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http://dx.doi.org/10.5012/bkcs.2014.35.8.2367

Synthesis and Biodistribution of Cat's Eye-shaped [57Co]CoO@SiO2 Nanoshell Aqueous Colloids for Single Photon Emission Computed Tomography (SPECT) Imaging Agent  

Kwon, Minjae (Advanced Functional Nanohybrid Material Laboratory, Department of Chemistry, Dongguk University-Seoul Campus)
Park, Jeong Hoon (ARTI, Korea Atomic Energy Research Institute (KAERI))
Jang, Beom-Su (ARTI, Korea Atomic Energy Research Institute (KAERI))
Jung, Hyun (Advanced Functional Nanohybrid Material Laboratory, Department of Chemistry, Dongguk University-Seoul Campus)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.8, 2014 , pp. 2367-2370 More about this Journal
Abstract
"Cat's eye"-shaped $[^{57}Co]CoO@SiO_2$ core-shell nanostructure was prepared by the reverse microemulsion method combined with radioisotope technique to investigate a potential imaging agent for a single photon emission computed tomography (SPECT) in nuclear medicine. The core cobalt oxide nanorods were obtained by thermal decomposition of $Co-(oleate)_2$ precursor from radio isotope Co-57 containing cobalt chloride and sodium oleate. The $SiO_2$ coating on the surface of the core cobalt oxide nanorods was produced by hydrolysis and a condensation reaction of tetraethylorthosilicate (TEOS) in the water phase of the reverse microemulsion system. In vivo test, micro SPECT image was acquired with nude mice after 30 min of intravenous injection of $[^{57}Co]CoO@SiO_2$ core-shell nanostructure.
Keywords
Cobalt; Nanoparticles; Silicate; Isotopic labeling; Imaging agents;
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