• 치위생과학회지
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• 제13권4호
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• pp.418-425
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• 2013

본 연구는 생활습관과 치주건강상태의 관련성을 파악하여 올바른 생활습관을 통한 치주질환의 예방 및 유지를 위한 기초자료를 제공하기 위하여 실시되었다. 연구대상은 일부지역 치과의원에 내원한 40~50대 성인 남녀 총 326명을 대상으로 하여 구조화된 설문지와 치주건강상태를 측정하여 조사 분석하였다. 수집된 자료는 IBM SPSS Statistics 19.0 통계프로그램을 이용하여 분석한 결과는 다음과 같다. 1. 흡연여부는 치은염 지수(p<0.01), 치주낭 깊이(p<0.001), 임상적 부착소실(p<0.001)에 따라 통계적으로 유의한 차이를 보였다. 2. 일일 흡연량은 치은염 지수(p<0.05), 치주낭 깊이(p<0.01), 임상적 부착소실(p<0.001)에 따라 통계적으로 유의한 차이를 보였다. 3. 흡연기간은 치은염 지수(p<0.05), 치주낭 깊이(p<0.01), 임상적 부착소실(p<0.001)에 따라 통계적으로 유의한 차이를 보였다. 4. 음주주기는 치은염 지수(p<0.05), 임상적 부착소실(p<0.05)에 따라 통계적으로 유의한 차이를 보였다. 5. 흡연을 하는 경우(p<0.05) 임상적 부착소실에 영향을 미치는 것으로 조사되었다. 이상의 결과에서 치과진료기관은 환자들에게 건강한 치주상태를 예방 및 유지하기 위해서는 과도한 흡연과 음주는 치주건강상태에 영향을 미친다는 사실을 인식시킬 필요가 있으며 더불어 체계적인 금연과 절주를 위한 교육프로그램 개발이 마련되어야 할 것이다.

• Korean Journal of Radiology
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• 제25권5호
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• pp.481-492
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• 2024

Objective: To evaluate the clinical and imaging characteristics of SARS-CoV-2 breakthrough infection in hospitalized immunocompromised patients in comparison with immunocompetent patients. Materials and Methods: This retrospective study analyzed consecutive adult patients hospitalized for COVID-19 who received at least one dose of the SARS-CoV-2 vaccine at two academic medical centers between June 2021 and December 2022. Immunocompromised patients (with active solid organ cancer, active hematologic cancer, active immune-mediated inflammatory disease, status post solid organ transplantation, or acquired immune deficiency syndrome) were compared with immunocompetent patients. Multivariable logistic regression analysis was performed to evaluate the effect of immune status on severe clinical outcomes (in-hospital death, mechanical ventilation, or intensive care unit admission), severe radiologic pneumonia (≥ 25% of lung involvement), and typical CT pneumonia. Results: Of 2218 patients (mean age, 69.5 ± 16.1 years), 274 (12.4%), and 1944 (87.6%) were immunocompromised an immunocompetent, respectively. Patients with active solid organ cancer and patients status post solid organ transplantation had significantly higher risks for severe clinical outcomes (adjusted odds ratio = 1.58 [95% confidence interval {CI}, 1.01-2.47], P = 0.042; and 3.12 [95% CI, 1.47-6.60], P = 0.003, respectively). Patient status post solid organ transplantation and patients with active hematologic cancer were associated with increased risks for severe pneumonia based on chest radiographs (2.96 [95% CI, 1.54-5.67], P = 0.001; and 2.87 [95% CI, 1.50-5.49], P = 0.001, respectively) and for typical CT pneumonia (9.03 [95% CI, 2.49-32.66], P < 0.001; and 4.18 [95% CI, 1.70-10.25], P = 0.002, respectively). Conclusion: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.

• 대한간호학회지
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• 제36권4호
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• pp.652-661
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• 2006

Purpose. The purposes of this study were to apply data mining tool to nursing specific knowledge discovery process and to identify the utilization of data mining skill for clinical decision making. Methods. Data mining based on rough set model was conducted on a large clinical data set containing NMDS elements. Randomized 1000 patient data were selected from year 1998 database which had at least one of the five most frequently used nursing diagnoses. Patient characteristics and care service characteristics including nursing diagnoses, interventions and outcomes were analyzed to derive the meaningful decision rules. Results. Number of comorbidity, marital status, nursing diagnosis related to risk for infection and nursing intervention related to infection protection, and discharge status were the predictors that could determine the length of stay. Four variables (age, impaired skin integrity, pain, and discharge status) were identified as valuable predictors for nursing outcome, relived pain. Five variables (age, pain, potential for infection, marital status, and primary disease) were identified as important predictors for mortality. Conclusions. This study demonstrated the utilization of data mining method through a large data set with stan dardized language format to identify the contribution of nursing care to patient's health.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8599-8604
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• 2016

Ovarian cancer is the main cause of mortality in gynecological malignancy and extensive studies have been conducted to study the underlying molecular mechanisms. The BRCA2 gene is known to be an important tumor suppressor in ovarian cancer, thereby BRCA2 alterations may lead to cancer progression. However, the BRCA2 gene is rarely mutated, and loss of function is suspected to be mediated by epigenetic regulation. In this study we investigated the methylation status and gene expression of BRCA2 in ovarian cancer patients. Ovarian cancer pateints (n=69) were recruited and monitored for 54 months in this prospective cohort study. Clinical specimens were used to study the in situ expression of aberrant BRCA2 proteins and the methylation status of BRCA2. These parameters were then compared with clinical parameters and overall survival rate. We found that BRCA2 methylation was found in the majority of cases (98.7%). However, the methylation status was not associated with protein level expression of BRCA2 (49.3%). Therefore in addition to DNA methylation, other epigenetic mechanisms may regulate BRCA2 expresison. Our findings may become evidence of BRCA2 inactivation mechanism through DNA methylation in the Indonesian population. More importantly, from multivariate analysis, BRCA2 expression was correlated with better overall survival (HR 0.32; p=0.05). High percentage of BRCA2 methylation and correlation of BRCA2 expression with overall survival in epithelial ovarian cancer cases may lead to development of treatment modalities specifically to target methylation of BRCA genes.

• Journal of Periodontal and Implant Science
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• 제31권4호
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• pp.803-810
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• 2001

The purposes of this study were to investigate the relationship between cigarette smoking levels and periodontal status. 199 subjects, consisting of male 127 and female 72, classified by smoking levels and duration were selected: Patients who had smoked for more than 20 cigarettes/day were considered heavy smokers, 10 to 19, moderate smokers; 1-9, light smokers:0, non-smoker. And smokers were divided into ones who had smoked for more than 20 years, 10-19 years, less than 10 years and non-smokers. Heavy smokers and moderate smokers showed significantly greater pocket depths, less clinical attachment levels, more molar furcation involvements, greater alveolar bone loss and higher scores of plaque index than light smokers and non-smokers,(p < 0.05). When the duration of smoking was considered as a factor, scores of clinical parameters were worse and alveolar bone loss were significantly greater in long-term smokers, who had smoked for more than 20 years. In conclusion, cigarette smoking is associated with periodontal status.

• Journal of Trauma and Injury
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• 제34권2호
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• pp.126-129
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• 2021

Fat embolism syndrome is a rare, but serious condition that occurs in patients with fractures of the long bones or who undergo orthopedic surgery. The main clinical features of fat embolism syndrome are an altered mental status, hypoxia, and petechial rash. Cerebral fat embolism is the most severe manifestation of fat embolism syndrome because it can lead to an altered mental status. The diagnosis of cerebral fat embolism is clinical, but brain magnetic resonance image (MRI) is helpful. There is usually an interval until symptoms, such as an altered mental status, develop after trauma. We report a case of cerebral fat embolism in which the patient's mental status deteriorated several hours after trauma and the initial findings were negative on diffusion-weighted MRI.

• 대한영양사협회학술지
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• 제23권1호
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• pp.1-13
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• 2017

It is well known that malnutrition is a predictor of mortality in hemodialysis patients. The number of diabetic nephropathy patients is increasing rapidly. This study aimed to investigate nutritional status and nutrient intake according to the presence of diabetes among hemodialysis patients. The nutritional intake and general characteristics of outpatients at Ajou University Hospital (24 with diabetes and 30 without diabetes) were investigated between July and September 2015. Patients' general data were collected, and nutritional status by Patient-Generated Subjective Global Assessment (PG-SGA) was evaluated. Nutrient intakes were assessed according to 3-day food records. There was no significant difference regarding body weight between the two groups. However, the non-diabetic group showed a better nutritional status by Patient-Generated Subjective Global Assessment (PG-SGA) ($5.2{\pm}4.4$ vs. $8.0{\pm}4.3$ score, non-diabetics vs. diabetics, P<0.05). There was no difference in daily calorie intake ($1,473.9{\pm}370.5$ vs. $1,503.8{\pm}397.5kcal$) and protein intake ($60.3{\pm}19.7$ vs. $65.6{\pm}20.5g$) in those with diabetes. Intakes of vegetables protein, sodium, potassium, vitamin C, folic acid and fiber were significantly higher in the diabetic group compared to those of the non-diabetic group. There was no difference in daily nutrient intake between the hemodialysis weekday and weekend groups. The non-diabetic group had higher calorie and sodium intakes per meal in the hemodialysis weekday group, but the difference was not significant. Based on these results, intervention should be performed to improve nutritional status in consideration of diabetes and dietary patterns.

• 대한물리치료과학회지
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• 제6권2호
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• pp.1007-1017
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• 1999

The purpose of this study was to evaluate the factors influencing the ambulatory status in hemiplegia with intracerebral hemorrhage after rehabilitation. Thirty patients with stroke who was admitted in the Chosun University Hospital, between from January 1st' 1998 and December 31st' 1998, were included in this study. The following variables as a potential predictors for ambulation were evaluated at treatment of the stroke onset; 1) general characteristics including age and sex, and 2) clinical characteristics including frequency and onset time of the stroke, affected side, duration of the treatment, time interval between onset and rehabilitation, manual muscle test of paretic limb, sitting and standing balance, proprioception, perception, cognitive function. We compared and analyzed the these variables to the two type of ambulatory status at the time of the discharge by Modified Barthel Index, independent, dependent. The data were analyzed by student t-test, Fisher-exact test, Mann Whitney-U test, $X^{2}$-test, correlation analysis(spearman's). The results were as follows; 1. Were no significantly inflenced independent ambulatory status among general characteristics. 2. Frequency of the stroke and proprioception (p<0.05), muscle strength of the lower limb, cognitive function and standing balance (p<0.01), perception and sitting balance (p<0.001) were significantly inflenced independent ambulatory status among clinical characteristics. 3. Independent Variable correlated with the ambulatory status were muscle strength of the lower limb, proprioception and sitting balance (p<0.05), standing balance, frequency of the stroke, perception and cognitive function (p<0.01). Therefore the muscle strength of the lower limb, proprioception, sitting balance, standing balance, frequency of the stroke, perception, cognitive function were the most significant influencing factors of ambulatory status after rehabilitation.

• 한국임상보건과학회지
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• 제6권2호
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• pp.1156-1170
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• 2018

Purpose. This study was conducted to analyze fatigue and subjective oral health status in the employees in educational institutions and provide basic data for the development of a program for the promotion of oral health. Methods. As for the subjects, this study conducted a survey with 468 educational personnel in elementary, middle, and high schools in the Daegu-Gyeongbuk area from March through June 2016 and utilized 407 copies finally. As for the items on the survey, this study conducted an investigation on their general characteristics, fatigue, and subjective oral health status(halitosis, xerostomia, temporomandibular disorder) with the self-administered method. With the data collected, this study conducted frequency analysis, t-test, ANOVA, and multiple regression analysis, using SPSS 20.0 statistical program, and the statistical significance level was .05. Results. As a result of this study, it turned out that by sex, fatigue was higher in women(4.59 points); by the place of work, those in 'elementary school' had higher fatigue(4.59 points); and by health condition and oral health status, most of them responded that they were 'not healthy'(4.81 and 4.84 points, respectively) and there was a statistically significant difference (p<.05). As for the correlation between fatigue and subjective oral health status, there were positive(+) impacts on halitosis(=.248, p<.001), xerostomia(=.097, p<.05), and temporomandibular disorder(=.148, p<.01), so it turned out that there was a correlation between fatigue and subjective oral health status. Conclusion. Based on the result of an analysis of the impacts of the fatigue level on subjective oral health status, it is judged that it would be necessary to continue to build up a program that can promote the oral health status of the educational personnel. In addition, it is necessary to conduct studies continuously for the development and application of a program for the change in lifestyle and behavior that can lower their fatigue.

• 대한치과의사협회지
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• 제13권4호
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• pp.335-337
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• 1975

The auther observed the oral status of the 14 twins clinically, the obtainde results were as follow : 1. In each twins, the color of the teeth, the form of the uper central incisors, the periodontal conditions and the oral hygiene status were resemble each other. 2. In one twin, the dentition and the size of the palatine tonsil were different each other. 3. In two twins, the occlusion and the number of the dental caries were different each other. 4. In four twins, the eruptions of teeth were different each other.