• Child Health Nursing Research
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• 제11권1호
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• pp.72-82
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• 2005

Purpose: The purpose of this study was to develop a tool to assess the need for child hospice care in families of children with cancer. Method: The research design was a methodological study. The tool was developed in 4 stages : first, preliminary items were developed based on a questionnaire about the needs for child hospice care that was given to 20 families of children with cancer; second, a panel of specialists reduced the number of preliminary items using 3 validity tests for the content; third, final items were selected from the results of a pre-test. Finally, from February to July 2004, reliability and validity were tested with a sample of 104 families who had a child with cancer. Results: The final tool on the need for child hospice care consisted of 22 items and Cronbach's alpha coefficient for internal consistency was .93. Using factor analysis, 5 factors were extracted and these factors explained 69％ of the total variance. Conclusion: The instrument, for assessing the need for child hospice care in families of children with cancer, developed in this study was identified as a tool with a high degree of reliability and validity. In this sense, this tool can be effectively utilized for implementing and improving hospice care for children with cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1031-1035
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• 2013

Background: There have been few studies in Turkey on the incidence of childhood cancers. A mother's knowledge about signs and symptoms of cancer is important for early diagnosis, effective treatment, and improvement of life expectancy. This study was conducted with a group of mothers of children, aged 0-13, at a Family Health Center (FHC) in Turkey's Eastern Black Sea Region, to analyze their knowledge about cancer symptoms in childhood. Materials and Methods: The study group of this descriptive/cross-sectional research comprised 2,061 mothers, ages 19-49, at an FHC in the Eastern Black Sea Region in February 1, 2011 - June 1, 2011. Before the study, permission was obtained from the local ethics board and the institutions concerned. A value of p<0.05 was accepted as statistically significant. Results: Of the mothers, 34.9% were between the ages of 40-47, 40.5% had three children, 73.8% had no experience with children with cancer, 45.9% said they learned about cancer on television, 39.7% stated that the primary reason for childhood cancer was the mother's smoking during pregnancy, 68.8% said that early diagnosis would save a child, and 98% wanted to learn about childhood cancer. Conclusion: It was determined that the mothers' knowledge of cancer was deficient.

• 대한간호학회지
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• 제29권3호
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• pp.679-687
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• 1999

The increased potential for the lifespan of a child with cancer is largely due to advances in drug treatment, radiation treatment, and surgical techniques. In this generation cancer has become associated with chronic illness. Therefore supportive nursing intervention for children with cancer is needed to promote normal growth and development. This study was designed to develop and test the supportive nursing intervention program for promoting body image and self-esteem of children with cancer The supportive nursing intervention program involved emotional, physical, informational, and social support. The subjects were 41 children with cancer(20 in intervention group, 21 in control group) in K city. Measurements were taken concerning body image and self-esteem from both groups during pre and post test The data were analyzed using Cronbach's alpha, x$^2$-test, paired t-test and t-test. The results were as follows : The intervention group had a more positive body image as measured by the Body Cathexis Scale (t＝2.436, p＝.020) and a more self esteem as measured by the Cpopersmith self-inventory (t＝2.768, p＝.009) than the control group at post test. According to this study, the supportive nursing intervention program was effective for promoting the body image and self-esteem of children with cancer. Repeated research is needed to develop a refined supportive nursing intervention program for children with chronic illness.

• Child Health Nursing Research
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• 제7권2호
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• pp.179-190
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• 2001

The purposes of the study were to develop an instrument for family value and to identify the relationships of family value, family hardiness, and family adaptation by appling the family value scale to family with cancer children. The study was conducted in three phases. 1) A survey was conducted from July 20 to August 20, 1999 and 18 items of general family value scale was modified from the data of 153 fathers and 164 mothers. 2) In-depth interviews were made with 29 parents of cancer children from April 20, 1998 to May 20, 1999 to develop family value scale with cancer children, and 12 statements were developed. 3) The final survey was conducted from July 18, 2000 to August 30, 2000 and the data from 309 parents of children who are diagnosed as cancer, 18 or less years of age, and treated either hospitalized or at the outpatient clinics were analyzed to identify the relationships of the concepts. The data analysis utilized SAS 6.12 and LISREL 8 for descriptive statistics, correlation, and Regression for path analysis. The study findings are as follows. The psychometric testing of general family value scale was Cronbach's alpha = 0.78. The reliability of the family value scale with cancer children showed the reliability as Cronbach's alpha = 0.73. Demographic characteristics showing significant correlations were cancer children's age, period of illness, period after completing treatment, mother's age, mother's education level, monthly income, payment type, confidence with health professional, and severity of children's illness. The correlation coefficients among major variables showed that family stressor was positively related with family strains(r=0.33, p<.001), and negatively related with family hardiness(r=-0.21, p<.001). Family strains was negatively related with family hardiness(r= -0.41, p<.001) and family adaptation(r=-0.46, p<.001). Correlations of family hardiness was positive with family value with cancer children(r=-0.31, p<.001), and negative with general family value(r=-0.16, p<.01). Family hardiness was positively related with family adaptation(r=0.35, p<.001). The causal relationship between study variables showed that family strains predicts general family value(γ=0.12, t=2.02), family value with cancer children predicts family hardiness(γ=0.31, t=6.30), family strains predicts family hardiness(γ=-0.40, t=-7.70), family value with cancer children predicts family adaptation(γ=-0.23, t=-4.11), and family hardiness predicts family adaptation(γ=0.43, t=7.78).

• Child Health Nursing Research
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• 제11권2호
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• pp.229-239
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• 2005

Purpose: The objective of this study was to provide an understanding of the difficulties for facing parents of children with terminal cancer. Method: The design of this study was an inductive and descriptive study. Thirty???]one parents of children with terminal cancer participated in???]depth were interviewed s. C in depth and content analysis was used for analyzing the data. Results: The main categories in the findings were 'difficulties in coping', 'physical and psychological suffering of children', 'suffering of family', 'bereavement with children', 'economic problems', 'incurable situation', 'preparation of death', 'social isolation', 'coping after a child dies', 'spiritual problems', receiving active treatment', 'informing children of their condition', 'a sense of meaninglessness', 'emotional iunstability', and 'giving up hope'. Conclusion: The main point identified from this result in this study was that parents who have a child with terminal cancer don't never give up the hope of recovery for their child even when the child is in by the terminal stage of their children, even though and they are unwillingly to prepare for their child's death. This is a unique characteristic in the attitude of the families' attitude in child hospice care and differs from that found in adult hospice care. This result can be used as an important guide for nurses to in assessing the parents' needs in the terminal care setting.

• 여성건강간호학회지
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• 제21권3호
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• pp.216-231
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• 2015

Purpose: The purpose of this study is to provide the basic data to develop the effective nursing intervention for the parent who have children with cancer by acquiring the deeper understanding of the mothers' adjustment of caring for their children with cancer. Methods: The ethnographic research method was used to find out the pattern of caring adjustment in Korean cultural context. Informants consisted of 12 mothers who were caring for their children with cancer. The data were collected using in-depth interviews, participant observation, and telephone interviews by maximum variation purposive sampling. The data were analyzed following Spradley's methodology. Results: The mothers' caring adjustment were organized into one cultural theme, four categories, and twelve properties. The cultural theme was 'standing alone as a mother with sin'. The four categories were 'blaming for falling illness', 'overcoming with motherhood', 'desperate struggling with side effects', and 'establishing new network as a dependent'. Conclusion: For the mothers who are caring children with cancer, the supportive nursing intervention based on the deeper understanding of mothers' pattern of caring adjustment for their children and centered on facilitating effective adjustment in each cultural context especially from the very early stage of caring in the hospital ward is extremely required.

• Clinical and Experimental Pediatrics
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• 제58권9호
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• pp.358-361
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• 2015

Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, splenomegaly, jaundice, and pathologic findings of hemophagocytosis in bone marrow or other tissues such as the lymph nodes and liver. Pleocytosis, or the presence of elevated protein levels in cerebrospinal fluid, could be helpful in diagnosing HLH. However, the pathologic diagnosis of the brain is not included in the diagnostic criteria for this condition. In the present report, we describe the case of a patient diagnosed with HLH, in whom the brain pathology, but not the bone marrow pathology, showed hemophagocytosis. As the diagnosis of HLH is difficult in many cases, a high level of suspicion is required. Moreover, the pathologic diagnosis of organs other than the bone marrow, liver, and lymph nodes may be a useful alternative.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1717-1723
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• 2016

Background: This study assessed parental experiences with chemotherapy-induced alopecia among children with cancer treated at an Indonesian academic hospital. Materials and Methods: Fifty parents of childhood cancer patients were interviewed using semi-structured questionnaires. Results: The moment that hair fell out was the moment that parents (84%) had to admit their child had cancer. Alopecia was a traumatizing painful experience (46%). Active strategies to hide alopecia, mainly hats, were used by 66% of children, while 34% never covered their bald head. If money had not been an issue, 40% would use another strategy. Alopecia made children limit outdoor daily activities (78%) and engagement with others (60%). Significantly more children from high-educated (95%) than low-educated (60%) parents received sympathy from other people (P=0.012). Significantly more Christian (29%) than Muslim (0%) families confirmed that alopecia lowered the quality of life (P=0.046). Most parents (82%) had no prior plans about alopecia management, yet for significantly more girls (26%) than boys (0%) such plans existed (P=0.044). Parents received most information about alopecia from other parents (66%). Parents (92%) needed more alopecia education from doctors. Of all school-attending children, 53% were bullied and 47% did not want to attend school due to alopecia. Significantly more high-educated than low-educated families received pity from teachers and pupils (94% vs. 0%, P=0.004), and acceptance by pupils (81% vs. 0%, P=0.021). Conclusions: Alopecia is a severe, far-stretching side-effect of chemotherapy with physical, psychological and social consequences for children and parents. Parents should be better informed about occurrence and impact of alopecia. Extra attention is required to facilitate children's return to school. Healthcare providers should facilitate optimal supportive care through open dialogue and provision of educational m aterials for parents, children and their community.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2447-2451
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• 2014

Human papillomavirus (HPV) is the primary etiologic agent of cervical cancer. Consideration of safety and non human leukocyte antigen restriction, protein vaccine has become the most likely form of HPV therapeutic vaccine, although none have so far been reported as effective. Since tumor cells consistently express the two proteins E6 and E7, most therapeutic vaccines target one or both of them. In this study, we fabricated DC vaccines by transducing replication-defective recombinant adenoviruses expressing E6/E7 fusion gene of HPV-16, to investigate the lethal effects of specific cytotoxic T lymphocytes (CTL) against CaSki cells in vitro. Mouse immature dendritic cells (DC) were generated from bone marrow, and transfected with pAd-E6/E7 to prepare a DC vaccine and to induce specific CTL. The surface expression of CD40, CD68, MHC II and CD11c was assessed by flow cytometry (FCM), and the lethal effects of CTL against CaSki cells were determined by DAPI, FCM and CCK-8 methods. Immature mouse DC was successfully transfected by pAd-E6/E7 in vitro, and the transfecting efficiency was 40%-50%. A DC vaccine was successfully prepared and was used to induce specific CTL. Experimental results showed that the percentage of apoptosis and killing rate of CaSki cells were significantly increased by coculturing with the specific CTL (p <0.05). These results illustrated that a DC vaccine modified by HPV-16 E6/E7 gene can induce apoptosis of CaSki cells by inducing CTL, which may be used as a new strategy for biological treatment of cervical cancer.

• 한국아동복지학
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• 제26호
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• pp.7-30
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• 2008

의학기술의 발전으로 소아암 환아의 생존율이 1960년대 30%미만에서 최근 75%이상으로 향상되었다. 이에 따라 소아암은 더 이상 불치병이 아닌 만성질환으로 분류되고 있으나, 장기간의 투병생활로 인해 소아암 환아들은 신체적, 심리사회적 문제를 겪고 있다. 특히 외모에 관심이 많고, 또래관계가 중요한 10대 소아암 환아들에게 있어 신체적, 심리사회적 변화는 이들의 신체상과 질병적응에 영향을 미칠 것으로 예상된다. 이에 본 연구에서는 소아암 환아의 신체상(신체왜곡도) 및 질병적응 수준을 알아보고, 인구사회학적 특성, 질병관련 특성 및 신체상이 소아암 환아의 질병적응에 미치는 영향에 대해 알아보았다. 본 연구는 2007년 10월 22일부터 11월 16일까지 자기기입식 설문조사로 이루어졌으며, 조사대상자는 암진단 후 3년 이내의 10세에서 18세 환아 82명이었다. 수집된 자료는 기술통계, t-검정, 상관관계, 위계적 다중회귀방법으로 분석하였다. 분석결과, 연령, 학교생활여부, 신체상이 소아암 환아의 질병적응에 영향을 미치는 요인으로 나타났다. 즉, 연령이 높을수록, 학교생활을 하고 있는 환아가 그렇지 않은 환아보다, 신체왜곡도가 낮을수록 질병적응에 긍정적 영향을 미치는 것으로 나타났다. 소아암 환아의 질병적응을 돕기 위해서는 소아암 환아가 학교생활을 지속할 수 있도록 돕는 정책적 제도 구축, 긍정적 신체상 형성을 위한 프로그램 개발, 소아암 환아의 연령을 고려한 심리사회적 접근 등이 필요하며, 이를 위해 사회복지사의 적극적인 개입이 이루어져야 할 것이다.