• Biomolecules & Therapeutics
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• 제4권3호
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• pp.275-279
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• 1996

We have synthesized the cinnamyl derivative of minoxidil, N-2-cinnamylamino-4-amino-6-piperidinopyrimidine 3-oxide(MINAMYL). Physicochemical properties and structural analysis on this compound were examined. And also, we have screened its antialopecic effect.

• Nuclear Engineering and Technology
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• 제1권2호
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• pp.87-90
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• 1969

Trans-cinnamyl chloride와 bromide의 방사성 Cl$^{-}$, Br$^{-}$ 및 I$^{-}$와의 교환 반응을 아세톤 용액에서 반응속도론적으로 연구하였다. 상대적인 할로겐 이온들의 친핵성과 이탈능을 HSAB 원리를 이용하여 논의하였다.

• 대한화학회지
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• 제39권10호
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• pp.830-833
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• 1995

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.268-268
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• 1996

새로운 발모제 개발에 관한 연구의 일환으로 현재 혈압 강하 및 발모제로 쓰여지고 있는 미녹시딜에 신나밀 클로라이드를 반응시켜 N-4-cinnamylamido-2-amino-6-piperidinopyrimidine 3-oxide (이하 MINAMYL 이라 칭함)을 만들어 이 화합물에 대하여 액성영향 및 반응시간 등 제반물성을 검토하였으며, 또한 정량법 및 결합구조 등에 관하여 검토하였다.

• Bulletin of the Korean Chemical Society
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• 제16권6호
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• pp.528-533
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• 1995

Metallic iridium and rhodium powders prepared from the reactions of [M(COD)(PhCN)2]ClO4 (M=Ir(1), Rh(2); COD=1,5-cyclooctadiene) with hydrogen at room temperature in methylene chloride show catalytic activities for hydrogenation of arenes at room temperature under atmospheric pressure of hydrogen. Most substituents (CH3, COOH, NO2, CH2OH, CHO, OPh, OCH3, C=C, halogens and CH2Cl) on aromatic ring suppress the rate of the hydrogenation of the aromatic ring while the aromatic ring hydrogenation of phenol and 1,4-dihydroxobenzene is faster than that of benzene over these metallic powders. Hydrogenation of benzoic acid occurs only at the aromatic ring leaving the COOH group intact over iridium metal powders while benzoic acid is not hydrogenated at all over rhodium metal powders. Carbonyl, nitro, acetylenic and olefinic groups on an aromatic ring are hydrogenated prior to the aromatic ring hydrogenation. Hydrogenolysis of OH groups of phenol, benzyl alcohol and 1,4-dihydroxobenzene, and hydrodehalogenation of halobenzenes, benzyl halides and cinnamyl chloride also occur along with the hydrogenation of aromatic ring.

• Bulletin of the Korean Chemical Society
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• 제4권1호
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• pp.3-9
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• 1983

Lithium n-butylborohydride was prepared from borane-dimethylsulfide (BMS) and n-butyllithium, and the approximate rates and stoichiometrics of its reactions with selected organic compounds containing representative functional groups were studied in THF at room temperature. Phenol and benzenetiol liberated hydrogen quickly and quantitatively, and the reactions of primary alcohols, 2,6-di-ter-butylphenol and 1-hexanethiol liberated hydrogen quantitatively within 3 hrs, whereas the reactions of secondary and tertiary alcohols were very slow. Aldehydes and ketones were reduced rapidly and quantitatively to the corresponding alcohols. Cinnamaldehyde utilized 1 equiv. of hydride rapidly, suggesting the reduction to cinnamyl alcohol. Carboxylic acids evolved 1 equiv. of hydrogen rapidly and further reduction was not observed. Anhydrides utilized 2 equiv. of hydride rapidly but further hydride uptake was very slow, showing a half reduction. Acid chlorides were reduced to the alcohol stage very rapidly. All the esters examined were reduced to the corresponding alcohol rapidly. Lactones were also reduced rapidly. Expoxides took up 1 equiv. of hydride at a moderate rate to be reduced to the corresponding alcohols. Nitriles and primary amides were inert to this hydride system, whereas tertiary amide underwent slow reduction. Nitroethane and nitrobenzene were reduced slowly, however azobenzene and azoxybenzene were quite inert. Cyclohexanone oxime evolved 1 equiv. of hydrogen rapidly, but no further reduction was observed. Phenyl isocyanate and pyridine N-oxide were proceeded slowly, showing 1.74 and 1.53 hydride uptake, respectively in 24 hours. Diphenyl disulfide was reduced rapidly, whereas di-n-butyl disulfide, sulfone and sulfonic acids were inert or sluggish. n-Hexyl iodide and benzyl bromide reacted rapidly, but n-octyl bromide, n-octyl chloride, and benzyl chloride reacted very slowly.