• 제목/요약/키워드: co-agent

검색결과 1,620건 처리시간 0.031초

DW1350, a Newly Synthetic Anti-osteoporotic Agent: 1. DW-1350 Inhibited Bone Resorption and Promoted Bone Formation

  • Lee, Jin-Soo;Whang, Yun-Ha;Ahn, Seok-Hoon;PanSoo;Jin, Sang-Mi;Yi, Sun-Shin;Jung, Young-Ho;Suh, Hong-Suk;Ryu, Jei-Man
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.154.2-155
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    • 2003
  • Recently, we developed a new anti-osteoporotic agent, DW-1350, which not only inhibited osteoclast formation but also induced osteoblast differentiation through the in vitro randomized screening studies. We identified inhibitory activities of DW-1350 for each step of osteoclast differentiation, fusion and pit formation process in co-culture system with mouse bone marrow and primary osteoblasts. (omitted)

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Poly(acrylic acid-co-maleic acid)로 가교된 Poly(vinyl alcohol)막을 이용한 에탄을 수용액의 투과증발분리 특성 (Pwevaporation Separation of Aqueous Ethanol Solution Through Poly(vinyl alcohol) Membranes Crosslinked Poly(acrylic acid-co-maleic acid))

  • 남상용;성경수;천세원;임지원
    • 멤브레인
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    • 제12권4호
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    • pp.255-261
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    • 2002
  • 폴리비닐알콜을 고분자계 가교제인 폴리아크릴산-말레산 공중합체를 이용하여 가교제의 농도를 변화시키면서 가교하여 막을 제조하였다. 제조한 막은 FT-IR과 수팽윤도 측정을 통하여 가교반응을 확인하였으며, 가교제 농도 증가에 따라서 수팽윤도가 감소하는 경향을 나타내었다. 고분자가교제인 폴리아크릴산-말레산 공중합체로 가교된 폴리비닐알콜 막은 글루탈알데히드로 가교된 폴리비닐알콜이나 변성 폴리비닐알콜 막에 비해서 수팽윤도가 감소하였다. 이는 고분자가교제에 의한 화학적가교와 더불어 물리적인 가교효과가 증가하여 막의 팽윤을 억제하기 때문으로 사료된다. 에탄올수용액에 대한 투과증발실험 결과 가교제의 농도가 증가할수록 선택도는 증가하며, 투과유량은 감소하는 경향을 나타내었으며, 공급액 중의 물의 농도가 증가할수록 선택도는 약간 감소하나 투과유량은 급격히 증가하고, 공급액 중의 물의 농도가 증가하여도 가소화현상이 나타나지 않는 것을 관찰하였다. 이는 고분자가교제에 의한 팽윤억제 메카니즘이 작용하기 때문으로 사료된다.

$TiH_2$$CaCO_3$를 이용한 마그네슘 합금의 제조 (Fabrication of Magnesium Alloy Foam Through $TiH_2$ and $CaCO_3$)

  • 서창환;성환구;양동휘;박수한;허보영
    • 한국주조공학회지
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    • 제26권6호
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    • pp.267-271
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    • 2006
  • Metal foam is a class of attractive materials, which exhibits unique combinations of physical, mechanical, thermal, electrical and acoustic properties. In particular, it is light and good at absorbing energy, which makes it attractive in automotive and aerospace applications weight is critical. In this paper, the Mg alloy foam was prepared by melt foaming method by addition of calcium as thickening agent, and $TiH_2$ or $CaCO_3$ powder as blowing agent. The macrostructural observation of foamed Mg showed that the pore structures of Mg alloy foam made by $CaCO_3$ as blowing agent were much better than that of foams made by $TiH_2$ as blowing agent. In addition, this paper showed the possible reason of fabrication magnesium alloy foam in proportion to blowing agent and the porosity range was about 40 to 76% as results value.

MBR 공정 적용을 위한 전처리 오존산화에 의한 형광증백제 제거 연구 (Study on the Removal of Fluorescent Whitening Agent by Pretreatment Ozone Oxidation for MBR Process Application)

  • 최장승;류승한;신동훈;이재훈;이수철;김성기;류재용;신원식;이슬기;박민수
    • 한국염색가공학회지
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    • 제29권1호
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    • pp.11-17
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    • 2017
  • In this study, ozone oxidation experiment was carried out for the removal of fluorescent whitening agent which is widely used in textile dyeing and paper industry. The stilbene fluorescent whitening agent has been industrialized since the earliest, and the amount of current production is the highest. Due to the characteristics of the fluorescent whitening agent that can not be removed by conventional wastewater treatment methods, the fluorescent whitening agent in wastewater treatment has difficulty in using as recycled water in the process. Pre-treatment ozone oxidation experiment was conducted prior to the introduction of Membrane Bio Reactor(MBR) treatment process by converting biodegradable materials into biodegradable materials. The removal efficiencies of fluorescent whitening agents, a diaminostilbenedisulfonic acid derivative by ozone oxidation were evaluated by $UV_{254}$ Scan, $COD_{Mn}$, T-N and color using a synthetic wastewater sample ($COD_{Mn}=433.0mg/{\ell}$) and paper and paper mill wastewater ($COD_{Mn}=157.2mg/{\ell}$).

Highly CO2-soluble 5-Amido-8-hydroxyquinoline Chelating Agents for Extraction of Metals in Sc-CO2

  • Chang, Fei;Park, Seo-Hun;Kim, Hakwon
    • Bulletin of the Korean Chemical Society
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    • 제29권7호
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    • pp.1327-1331
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    • 2008
  • Novel $CO_2$-soluble 8-hydroxyquinoline (8-HQ) chelating agents were synthesized and evaluated for solubility and metal ion extraction ability in supercritical $CO_2\;(Sc-CO_2)$. Among them, secondary amide-containing 8- HQ derivatives cannot be dispersed well into Sc-$CO_2$, but tertiary amide-containing derivatives can dissolve completely in Sc-$CO_2$ even at low CO2 pressures, perhaps owing to the predominant intermolecular interaction between the chelating agent and the $CO_2$ molecule. Based on 8-HQ chelating agent solubility data, we investigated the extraction of metal ions ($Co^{2+}$, $Cu^{2+}$, $Sr^{2+}$, $Cd^{2+}$, and $Zn^{2+}$) using two highly $CO_2$-soluble 8-HQ derivatives (4d, 4e) in Sc-$CO_2$. The extraction efficiency of tertiary amide-containing 8-HQ ligands, both fluorinated and non-fluorinated forms, was dramatically increased in the presence of diethyl amine (organic base). We suggest that diethyl amine could play an important synergistic role in the stronger metal binding ability of 8-HQ through an in situ deprotonation reaction in Sc-$CO_2$ medium.

DW1350, a Newly Synthetic Anti-osteoporotic Agent: 2. Effect on Ovariectomized Osteoporosis Rat Model, a Histomorphometrical Aspect

  • Lee, Jin-Soo;Ku, Sae-Kwang;Jung, Da-Hee;Jin, Youn-Goo;Park, Jae-Hoon;Yang, Hee-Bok;Jung, Yong-Ho;Ryu, Jei-Man
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.155.1-155.1
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    • 2003
  • In the present study, the effect of DW-1350, a newly synthesized anti-osteoporotic agent, was evaluated in ovariectomized Rat. Female SD Rat mice underwent bilateral ovariectomy for prevention study that test article was administered from 2 days after ovariectomy for 6 weeks, for therapeutic study it was conducted from 6 weeks after ovariectomy for three months. (omitted)

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Distributed CoAP Handover Using Distributed Mobility Agents in Internet-of-Things Networks

  • Choi, Sang-Il;Koh, Seok-Joo
    • Journal of information and communication convergence engineering
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    • 제15권1호
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    • pp.37-42
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    • 2017
  • The constrained application protocol (CoAP) can be used for remotely controlling various sensor devices in Internet of Things (IoT) networks. In CoAP, to support the handover of a mobile sensor device, service discovery and message transmission needs to be repeated, although doing so would increase the handover delay significantly. To address this limitation of CoAP, a centralized CoAP scheme has been proposed. However, it tends to result in performance degradation for an inter-domain handover case. In this letter, we propose a distributed CoAP handover scheme to support the inter-domain handover. In the proposed scheme, a distributed mobility agent (DMA) is used for managing the location of mobile sensors in a domain and performing handover control operations with its neighboring DMAs in a distributed manner. A performance comparison reveals that the proposed scheme offers a performance improvement of up to 29.5% in terms of the handover delay.

아민계 분산제가 실리카 고무배합물의 물성에 미치는 영향 (Influence of Amine Base Dispersing Agent on Properties of Silica Filled Rubber Compounds)

  • 박성수;길상규;장병만;송기찬;김수경
    • 폴리머
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    • 제25권4호
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    • pp.503-511
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    • 2001
  • 기존 실리카 분산제는 주로 Zn, K의 지방산 유도체이며 지방산과 금속비누의 혼합물은 활성을 높이는데 사용되었다. Zn-K 비누 형태의 실리카 분산제는 탄화수소 사슬의 유동성을 증가시켜 실리카가 함유된 고무 배합물의 점도를 낮추어 주며 그 결과 가공성이 향상된다. 실리카 분산제는 가류 특성에 영향을 미쳐서는 안되는데 Zn-K 비누형태의 분산제는 스코치 및 가류시간을 단축시켰다. 그러나 새로이 개발된 분산제의 경우 금속을 함유하지 않은 non-metal 형태이며 분산제가 실리카와 고무간의 interaction을 유도하여 실리카 분산도를 크게 향상시켰으며 이로 인해 경도 및 점도 저하를 유도하였다. 또한 새로운 분산제는 실리카 고무배합물의 가교특성 및 스코치 안정성에 영향을 미치지 않았다.

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이산화탄소를 가압원으로 하는 할론대체 소화기용 청정소화약제에 대한 연구 (A Study on Clean Agents for Halon Replacement in the Portable Extinguisher with CO2 as an Expellant Gas)

  • 정기신
    • 한국화재소방학회논문지
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    • 제33권3호
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    • pp.51-55
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    • 2019
  • CFC의 오존층 파괴로 인해 이를 대체할 냉매, 세정제, 발포제의 개발과 더불어 소방분야에서는 할론대체소화약제개발에 주력하여 왔다. 특히 소화기분야에서는 할론1211 소화기를 대체할 청정소화약제를 개발하여 왔다. 그 결과로 개발된 소화기용 청정소화약제 중 가장 널리 사용되는 소화약제가 HCFC-123이다. 대부분의 청정소화약제들은 자체 증기압이 약하기 때문에 어떠한 가압원을 사용할 것인가가 중요한 문제 중 하나이다. 본 연구에서는 소화기용 소화약제들 중 HCFC-123, HCFC-124, HFC-125, Novec-1230을 선정하여 이들 약제에 대한 가압원으로 보조소화효과를 기대할 수 있는 CO2를 사용하였다. 각 소화약제별로 약제량과 CO2량을 조절하며 시험을 실시한 결과 HCFC-123 소화약제로부터 기대한 소화효과를 확인할 수 있었다. 현재 시중에 판매되고 있는 소화기인 HCFC-123 2.5 kg을 질소로 가압하여 소화능력 ABC 각 1단위인 소화기보다 소화약제가 적은 HCFC-123 1.5 kg과 CO2 1.5 kg을 혼합한 소화기로 동일한 소화능력시험에 성공하였다. 이러한 소화시험의 결과는 가압원인 CO2의 보조소화효과를 확인한 것이라 할 수 있다. 이는 중간대체물질로 분류되어 있는 HCFC계열의 소화약제를 줄일 수 있어 기존의 소화기보다 친환경적이고 경제적이라 할 수 있으며 B,C급 화재용 소화기인 CO2 소화기로 A급 가연물이 많은 전기, 전자 관련 시설을 방호하는 불합리함을 해결하는데 기여할 수 있으리라 기대한다.

The Effect of the Mixture of Nonionic Surfactant and Bioactive Agent for Surfactant-enhanced Soil Flushing (SESF) of TCB Contaminated Soil

  • Lee, Dal-Heui;Cho, Heuy Nam;Chung, Sung-Lae
    • 한국지하수토양환경학회지:지하수토양환경
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    • 제19권2호
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    • pp.1-6
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    • 2014
  • The objective of this study was to find the effect of the mixture of the nonionic surfactant and bioactive agent that solubilizes trichlorobenzene (TCB) present as a contaminant for surfactant-enhanced soil flushing (SESF). Three different nonionic surfactants and two different bioactive agents were obtained from four companies. Separate funnel experiments and shaker table agitation / centrifugation experiments were used for the test. Based on the separate funnel experimental results, three suitable mixture agents (APG + OSE, Brij 35 + MOSE, T-Maz 60 + MOSE) were selected. In the shaker table agitation / centrifugation experiments, these three different mixture agents were reduced to one (T-Maz 60 +MOSE). The maximum removal (95%) of TCB was obtained using a mixture of the nonionic surfactant and bioactive agent. Therefore, the used test methods and results can be used for SESF.