• 동의생리병리학회지
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• 제18권1호
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• pp.306-309
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• 2004

Liver cirrhosis is caused by virus, alcohol, toxins, drugs and chronic hepatitis. Clinical symptoms of liver cirrhosis are severe fatigue, nausea, fever, dyspepsia, anorexia, RUQ pain, jaundice, ascites. We applied oriental medicines to patient who had chronic hepatitis and liver cirrhosis. Sodalgeonbitang-gamibang has been used to treat hepatitis and liver cirrhosis because of its beneficial effects. The patient symptoms began to improve after about one month of treatment. After medication we could find remarkable effect on clinical symptoms and blood test. So we hope that this clinical study is helpful in treat a patient with hepatic disease.

• 디지털융복합연구
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• 제13권4호
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• pp.271-281
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• 2015

본 연구는 간경변증 환자의 삶의 질의 예측요인을 알아보고자 불쾌증상이론을 융합하여 시도하였다. 연구방법은 간경변증 진단을 받은 환자 198명을 대상으로 증상경험과 생리적 요인, 심리적 요인, 상황적 요인, 삶의 질 등을 설문조사하였다. 자료수집은 2014년 4월부터 5월까지 이루어졌으며, 자료분석은 PASW (SPSS) 21.0 프로그램을 이용하여 one-way ANOVA, Pearson correlations와 multiple regressions analysis하였다. 분석결과, 간경변증 환자의 삶의 질은 질병기간(${\beta}=.19$, p<.001), 증상경험(${\beta}=.19$, p=.032), 생리적 요인(${\beta}=.15$, p=.008), 심리적 요인(${\beta}=.39$, p<.001), 상황적 요인(${\beta}=.32$, p<.001) 등이 유의하게 나타났으며, 이들 변인은 삶의 질에 51.8% 설명하였다(F=15.57, p<.001). 간경변증 환자의 삶의 질은 불쾌증상이론의 요인과 관련성이 높았으며, 이들 변인을 고려한 맞춤형 중재프로그램을 제안한다.

• 동의생리병리학회지
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• 제23권5호
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• pp.1161-1165
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• 2009

Daekumeumja is a herb-medication which has been used for alcoholic damage. This is a report about the effect of Daekumeumja on Ascites in alcoholic liver cirrhosis. The study of abdominal CT and ultrasonography were performed to evaluate the volume change of ascites. And blood tests were done to measure the liver's and kidney's functions. Reduction of ascites is proved by abdominal CT & ultrasonography. And lab findings of liver functions showed improvement. This study suggests that Daekumeumja is probably effective in the treatment of ascites in alcoholic liver cirrhosis.

• 사상체질의학회지
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• 제17권3호
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• pp.135-141
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• 2005

1. Objectives The purpose of this case is to report that a soeumin patient diagnosed as liver cirrhosis with jaundice was treated with 'Sibimiguanjung-tang gamibang' and then his symptoms and Liver function improved. 2. Methods We dignosed the patient as Soeumin-Taeum syndrome. So we treated him with Sibimiguanjung-tang gamibang 3. Results After we treated the patient with Sibimiguanjung-tang gamibang, his symptom and liver function was improved. 4. Conclusions Sibimiguanjung-tang gamibang may have an effect on treatment of jaundice with liver cirrhosis of Soeumin.

• 대한한방내과학회지
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• 제43권6호
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• pp.1219-1228
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• 2022

Objectives: The aim of this study was to report a clinical case of decompensated liver cirrhosis in a patient with jaundice who showed improvement with Korean medicine treatment. Methods: A patient with decompensated liver cirrhosis with jaundice was treated with herbal medicine (Injinoryung-tang, Galgeunjowi-tang), acupuncture, cupping, and moxibustion. Changes in jaundice, fatigue, and dysuria were measured with subjective parameters. Liver function was checked by performing a blood test 8 times. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT), total bilirubin (TB), albumin, and platelets (Plt), prothrombin time (PT), and international normalized ratio (INR) were recorded. Results: The Korean medicine treatment improved jaundice, fatigue, and dysuria and lowered the AST, ALT, ALP, GGT, and TB levels. Conclusions: Korean medicine treatment containing Galgeunjowi-tang positively improves clinical symptoms and liver function.

• Advances in Traditional Medicine
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• 제2권2호
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• pp.94-100
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• 2002

Liver cirrhosis is characterized by hyperaccumulation of fibrous tissue components and is commonly observed in latter or terminal states of chronic hepatic diseases. In this study, the antifibrotic effects of GLM001 on liver cirrhosis were examined in bile duct ligated rats and patients with hepatic diseases. GLM001 (250 mg/kg rat weight/ day) was administrated to cirrhotic rats for 4 weeks and to humans for 14 weeks. Bile duct ligated rats significantly increased liver collagen content and biochemical markers of hepatic injury. Liver histology showed collagen fiber deposition was increased and the normal architecture was lost with large zones of necrosis being observed frequently. GLM001 administrated rats showed significantly decreased liver collagen content, and accumulation of collagen fiber in histological analysis. Patients, who were treated with GLM001, showed decreases in biochemical markers of hepatic diseases. These results demonstrate the usefulness of GLM001 as an antifibrotic agent for liver cirrhosis.

• Tuberculosis and Respiratory Diseases
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• 제44권3호
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• pp.639-648
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• 1997

배 경 : 환자에서 동맥혈 저산소증이 생길 수 있다는 보고가 있는데 기관지혈관 확장에 의해서 확산 장애에 의해 동맥혈 산소분압이 감소한다고 한다. Cabanes 등은 좌심실부전 환자에서 메타콜린에 기관지 반응이 증가함을 보고하면서 기관지혈관 확장이 한 기전이라고 주장하였다. 이에 저자들은 간경변증 환자에서 문맥고혈압에 의하여 메타콜린에 대한 기관지반응이 증가할 것이라는 가설하에 간경변증 환자에서 기관지수 축유발검사를 시행하고, 간경변증정도 및 식도 정맥류 정도와의 기관지반응과의 관계를 알아보기 위해 본 연구를 시행하였다. 방 법 : 임상적 문맥고혈압을 가진 간경변증 환자 22명에게 메타콜린 기관지수축유발검사를 시행하였고 또한 간경변 정도를 Pugh-Child 분류법에 따라 분류하고 식도내시경 검사를 시행하였다. 성적 : 총 22명의 임상적으로 문맥고혈압을 가진 간경변증 환자중 남자는 17명, 여자는 5명이었고, 연령분포는 19세에서68세 까지이며 평균연령은 48세였으며, 간경변증 원인은 알콜성 간염에 의한 경우가 9예, B형 바이러스성 간염에 의 한것이 12예였고 C형 바이러스성 간염에 의한것이 1예였다. 22명의 환자중 15예(68.2%)가 메타콜린 기관지 수축유발검사 양성이였고, 양성인 환자 15명의 $PC_{20}$은 $0.3mg/m{\ell}$에서 $16.6mg/m{\ell}$로 다양하였으며 평균값은 $6.5{\pm}5.1mg/m{\ell}$ 이다. 메타콜린 기관지 수축유발검사 $PC_{20}FEV_1$값과 Pugh-Child 분류법에 의한 간경변의 정도 사이에는 통계학적으로 상관관계가 없었다(p>0.05). 메타콜린 기관지 수축유발검사 $PC_{20}FEV_1$ 값과 식도 내시경상 식도정맥류의 심한 정도 사이에도 통계적으로 유의한 상관관계가 없었다(p>0.05). 결 론 : 이상의 결과에서 간경변증 환자에게서 메타콜린 기관지 반응이 증가(68.2%)함을 수 있었고 간경변증 정도나 식도정맥류 정도 사이에는 유의한 상관관계가 없었다.

• Tuberculosis and Respiratory Diseases
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• 제66권1호
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• pp.47-51
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• 2009

간폐증후군은 간질환이 있는 환자에서 저산소증이 유발되는 상태로 폐내 혈관 확장으로 인해 폐내 동맥혈 산소공급에 결함이 발생하는 질환이다. 현재까지 간이식 외에 간폐증후군에 대한 다른 효과적인 치료법은 없는 것으로 알려져 있다. 국내에서는 간폐증후군의 증례 보고가 드물고, 특히 Child-Pugh 분류 A군에서의 발생 빈도는 낮은 것으로 보인다. 이에 저자들은 Child-Pugh 분류 A군인 대상성 간경화 환자에서 발생한 간폐증후군 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

• 대한영상의학회지
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• 제84권3호
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• pp.750-756
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• 2023

자발적 동맥 출혈은 드물며, 속가슴동맥의 자발적 파열에 의한 혈종은 이전에 보고된 바가 없다. 간경화증이 있거나 과음하는 환자는 출혈의 위험성이 더 큰 것으로 알려져 있다. 저자들은 알코올성 간경화증을 가진 39세 여성에서 자발적 속가슴동맥 출혈로 인해 발생한 거대한 종격동 혈종의 증례를 보고하고자 한다.

• Journal of Nutrition and Health
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• 제30권1호
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• pp.48-60
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• 1997

The purpose of this study was to evaluate alcohol consumption and nutritional status in patients with alcoholic liver disease. The subjects were 80 patients with alcoholic liver cirrhosis and 12 patients with alcoholic fatty liver. Also 57 alcoholics without liver disease, 32 patients with viral liver cirrhosis and 194 normal men were included as control groups. Data on anthropometric index, socioeconomic status, alcohol consumption, dietary habits and dietary intakes were collected by individual interview. Alcoholic liver disease group had significantly lower triceps skinfold thickness and mid-uppr-arm circumferences than other groups. Socioeconomic status of alcholoci subjects was middle class or lower than that. The amount, duration and frequency of alcohol consumption were significantly higher and the quality of side dishes consumed with alcoholic beverage was significantly poorer in patients with alcoholic liver cirrhosis than others. Patients with alchololic liver disease ingested approximately 40% of daily caloric intake as alcohol and all alcoholic subjects had lower average intakes of protein, carbohydrates, fat, vitamins and minerals as compared with Korean adult average intakes. The results suggest that alcohol and poor dietary intake could cause malnutrition and might be two of the important risk factors to develop alcoholic liver disease in alcoholics. But other factors like genetic and immunological factors should be also considered in elucidating the causes of alcoholic liver disease. An extensive nutritional education should be emphasized for alcohol consuming population to prevent development of alcoholic liver disease.