• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.273-275
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• 2022

The use of drugs by pregnant women poses a potential risk to the fetus. Therefore, it is essential to classify drugs that pregnant women should prohibit. However, the fetal toxicity of most drugs has not been identified. This takes a lot of time and cost. In silico approaches, such as virtual screening, can identify compounds that may present a high risk to the fetus for a wide range of compounds at the low cost and time. We collected class information of each drug from the hazard classification lists for prescribing drugs in pregnancy by the government of Korea and Australia. Using the structural and chemical features of each drug, various machine learning models were constructed to predict fetal toxicity of drugs. For all models, the quantitative performance evaluation was performed. Based on the attention algorithm, important molecular substructures of compounds were identified in the process of predicting the fetal toxicity of the drug by the proposed model. From the results, we confirmed that drugs with a high risk of fetal toxicity can be predicted for a wide range of compounds by machine learning. This study can be used as a pre-screening tool for fetal toxicity predictions, as it provides key molecular substructures associated with the fetal toxicity of compounds.

• Korean Journal of Health Psychology
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• v.14 no.1
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• pp.1-26
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• 2009

This paper deals with fundamental questions how we should understand and approach the gambling addiction problems optimally. We attempted to define the nature of gambling behaviors first and to understand gambling addiction as an extreme class of behaviors on a behavioral continuum. This frame of reference would allow researchers to diagnose, classify, and evaluate gambling problems clearly, and to estimate prevalence rate and incidence rate more accurately from a perspective of behavioral sciences. Also, we emphasized to get out of a dichotomy in classifying gambling behaviors(i.e., either pathological or non-pathological). In addition, we introduced multi-agent and multi-level approaches to understanding gambling problems. With these approaches, each of the agents pertinent to the gambling problems can take its own responsibility and collaborate with other agents to solve the problems together. Also it is a proper time to develop a new scale overcoming the limitations of existing scales. So we presented several cautions in developing new scales for evaluating gambling problems. Lastly, in building a gambling policy, the estimation of prevalence and incidence rate is an important issue. So we suggested various ways for accurate estimation of prevalence and incidence rates reflecting the nature of gambling problems.

• The Journal of the Convergence on Culture Technology
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• v.9 no.5
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• pp.837-842
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• 2023

This study analyzed the awareness and actual condition on metaverse utilization in education for design major students. An online survey was conducted for 14 days from May 10 to 23, 2023, targeting 120 students majoring in design at D University. The evaluation method of the questionnaire was a nominal scale and a 5-point scale, and the questionnaire results were analyzed through SPSS 29.0. First, it is necessary to sufficiently share the advantages of metaverse utilization in education with students, and to provide basic literacy programs utilizing the characteristics of metaverse and supporting class activities. Second, students' response will be higher in studio classes where practical training is conducted rather than information delivery or understanding-oriented lectures. Third, in order for the metaverse to become a means of education in the digital transformation era rather than just a temporarily medium in COVID-19 era, specific and systematic design education programs reflecting the characteristics of the metaverse need to be continuously developed. In addition, it is important for instructors to actively review the use of the metaverse and search for various ways to utilize it.

• Journal of the Korea Society of Computer and Information
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• v.28 no.10
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• pp.27-35
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• 2023

In this paper, we propose a process of increasing productivity by applying a deep learning-based defect detection and classification system to the prepreg fiber manufacturing process, which is in high demand in the field of producing composite materials. In order to apply it to toe prepreg manufacturing equipment that requires a solution due to the occurrence of a large amount of defects in various conditions, the optimal environment was first established by selecting cameras and lights necessary for defect detection and classification model production. In addition, data necessary for the production of multiple classification models were collected and labeled according to normal and defective conditions. The multi-classification model is made based on CNN and applies pre-learning models such as VGGNet, MobileNet, ResNet, etc. to compare performance and identify improvement directions with accuracy and loss graphs. Data augmentation and dropout techniques were applied to identify and improve overfitting problems as major problems. In order to evaluate the performance of the model, a performance evaluation was conducted using the confusion matrix as a performance indicator, and the performance of more than 99% was confirmed. In addition, it checks the classification results for images acquired in real time by applying them to the actual process to check whether the discrimination values are accurately derived.

• Journal of the Korean Society of Marine Environment & Safety
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• v.29 no.7
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• pp.950-957
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• 2023

For safe mooring and towing between the ship and port, the equipment must be designed in accordance with the relevant international regulations. However, some small shipyards and engineering companies often do not fully comprehend the core contents. Therefore, the international regulations regarding towing and mooring equipment are reviewed and the bollard and chock are newly developed based on the Mooring Equipment Guideline 4 (MEG4) standards. A bollard is a mooring equipment used to fix a mooring rope to the hull. It has two columns and is mostly used in a figure eight pattern knots under the mooring condition. The chock, which is used to change the mooring rope direction coming into the ship from outside, is manufactured using a casting with curvature. The two mooring equipment are widely used in the stern, bow, and mid-side. Owing to the increase in the size of container vessels and LNG ships, the mooring rope load has increased and the safe working load of the mooring equipment must be revised. This study summarizes and examines the results of the allowable stress method obtained using finite element analysis modelling. To consider the mesh size effect, a reasonable criteria was suggested by referring the existing class guidance. Additionally, the safe working load was verified through nonlinear collapse analysis, and the elastic region against load increments was confirmed. Furthermore, the proposed evaluation method can be used to develop similar equipment in the near future.

• Journal of Soil and Groundwater Environment
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• v.28 no.6
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• pp.71-89
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• 2023

A groundwater potential map (GPM) was built for the Nakdonggang River Basin based on ten variables, including hydrogeologic unit, fault-line density, depth to groundwater, distance to surface water, lineament density, slope, stream drainage density, soil drainage, land cover, and annual rainfall. To integrate the thematic layers for GPM, the criteria were first weighted using the Analytic Hierarchical Process (AHP) and then overlaid using the Technique for Ordering Preferences by Similarity to Ideal Solution (TOPSIS) model. Finally, the groundwater potential was categorized into five classes (very high (VH), high (H), moderate (M), low (L), very low (VL)) and verified by examining the specific capacity of individual wells on each class. The wells in the area categorized as VH showed the highest median specific capacity (5.2 m³/day/m), while the wells with specific capacity < 1.39 m³/day/m were distributed in the areas categorized as L or VL. The accuracy of GPM generated in the work looked acceptable, although the specific capacity data were not enough to verify GPM in the studied large watershed. To create GPMs for the determination of high-yield well locations, the resolution and reliability of thematic maps should be improved. Criterion values for groundwater potential should be established when machine learning or statistical models are used in the GPM evaluation process.

• Journal of Life Science
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• v.34 no.4
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• pp.215-226
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• 2024

Aralia continentalis is widely distributed in Far East Asian countries such as Korea, China, and Japan. A. continentalis has traditionally been used as an herbal remedy for various conditions, including analgesia, headache, inflammation, lameness, lumbago, rheumatism, and dental diseases in Korea. Previously, epi-continentalic acid, continentalic acid, and kaurenoic acid as major active biological compounds belonging to the diterpenoid class were identified. To synthesize diterpenoid derivatives with enhanced bioavailability, Fusarium fujikuroi was employed to biotransform diterpenoids due to its known antibacterial activity. This yielded two derivatives of kaurenoic acid, namely 16α-hydroxyent-kauran-2-on-19-oic acid and 2β, 16α-dihydroxy-ent-kauran-19-oic acid, with their chemical structures elucidated via NMR analysis. These derivatives exhibited increased polarity compared to kaur- enoic acid, as evidenced by their retention time on preparative HPLC using the ODS-A column and structural modifications. Evaluation of their antidiabetic activity targeting PTP1B, a negative regulator of the insulin signaling pathway, revealed inhibitory activities of 30.8% and 27.6%, respectively, at a concentration of 4 ㎍/ml. Additionally, both derivatives demonstrated low cytotoxicity, with an IC50 value 18 times higher than kaurenoic acid. Therefore, the augmented water solubility and reduced toxicity of 16α-hydroxy-ent-kauran-2-on-19-oic acid and 2β, 16α-dihydroxy-ent-kauran-19-oic acid, resulting from biotransformation by F. fujikuroi, render them promising candidates for industrial applications.

• Journal of the Korean Chemical Society
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• v.68 no.2
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• pp.93-106
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• 2024

This study investigated differences in presence, immersion, and situational interest in small group learning using augmented reality, based on the degree of tool sharing. 84 eighth-grade students participated in small groups of four. Each group was randomly assigned to one of three environments based on marker and device sharing: the shared environment (shared marker and device usage), the mixed environment (shared marker and individual device usage), and the individual environment (individual marker and device usage). Small group learning using augmented reality was conducted for three class periods, focusing on the "Characteristics of Matter" unit. One-way ANOVA results for the dependent variables revealed that, compared to the shared environment, presence and situational interest were significantly higher in the mixed environment, while immersion and situational interest were significantly higher in the individual environment. MANOVA results for the sub-components of each dependent variable showed significant differences in realness for presence, antecedents and experiences for immersion, and instant enjoyment, novelty, and total interest for situational interest. Analysis of interviews and classroom observations indicated that students in shared and individual environments tended to use their devices individually when utilizing augmented reality. However, in mixed environments, students showed a tendency to use their devices collaboratively, leading to more active interactions. Based on these findings, environments for using tools to enhance the effectiveness of small group learning using augmented reality are discussed.

• Korean Journal of Radiology
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• v.24 no.4
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• pp.349-361
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• 2023

Objective: To quantitatively assess the pulmonary vasculature using non-contrast computed tomography (CT) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) pre- and post-treatment and correlate CT-based parameters with right heart catheterization (RHC) hemodynamic and clinical parameters. Materials and Methods: A total of 30 patients with CTEPH (mean age, 57.9 years; 53% female) who received multimodal treatment, including riociguat for ≥ 16 weeks with or without balloon pulmonary angioplasty and underwent both non-contrast CT for pulmonary vasculature analysis and RHC pre- and post-treatment were included. The radiographic analysis included subpleural perfusion parameters, including blood volume in small vessels with a cross-sectional area ≤ 5 mm² (BV5) and total blood vessel volume (TBV) in the lungs. The RHC parameters included mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), and cardiac index (CI). Clinical parameters included the World Health Organization (WHO) functional class and 6-minute walking distance (6MWD). Results: The number, area, and density of the subpleural small vessels increased after treatment by 35.7% (P < 0.001), 13.3% (P = 0.028), and 39.3% (P < 0.001), respectively. The blood volume shifted from larger to smaller vessels, as indicated by an 11.3% increase in the BV5/TBV ratio (P = 0.042). The BV5/TBV ratio was negatively correlated with PVR (r = -0.26; P = 0.035) and positively correlated with CI (r = 0.33; P = 0.009). The percent change across treatment in the BV5/TBV ratio correlated with the percent change in mPAP (r = -0.56; P = 0.001), PVR (r = -0.64; P < 0.001), and CI (r = 0.28; P = 0.049). Furthermore, the BV5/TBV ratio was inversely associated with the WHO functional classes I-IV (P = 0.004) and positively associated with 6MWD (P = 0.013). Conclusion: Non-contrast CT measures could quantitatively assess changes in the pulmonary vasculature in response to treatment and were correlated with hemodynamic and clinical parameters.

• Journal of Service Research and Studies
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• v.14 no.1
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• pp.108-123
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• 2024

In particular, as the current educational institutions are becoming more competitive, universities need to make efforts to survive the fierce competition by improving their service qualities. In this situation, this study was conducted to confirm the effect of international students' evaluation of university service quality on university loyalty through university satisfaction and service engagements, And several implications can be suggested as follows. First, the dimensions of university service quality were identified as important factors that had a great influence on the university satisfaction of international students. Among the service quality dimensions, support services related to international students were found to be the most important variable in university satisfaction. The school's efforts to solve the inconvenience of international students and the grievances of students who feel difficulties that their own students do not feel are considered a very important factor in the satisfaction of international students. Second, it was found that international students' class engagement or friendship engagement can be increased through satisfaction with the school, and eventually, the increased engagements affect university loyalty. In particular, it has been verified that for international students, the loyalty of the school can be increased by establishing friendships with students from various countries and participating in various school programs. Finally, according to the purposes of studying abroad, the difference was confirmed between the groups studying for academic development and better employment and the group employed for overseas experience and immigration.