• The Korean Journal of Physiology and Pharmacology
• /
• v.21 no.3
• /
• pp.279-286
• /
• 2017

The root bark extract of Aralia taibaiensis is used traditionally for the treatment of diabetes mellitus in China. The total saponin extracted from Aralia Taibaiensis (sAT) has effective combined antihyperglycemic and hypolipidemic activities in experimental type 2 diabetic rats. However, the active compounds have not yet been fully investigated. In the present study, we examined effects of twelve triterpenoid saponins on AMP-activated protein kinase (AMPK) activation, and found that compound 28-O-${\beta}$-D-glucopyranosyl ester (AT12) significantly increased phosphorylation of AMPK and Acetyl-CoA carboxylase (ACC). AT12 effectively decreased blood glucose, triglyceride (TG), free fatty acid (FFA) and low density lipoprotein-cholesterol (LDL-C) levels in the rat model of type 2 diabetes mellitus (T2DM). The mechanism by which AT12 activated AMPK was subsequently investigated. Intracellular ATP level and oxygen consumption were significantly reduced by AT12 treatment. The findings suggested AT12 was a novel AMPK activator, and could be useful for the treatment of metabolic diseases.

• Journal of The Korean Astronomical Society
• /
• v.50 no.6
• /
• pp.191-200
• /
• 2017

We analyze the time data recorded in Korean astronomical almanacs for the years from 1913 to 1945, which belong to the period in which Japan occupied Korea (1910-1945). These almanacs, published by Japanese scholars, differ from previous almanacs in terms of organization, content, and calendrical methods. In this study, we first extract twelve kinds of time data from the almanacs at the following times: solar terms, rising and setting of the Sun and Moon, transit of the Sun, phases of the Moon (i.e., new Moon, first quarter Moon, full Moon, and last quarter Moon), and eclipses of the Sun and Moon. Then, we compare the time data with that obtained from modern calculations. Even though all time data in the almanacs are tabulated in units of minutes, we calculate the data in units of seconds and determine the root mean square (RMS) deviation values for each kind of time data to estimate the accuracy of the data. Our findings are as follows: First, the kind and tabulation method of time data changes several times. For instance, solar transit time is listed only for six years from 1937 to 1942. Second, the times of two equinoxes and those of a new Moon are considerably close to midnight. Third, there are some typographical errors in the almanacs, particularly in the times of moonrise and moonset. Fourth, the contact times for lunar eclipses represent the times of the umbra and not of the penumbra, which is different from the times for solar eclipses. Finally, the RMS deviation values are approximately 0.5 min on average in all kinds of time data, even though they show slightly large differences in the times related to the Moon. In conclusion, we believe that this study is useful for investigating the time data in the almanacs of other East Asian countries that were published during the same period, such as China, Japan, and Manchuria.

• Microbiology and Biotechnology Letters
• /
• v.38 no.2
• /
• pp.190-197
• /
• 2010

To develop the safe and natural antimicrobial agents, the 68 ethanol extracts from the 61 different kinds of oriental herbal medicine were prepared and their antimicrobial activities were evaluated. The herbal medicine used were from China (46 kinds), South Korea (14 kinds), North Korea (5 kinds) and Vietnam (3 kinds), respectively, and the root (27 species) was popular part in this study. The average water content and extraction ratio for ethanol were 7.10% and 6.75%, respectively. Determination of antimicrobial activity by disc-diffusion assay at 0.5 mg/disc concentration showed that the extract of Angelica tenuissima Nakai (china), Illicium verum, Junci medulla, Rhus javanica L., Salvia miltiorrhiza Bunge and Syzygium aromaticum has strong antimicrobial activities against different food spoilage and pathogenic bacteria and fungi. Determination of MIC and MBC/MFC further showed that the extract of Syzygium aromaticum has MIC of 1.25 mg/mL and MBC/MFC of 1.25~5.00 mg/mL against Listeria monocytogenes, Bacillus subtilis, Staphylococcus epidermidis, Staphylococcus aureus, Salmonella typhimurium, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Saccharomyces cerevisiae. And, the extract of Junci medulla, Rhus javanica L. and Salvia miltiorrhiza Bunge showed strong antibacterial activities with MIC of 0.08~0.63 mg/mL and MBC/MFC of 0.08~2.50 mg/mL against the tested bacteria except E. coli and P. aeruginosa. In a while, the results of hemolytic activity of 68 different herbal extracts against human red blood cells showed that the extract of Angelica tenuissima Nakai has hemolytic activity at 0.5 mg/mL concentration. Therefore, Illicium verum, Junci medulla, Rhus javanica L., Salvia miltiorrhiza Bunge and Syzygium aromaticum were finally selected for natural antimicrobial resources. Further research on active substances and the mode of action of the selected herbal medicine is necessary.