• Title/Summary/Keyword: co-administration

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Decreases Nitrous Oxide Emission and Increase Soil Carbon via Carbonized Biomass Application of Orchard Soil (과수원 토양의 탄화물 시용에 따른 아산화질소 발생량 감소와 토양탄소 증가효과)

  • Lee, Sun-il;Kim, Gun-yeob;Choi, Eun-jung;Lee, Jong-sik;Jung, Hyun-cheol
    • Korean Journal of Environmental Agriculture
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    • v.36 no.2
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    • pp.73-79
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    • 2017
  • BACKGROUND: Carbonized biomass is a carbon-rich solid product obtained by the pyrolysis of biomass. It has been suggested to mitigate climate change through increased carbon storage and reduction of greenhouse gas emission. The objective of this study was to evaluate carbon dioxide ($CO_2$) and nitrous oxide ($N_2O$) emissions from soil after carbonized biomass addition. METHODS AND RESULTS: The carbonized biomass was made from a pyrolyzer, which a reactor was operated about $400{\sim}500^{\circ}C$ for 5 hours. The treatments were consisted of a control without input of carbonized biomass and two levels of carbonized biomass inputs as 6.06 Mg/ha for CB-1 and 12.12 Mg/ha for CB-2. Emissions of $CO_2$ and $N_2O$ from orchard soil were determined using closed chamber for 13 weeks at $25^{\circ}C$ of incubation temperature. It was shown that the cumulative $CO_2$ were $209.4g\;CO_2/m^2$ for CB-1, $206.4g\;CO_2/m^2$ for CB-2 and $214.5g\;CO_2/m^2$ for the control after experimental periods. The cumulative $CO_2$ emission was similar in carbonized biomass input treatment compared to the control. It was appeared that cumulative $N_2O$ emissions were $4,478mg\;N_2O/m^2$ for control, $3,227mg\;N_2O/m^2$ for CB-1 and$ 2,324mg\;N_2O/m^2$ for CB-2 at the end of experiment. Cumulative $N_2O$ emission contents significantly decreased with increasing the carbonized biomass input. CONCLUSION: Consequently the carbonized biomass from byproducts such as pear branch residue could suppress the soil $N_2O$ emission. The results fromthe study imply that carbonized biomass can be utilized to reduce greenhouse gas emission from the orchard field.

The Effects of a Mineral Supplement (Aquamin $F^{(R)}$) and Its Combination with Multi-Species Lactic Acid Bacteria (LAB) on Bone Accretion in an Ovariectomized Rat Model

  • Lee, Hyun-Gi;Lee, Tae-Hee;Kim, Jung-Ha;Seok, Ju-Won;Lee, Seung-Hoon;Kim, Yong-Hwan;Kim, Jin-Eung;Chung, Myung-Jun;Yeo, Moon-Hwan
    • Biomedical Science Letters
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    • v.16 no.4
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    • pp.213-220
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    • 2010
  • Although an adequete intake of calcium (Ca) is recommended for the treatment and prevention of osteoporosis, the intake of Ca should be restricted because of its low rate of intestinal absorption. The purpose of this experiment was to identity the effect of the combined administration of Aquamin F (AQF) (a calcium agent) and lactic acid bacteria (LAB) on osteoporosis. Thirty ovariectomized (OVX) rats and six control rats were assigned to the following six groups, with six animals per group: sham Ca-deficient diet (Ca-D), OVX, LAB, AQF, and LAB-AQF. During the experiment, the body weight was measured; and after the experiment was completed, the serum biochemical analysis, the alkaline phosphatase, calcium, and inorganic phosphorus leves were measured. The tissue of the femur was stained and then scanned via CT. The body weight of the OVX group increased more significantly than that of the control group. The results of the bone mineral content (BMC), Bone mineral density (BMD), serum biochemical analysis and histological test on the femur epiphysis showed no difference between the OVX group and the LAB group, whereas the results of the AQF group were more significant than those of the OVX group. In particular, the LAB+AQF group showed more significant increases in the aforementioned results than the AQF group. This experiment showed that the combined administration of AQF and LAB in ovariectomized rats more significantly increased bone density than did a single administration of either AQF or LAB.

A Study on Fisheries Financial Systems in Japan (일본의 수산긍융 시스템에 관한 연구)

  • 송정헌
    • The Journal of Fisheries Business Administration
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    • v.31 no.2
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    • pp.93-117
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    • 2000
  • Fisheries finance is divided into the policy time of long period of time and low interest and the special financing institutions, such as Fisheries Co-operatives. Union system finance is the system finance, which supports the fisheries system organization. Fisheries Co-operatives in cities, towns and villages are the independent management objects. Prefecture federation of Fisheries Co-operative is in prefecture stage. Norm Chukin Bank is in national stage. Each shares functions in these three stages, and finance is performed systematically, Fisheries policy finance comprises government financial institution capital such as the Agriculture, Forestry and Fishery Finance Corporation whish is based on the capital of a country or a prefecture financial fund, and fishery Modernization Capital used as financial funds through the government. Moreover, to complement such finance institutionally, Fisheries Credit Foundations, Agriculture and Fisheries Saving Insurance Corporation and National fisheries Co-operative Trust Enterprise Mutual Aid system have been established

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Prediction of carbon dioxide emissions based on principal component analysis with regularized extreme learning machine: The case of China

  • Sun, Wei;Sun, Jingyi
    • Environmental Engineering Research
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    • v.22 no.3
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    • pp.302-311
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    • 2017
  • Nowadays, with the burgeoning development of economy, $CO_2$ emissions increase rapidly in China. It has become a common concern to seek effective methods to forecast $CO_2$ emissions and put forward the targeted reduction measures. This paper proposes a novel hybrid model combined principal component analysis (PCA) with regularized extreme learning machine (RELM) to make $CO_2$ emissions prediction based on the data from 1978 to 2014 in China. First eleven variables are selected on the basis of Pearson coefficient test. Partial autocorrelation function (PACF) is utilized to determine the lag phases of historical $CO_2$ emissions so as to improve the rationality of input selection. Then PCA is employed to reduce the dimensionality of the influential factors. Finally RELM is applied to forecast $CO_2$ emissions. According to the modeling results, the proposed model outperforms a single RELM model, extreme learning machine (ELM), back propagation neural network (BPNN), GM(1,1) and Logistic model in terms of errors. Moreover, it can be clearly seen that ELM-based approaches save more computing time than BPNN. Therefore the developed model is a promising technique in terms of forecasting accuracy and computing efficiency for $CO_2$ emission prediction.

Comparative Studies on Concentration of Decursinol in Plasma after Oral Administration of Angelicae Gigantis Radix Extract and Combined Use of Decursin and Cnidii Rhizoma Extract or Bupleuri Radix Extract in Rats (당귀와 천궁 및 시호의 병용 경구 투여에서 흰쥐 혈중 Decursinol 농도의 비교 검토)

  • Park, Roh-Jeong;Kim, Nam-Jae;Lee, Kyung-Tae;Seo, Seong-Hoon
    • Korean Journal of Pharmacognosy
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    • v.32 no.1 s.124
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    • pp.72-78
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    • 2001
  • This study was performed to elucidate the influence on the plasma decursinol concentration after administration of combined decursin and Cnidii Rhizoma or decurisin and Bupleuri Radix extracts in comparison with single decursin administration. The identification of decursinol isolated from Angelica gigas was carried out by GC/MS and the concentration of decursinol in the plasma after oral administration was determined by HPLC. The value of area under the plasma concentration (AUC) and the maximal concentration (Cmax) of decursinol after administration of methanol and ether Angelicae Gigantis Radix extract was higher than those of single decursin-treated group. It was also found that the AUC and the Cmax of decursinol after combined administration with decursin and Cnidii Rhizoma were higher than those of decursin administration, whereas those of combined with decursin and Bupleuri Radix was lower. Moreover, the studies were performed with decursinol only or with combined decursinol and Cnidii Rhizoma/Bupleuri Radix, both of combined treatment increased the plasma decursinol concentrations compared with decursinol-treated group in rats. On the basis of these results, it is concluded that co-existing substances or co-administration with other drugs may influence the plasma levels of decurisinol after oral administration.

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Pharmacokinetics of Ethanol After Oral Administration of Aspartate-Containing Compositions (Aspartate함유 복합성분과 Ethanol의 약물동태학적 거동)

  • Kim, Tae-Wan;Lee, Beom-Jin;Choi, Han-Gon;Kim, Chong-Kook;Shin, Hee-Jong;Kim, Jung-Woo
    • Journal of Pharmaceutical Investigation
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    • v.27 no.3
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    • pp.181-187
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    • 1997
  • The purpose of this work was to investigate pharmacokinetics of alcohol as a function of dose and time of administration of ethanol. The pharmacokinetics of alcohol 15 min after and before oral administration of aspartate-containing compositions to rats were also evaluated. The retention time of acetaldehyde, alcohol and isopropyl alcohol an internal standard in gas chromatogram was 3.6, 6.0 and 10.5 min, respectively. The maximum concentration of alcohol $(C_{max})$ and area under the blood concentration (AUC) were significanly increased as a function of ethanol dose in a nonlinear fashion. The significant diurnal variation of alcohol pharmacokinetics was also noted, showing fast metabolism and elimination when given orally in the night time. When APAP was given after administration alcohol (1g/kg) to rats, AUC and $C_{max}$ were increased when compared to alcohol only. However, AUC and $C_{max}$ were decreased when aspartate or standard complex compositions containing aceaminophen (APAP, 250mg). sodium L-aspartate(25 mg), dl-methionine (125 mg) and anhydrous caffeine (25 mg) was orally given by coupling malate/asparate shuttle in hepatocyte. The blood alcohol concentration profiles between aspartate and standard complex compositions were similar when given before or after administration alcohol (1g/kg) to rats. No significant difference of administration sequence was observed. However, it was noted that AUC and $C_{max}$ of standard complex compositions given before alcohol administration were significantly lower when compared with alcohol only. Based on these findings, dose, time of administration and composition of drugs to improve alcohol metabolism and elimination were considered to be important in the pharmacokinetics of alcohol. The administration sequence of drug compositions and alcohol might be also considerd.

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Effect of Gamiondam-tang (GMODT), a Polyherbal Formula on the Pharmacokinetics Profiles of Tamoxifen in Male SD Rats (2) - Single Oral Combination Treatment of Tamoxifen 50 mg/kg with GMODT 100 mg/kg with 2.5 hr-intervals -

  • Ryu, Eun-A;Kang, Su-Jin;Song, Chang-Hyun;Lee, Bong-Hyo;Choi, Seong-Hun;Han, Chang-Hyun;Lee, Young-Joon;Ku, Sae-Kwang
    • Journal of Society of Preventive Korean Medicine
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    • v.21 no.2
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    • pp.127-137
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    • 2017
  • Objectives : In our previous study, single co-administration GMODT within 5 min significantly inhibited the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen. Therefore, the object of this study was to elucidate the possible effects on the pharmacokinetics of tamoxifen after single oral co-administration of GMODT with 2.5 hr-intervals. Methods : After 50 mg/kg of tamoxifen treatment, GMODT 100 mg/kg was administered with 2.5 hr-intervals. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMODT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with tamoxifen single administered rats. Results : Two-half hr-interval co-administration with GMODT induced variable changes on the plasma tamoxifen concentrations as compared with tamoxifen single treated rats, and especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5 (199.61%) and 1 hr (101.06%) after end of co-administration with GMODT, and also related significant (p<0.05) decreases of $t_{1/2}$ (-39.54%) and $MRT_{inf}$ (-43.94%) as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 50 mg/kg and GMODT 100 mg/kg with 2.5 hr-intervals, in this experiment. Conclusions : According to the results, GMODT critically decreased on the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen. Hence, the co-administration of GMODT and tamoxifen should be avoided in the comprehensive and integrative medicine, combination therapy of tamoxifen with GMODT on the breast cancer.

Effect of the Rainfall during Typhoon Periods on the Variation of Concentration of Ambient Air Pollutants (PM10, NO2, CO, SO2) in the Korean Peninsula (태풍 내습 시 강수에 의한 대기오염물질 (PM10, NO2, CO, SO2)의 농도 변화 분석)

  • Ahn, Suk-Hee;Park, So-Yeon;Kim, Jeoung-Yun;Kim, Baek-Jo
    • Journal of Korean Society for Atmospheric Environment
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    • v.30 no.2
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    • pp.128-138
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    • 2014
  • This study has analyzed the concentration variation of four air pollutants ($PM_{10}$, $NO_2$, CO, and $SO_2$) during the typhoon periods over 10 years (2002~2011). In this study, 10 typhoon events which had rainfalls in Korean Peninsula were selected during the study period. The analysis was performed using the observation data of both the air pollutants and rainfall. In order to examine and compare the concentrations of the air pollutants between normal periods and typhoon periods, we have obtained monthly average concentrations from July to September and daily average concentrations during typhoon periods. For the period from July to September, 34% of the total rainfalls can be explained by typhoons, and the concentration of air pollutants during the typhoon period was lower than the normal period. In addition, the concentration variations of the pollutants during the typhoon period were analyzed according to two categories: differences in the concentrations between the day before and the day of the typhoon (Case 1) and between the day before and after the typhoon (Case 2). The results indicated that the reduction rate of $PM_{10}$, $NO_2$, CO, and $SO_2$ was 30.1%, 17.9%, 11.6%, 9.7% (Case 1) and 22.8%, 21.0%, 9.0%, 8.0% (Case 2), respectively. This result suggested that air quality was significantly improved during the typhoon period than after the typhoon period by the rainfall.

Simultaneous Determination of Paeoniflorin, Trans-cinnamic Acid, Schisandrin and Glycyrrhizin in So-Cheong-Ryong-Tang by HPLC-DAD and HPLC-ESI-MS

  • Lee, Mi-Kyeong;Lee, Ki-Yong;Park, Jung-Hyun;Kim, Seung-Hyun;Choi, Ok-Gyung;Park, Jin-Ho;Cho, Jung-Hee;Kim, Do-Hoon;Baek, Ju-Hyun;Oh, Mi-Hyune;Kim, Hyo-Jin;Sung, Sang-Hyun
    • Natural Product Sciences
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    • v.16 no.1
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    • pp.26-31
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    • 2010
  • High performance liquid chromatographic method with diode-array detection (HPLC-DAD) has been performed for the simultaneous determination of four marker constituents, paeoniflorin, trans-cinnamic acid, schisandrin and glycyrrhizin in traditional herbal medicinal preparation, So-Cheong-Ryong-Tang (SCRT). The presence of paeoniflorin, trans-cinnamic acid, schisandrin and glycyrrhizin in this decoction was ascertained by retention time, spiking with each authentic standard, UV spectrum and ESI mass spectrum. All four compounds showed good linearity ($r^2$ > 0.998) in a relatively wide concentration ranges. The RSD for intra-day and inter-day precision was less than 3% and the limits of detection (LOD) were less than 30 ng. The mean recovery of each compound was 94.1-113.0% with RSD values less than 3.0%. These results suggest that the developed HPLC method is simple, effective and could be readily utilized as a quality control method for commercial SCRT products.