast cancer in the North Central Cancer Treatment Group N9831 trial. J Clin Oncol, 31, 2115-22. |
22 | Perez-Tenorio G, Alkhori L, Olsson B, et al (2007). PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res, 13, 3577-84. DOI |
23 | Perren A, Weng LP, Boag AH, et al (1999). Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol, 155, 1253-60. DOI |
24 | Saal LH, Holm K, Maurer M, et al (2005). PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res, 65, 2554-9. DOI |
25 | Prat A, Baselga J (2013). Dual human epidermal growth factor receptor 2 (HER2) blockade and hormonal therapy for the treatment of primary HER2-positive breast cancer: one more step toward chemotherapy-free therapy. J Clin Oncol, 31, 1703-6. DOI |
26 | Razis E, Bobos M, Kotoula V, et al (2011). Evaluation of the association of PI3KCA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer. Breast Cancer Res Treat, 128, 447-56. DOI |
27 | Ross JS, Slodkowska EA, Symmans WF, et al (2009). The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine. Oncologist, 14, 320-68. DOI |
28 | Slamon DJ, Leyland-Jones B, Shak S, et al (2001). Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med, 344, 783-92. DOI |
29 | Song CH, Park SY, Eom KY, et al (2010). Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers. Breast Cancer Res, 12, 20. |
30 | Spataro VJ, Litman H, Viale G, et al (2003). Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results from International Breast Cancer Study Group Trial V. Cancer, 97, 1591-600. DOI |
31 | Yakes FM, Chinratanalab W, Ritter CA, et al (2002). Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res, 62, 4132-41. |
32 | Spector NL, Blackwell KL (2009). Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol, 27, 5838-47. DOI |
33 | Tsutsui S, Inoue H, Yasuda K, et al (2005). Inactivation of PTEN is associated with a low p27Kip1 protein expression in breast carcinoma. Cancer, 104, 2048-53. DOI |
34 | Wilken JA, Maihle NJ (2010). Primary trastuzumab resistance: new tricks for an old drug. Ann Y D Acad Sci, 1210, 53-65. DOI |
35 | Yonemori K, Tsuta K, Shimizu C, et al (2009). Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy. Med Oncol, 26, 344-9. DOI |
![]() |