• 제목/요약/키워드: chronic gastritis

검색결과 149건 처리시간 0.029초

자기 진술에 의한 유.무배우 여자노인의 생활실태 (A Study on the Living Status of Widowed and Unwidowed Elderly Women Based on the Self-Report)

  • 이신숙
    • 한국가정과학회지
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    • 제7권2호
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    • pp.59-79
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    • 2004
  • The purpose of this study is to investigate the living status of widowed and unwidowed elderly women by means of the case study employing in depth interviews. The main results are following : First, In the case of economic status of elderly women was very low: widowed, it was significantly low. The allowances were provided by their children. And they were spent for medical expenses¬Second, Most elderly women have one or two chronic diseases, mostly Arthritis, Gastritis, Hyperpiesia. Third, The emotional relationship of the elderly women centered around their children. Fourth, Leisure activities of the elderly women were not partially formed, usually T.V. watching, chatting, playing Korea cards. Fifth, The elderly women wanted most to work for house chores, do light exercises, and to earn pocket money. Sixth, The wish for the goverment was financial support! health support! and emotional welfare support.

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Helicobacter pylori 감염과 비타민 C: 과거, 현재, 미래 (Helicobacter pylori Infection and Vitamin C: Past, Present and Future Perspectives)

  • 윤희상;이광호
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제11권sup1호
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    • pp.83-92
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    • 2008
  • Helicobacter pylori is the causative agent of chronic gastritis and has a role in the pathogenesis of peptic ulcer diseases, and gastric cancer. There have been reports suggesting a close link between these gastroduodenal disorders and a state of vitamin C deficiency. In this paper, the past, present and future perspectives on H. pylori infection and vitamin C will be discussed under the following view points. Since the ecological niche of H. pylori is the mucus layer and intercellular junctions of the gastric epithelium, the various kinds of host inflammatory cells motivated by the local and systemic immune responses cannot eliminate the microorganisms. When the invading foreign body is not removed, despite full activation of defense mechanisms, adverse consequences of the immune responses develop on the host gastric mucosa. The reasons for the body vitamin C depletion could be explained as follows; 1) the increased vitamin C consumption by increased oxygen free radical production through the prolonged hypersensitivity reactions in the gastric mucosa, 2) the increased vitamin C oxidation by the nitrite which is formed from nitrate reduction by the intragastric bacteria proliferated in the hypochlorhydric gastric cavity, 3) the strong ${\gamma}$-glutamyltranspeptidase activity of H. pylori which depletes the glutathiones in gastric mucosa. Depletion of glutathiones in the stomach favors irreversible oxidative destruction of ascorbic acid. Both persistent inflammatory burdens in the stomach by H. pylori and resultant vitamin C depletions synergistically and uninhibitedly might aggravate the hypothetical sequence of gastric carcinogenesis: atrophic gastritis${\rightarrow}$intestinal metaplasia${\rightarrow}$dysplasia${\rightarrow}$gastric adenocarcinoma. High intake of vitamin C could reverse the hypothetical sequence of the gastric carcinogenesis via direct and indirect effects on H. pylori and host-parasite relationships.

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위장관 질환자의 임상진단과 치료방법 (Clinical Diagnosis and Its Medical Managements from Patients with Gastrointestinal Diseases)

  • 김재웅
    • 한국식품영양학회지
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    • 제10권2호
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    • pp.186-192
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    • 1997
  • 성별, 직업, 성품, 생활양식이 전혀 다른 K43과 C45 환자의 위 내시경적 소견과 치료방법을 논의하였다. K43은 잘못된 식습관과 스트레스에 의한 미란성 위염환자로서 제산제와 함께 H2-수용체 길항제, H+/K+-pump 억제제, prostaglandin 제제, colloidal bismuth, sucralfate prokinetics 등 전통적인 약물에서부터 부작용을 감소시킨 최근에 개발된 약물에 이르기까지 효과가 인정된 약물들을 폭넓게 사용하였으나 증상을 개선치 못하였으며, 임상병리 검사와 상복부 초음파 검사는 정상이었으나, 소화생리기능 검사에서 visceral hypersensitivity를 나타내었다. 그러나 C45는 평소에 두통으로 NSAIDs를 습관적으로 복용한 경험에 의하여 발생되었을 것으로 추정되는 전형적인 위·십이지장 궤양의 환자로서 H. pylori 박멸제와 함께 일반적인 소화성 궤양의 치료제로 활동기에서 치유기로 증상을 크게 완화시켰다. 특히 K43은 amitryptyline을 투여하였으나 난치성 환자로 남아 있다. 이러한 원인불명의 비궤양 환자는 미국에서 해마다 15%씩 증가하는 추세에 있고 적절한 치료법도 없으며, 우리 나라에서는 통계치도 없는 실정인 점을 지적하고 싶다.

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Chemopreventive effects of garlic and mugwort mixture extract on Helicobacter pylori-associated mouse gastric carcinogenesis

  • Youm, So-Young;Kim, Tae-Wang;Shin, Sang Kyung;Jeong, Heon Sang;Kang, Jong-Koo;Kim, Tae Myoung;Kim, Kil Ho;Ahn, Byeongwoo
    • 대한수의학회지
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    • 제54권3호
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    • pp.171-177
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    • 2014
  • Garlic and mugwort have long been used in traditional medicine to prevent various diseases. Several in vitro studies have reported protective efficacies of garlic and mugwort in cases of gastric cancer. In the present study, we investigated the cancer preventive effects of garlic and mugwort mixture extract (GME) in a Helicobacter (H.) pylori-associated gastric carcinogenesis mouse model. To induce gastric cancer, C57BL/6 mice were treated with N-methyl-N-nitrosourea and H. pylori. Various concentrations of GME (0, 100, 500, and 1,000 ppm) were then fed to the mice for 38 weeks, after which the tumor tissues were examined for histopathology, mucin histochemistry and ${\beta}$-catenin. The incidence of gastric tumors was significantly lower in the highest dose GME-treated mice (46.7%) than control mice (85.7%) (p < 0.05). The multiplicity and size of tumors were also significantly reduced by GME feeding in a dose-dependent manner (p < 0.01). Furthermore, GME suppressed the H. pylori-associated chronic inflammation measured by histologic grading of H. pylori density, chronic gastritis, glandular atrophy and intestinal metaplasia in non-tumorous gastric mucosae. Our data suggest that GME suppresses gastric tumorigenesis via suppression of H. pylori-associated chronic inflammation.

개에서의 만성 비후성 유문 위장애에 대한 수술적 치료 (Surgical Correction of Chronic Hypertropic Pyloric Gastropathy in a Dog)

  • 김준영;정순옥;박상혁;윤헌영;한현정;장하영;이보라;김구용
    • 한국임상수의학회지
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    • 제21권4호
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    • pp.398-401
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    • 2004
  • 10년령의 암컷 요크셔테리어 개가 간헐적인 구토와 만성 채중감소, 다갈증 그리고 쇠약증으로 건국대학교 수의과대학 부속 동물병원에 내원하였다. 방사선 검사에서 가스와 액체가 찬 위 확장이 확인 되었고, 조영제 투여 후 60분이 경과하여도 조영제가 위에서 소장으로 내려가지 않았다. 초음파 상에서는 위체 부위에 상당량의 액체가 저류 되어 있었고, 유문부 점막이 부후되어 있는 것이 확인되었다. 그래서 유문부 협착으로 의한 위 폐쇄가 강력하게 의심되었다. 수술에서 비대된 위점막은 충분히 제거하였고, Heineke-Mikulicz 유문성형술을 적용하였다. 조직학적 소견상 위점막의 비후와 미약한 미만성의 림포구성 형질세포성 위염을 나타내었다. 모든 소견을 종합하여 볼 때, 만성 비후성 유문 위장애로 진단하였다. 간혈적인 구토와 활력저하는 수술 후 9일간 보였다. 이후 환축은 점차적으로 회복되었다. 한달 뒤 환축은 정상적인 식욕과 활력을 나타내었다.

동병하치 확산을 위한 전략적 방향과 이행방안 (Strategic Direction and Road Map of Expanding Prevention of Winter Disease in the Summer)

  • 송호섭
    • Journal of Acupuncture Research
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    • 제27권3호
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    • pp.147-157
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    • 2010
  • Objectives : The purpose of this study was to propose appropriate strategic directions and road maps for successful achievement of programs preventing winter disease in the summer. Methods : Details on programs preventing winter disease in the summer such as clear concept, theoretical basis, current status, intervention or available prescriptions and indication/contraindication/caution were prepared through the related journal review, upon which an observational study was devised and done for simulation to find out even a trivial problem and to guarantee the safety beforehand. The experimental group was divided into 5 groups by the size of pill and the way ginger is treated; 1cm pill with ginger group, 3cm pill group without ginger, 3cm pill group dipped into ginger, 3cm pill group applying ginger to acupoints and 3cm pill group with ginger Results 1. program preventing winter disease in the summer was defined as representative winter diseases such as common cold, influenza, chronic asthma, chronic bronchitis, allergic rhinitis, emphysema, chronic gastritis and rheumatoid arthritis, and preventive care in the summer, reinforcing deficient yang qi of five viscera by using exuberant yang qi from summer heat. 2. It was based upon historically established theories which is 'nourishing yang qi in the spring and summer', 'long summer, namely rainy spell in the summer overwhelms the winter, because of earth winning water according to the five phases theory' and 'To replenish yang qi is major principle to treat winter diseases, which can be most appropriately and timely applied to the patient with deficient yang qi of five viscera inherently, especially in the three dog days of the summer, because of exuberant exterior yang qi and deficient interior yang qi in the five viscera'. 3. In the adjacent China and Taiwan, acupoint applying method in the three dog days named 'San Fu Tie' have been stirring a boom throughout the nation, in which Xiaochuan Gao was used as a basic prescription and it mainly was applied at bilateral $BL_{13}$, $_{15}$ and $_{17}$ for about 4 hours. As far as domestic current status, the necessity of adopting the above method prior to Herbal formula was also recognised, because not a few koreans have apprehension for the safety of it including medicinal herbs and are reluctant to take it any more due to negative advertisement of narrow minded doctors' association. 4. Indication of acupoint applying method in the three dog days included most of winter diseases such as common cold, influenza, chronic asthma, chronic bronchitis, allergic rhinitis, emphysema, chronic gastritis. contraindication was pregnant woman and the weak such as infants and the old. More attention was paid to grasp firmly the normal reaction following the treatment for preventing side effect and teasing blister. recommendation was also given to abstain from food inducing phlegm and dampness such as meat, shrimp and crab as well as cold drinks and foods 5. In the simulation observational study based upon the above findings following review the related articles, no blister was shown on the acupoints icluding bilateral $BL_{13}$, $_{15}$ and $_{17}$ in every experimental group during 24hr observation following the acupoint applying treatment with pills made by modified and devised prescription. At 4 hr, the effectiveness of it reached a peak showing redness and mild tenderness and there is little difference between groups 3cm pills groups regardless of the way ginger was treated. abdominal distention and growling was found in all the volunteers during the treatment at CV 8. Strategic directions and road maps : Through successful fulfillment of the program preventing winter disease in the summer, Korean traditional medicine should be integrated into mainstream national health care services. Cultural access was thought to be as important as Scientific EBM approach. First of all, To evoke potential cultural homogeneity from campaigns and press advertisement was needed for promoting public awareness about preventing winter disease in the summer by enhancing immunity via acupoint applying treatment in the three dog days, and then indigenous name as Sambokcheop, protocol, Clinical Research Form for data collection of it should be developed and prepared. Once the first step was taken this summer, through a thorough data collection and scrutinized scientific evaluation, drawbacks should be compensted for and the efficacy and safety should be substantiated.

악성 빈혈환자에서 발병한 위암 1예 보고 (Gastric Adenocarcinoma in Patient with Pernicious Anemia: A Case Report)

  • 김병수;김종원;이인규;김동출;김우호;이혁준;양한광
    • Journal of Gastric Cancer
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    • 제7권1호
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    • pp.38-41
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    • 2007
  • 악성빈혈을 동반한 자가면역성 만성 위축성 위염은 위암의 전구 병변으로 알려져 있다. 저자들은 악성빈혈에 동반된 위암 1예를 경험하였기에 보고한다. 40세 여자환자가 어지럼증과 공복 시 속쓰림으로 시행한 혈액검사상 혈색소 4.2 g/dl으로 측정되었다. 상부위장관 내시경상에서는 위 고위 체부의 편평 융기성 병변이 관찰되었고 조직검사상 위선암으로 보고되었다. 위전절제술을 시행하였고 병리조직 검사상 병변은 고위 체부 전벽에 점막하층(SM2)까지 침범한 조기위암이었으며, 검사된 림프절 44개 중에 전이된 림프절은 없었다. 악성빈혈 환자에서 위축성 위염이 동반된 경우 위암의 호발연령이 되면 위암의 발생 가능성이 있으므로 상부위장관 내시경의 주기적인 시행이 중요하리라 생각된다.

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상부 위장관 증세가 있는 소아의 위십이지장병변 및 Helicobacter pylori 감염 (Helicobacter pylori Infection and Gastroduodenal Pathology in Children with Upper Gastrointestinal Symptoms)

  • 윤영란;김미령;임재영;최명범;박찬후;우향옥;윤희상;고경혁;강형련;백승철;이우곤;조명제;이광호
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제6권2호
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    • pp.103-111
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    • 2003
  • 목 적: 만성 반복성 복통, 식사 후 상복부 불쾌감, 잦은 구토나 구역질이 있는 소아를 대상으로 위내시경을 시행하여 위십이지장 병변을 확인하고, 생검체를 이용한 위십이지장 조직학적 검사와 H. pylori 검출 그리고 면역블롯팅을 통해 혈청 내에 H. pylori 특이 항체 존재를 확인하여 한국에서 관찰되는 소아의 위장관 증세와 위십이지장병변 및 H. pylori 감염과의 관계를 조사하고자 하였다. 방 법: 1990년 6월부터 1991년 4월까지 경상대학교병원 소아과에서 상부 위장관 증상으로 위내시경을 시행 받은 184명 중 위 전정부에서 생검이되었고, 요소분해효소 검사, Warthin-Starry 은염색 혹은 Hematoxylin-Eosin 염색으로 조직학적에서 H. pylori의 존재유무를 확인할 수 있었던 107명을 대상으로 위십이지장 조직학적 검사와 IgG 면역블롯팅에 의한 항-H. pylori 항체 보유 유무를 확인하였다. 결 과: 1) 대상 환아 107명 중 남아가 61명(57%), 여아가 46명(43%)이었으며, 연령은 2세부터 15세까지 분포하였고 평균연령은 10.7세로서 10세에서 15세 사이가 가장 많았다. 2) 내시경상 15%에서 위출혈 반점, 위궤양, 십이지장궤양, 십이지장 미란, 출혈성 십이지장염 등이 관찰되었고 대부분은 다양한 정도의 위점막 발적이 관찰되었다. 3) 107명 중 94명(88%)에서 경도 이상의 조직학적 만성위염이 있었으며, 십이지장 조직이 검사 가능하였던 99명 전원에서 만성십이지장염이 있었다. 4) 요소분해효소 검사는 위에서는 45%, 십이지장에서는 25.6%에서 양성으로 판정되었다. H&E 염색 검사에서 38.7%, Warthin-Starry 은염색 검사에서는 40%에서 HPLO 양성이었다. 이 세가지 검사 중 1개 검사에서 양성인 경우인 조직학적 H. pylori 양성은 57%이었다. 5) IgG 면역블롯팅 양성은 96%이었다. 6) 연령군별 조직학적 H. pylori 양성은 0∼4세 군에서는 29%, 5∼9세 군에서는 41%, 10∼15세 군에서는 68%로 연령이 증가할수록 양성률이 증가하였으나, 조직학적 만성위염 및 만성십이지장염 빈도와 면역블롯 양성 빈도는 연령군별 차이가 없이 높은 양성률을 유지하였다. 결 론: 상부 위장관 증세가 있는 소아의 대부분은 조직학적 만성위염 및 만성십이지장염과 동시에 H. pylori에 대한 특이 IgG 항체를 보유하고 있었다.

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Effects of the Hippo Signaling Pathway in Human Gastric Cancer

  • Zhou, Guang-Xi;Li, Xiao-Yu;Zhang, Qi;Zhao, Kun;Zhang, Cui-Ping;Xue, Chang-Hu;Yang, Kun;Tian, Zi-Bin
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권9호
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    • pp.5199-5205
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    • 2013
  • Background/Aim: The Hippo signaling pathway is a newly discovered and conserved signaling cascade, which regulates organ size control by governing cell proliferation and apoptosis. This study aimed to investigate its effects in human gastric cancer. Methods: Tumor tissues (n=60), adjacent non-tumor tissues (n=60) and normal tissues (n=60) were obtained from the same patients with primary gastric cancer (GC). In addition, 70 samples of chronic atrophic gastritis (CAG) tissues were obtained from patients with intestinal metaplasia (IM) by endoscopic biopsy. Hippo signaling molecules, including Mst1, Lats1, YAP1, TAZ, TEAD1, Oct4 and CDX2, were determined by quantitative polymerase chain reaction (qPCR). Protein expression of Mst1, Lats1, YAP1, TEAD1 and CDX2 was assessed by immunohistochemistry and Western blotting. Results: Mst1, Lats1 and Oct4 mRNA expression showed an increasing tendency from GC tissues to normal gastric tissues, while the mRNA expression of YAP1, TAZ and TEAD1 was up-regulated (all P<0.01). Mst1 and Lats1 protein expression presented a similar trend with their mRNA expression. In addition, YAP1 and TEAD1 protein expression in GC was significantly higher than in the other groups (all P<0.01). CDX2 mRNA and protein expression in the CAG group were higher than in the other groups (all P<0.01). In GC, mRNA expression of Mst1, Lats1, Oct4, YAP1, TAZ, TEAD1 and CDX2 had a close correlation with lymphatic metastasis and tumor TNM stage (all P<0.01). Furthermore, protein expression of Mst1, Lats1, YAP1, TAZ, TEAD1 and CDX2 had a close correlation between each other (P<0.05). Conclusion: The Hippo signaling pathway is involved in the development, progression and metastasis of human gastric cancer. Therefore, manipulation of Hippo signaling molecules may be a potential therapeutic strategy for gastric cancer.

Ursolic acid의 위 손상에 대한 방어 효과 (Protective Effects on Gastric Lesion of Ursolic acid)

  • 김선회;황인영;이선이;정춘식
    • 한국식품위생안전성학회지
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    • 제31권4호
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    • pp.286-293
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    • 2016
  • 본 연구에서는 ursolic acid의 위의 보호효과를 위한 실험을 실시하였다. 위장 질병에 대한 ursolic acid의 효과를 확인하기 위해서 급성, 만성위염은 각각의 HCl ethanol과 indomethacin에 의해 유도된 위염 동물 모델을 사용하여 관찰하였다. 대표적인 공격인자인 위산에 관해서는 PPI activity를 통해서 확인하였고, 위의 손상에 대한 보호인자에 관해서는, $PGE_2$를 정량적으로 분석하였다. 항균활성 실험은 만성위염, 위궤양, 위암에 원인인자로 잘 알려진 H. pylori로 실험하였다. AGS cell를 이용하여 DAPI 염색, Flow cytometry assay를 통하여 ursolic acid가 위암세포의 apoptosis에 관여하는지를 확인하였다. 그 결과 ursolic acid는 HCl ethanol과 indomethacin에 의해 유도된 급성, 만성에 대한 위손상을 억제하였다. Ursolic acid는 위산분비의 마지막 단계인 위염분비효소인 proton pump를 억제시킴으로써 산의 분비를 억제하였다. 그리고 ursolic acid는 위 점막의 보호인자인 $PGE_2$의 농도가 증가함으로써 위 점막 보호 효과를 확인하였다. 또한 ursolic acid는 공격인자인 H. pylori colonization을 억제하였다. DAPI를 이용한 핵 염색에서, 대조군과는 달리, 핵 형상의 변형과 함께 수축 된 세포 또는 염색질의 응축현상이 관찰되었다. Flow cytometry assay에서 ursolic acid에 의해 apoptosis가 증가하는 것을 확인 하였다. 이를 통하여 ursolic acid는 위 손상에 대한 방어 효과가 있음을 확인할 수 있었다.