• The Korean Journal of Physiology and Pharmacology
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• 제25권3호
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• pp.227-237
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• 2021

Carbon monoxide (CO) is a cardioprotectant and potential cardiovascular therapeutic agent. Human cardiac fibroblasts (HCFs) are important determinants of myocardial structure and function. Large-conductance Ca2+-activated K+ (BK) channel is a potential therapeutic target for cardiovascular disease. We investigated whether CO modulates BK channels and the signaling pathways in HCFs using whole-cell mode patch-clamp recordings. CO-releasing molecules (CORMs; CORM-2 and CORM-3) significantly increased the amplitudes of BK currents (IBK). The CO-induced stimulating effects on IBK were blocked by pre-treatment with specific nitric oxide synthase (NOS) blockers (L-NG-monomethyl arginine citrate and L-NG-nitroarginine methyl ester). 8-bromo-cyclic GMP increased IBK. KT5823 (inhibits PKG) or ODQ (inhibits soluble guanylate cyclase) blocked the CO-stimulating effect on IBK. Moreover, 8-bromo-cyclic AMP also increased IBK, and pre-treatment with KT5720 (inhibits PKA) or SQ22536 (inhibits adenylate cyclase) blocked the CO effect. Pre-treatment with N-ethylmaleimide (a thiol-alkylating reagent) also blocked the CO effect on IBK, and DL-dithiothreitol (a reducing agent) reversed the CO effect. These data suggest that CO activates IBK through NO via the NOS and through the PKG, PKA, and S-nitrosylation pathways.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.698-699
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• 2003

DA-3711 is a novel, anti wrinkle agent containing growth factors derived from human skin culture. In this study, effect of topical application of DA-3711 on chronic ultraviolet B (UVB)-induced skin damage was evaluated in hairless mice model. Exposure to UVB for 8 weeks induced apparent wrinkles on the back skin of the mice. The dorsal surfaces were exposed to UVB for a further 8 weeks, during which the surfaces where treated daily by topically application of a lotion containing either 35％ or 70％ of DA-3711. For comparison, lotion base, lotion base containing Cylasphere Retinol(equation omitted) (2500 I.U., Coletica) and NouriCe $l^{(R)}$ (Biozhem) were applied topically once a day for 8 weeks.(omitted))

• 대한의생명과학회지
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• 제12권3호
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• pp.161-170
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• 2006

A new piperazine derivative, 8J-8029, is a synthetic anti-cancer agent which exhibits both microtubule and topoisomerase II inhibiting activities. In this study, we investigated the ability of 8J-8029 for anti-angiogenesis and apoptosis. 8J-8029 decreased the bFGF-induced angiogenesis in the CAM and the mouse Matrigel implants, in vivo. 8J-8029 inhibited the proliferation, migration, invasion, tube fonnation, and expression of MMP-2 in BAECs. In addition, 8J-8029 reduced the cell viability in HepG2 cells, caused the production of fragmented DNA and the morphological changes corresponding to apoptosis. 8J-8029 also elicited the release of cytochrome c and the activation of caspase-3. Taken together, these results suggest 8J-8029 may be a candidate for anti-cancer agent with the ability to inhibit the angiogenesis of endothelial cells and to induce the apoptosis of tumor cells.

• 한국주조공학회지
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• 제26권6호
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• pp.272-276
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• 2006

[ $CaCO_3$ ]를 발포제로 사용하여 균일한 기공구조를 가지는 AZ91과 AM60 마그네슘 합금의 발포 금속을 주조법을 통하석 제조하였다. 발포 금속의 제조가 가능한 이유와 발포 마그네슘 합금의 기공구조가 연구를 통하여 논의되었다. 마그네슘 합금의 용탕은 $CaCO_3$의 분해 거동에 영향을 미친다. 제조된 AZ91 마그네슘 합금의 발포 금속은 높은 기공률과 큰 기공의 크기를 가졌으며, 발포 금속들 중에서 상대적으로 쉽게 발포되는 것으로 판단된다.

• 한국자동차공학회논문집
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• 제22권5호
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• pp.5-12
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• 2014

Weatherstrip coatings of urethane and silicon type which are fit to EPDM and thermoplastic materials are used in sealing systems for automotive applications for noise reduction and high slip characteristics for external applications, respectively. Polyurethane binder was successfully synthesized from poly(butyladiphate)diol (PBAD), poly(tetramethylene)glycol (PTMG) and isocyanate as starting materials. Then, polyurethane coating agents were prepared by using various additives. To investigate effects of segment types on the abrasion resistance of polyurethane coating agents, thin films based on polyurethane coating materials were fabricated. With increasing the amount of hard segment in the coating agent, abrasion resistance, modulus and tensile strength of the coating films were improved, but the elongation of the coating films was decreased.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2367-2370
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• 2014

"Cat's eye"-shaped $[^{57}Co]CoO@SiO_2$ core-shell nanostructure was prepared by the reverse microemulsion method combined with radioisotope technique to investigate a potential imaging agent for a single photon emission computed tomography (SPECT) in nuclear medicine. The core cobalt oxide nanorods were obtained by thermal decomposition of $Co-(oleate)_2$ precursor from radio isotope Co-57 containing cobalt chloride and sodium oleate. The $SiO_2$ coating on the surface of the core cobalt oxide nanorods was produced by hydrolysis and a condensation reaction of tetraethylorthosilicate (TEOS) in the water phase of the reverse microemulsion system. In vivo test, micro SPECT image was acquired with nude mice after 30 min of intravenous injection of $[^{57}Co]CoO@SiO_2$ core-shell nanostructure.

• 한국화재소방학회논문지
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• 제21권4호
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• pp.1-11
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• 2007

본 연구에서는 할론 1301 및 이산화탄소를 비롯한 가스계소화설비의 성능을 시험하고 평가하기 위한 가장 중요한 핵심 요소인 배관내 약제비율, 관경비 등 소화성능에 영향을 미치는 가스계소화설비의 제한사항 및 성능확보에 필요한 요소에 대하여 연구하였다. 또한 본 연구에서는 관련 국내외 기준 분석 및 국내 가스계소화설비의 성능평가에 관한 인정기준(KFIS 002)에 따른 시스템 성능시험을 실시하고 결과를 비교 분석하였다.

• 대한화장품학회지
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• 제14권1호
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• pp.16-37
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• 1988

A new quaternary ammonium compound, hydrolyzed ginseng-sapoin quaternary (HGSQ), from hydrolyzed Korean ginseng-saponin and 2, 3-epoxypropyltrimethyl ammonium chloride has been developed as a conditioning agent for hair care products. This structure has the hydrophilic group from the introduced cationic and the hydrophobic group from the aglycone of ginseng saponin. Its properties: surface tension, conductivity, critical micelle concentration, eye irritation, sorption onto hair, force reduction (%) for 20% extension and moisture retention effect comparing with the commercial standards. Also half-head tests of HGSQ-containing shampoo were carried out to compare the conditioning effects in shampoos.

• Korean Chemical Engineering Research
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• 제54권6호
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• pp.767-774
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• 2016

졸-겔법에 의해 출발물질로 aluminum isopropoxide를 사용하여, 메탄올용매 내에서 가수분해 시킨 후 해교제인 초산, 질산 또는 염산을 각각 첨가하여 해교 시켜 3종류의 alumina sol을 제조하였다. 또한 이 sol에 실란커플링제인(3-glycidyloxypropyl) trimethoxysilane을 첨가하여 코팅 용액을 제조한 후, 이용액을 polycarbonate 기재 위에 담금 코팅 후 열 경화시켜 코팅 도막을 형성하였다. 이 과정 중 해교제의 종류 변화가 코팅 도막의 물성에 미치는 영향을 연구하였다. 그 결과 해교제로서 강산인 염산이나 질산을 사용한 코팅 도막은 H나 2H의 연필경도와 5B의 부착력을 나타내어 우수한 물성을 나타내었다. 반면에 해교제로서 약산인 초산을 사용한 경우에는 HB의 연필경도와 3B의 부착력을 보여 좋지 못한 물성을 나타내었다.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 1995년도 추계학술강연 및 발표대회 강연 및 발표논문 초록집
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• pp.11-11
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• 1995