• 대한상한금궤의학회지
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• 제8권1호
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• pp.99-108
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• 2016

Objective : The purpose of this paper is to report the improvement of patient with chronic cough treated by herb medication based on Shanghanlun disease pattern identification diagnostic system. Methods : According to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions', the patient diagnosed with Taeyang-byung, number 96 provision, and took Soshiho-tang herb medication 50days. The changing symptom of chronic cough was estimated by LCQ(Leicester Cough Questionnaire) and VAS(Visual Analogue Scale). Results : The LCQ score changed 57 to 111 and VAS changed 10 to 0. Conclusions : On the number 96 provision of Shanghanlun, '或欬' means 'H or K' sound cough. This is the first case report treating the chronic cough with herb medication of shanghanlun in Korea.

• 대한상한금궤의학회지
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• 제9권1호
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• pp.115-123
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• 2017

Objective : The purpose of this paper is to report the improvement of patient with Chronic Fatigue Syndrome(CFS) treated by herb medication based on Shanghanlun disease pattern identification diagnostic system. Methods : According to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions', the patient was diagnosed with Eumyangyeokchahunobok-byung, number 393 provision, and took Jisilchija-tang herb medication for 75days. The changing symptom of chronic fatigue syndrome was estimated by QOL-CFS(Chalder Fatigue Scale) and VAS(Visual Analogue Scale). Results : The QOL-CFS changed 21 to 8 and VAS changed 10 to 1. Conclusions : It is existing theory that Eumyangyeokchahunobok-byung is caused by 'having too much sex relation'. But the author diagnosed Eumyangyeokchahunobok-byung as 'Symptoms worsen when awaken at night, and sleep at day caused by poor sleep pattern' according to the palaeography about shanghanlun, and got a good results.

• Tuberculosis and Respiratory Diseases
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• 제81권3호
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• pp.228-232
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• 2018

Background: Chronic bronchitis (CB) is an important phenotype in chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate different pattern of COPD assessment test (CAT) score between CB and non-CB patients. Methods: Patients were recruited from 45 centers in Korea, as part of the Korean COPD Subgroup Study cohort. CB was defined when sputum continued for at least 3 months. Results: Total 958 patients with COPD were eligible for analysis. Among enrolled patients, 328 (34.2%) were compatible with CB. The CAT score was significantly higher in patients with CB than non-CB, and each component of CAT score showed a similar result. CB was significantly associated with CAT score when adjusted with age, sex, modified Medical Research Council, and post-bronchodilator forced expiratory volume in 1 second. Each component of CAT score between patients with CB and non-CB showed different pattern according to Global Initiative for Chronic Obstructive Lung Disease grade. Conclusion: CAT score is significantly higher in patients with CB than non-CB. Each component of CAT score was significantly different between two groups.

• 대한예방한의학회지
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• 제21권2호
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• pp.23-34
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• 2017

Objectives : The aim of this study was to survey the present utilization of pattern identification(PI) by chronic disease and using PI system in the clinical field among Korean medicine doctors. Methods : This survey was conducted from Oct. 1 to Oct. 31, 2014 by face-to-face interview using structured questionnaire. The subjects were 400 Korean medicine doctors who worked in hospitals or clinics. The questionnaire consisted of whether use clinical experience by chronic disease and the utilization of PI, the utilization of PI systems, the PI utilization rate, and the correlation between utilization PI and so on. General elements consisted of sex, age, clinical experience, place of work, district and so on. Results and Conclusions : This study revealed that clinical experience by chronic disease used 24.0-90.8%. The most chronic diseases were chronic fatigue and chronic pain, and least disease was cancer. Experience of the utilization of PI among Korean medicine doctors who have clinical experience was 87.8-97.1%. Also, the most utilized disease was chronic gastritis & gastric ulcer, and least disease was dyslipidemia. In this case, the most common cases were using the one PI between the utilization of PI systems, and the utilization ratio of Visceral PI was the highest. Phi coefficient between the PI systems in chronic diseases divided into positive correlation and negative correlation. The correlation of dementia between Triple energizer PI and Six excesses PI was the highest at positive correlation, and the frequency of occurrence between Defense, Qi, Nutrient and Blood PI was the highest at positive correlation. The correlation of osteoarthropathy between Meridian and Collateral PI and Sasang Constitutional Medicine was the highest at negative correlation. Also the frequency of occurrence between Qi, Blood, Fluid and Humor PI and Sasang Constitutional Medicine was the highest at negative correlation. We hope that additional studies on systematic PI research of chronic disease which needed to be in korean oriental medicine and meet the needs of clinical consumer continue based on this study.

• 대한상한금궤의학회지
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• 제15권1호
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• pp.149-160
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• 2023

Objective: To report a chronic cough that has improved after administering the Gyejigahubakhaengja-tang using Shanghanlun DPIDS(disease pattern identification diagnostic system). Methods: Chronic cough patient who occurred after COVID-19 was presumed to be diagnosed with cough variant asthma. After that, it was diagnosed as Taeyang-byung, number 43 provision according to Shanghanlun DPIDS, and the result of taking the Gyejigahubakhaengja-tang for 30 days was evaluated as VAS (visual analogue scale) and LCQ (leicester cough questionnaire). Results: After taking Gyejigahubakhaengja-tang for 30 days, chronic cough decreased from VAS 10 to VAS 1. The LCQ increased from 24 to 122. Conclusions: For chronic cough patients, 喘 at Shanghanlun DPIDS can be considered as the cause.

• Biomolecules & Therapeutics
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• 제31권4호
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• pp.395-401
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• 2023

Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.

• 대한상한금궤의학회지
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• 제13권1호
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• pp.165-178
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• 2021

Objective: This study aimed to report the improvement of a patient with chronic insomnia who was treated with Baekho-tang based on the Shanghanlun disease pattern identification diagnostic system (DPIDS). Methods: The patient's symptoms were checked on days 19, 37, and 52 after taking Baekho-tang. Chronic insomnia was evaluated by the degree of insomnia, hours spent asleep, and the number of times the patient woke up during the night, which were all assessed by a visual analog scale (VAS) with the Leeds Sleep Evaluation Questionnaire. In addition, new clinical implications for the interpretation of the 350th Shanghanlun provision were reviewed. Results: After administering Baekho-tang for 52 days, based on the 350th Shanghanlun provision according to the DPIDS, the VAS score decreased from 10 to 1. Conclusions: The patient recovered from chronic insomnia. This case report suggests that the words "滑," "厥," and "裏" in the 350th provision of Shanghanlun mean physical and psychological causes of insomnia. In addition, Baekho-tang had a therapeutic effect in improving the chief complaint of the patient. Therefore, the interpretation of the 350th Shanghanlun provision requires a new definition that includes the patient's lifestyle, family conflict, and past history of the patient as a cause of chronic insomnia.

• 대한상한금궤의학회지
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• 제13권1호
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• pp.189-196
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• 2021

Objective : This study aimed to report the improvement of a patient with chronic rhinitis treated with herbal medication using the disease pattern identification diagnostic system (DPIDS) based on the Shanghanlun provisions. Methods : According to the Shanghanlun DPIDS and an etymological interpretation of Chinese characters, the patient was diagnosed with Reverting yin disease (provision 352) and took Dangguisayeokgaosuyusaengang-tang herbal medication for 50 days. The change in symptoms of chronic rhinitis were estimated using the Total Nasal Symptom Score (TNSS), the Rhinitis Control Assessment Test (RCAT), and a visual analog scale (VAS). Results : The TNSS score decreased from 8 to 3, the RCAT score decreased from 14 to 24, and the VAS decreased from 10 to 2. Conclusions : The main causes of the disease were 厥 and 內. This is the first case report of describing the treatment of chronic rhinitis with Dangguisayeokgaosuyusaengang-tang.

• Journal of Preventive Medicine and Public Health
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• 제33권3호
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• pp.323-333
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• 2000

Objectives : Chronic HBsAg carriers are the principal source of infection for other susceptible people, and are themselves at high risk of developing serious liver diseases. In Korea, it has been estimated that 65-75% of the HBsAg positives remained as persistent carriers. Additionally, familial clustering of MBV infection has frequently been observed among carriers. Some would become progressive, chronic hepatitis patients, and others would not. The aim of this study was to evaluate the association between various factors, such as the duration of infection, type of virus, mutation of precore/core region in HBV, major histocompatibility class-I, and developing chronic liver diseases among familial HBV carriers. Methods : Chronic carrier status was identified by repeated serological tests for HBsAg at intervals of six months or more. A familial chronic carrier was defined when the disease was observed in a family member over two generations. Two families were recruited, among which a total of 20 chronic HBsAg carriers(11 carriers in No.1, and 9 in No.2 family) were identified. Data on the general characteristics and liver disease status were collected. Identification of the HBV-DNA was successful only for 13 subjects among the 20 carriers. Analysis of viral DNA in terms of subtype, pre-core and core region mutations was carried out. The type of major histocompatibility class-1 for the 13 subjects was also analysed. Results & Conclusions : Seven of 10 chronic HBV carriers of the 1st generation and one of 10 of the 2nd generation were clinical patients with chronic hepatitis, the others, three of the 1 st and nine of the 2nd generation, were asymptomatic carriers. This data indicates that the duration of HBV carriage is one of the major factors for disease severity. The subtype of HBsAg analysed using MBV-DNA identified in 13 carriers were adr, and the pattern of precore nonsense mutation in HBV-DNA was identical among family members, which meads that the same virus strains were transmitted between the family members. The association between the precore or core mutations in HBV-DNA and the disease severity was not observed. While it was suggested that a specific type of MHC class-I may be related to disease progression.

• 보건교육건강증진학회지
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• 제28권3호
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• pp.17-29
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• 2011

Objectives: This study was to explore how elderly with chronic disease in a health management program managed their health and to describe their health management strategies. Methods: The data were collected through in-depth interviews, with a purposeful sample of twelve in an urban community. The collected information was analyzed through grounded theory approaches by Strauss and Corbin. Results: Though open coding process, 35 concepts, 17 subcategories, 8 categories were identified. As for the participation experience process, four stages had surfaced, namely, 'Perception of chronic disease', 'Concerned about health', 'Developing life pattern', 'Restoring health'. These processes were within 'Restoring Health Equilibrium', core category. Consequently, the participants revealed in restoring relationship-oriented life and settling in family-focused life. Conclusions: These findings have implications for the understanding of health promotion for the elderly with chronic diseases and contributing to make a basic data for developing elderly health management program.