• Asian-Australasian Journal of Animal Sciences
• /
• 제25권5호
• /
• pp.648-652
• /
• 2012

This study was conducted to determine the effects of dietary addition of tea saponins (TS) and soybean oil (SO) on fatty acid profile and gene expression of stearoyl-CoA desaturase (SCD) in longissimus dorsi (LD) muscle of growing lambs. Thirty-two Huzhou lambs were assigned to four dietary treatments in a $2{\times}2$ factorial arrangement with main effects of TS (0 or 3 g/d) and SO (0 or 30 g/kg of diet DM). The diet without additives was considered as NTNS (no TS or SO). After a feeding trial for 60 d, four lambs of each treatment were slaughtered to collect the samples of LD muscle. Percentage of trans-11 vaccenic acid was enhanced (p<0.05) in muscle of lambs fed TS and SO. The proportion of total conjugated linoleic acid (CLA) was increased (p<0.05) by SO, but decreased (p<0.05) by TS in LD muscle. The percentage of total saturated fatty acids in muscle was decreased (p<0.05) by addition of TS and SO, while addition of SO increased (p<0.05) the percentage of total polyunsaturated fatty acids. The ratio of cis-9, trans-11 CLA to tran-11 vaccenic acid was decreased (p<0.05) by TS, but increased (p<0.05) by SO. The same effects were observed in SCD mRNA expression. From these results it is indicated that including TS and SO in the diet of growing lambs affect the fatty acid profiles of LD muscle and that the proportion of cis-9, trans-11 CLA in the muscle influenced by TS and SO may be related to the SCD gene expression.

• 정보처리학회논문지B
• /
• 제9B권4호
• /
• pp.471-480
• /
• 2002

본 논문에서는 블록화된 영상의 관심영역 가중치 비교 알고리즘과 형상특징 가중치 비교 알고리즘을 결합하여 지폐를 실시간으로 분류하는 시스템을 하드웨어로 구현하였다. 구현된 시스템은 영상획득부, 전처리 및 영상처리부로 구성되어 있다. 영상획득부는 CIS(contact image sensor)에 의해 영상이 얻어지고, A/D 변환기와 PLD에서 전처리를 한다. 영상처리부는 전처리된 영상을 제안된 알고리즘에 의해 DSP에서 수행한다. 제안한 방법은 시뮬레이션을 통해 질의영상과 비교영상간의 식별율을 높일 수 있고 오염되거나 회전, 이동된 지폐에서도 향상된 성능을 가진다. 그리고 제안 방법은 영상의 블록화 효과에 따른 계산량의 감소와 병렬처리를 할 수 있는 시스템으로 구성할 수 있어서 검색율을 높이거나 검색시간을 줄일 수 있는 장점이 있다.

• 전자공학회논문지
• /
• 제50권7호
• /
• pp.149-156
• /
• 2013

본 논문에서는 bump 회로를 이용한 하드웨어 기반의 윤곽선 검출 회로를 제안한다. 하나의 픽셀은 빛을 전기적인 신호로 변환하는 active pixel sensor (APS)와 주변 픽셀의 밝기 차이를 비교하는 bump회로로 구성된다. 제안하는 회로는 $64{\times}64$의 이미지를 대상으로하며, 각 열(column)마다 비교기를 공유한다. 비교기는 외부에서 인가되는 기준전압을 통해 최종적으로 대상픽셀의 윤곽선 여부를 판별한다. 또한 기존의 4개 혹은 그 이상의 픽셀 데이터를 비교하는 윤곽선 검출 알고리즘을 상대적으로 간소화하여 대상픽셀을 포함하여 3개의 픽셀만으로 윤곽선 검출을 가능토록 제안하였다. 따라서 하나의 픽셀에 비교적 적은 수의 트랜지스터로 구성하였다. 따라서 제한적인 픽셀 크기에서 fill factor를 충분히 확보함으로써 수용 가능한 조도의 범위를 확장하였고, 기준전압을 외부에서 입력 받기 때문에 윤곽선 레벨을 조절 할 수 있다. Bump 회로기반의 윤곽선 검출 회로는 0.18um CMOS 공정에서 설계되었으며, 1.8V의 공급전압에서 픽셀 당 0.9uW의 전력 소모율, 34%의 fill factor을 갖는다. 이는 기존회로대비 전력 소모율을 90% 개선하였고, 기존 회로에 비하여 면적은 약 18.7%, fill factor는 약 16%를 더 확보하였다.

• 한국식품영양과학회지
• /
• 제21권3호
• /
• pp.302-307
• /
• 1992

들깻잎의 메탄을 추출물이 S. typhimurium TA98과 100에서 aflatoxin B$_1$(AFB$_1$)의 돌연변이 유발성을 억제시키는 효과가 있었다. 메탄을 추출물을 silica gel column을 사용하여 더욱 분획하여 항돌연변이 효과를 시험하였으며, 그중 효과가 가장 컸던 fraction 중의 화합물을 분리, 동정한 결과 2-ethoxy acetate, 1, 2, 3, 4-tetramethyl-cis-cyclobutene, 두 개의 methyl 11, 14, 17-eicosatrienoate 이성체, 12-acetyl-9-octadecanoic acid, 그리고 Phytol이 있음이 잠정적으로 밝혀졌다. Phytol과 methyill, 14, 17-eicosatrienoate의 표준품을 사용하여 AFB$_1$및 Trp-P-2에 대한 항돌연변이 효과를 시험한 결과 그 효과가 컸음이 밝혀졌다.

• 한국통신학회논문지
• /
• 제39B권7호
• /
• pp.459-466
• /
• 2014

본 논문에서는 권종 인식을 위하여 범용 CIS(contact image sensor)를 사용하여 각 권종별로 취득된 지폐 반사 전체 이미지의 특징 데이터(feature data) 성분을 추출하여 권종 인식의 데이터로 사용함으로써 개별 객체의 특색이나 특징들의 집합인 패턴을 이용한 효과적인 이미지 처리 방법을 제안하였다. 본 논문에서 제안한 방법을 통하여 각 권종별 추출된 이미지의 특징 데이터는 이미지 변화에 덜 민감하면서 공간적인 분포를 잘 나타내기 때문에 권종 인식을 하는데 있어서 우수한 방법이 될 수 있다. 제안된 알고리즘의 테스트를 위하여 시료 진폐는 각 국가 및 권종 당 100매씩을 테스트 하였으며, 제한적인 시료로 인한 판정 결과의 신뢰도를 확보하고자 방향별 총 10회씩 투입하였다. 시험 결과 한국 원화는 100% 인식하였으며, 유로화는 5유로의 경우 99.9%, 20유로의 경우 99.8%의 인식률을 보였으며, 터키 리라화는 20리라의 경우 99.8.%, 50리라의 경우 99.8%의 인식률을 보였고, 나머지 미국 달러화, 중국 위안화, 영국 파운드화 등의 권종은 100% 인식되어 제안된 알고리즘이 상용 제품에 적용 가능함을 보였다.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
• /
• pp.89-89
• /
• 2003

Exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a variety of biological and toxicology effects, most of which are mediated by aryl hydrocarbon receptor (AhR). The ligand-bound AhR as a heterodimer with AhR nuclear translocator (ARNT) binds to its specific DNA recognition site, the dioxin-responsive element (DRE), and it results in increased transcription of CYP1A1 gene. Retinoic acid (RA) regulates the transcription of various genes for several essential functions through binding to two classes of nuclear receptors, the retinoic acid receptor (RAR) and retinoid X receptor (RXR). Constitutive androstane receptor (CAR) also regulates the transcription of gene. In this study, we have examined how RAR, RXR and CAR regulated CYP1A1 in rainbow trout hepatoma cell (RTH 149) using luciferase reporter gene assay system. We did transient transfection with CYP1A1 luciferase reporter gene and treated with TCDD, all-trans RA, 9-cis RA and phenobarbital. Treatment of all-trans RA, 9-cis RA or phenobarbital decreased the TCDD induced transcription of CYP1Al. When we did transient cotransfection with CYP1A1 luciferase reporter gene and RXR, as increase of RXR concentration, the TCDD induced transcription of CYP1A1 was decreased. Transfection with CAR also decreased the TCDD induced transcription of CYP1A1 in RTH 149 cells.

• 대한후두음성언어의학회지
• /
• 제9권2호
• /
• pp.115-127
• /
• 1998

Laryngopharyngeal reflux(LPR) is one firm of the gastroesophageal reflux diseases(GERD). It is known to cause various kinds of otolaryngologic symptoms such as hoarseness, foreign body sensation in throat, chronic throat clearing, chronic cough, etc. Disease entities diagnosed by otolaryngologists as posterior laryngitis, globus pharyngeus should be suspected as LPR-related diseases. In this multi-center trial, we tried to evaluate the effect of cisapride(10mg tid) on LPR-related symptoms as the part I study(CIS-KOR-051) in 19 centers, and as the part II study(CIS-KOR-052) comparative evaluation of effect between cisapride(10mg tid) and ranitidine(150mg bid) on LPR-related symptoms in 4 centers. In part I study, efficacy of cisapride on LPR-related symptoms after 4 weeks was 53.5% and that of after 8weeks was 77.9% in per protocol(PPA) analysis group. In part II study, efficacy of the cisapride was much better than that of ranitidine not only from 8 weeks trial(p<0.001) but also from 4 weeks trial(p<0.021) in PPA group. In the multiple logistic regression analysis among the parameters which affect the efficacy of the treatment, cisapride prescribed group showed 10 times greater than that of ranitidine prescribed group(p<0.0001, Odds ratio : 10) in PPA group. LPR was proved by 24Hr double probe pHmetry in 13 patients out of 19 patients tested(68.4%). Thus these results indicated that inducing the improvement of motility functions could affect the amelioration of the LPR-related symptoms much better than reducing acid secretion from the stomach. And maybe it suggests that LPR-related symptoms mainly developed by the reduced motility functions of the esophagus and/or delayed gastric emptying.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권9호
• /
• pp.3759-3765
• /
• 2015

Background: Approaches in disruption of MDM2-p53 interactions have now emerged as an important therapeutic strategy in resurrecting wild type p53 functional status. The present study highlights virtual screening strategies in identification of high affinity small molecule non-peptidic inhibitors. Nutlin3A and RG7112 belonging to compound class of Cis-imidazoline, MI219 of Spiro-oxindole class and Benzodiazepine derived TDP 665759 served as query small molecules for similarity search with a threshold of 95%. The query molecules and the similar molecules corresponding to each query were docked at the transactivation binding cleft of MDM2 protein. Aided by MolDock algorithm, high affinity compound against MDM2 was retrieved. Patch Dock supervised Protein-Protein interactions were established between MDM2 and ligand (query and similar) bound and free states of p53. Compounds with PubCid 68870345, 77819398, 71132874, and 11952782 respectively structurally similar to Nutlin3A, RG7112, Mi219 and TDP 665759 demonstrated higher affinity to MDM2 in comparison to their parent compounds. Evident from the protein-protein interaction studies, all the similar compounds except for 77819398 (similar to RG 7112) showed appreciable inhibitory potential. Of particular relevance, compound 68870345 akin to Nutlin 3A had highest inhibitory potential that respectively showed 1.3, 1.2, 1.16 and 1.26 folds higher inhibitory potential than Nutilin 3A, MI 219, RG 7112 and TDP 1665759. Compound 68870345 was further mapped for structure based pharamacophoric features. In the study, we report Cis-imidazoline derivative compound; Pubcid: 68870345 to have highest inhibitory potential in blocking MDM2-p53 interactions hitherto discovered.

• 대한화학회지
• /
• 제36권5호
• /
• pp.661-668
• /
• 1992

MoCl_5와 NaNO_2 및 산성화시킨 FeSO_4의 reductive nitrosylation 반응을 통해 다핵 화합물인 [{Mo(NO)_2Cl_2}n]을 합성하였다. 이 [{Mo(NO)_2Cl_2}n]와 한자리 및 두자리 리간드를 반응시켜 높은 수득률(80∼90%)로 중성의 단핵 화합물인 [Mo(NO)2Cl2L2(or L-L)]을 얻었다. 사용한 리간드는 3,5-Lutidine, {\gamma}-Cyanopyridine, 1,2-Phenylenediamine, 1,10-Phenanthroline, sym-Diphenylethylenediamine, 9,10-Phenanthrenequinone, 1,3-Bis(diphenylphosphino)propane 및 8-Hydroxyquinoline 이였다. 합성한 dinitrosylmolybdenum 착물은 원소분석과 적외선, 핵자기 공명 및 전자 흡수 스펙트럼 등을 이용해서 그 특성을 조사하였다. 적외선 스펙트럼은 모든 화합물이 팔면체 구조로서 두 개의 NO 기가 cis 위치로 배위되어 있음을 보였다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제16권8호
• /
• pp.1171-1176
• /
• 2003

The effects of dietary conjugated linoleic acid (CLA) on lipid concentrations and fatty acid composition of various tissues were studied in young chicks. From 7 days of age, a total of 160 chicks were divided into 4 groups, placed into 4 pens per group (10 birds per pen) and fed one of four experimental diets containing 6% tallow (TO 6%), 4% tallow plus 2% CLA (TO 4%-CLA 2%), 2% tallow plus 4% CLA (TO 2%-CLA 4%) or 6% CLA (CLA 6%) for 3 weeks. There were no significant differences in growth performances and the relative weights of various organs, but relative liver weight of chicks fed dietary CLA at 4 and 6% levels was significantly higher (p<0.05) than that of TO 6% group. The chemical compositions of leg muscle were not affected by CLA feeding. However, hepatic total lipid of chicks fed 6% CLA diet was significantly higher (p<0.05) than those of TO 6% and TO 4%-CLA 2% groups. The concentrations of various lipid fractions in serum were not affected by CLA feeding. With the increase in dietary CLA levels, cis 9-trans 11 CLA, trans 10-cis 12 CLA and total CLA of leg muscle increased linearly. The relative proportions of C18:1 $\omega$ -9 and C20:4 $\omega$-6 fatty acids in the leg muscles of chicks fed the CLA containing diets were significantly lower (p<0.05) than those of TO 6% group. These results indicate that the levels of CLA isomers were increased linearly in dose-dependent manner after feeding of synthetic CLA source. But it was also observed that excessive amount of dietary CLA resulted in the possible adversely effects, such as increase of liver weight, hepatic lipid accumulation and serum GOT level.