• Journal of Life Science
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• v.24 no.10
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• pp.1144-1150
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• 2014

The eIF4E protein is the key regulator of translation initiation. The interaction of eIF4E with eIF4G triggers the translation of mRNA, and several proteins interrupt this association to modulate translation. Human 4E-T is one of the eIF4E-binding partners that represses the translation of bound mRNAs, and it is involved in the transport of eIF4E to processing bodies (P-bodies). Although Clast4, the mouse homolog of human 4E-T, might play critical roles in the regulation of translation, its properties are not well known. In this report, we deciphered the properties of Clast4 by determining its phosphorylation state, binding to eIF4E, and effects of overexpression on cell proliferation. Clast4 was phosphorylated by protein kinase A (PKA) in vivo on several residues of its amino terminus. Nevertheless, the PKA phosphorylation of Clast4 appeared to have no effect on either its eIF4E-binding ability or localization. Clast4 interacted with eIF4E1 and CPEB. The conserved eIF4E-binding sequence in Clast4, $YXXXXL_{\phi}$, was important for binding eIF4E1A but not eIF4E1B. Similar to that of another well-known eIF4E regulator, the eIF4E binding protein (4E-BP), the overexpression of Clast4 decreased cell proliferation. These results suggest that Clast4 acts as a global translation regulator in cells.

• Ocean and Polar Research
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• v.24 no.3
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• pp.289-300
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• 2002

The Lago Sofia conglomerates encased in the Cretaceous Cerro Toro Formation, southern Chile, represent a gigantic submarine channel system developed along a foredeep trough. The channel system consists of several tributaries along the trough margin and a trunk channel along the trough axis. Voluminous debris flows were generated ubiquitously along the tract of the submarine channel mainly by the failure of nearby channel banks or slopes. The flows transformed immediately into multiphase flows and resulted in very thick-bedded mass-flow deposits with a peculiar structure sequence. The mass-flow deposits commonly overlie fluted or grooved surfaces and consist of a lower division of clast-supported and imbricated pebble-cobble conglomerate with common basal inverse grading, and an upper division of clast- to matrix-supported and disorganized pebble conglomerate or pebbly mudstone with abundant intraformational clasts. The structure sequence suggests a temporal succession of a turbidity current, a bipartite hyperconcentrapted flow with active clast collisions near the flow base, and a cohesive debris flow probably with a rigid plug. The multiphase flow is interpreted to have resulted from transformation of clast-rich but cohesive debris flows. Cohesive debris flows appear to transform more easily into dilute flow types in subaqueous environments because they are apt to hydroplane. This is in contrast to the flow transitions in subaerial environments where noncohesive debris flows are dominant and difficult to hydroplane.

• Ocean and Polar Research
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• v.23 no.2
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• pp.97-107
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• 2001

The Sejong Formation of Late Paleocene to Eocene is a lower volcaniclastic sequence unconformably overlain by upper volcanic sequence, and distributed along the southern and southeastern cliffs of the Barton Peninsula. The Sejong Formation is divided into five sedimentary facies; disorganized matrix-supported conglomerate (Facies A), disorganized clast-supported conglomerate (Facies B), stratified clast-supported conglomerate (Facies C), thin-bedded sandstone (Facies D), and lapilli tuff (Facies E), based on sedimentary textures, primary sedimentary structures and bed geometries. Individual sedimentary facies is characterized by distinct sedimentary process such as gravel-bearing mudflows or muddy debris flows (Facies A), cohesionless debris flows (Facies B),unconfined or poorly confined hyperconcentrated flood flows and sheet floods (Facies C), subordinate streamflows (Facies D), and pyroclastic flows (Facies E). Deposition of the Sejong Formation was closely related to volcanic activity which occurred around the sedimentary basin. Four different phases of sediment filling were identified from constituting sedimentary facies. Thick conglomerate and sandstone were deposited during inter-eruptive phases (stages 1, 3 and 4), whereas lapilli tuff was formed by pyroclastic flows during active volcanism (stage 2). These records indicate that active volcanism occurred around the Barton Peninsula during Late Paleocene to Eocene.

• Journal of the Korean earth science society
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• v.27 no.7
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• pp.757-767
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• 2006

Alluvial-plain deposits in the southeastern part of the Eumsung Basin (Cretaceous) are characterized by coarse-grained channel fills encased in purple siltstone beds. It represents distinct channel geometry, infill organization, and variations in facies distribution. The directions of paleocurrent, sedimentary facies changes, and channel-fill geometry can be used to reconstruct a channel network in the alluvial system developed along the southeastern margin of the basin. The channel-fill facies represent downstream changes: 1) down-sizing and well-sorting in clast and martix of channel fills and 2) internal organization of scour fill or gravel lag and overlying cross-stratified, planar-stratified beds. These findings suggest multiple stages of channel-filling processes according to flooding and subsequent stream flows. In the small-scale pull-apart Eumsung Basin (${\sim}7{\times}33km^2$ in area), vertical-stacked alluvial architecture of the coarse-grained channel fills encased in purple siltstone is expected to result from episodic channel shifting under a rapidly subsiding setting.

• Journal of the Korean earth science society
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• v.31 no.1
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• pp.18-35
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• 2010

Facies analysis of the Late Triassic Hajo Formation, the lowest stratigraphic unit in the Chungnam Basin, shows that the lower part is composed mainly of breccias or conglomerates; the middle part, conglomerates; and the upper part, conglomerates and sandstones. The formation consists of 13 facies, which include horizontally stratified clastsupported conglomerate, clast-supported massive breccia, matrix-supported massive breccia or conglomerate, matrixsupported graded conglomerate, massive pebbly sandstone, horizontally laminated sandstone, massive sandstone, graded sandstone, inversely graded sandstone, planar cross-bedded sandstone, trough cross-bedded sandstone, low angle crossbedded sandstone, and massive mudstone. These are grouped into 4 facies associations (FA). FA I consisted of clastsupported and matrix-supported massive breccias presumably deposited in the talus or upper fan delta environment. FA II consists of matrix-supported massive conglomerate and horizontally stratified clast-supported conglomerate of cobble size and it seems to have been deposited in the upper fan delta environment. FAIII consisted of matrix-supported massive conglomerate of pebble size, horizontally laminated sandstone and massive sandstone may have been deposited in the middle fan delta environment. FAIV consists of massive pebbly sandstone, horizontally laminated sandstone and massive sandstone and presumably was deposited in the lower fan delta environment. In general the Hajo Formation is interpreted to have been deposited at the talus/upper fan delta environment in early stage; it might have been deposited in the alternating environments of upper and middle fan delta in middle stage; and it seems to have been deposited in alternating environments of middle and lower fan delta in late stage.

• Ocean and Polar Research
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• v.39 no.2
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• pp.85-106
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• 2017

The Lago Sofia conglomerate in southern Chile is a deep-marine gravelly deposit, which is hundreds of meters thick and kilometers wide and extends laterally for more than 100 km, filling the foredeep trough of the Cretaceous Magallanes Basin. For understanding the depositional processes and environments of this gigantic deep-sea conglomerate, detailed analyses on sedimentary facies, architecture and paleoflow patterns were carried out, highlighting the differences between the northern (Lago Pehoe and Lago Goic areas) and southern (Lago Sofia area) parts of the study area. The conglomerate bodies in the northern part occur as relatively thin (< 100 m thick), multiple units intervened by thick mudstone-dominated sequences. They show paleoflows toward ENE and S to SW, displaying a converging drainage pattern. In the southern part, the conglomerate bodies are vertically interconnected and form a thick (> 400 m thick) conglomerate sequence with rare intervening fine-grained deposits. Paleoflows are toward SW. The north-to-south variations are also distinct in sedimentary facies. The conglomerate bodies in the southern part are mainly composed of clast-supported conglomerate with sandy matrix, which is interpreted to be deposited from highly concentrated bedload layers under turbidity currents. Those in the northern part are dominated by matrix- to clast-supported conglomerate with muddy matrix, which is interpreted as the products of composite mass flows comprising a turbidity current, a gravelly hyperconcentrated flow and a mud-rich debris flow. All these characteristics suggest that the Lago Sofia conglomerate was formed in centripetally converging submarine channels, not in centrifugally diverging channels of submarine fans. The tributaries in the north were dominated by mass flows, probably affected by channel-bank failures or basin-marginal slope instability processes. In contrast, the trunk channel in the south was mostly filled by tractive processes, which resulted in the vertical and lateral accretion of gravel bars, deposition of gravel dunes and filling of scours and channels, similar to deposits of terrestrial gravel-bed rivers. The trunk channel developed along the axis of foredeep trough and its confinement within the trough is probably responsible for the thick, interconnected channel fills. The large-scale architecture of the trunk-channel fills shows an eastward offset stacking pattern, suggesting that the channel migrated eastwards most likely due to the uplift of the Andean Cordillera.

• Proceedings of the Korean Geotechical Society Conference
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• 2003.03a
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• pp.469-474
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• 2003

Talus topography is that rock clasts that is weathered is accumulated dropping in steep slope to action of gravity. Rock fall talus is formed by the accumulation of rock debris falling as individual particles from a cliff. If the collapse is produced in talus slope, it will be possible the loss of manpower and country. Despite correct access about talus is required, domestic research was scientific access about talus short. The aim of the present study is to review and compare fabric data derived from rock fall talus about orientation, distribution and morphology in Sukam area. These deposits tend to have approximately equal amounts of clasts oriented parallel and perpendicular to the dip direction of the slope. And, platy-shaped clasts dominate the proximal and intermediate parts of the talus, whereas blocky-shaped clasts is more common in the distal part.

• Journal of The Geomorphological Association of Korea
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• v.23 no.3
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• pp.93-104
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• 2016

High school textbooks of world geography show geomorphic featuresin arid environments such as sand dune, yardang and ventifact which are largely created by aeolian processes. Desert pavements, ubiquitous armored surfaces composed of a mosaic of clasts in hot and arid regions, are introduced as a major landform which can be attributed to wind erosion. However, they are formed by a variety of processes including deflation, surface runoff, upward clast migration and dust accretion that cause coarse particles concentration at the surface. The deflation by wind leaving a lag of coarse clasts has been solely regarded at home, even though the classical mechanism of deflation has been evaluated as a relatively unimportant process of pavement formation abroad through empiricalstudies. The accretionary model is gaining wider acceptance, thus implying that desert pavements could be formed through deposition of aeolian material. In addition, sheetflood and upward migration of clasts, irrelevant to the aeolian processes, could also create stone pavements. As a consequence, the deflation process in high school textbooks has to be urgently modified into a range of processes including aeolian mantling. By stressing that desert pavements are an exceptional geomorphic feature in deserts where wind is a predominant geomorphic agent, they can be used as a good example to demonstrate that a landform is not monogenetic.

• Economic and Environmental Geology
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• v.29 no.5
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• pp.639-660
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• 1996

The lowest formation of the Cretaceous Gyeongsang Supergroup, the Nakdong Formation, unconformably overlies the gneiss complex basement in Hadong, Gyeongsangnam-do and Gwangyang, Chullanam-do. The Nakdong Formation of the study area is 500-600 m thick and occurs as a belt shape. Based upon lithology, sedimentary structure, and bedding geometry the formation consists of three conglomerate facies (Gd, Gn, Gic), five sandstone facies (Sh-n, Sh-i, Sp, Sr, Sm), and four mudstone facies (Mf, Mfn, Mc, Mv). Sandstone facies are the most prominent in the study area. The twelve facies can be grouped into five facies associations. The depositional settings are elucidated from analyses of 12 facies and five facies associations of the formation. The lower part of the Nakdong Formation was deposited in alluvial plain, and the middle and upper parts were in a riverine system. The lithologies of the Nakdong Formation of the Gyeongsang Basin have been considered to consist of generally conglomerates and pebbly sandstones that were accumulated in alluvial fans. But the common lithology of the study area is sandstone which was formed in lower part of alluvial fan or fluvial setting. It is supposed that the coarser sedimentary sequence distributed west to the study area should be eroded out after deposition and early uplift, and the finer sandstone sequence in the east remains behind. The mineral composition of sandstones and the clast composition of conglomerates indicate that the Nakdong Formation was derived mainly from the metamorphic source rocks. Some reworked intraclasts were also supplied from the intrabasinal sedimentary layers. Paleocurrent data collected from cross-beddings, ripple marks, asymmetric sand dune suggest that most sediments were transported from north to south during the Nakdong Formation time.

• Journal of Periodontal and Implant Science
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• v.29 no.4
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• pp.995-1005
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• 1999

Alveolar bone destruction is a character-istic of periodontal disease. Treponema denticola are found in significantly increased numbers in the sites affected with periodontal disease. In order to clarify the role of T. denticola in destruction of alveo-lar bone in periodontal disease, this study was undertaken to determine the effect of sonicated extract of T. denticola on osteo-clast differentiation in co-culture system of mouse bone marrow cells and calvaria cells. The ability of osteoclast formation was estimated by counting the number of tar-tartrate resistant acid phosphatase(TRAP) positive cells. Sonicated extract of this bacteria stimulated osteoclast formation in a dose dependent manner(p<0.05). Indomathacin, an inhibitor of prostaglandin synthesis, decreased osteoclast formation induced by sonicated extract of this bacte-bacteria(p<0.05). Extract-induced osteoclast formation was decreased, when sonicated extract of bacteria was heated(p<0.05). These findings suggest that T. denticola induces osteoclast differentiation, and protein component of this bacteria and $PGE_2$ may play an important role in this process.