• 제목/요약/키워드: clear

검색결과 11,412건 처리시간 0.037초

Profiling of Gene Expression According to Cancer Stage in Clear Cell Type of Renal Cell Carcinoma

  • Won, Nam-Hee;Ryu, Yeon-Mi;Kim, Ki-Nam;Kim, Meyoung-Kon
    • Molecular & Cellular Toxicology
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    • 제1권1호
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    • pp.62-71
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    • 2005
  • For toxicity model in the kidney, renal cell carcinoma (RCC) is one of the most important model to assess the structural and functional alterations. Most RCCs are sporadic, and environmental agents are suspected to play a role in the etiology of the disease. In this study, we discovered novel evidence for previously unknown gene expression patterns related to progression according to cancer stage in RCC. Four clear cell RCC tissue samples along with five corresponding patient-matched normal kidney tissue samples were obtained from patients undergoing partial or radical nephrectomy. To examine the difference of gene expression profile in clear cell RCC, radioactive cDNA microarrays were used to evaluate changes in the expression of 1,152 genes in a total. Using $^{33}P-labeled$ probes, this method provided highly sensitive gene expression profiles including drug metabolism, and cellular signaling. 29 genes were identified with expression levels that differed by more than 2.0 value of z-ratio, compared with that in control. Whereas expression of 38 genes were decreased by less than-2.0 value of z-ratio. In conclusion, this study has identified 67 gene expression alterations in clear-cell type of RCC. Most notably, genes involved in cell growth were up-regulated in stage I more than stage III whereas genes involved in signal transduction were down-regulated in which both stage I and stage III. The identified alteraions of gene expression will likely give in sight in to clear cell RCC and tumor progression.

소아의 견갑골에 생긴 투명세포연골육종 - 1예 보고 - (Clear Cell Chondrosarcoma of the Scapula in a Child -A Case Report-)

  • 이경지;이안희;김진아;김형민;이교영
    • 대한골관절종양학회지
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    • 제15권2호
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    • pp.155-159
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    • 2009
  • 투명세포연골육종은 모든 연골육종의 2%를 차지하는 매우 드문 저등급성 종양이다. 주로 긴뼈의 뼈끝에서 발생하며 대퇴골과 상완골의 근위부에서 가장 흔하고, 견갑골을 포함한 납작뼈에는 드물다. 25-50세 사이의 연령에서 호발하며, 20세 이전의 발생은 흔치 않다. 조직학적으로 종양 세포는 소엽상 무리를 지어 관찰되며, 투명하고 풍부한 세포질을 특징적으로 가진다. 저자들은 8세 여아의 견갑골에서 발생된 투명세포연골육종을 보고하고자 한다.

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대학생의 간호사에 대한 이미지 (College Students' Images of Nurses)

  • 김복랑;김선희;김옥숙;남영화;이길자;정복례
    • 대한간호
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    • 제35권4호
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    • pp.75-91
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    • 1996
  • The purpose of this study was to identify the college students' images of Nurses. Data were collected by open-ended questionnaire. 326 subjects were composed of nursing students and non nursing students who attended in universities and junior colleges at Pusan, Kyung-buk, and Chung-buk from April 30 to May 31, 1995. Collected data were analyzed by all researchers. Statements were categorized and endowed with Key meaning. The results were 1. Positive images of nurses were classified into 21 categories. They were , , , , , , , , , , , , , , , , , , , . 2. Among the positive images categories, statements about the were the most. Statements about , , , were a lot. 3. For nusing students, statements about the were the most. Statements about , , , were a lot 4. For non-nursing students statements about the were the most. Statements about , , , were a lot. 5. For nursing students who have no experience of the clinical practice statements about , , were a lot. 6. For nursing students who have not experience of the clinical practice, statements about , , were a lot. 7. Negative images of nurses were classified into 21 categories. They were , , , , , , , , , , , , , , , , , , , . 8. Among the negative image categories, statements about the were the most. satements about , , , , were a lot.

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Prevalence and Clinical Significance of Mammalian Target of Rapamycin Phosphorylation (p-mTOR) and Vascular Endothelial Growth Factor (VEGF) in Clear Cell Carcinoma of the Ovary

  • Khemapech, Nipon;Pitchaiprasert, Sunaree;Triratanachat, Surang
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권12호
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    • pp.6357-6362
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    • 2012
  • Background: To determine the prevalence of mammalian target of rapamycin phosphorylation (p-mTOR) and vascular endothelial growth factor (VEGF) and any correlation with clinical characteristics and prognosis in ovarian clear cell carcinoma patients. Materials and Method: Seventy four paraffin-embedded specimens of such carcinomas frompatients who underwent surgery, received adjuvant chemotherapy and were followed up at King Chulalongkorn Memorial Hospital during January 2002 to December 2008 were stained with rabbit monoclonal IgG p-mTOR and rabbit polyclonal IgG VEGF using immunohistochemical methods. Medical records were reviewed and clinical variables were analysed. Results: The prevalence of positive p-mTOR in ovarian clear cell carcinoma was 87.9% and significantly higher in advance-stage than early-stage patients (100% versus 83.6%, P<0.05). Two-year disease free survival and 2-year overall survival in patients with positive p-mTOR expression were 60% and 69.2% with no differences from patients with negative p-mTOR expression (p>0.05). The prevalence of VEGF expression was 63.5% and significantly higher in chemo-sensitive than chemo-resistant patients (70.7% versus 37.5%, P<0.05). Two-year disease free survival and 2-year overall survival in patients with VEGF expression were 72.3% and 83% respectively which were significantly different from patients with negative VEGF expression (p<0.05). Conclusions: p-mTOR expression in ovarian clear cell carcinoma was significantly correlated with the stage of disease. VEGF expression was significantly correlated with chemosensitivity, and survival. Further studies of related targeted therapy might be promising.

한국산 삽주의 기능성 (Functional Properties of Korean Atractylodes japonica Koidz)

  • 강은미;정창호;심기환
    • 한국식품저장유통학회지
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    • 제8권1호
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    • pp.86-91
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    • 2001
  • 생삽주의 기능성을 분석한 결과, 추출 수율은 ethanol 추출물에 14.8%와 water 분획물에 17.7%를 나타내었다. Acetone 추출물과 butanol 분획물의 수소공여 능은 각각 72.9%와 74.2%로 높게 나타났으며, methanol 추출물과 butanol 분획물의 아질산염 소거 효과는 각각 95.0%와 79.2%로 가장 높게 나타났다. 생삽주의 용매별 추출물 중 methanol 추출물이 높은 항균 활성을 나타내었는데, Bacillus subtilis에 대해 20 mm clear zone을 나타내었으며, Pseu. aeruginosa에 대해 19 mm clear zone을 나타내었다. 항균 활성이 가장 높은 methanol 추출물을 계통분획하여 항균 활성을 확인한 결과, butanol 분획물이 높은 항균 활성을 나타내었는데, Bac. subtilis, V. parahaemolyticus에 대해 각각 18 mm clear zone을 나타냈다. Methanol 추출물과 butanol 분획물을 이용하여 최소저해농도를 확인한 결과 대체로 gram(+)균에 대해 2 mg/disc와 4 mg/disc에서 나타났구 gram(-)균에 대해서는 6 mg/disc에서 저해활성을 나타내었다.

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국조리의 과학화에 관한 연구 - 맑은장국을 중심으로 - (A Study on the standardizing of Recipe for Soup Making - Focused on Clear Soup -)

  • 홍진숙
    • 한국식품조리과학회지
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    • 제15권6호
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    • pp.595-602
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    • 1999
  • This study was intended to develop traditional Korean soup recipe which can be used for food service and meet consumers' taste with a focus on clear soup such as clear radish soup, sea mustard soup, dried pollack soup, croaker soup, and backbone soup. The developed sample(S1) showed the highest level of overall preference among consumers. There were significant differences in sensory characteristics of the samples especially between S1 and others. The sensory characteristics of each soup showed a slight difference depending on the kind of soup, however, all items had an effect on overall preference. One of the standardized recipe to make broth was presented as follows: The ingredients for broth consists of the shank or brisket of beef(100 g), water(10 cup), spring onion(20 g), onion(30 g), garlic(10 g), salt(1 teaspoonful), and black pepper power(1/10 teaspoonful). 1) The meat part of shank or brisket is prepared. 2) The unfrozen meat is immersed in cold water for 20 min, whereby blood is extracted from the meat. 3) 10 cups of water are poured into the pan and boiled enough. 4) After water has boiled enough, the lump of meat with blood extracted is cut into 2 or 3 pieces and is boiled in the boiling water by high-intensity heat with the pan lid uncovered, and dirty foam is scooped out while boiling. 5) If the broth begins to be extracted, the intensity of heat is lowered for boiling for one hour or so, and then again boiled for 30 min with spring onion, garlic, onion and the like. If the broth is extracted enough, spring onion, garlic, onion, and others are removed from the pan. the broth is seasoned with salt and black pepper powder, and foam is removed by using fine mesh sieve or gauze. Then, 6 cups of clear broth is obtained finally.

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IEEE 802.15.4 Network의 전송효율 향상을 위한 Enhanced Semgentized Clear Channel Assessment 기법 (Enhanced Segmentized Clear Channel Assessment Method for IEEE 802.15.4 Network)

  • 손규정;장태규
    • 전기전자학회논문지
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    • 제20권3호
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    • pp.322-325
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    • 2016
  • 본 논문에서는 Enhanced Segmentized Clear Channel Assessment(ESCCA)를 수행하여 디바이스의 데이터 전송 기회를 증가시킴으로써 전체 네트워크의 전송효율을 향상시킬 수 있는 기법을 제시하였다. 본 논문에서 제시한 기법은 IEEE 802.15.4 에서 채널 상태탐지를 위해 수행되는 Energy detection based CCA 의 기간을 반으로 나누고, 채널 상태에 따라 CCA 를 추가적으로 수행함으로써 디바이스의 패킷 전송기회를 증가시켜 전체 네트워크의 전송 효율을 향상시킨다. 제시한 기법의 타당성을 확인하기 위하여 star topology 네트워크에서 디바이스들이 코디네이터로 패킷을 전송하는 환경에 본 논문에서 제시한 기법을 적용하여 IEEE 802.15.4 의 CCA 및 Segmentized CCA 기법을 적용한 결과와 성능을 비교하였다. 실험결과, throughput은 IEEE 802.15.4 CCA에 비해 최대 약 10kbps, 평균 CCA 횟수는 최대 약 15회 감소하였음을 확인하였다.

한국산 산민달팽이 ( Incilaria fruhstorferi ) 후촉각의 형테 및 조직화학적인 연구 (A Morphological and Histochemical Study on the Posterior Tentacle Antenna of the Korean Slug , Incilaria fruhstorferi)

  • 김영언;장남섭
    • 한국패류학회지
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    • 제12권1호
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    • pp.1-17
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    • 1996
  • Morphological and histochemical characteristics of the cells in posterior tentacle antenna of Korean slug, Incilaria fruhstorferi were observed with light microscope. The epithelium of the posterior tentacle antenna was composed of supporting cells, sensory neurons and type-a clear cell. The columnar supporting epithelium was widely distributed in the posterior tentacle antenna, and the upper end of the cell was covered with acidic mucopolysaccharide. Nerve endings of the sensory neuron were distributed between type-a clear cells. It was usually located in tentacular knob, and the number of them gradually decrdased as close as tentacular stalk. Several cilia were observed on the nerve ending. Type-a clear cells were very brightly stained with all staining used, and the neutral mucous guanules distributed in the cytoplasm. Collar cells, type-b clear cell and various types of secrdtory cells distributed in the connective tissue. The collar cells were clustering in connective tissue, and the cytoplasm were filled with neutral mucous guanules. The cells and granules were stained with dark brown by silver nitrate stain. Type-b clear cells were irregular in shape and their cytoplasms were brightly stained wth many stains used. Ten types of secretory cells evenly distributed in the connective tissue and muscle layers of the posterior tentacle antenna. The five types of the secretory cells(A, B, E, J and L)seemed to secrete acidic mucopolysaccharide, and the other five type of the cell(C, D, F, H, and L)seemed to secrete neutral mucopolysaccharide. Muscular tissue composed of well-developed thick longitudinal muscle layers and thin circular muscle layers. Type-L secretory cells clustered only in muscular layers and they contained acidic mucopolysaccharides.

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투광형 박막 BIPV 창호 적용에 따른 냉난방 및 조명 부하 저감에 관한 연구 (A Study on Analysis for Energy Demand of the Heating, Cooling and Lighting in Office Building with Transparent Thin-film a-Si BIPV Window)

  • 윤종호;안영섭;박장우;김빛나
    • KIEAE Journal
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    • 제13권3호
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    • pp.91-96
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    • 2013
  • The purpose of this study was to analyze the annual energy demand including heating, cooling and lighting according to kind of windows with transparent thin-film a-Si Building Integrated Photovoltaic(a-Si BIPV) for office building. The analysis results of the annual energy demand indicated that the a-si BIPV window was reduced by 8.4% than the clear gazing window. The base model A was combinate with a-Si BIPV window area of 67% and clear window area of 33% among the total exterior area. The model B is to be applied with low-e clear glass instead of clear glass of the base model A. The model B was reduced to annual energy demand of 1% more than the model A. Therefore, By using a-si BIPV solar module, the cooling energy demand can be reduced by 53%(3.4MWh) and the heating energy demand can be increase by 58%(2.4MWh) than clear glazing window in office building. Also, Model C applied to the high efficient lighting device to the model B was reduced to annual energy demand of 14.4% more than the Model D applied to the high efficient lighting device to the model A. The Model E applied with daylight dimming control system to the Model C was reduced to annual energy demand of 5.9% more than Model C.

일축인장시험을 통한 투명교정장치용 고분자 소재의 역학적 특성 분석 (Analysis of Mechanical Properties of Polymer Material for Clear Aligner using Uniaxial Tensile Test)

  • 정지영;제태진;전은채
    • 한국기계가공학회지
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    • 제17권5호
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    • pp.64-69
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    • 2018
  • Clear aligners are popular in the field of dental orthodontic treatment because they offer a discreet alternative to braces due to their use of transparent materials. They are formed from flat transparent polymer materials by hot pressed molding. It is necessary to know the mechanical properties of the polymer materials to be able to form the exact shapes of the clear aligners. However, this information is not publicly available. In this study, we present a method to reliably measure the mechanical properties of clear aligner polymer materials and analyze the factors effecting these mechanical properties. First, we surveyed standards related to the mechanical properties of polymer materials to obtain reliable data. Consequently, ISO 527 was selected for use in this study because of the size and thickness of the flat transparent polymer material. The uniaxial tensile tester was constructed and it was verified whether displacement of a crosshead could be regarded as a displacement of gauge-length by optical analysis. Uniaxial tensile tests of three thicknesses from three different companies were performed and each engineering stress-strain curve was measured. Tensile strengths and elastic moduli were obtained by analysis of the stress-strain curves. The tensile strength and elastic modulus of ISO 527 was found to be approximately 50MPa and 2.3GPa, respectively. Both values showed material and thickness dependency.