• Title/Summary/Keyword: chiral resolution

Search Result 168, Processing Time 0.031 seconds

Development of Optically Active Chelate Resin for Direct Resolution of Enantiomers(III)-Synthesis of Copper(II) L-Proline Chelate Resin and Resolution of Enantiomers- (Enantiomer의 분리에 이용될 수 있는 Chelate Resin의 개발(제 3보)-Copper(II) L-Proline Chelate Resin의 제조 및 Enantiomer 분리-)

  • Kim, Kil-Soo;Jeon, Dong-Won
    • Journal of Pharmaceutical Investigation
    • /
    • v.19 no.3
    • /
    • pp.117-121
    • /
    • 1989

  • A metal complex, copper (II) L-proline was chemically bound to ethylene glycol dimethacrylate and divinylbenzene crosslinked chloromethylated polystyrene and they were used as chiral chelate resin matrix for column chromatography to resolve enantiomers of DL-amino acids. The L-enantiomers eluted first and the degree of resolution on the polymer crosslinked with ethylene glycol dimethacrylate was superior to the polymer crosslinked with divinylbenzene.

  • PDF