• 한국임상약학회지
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• 제23권3호
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• pp.232-238
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• 2013

Background: Although thromboembolism is common and one of the major causes of mortality in cancer patients, maintaining therapeutic anticoagulation effect with warfarin is challenging. This study aimed to determine the prevalence and the causes of non-therapeutic INR (International Normalized Ratio) in cancer patients. Methods: Medical and pharmacy records for cancer patients managed by the pharmacist-run anticoagulation service (ACS) between May, 2010 and April, 2011 at Seoul National University Hospital were retrospectively reviewed. The causes of non-therapeutic INR were identified and compared with the results from a former study with mechanical heart valve patients. Results: A total of 335 cancer patients and 6,737 patient-visits were analyzed producing 68% (n=4,590) of non-therapeutic INR readings. Eighty-five percent of the non-therapeutic INR readings were categorized as sub-therapeutic. Frequent causes linked to non-therapeutic INR included inadequate dosage adjustment (21.8%), changes in health status (11.8%), dietary changes (8.1%), and drug interactions (4.2%). More than half of the non-therapeutic INR values had no known etiology. As causes for non-therapeutic INR, changes in health status (p<0.0001), adverse reactions (p<0.0001), and dietary changes (p=0.017) were statistically more frequent in cancer patients than in patients with mechanical heart valves. Furthermore, exposure to sub-therapeutic INR were more prevalent in cancer patients than in patients with mechanical heart valve (p<0.0001). Conclusions: This study shows that there is a tendency to keep the level of INR low and that health status change, dietary change, and drug interactions are found to be frequent causes for non-therapeutic INR in cancer patients.

• Clinical Nutrition Research
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• 제12권2호
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• pp.99-115
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• 2023

Patients with colorectal cancer may experience symptoms such as diarrhea, nausea, and anorexia, during surgery and chemotherapy, which can increase the risk of malnutrition. In addition, dietary habits play a key role in the onset of colorectal cancer; therefore, it is necessary to improve dietary habits to prevent recurrence during treatment after diagnosis. In this study, a clinical nutritionist conducted 4 interviews for patients diagnosed with colorectal cancer and scheduled for colectomy: before surgery, after surgery, 1st chemotherapy, and 2nd chemotherapy, and provided nutrition care for each treatment course to determine its effects on nutrition status and disease prognosis. Significant weight loss but no decrease in muscle mass was observed during treatment. Body fat mass, although not statistically significant, showed a decreasing tendency. The percentage of people who responded 'yes' to the below items increased after compared to before receiving nutrition education: 'I eat meat or eggs more than 5 times a week,' 'I eat seafood at least three times a week,' 'I eat vegetables at every meal,' 'I eat fruits every day,' and 'I eat milk or dairy products every day.' These results indicate that the patients changed their dietary habit from a monotonous eating pattern to a pattern of consuming various food groups after receiving nutrition education. These results suggest that continuous nutrition care by clinical dietitians, according to the patient's treatment process, can help improve the patient's nutritional status and establish healthy eating habits.

• 한국콘텐츠학회논문지
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• 제13권2호
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• pp.322-330
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• 2013

본 연구는 치과위생사의 비판적 사고성향, 직무만족도, 임상적 의사결정능력을 알아보고, 변인간의 관계를 규명하여 치과위생사 교육 전략 수립의 기초 자료를 제공하고자 한다. 대상자의 대부분은 평균연령 30.6세, 여성, 전문대학졸업, 7년 이상 경력, 치과의원에 근무하는 것으로 나타났다. 비판적 사고성향에서 진실추구 3.36점, 성숙 3.00점으로 나타났다. 임상적 의사결정능력에서는 가치와 목표에 대한 검토가 3.39점, 대안과 선택에 대한 조사가 3.10점으로 나타났다. 직무만족에서 전문적 위치 3.20점, 보수 및 승지에서 2.84점으로 나타났다. 비판적 성향에서는 종교, 학력, 총 근무경력, 근무현장에서 통계학적으로 유의한 차이가 있었으며, 임상적 의사결정능력에서는 종교와 학력에서 유의한 차이가 있었고, 직무만족에서는 종교, 학력, 총 근무경력, 근무현장에서 그룹간의 유의한 차이가 있었다. 비판적 사고성향은 임상적 의사결정능력 및 직무만족도에서 정적인 상관관계를 나타났다. 임상적 의사결정능력은 직무만족도에서 정적인 상관관계를 나타냈다. 본 연구결과를 통해 비판적 사고성향과 임상적 의사결정능력과 직무만족도간에 유의한 상관관계를 보여주므로, 학부 교육 과정에서부터 비판적 사고성향과 임상적 의사결정 능력과 직무만족을 향상시킬 수 있는 내용을 포함시키고, 임상현장에 있는 치과위생사를 위한 지속적인 추가 실무교육을 실시해야 한다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.366-370
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• 2005

Tissue microarry is one of the high throughput technologies in the post-genomic era. Using tissue microarray, the researchers are able to investigate large amount of gene expressions at the level of DNA, RNA, and protein The important aspect of tissue microarry is its ability to assess a lot of biomarkers which have been used in clinical practice. To manipulate the categorical data of tissue microarray, we applied Bayesian network classifier algorithm. We identified that Bayesian network classifier algorithm could analyze tissue microarray data and integrating prior knowledge about gastric cancer could achieve better performance result. The results showed that relevant integration of prior knowledge promote the prediction accuracy of survival status of the immunohistochemical tissue microarray data of 18 tumor suppressor genes. In conclusion, the application of Bayesian network classifier seemed appropriate for the analysis of the tissue microarray data with clinical information.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.171-173
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• 2002

Present status of the proton therapy project at the Wakasa Wan Energy Research Center, Japan, is reported. Construction of the accelerator system was finished in 2001, followed by some trials of the production of the flat clinical irradiation field for the clinical usage. After the patient positioning system with X-ray CT was verified, the first clinical trial was started for two patients with prostate cancer.

• 대한한의학회지
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• 제28권4호
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• pp.13-17
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• 2007

Owing to improvement of socioeconomic status during recent decades in Korea, incidence of hepatitis A has rapidly decreased, especially among children. However, this status has paradoxically caused a steady increase of adult patients with HAV infection, causing new medical issues associated with aggravated clinical symptoms. The present study reports an adult case of acute viral hepatitis type A treated with oriental medicine. The elevated biochemical findings(AST, ALT, gamma-GTP, bilirubin), physical symptoms (general weakness, nausea, right flank pain, itching sign), and serological makers (anti-HAV IgM and anti-HAV IgG) were normalized within four weeks. Also, sonographic examination showed a normal pattern on an enlarged liver image. This study informed us about the clinical capacity of oriental medicine for adult patients with acute viral hepatitis type A.

• 대한임상검사과학회지
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• 제39권2호
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• pp.86-90
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• 2007

Intestinal parasitic infections remain a serious public health problem globally and have usually been associated with human malnutrition. This study was performed to observe the present status of intestinal helminthes infections among the primary school children in Iksan, Korea, during the period from June to August, 2006. A total of 974 fecal samples (male 479, female 495) were collected and examined by formalin-ether sedimentation technique for intestinal helminthes eggs. Of the 974 samples examined, 2 (0.2%) were egg positive for intestinal helminthes, and only eggs of Clonorchis sinensis were observed in the 2 cases. These C. sinensis egg were found in grade 5 (male, 1 case) and grade 6 (female, 1 case), respectively. The egg positive rate of male and female were 0.2%, respectively. Through this survey, I found that the C. sinensis infection is prevalent among primary school children in Iksan, Jeonbuk, and a continuous health education for school children is recommended to prevent the potential infection of C. sinensis.

• Journal of Periodontal and Implant Science
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• 제28권2호
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• pp.273-280
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• 1998

This study was to compare the patients wearing comfortable distally extending cantilever bridges (DECBs) with those having discomfortable ones, in the aspect of the periodontal condition & prosthodontic status. The subjects in the present study were 164 patients appointed to Seoul National University Dental Hospital. One group was consisted of 101 patients wearing comfortable DECBs and the other group were made of 64 patients who had felt discomfort. On clinical parameters, there were no significant difference between 2 groups in plaque index, tooth mobility & probing depth, but gingival index was higher in group wearing discomfortable DECBs. In prosthodontic status, the ratio of pontic oversize was higher in the group of discomfortable DECBs, but there were no significant difference in the view of crown overcontour, overhanging margin & interproximal space closure between 2groups. This study failed to clarify causal factors of discomfortable DECBs.

• 대한임상검사과학회지
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• 제46권3호
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• pp.85-90
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• 2014

The purpose of this study was to investigate the prevalence and differences of risk factors of Metabolic syndrome according to menopausal status. From the database of the 5th Korea National Health and Nutrition Examination Survey (KNHANES V) conducted in 2012, data of 3,537 women who responded to health interview and health examination questionnaires. The presence of Metabolic syndrome was assessed using the International Diabetes Federation (IDF) criteria. The prevalence of Metabolic syndrome was 17.3% in premenopause and 54.3% in postmenopause. BMI, waist circumference, blood pressure, total cholesterol, LDL cholesterol, triglyceride, and Ferritin were higher in postmenopausal women compared to premenopausal women. However, postmenopausal women had lower HDL cholesterol and TIBC when compared to premenopausal women. Hypertension was the most prominent characteristic of postmenopausal women. Low HDL cholesterol showed up as a meaningful factor in premenopausal women. According to multiple regression analysis, waist circumference, fasting glucose, and HDL cholesterol were independent predictors of menopause. Therefore, obesity control and blood lipids management is recommended for postmenopausal women.

• 지역사회간호학회지
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• 제17권4호
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• pp.451-460
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• 2006

Purpose: The purpose of this research was to examine the effects of an exercise program on the physical, physiological, and emotional status of the aged. Method: This research adopted a nonequivalent control group pretest-posttest design. The subjects were 46 elders aged over 60 who were selected from those registered at three local health centers in G City, and 27 of them were assigned to the experimental group and 19 to the control group. The independent variable was the exercise program, and the dependent variables were physical status, physiological status, and emotional status. The exercise program was Performed for 60 minutes per time, 3 times a week and for 6 weeks. Data were collected from October to November, 2005. Result: Compared to the control group, the experimental group showed significant improvements in right lower extremity strength (F=46.119, p=.000), left lower extremity strength (F=53.265, p=.000) and waist flexibility (t=3.183, p=.003) as physical status, and in depression (t=-3.703, p=.001), perceived health status (t=4.821, p=.000), and self efficacy (t=3.866, p=.000) as emotional status. Conclusion: The results showed that the exercise program was effective in promoting the physical status, physiological status, and emotional status of the aged. Therefore, it is recommended to apply the program as a nursing intervention in clinical practice and education in communities.