• Analytical Science and Technology
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• v.18 no.5
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• pp.381-385
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• 2005

The title compound, $\{H_2NCH_2CH_2NH_2CH_2CH_2\}\{Cu(H_2O)_6\}(SO_4)_2$, I, has been synthesized under solvo/hydrothermal conditions and their crystal structure analyzed by X-ray single crystallography. Compound I crystallizes in the monoclinic system, $P2_1/n$ space group with a = 6.852(1), b = 10.160(2), $c=11.893(1){\AA}$, ${\beta}=92.928(8)^{\circ}$, $V=826.9(2){\AA}^3$, Z = 2, $D_x=1.815g/cm^3$, $R_1=0.031$ and ${\omega}R_2=0.084$. The crystal structure of the piperazine templated Cu(II)-sulfate demonstrate zero-dimensional compound constituted by doubly protonated piperazine cations, hexahydrated copper cations and sulfate anions. The central Cu atom has a elongated octahedral coordination geometry. The crystal structure is stabilized by three-dimensional networks of the intermolecular $O_{water}-H{\cdots}O_{sulfate}$ and $N_{pip}-H{\cdots}O_{sulfate}$ hydrogen bonds between the water molecules and sulfate anions and protonated piperazine cations. Based on the results of thermal analysis, the thermal decomposition reaction of compound I was analyzed to have three distinctive stages.

• Korean Chemical Engineering Research
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• v.50 no.3
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• pp.588-593
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• 2012

Compatibility of unsaturated polyester (UP) and low profile agent (LPA) of polystyrene (PS) have been investigated under various mixing conditions such as the ratio of UP and LPA, mixing time, mixing temperature, and input amount of 2nd UP. It was possible to obtain mixture with small particle size and low phase separation in condition of 35 g of LPA, 25 g of 1st UP input, 5 min of mixing time, 1700 rpm of mixing speed, and 45 g of 2nd UP input. It was found that compatibility of UP and LPA was very sensitive to mixing conditions. In addition, molded sample using sheet molding compound prepared by stable mixing condition appeared good properties such as low water adsorption, low shrinkage, and high gloss.

• Journal of Microbiology and Biotechnology
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• v.6 no.4
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• pp.265-269
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• 1996

An isolate of Streptomyces rochei synonym was found to produce antibiotics with narrow anti-microbial spectrum against Streptococcus and Xanthomonas sp. Among the antibiotic complex produced by the strain, the main active compound was isolated, and its physico-chemical properties and biological activities were investigated. Molecular weight of the compound was determined to be ${[M+H]}^+$ 797 (FAB-MS). UV, $^1H \;and\;^{13}C$ NMR, and IR spectra suggested that the compound is a kirromycin-like aurodox group antibiotic. However, the anti-microbial spectrum of the main compound was slightly different from that of kirromycin. In addition, it was newly found that kirromycin showed a selective anti-microbial activity against Streptococcus pyogenes and phytopathogenic Xanthomonas sp.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1571-1576
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• 2012

A diarylurea compound 1 possessing pyrrolo[3,2-$c$]pyridine nucleus was designed and synthesized with structure similarity to Sorafenib. Compound 1 was tested over 60-cancer cell line panel at a single dose concentration of 10 ${\mu}M$ and showed high activity. It was further tested in a five-dose mode to determine its $IC_{50}$, TGI, and $LC_{50}$ values over the 60 cell lines. Compound 1 showed high potency and good efficacy, and was accordingly tested at a single dose concentration of 10 ${\mu}M$ over a panel of 40 kinases. At this concentration, it completely inhibited the enzymatic activities of a number of oncogenic kinases, including ABL, ALK, c-RAF, FLT3, KDR, and TrkB. The target compound was subsequently tested over these 6 kinases in 10-dose testing mode in order to determine its $IC_{50}$ values.

• Bulletin of the Korean Chemical Society
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• v.35 no.3
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• pp.919-924
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• 2014

Ambient ionization can be achieved by generating an electrospray directly from plant tissue ("leaf spray"). The resulting mass spectra are characteristic of ionizable phytochemicals in the plant material. By subtracting the leaf spray spectra recorded from the petals of two hibiscus species H. moscheutos and H. syriacus one gains rapid access to the metabolites that differ most in the two petals. One such compound was identified as the sambubioside of quercitin (or delphinidin) while others are known flavones. Major interest centered on a $C_{19}H_{29}NO_5$ compound that occurs only in the large H. moscheutos bloom. Attempts were made to characterize this compound by mass spectrometry alone as a test of such an approach. This showed that the compound is an alkaloid, assigned to the polyhydroxylated pyrrolidine class, and bound via a $C_3$ hydrocarbon unit to a monoterpene.

• Journal of the Korean Society for Heat Treatment
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• v.16 no.2
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• pp.71-77
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• 2003

We investigate the phase formation in the compound layer of cast irons during the gaseous nitrocarburising of four different cast irons, that contain different types of graphites in the shape and size. We examine the change in the surface roughness with the nitrocarburising time. The observation of cross-sectional microstructure and X-ray diffraction analysis indicate that the compound layer consists of single ${\varepsilon}-Fe_{2-3}(N,C)$ phase and that its thickness increases in a parabolic manner with the treatment time. The surface roughness parameters, Rz and Ra increase with increasing treatment time. In other words, the roughness parameters increase as the thickness of compound layer increases. The parameters also depend on the shape and size of graphite in the individual cast irons.

• Bulletin of the Korean Chemical Society
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• v.35 no.4
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• pp.1154-1158
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• 2014

Hsp90 is an ubiquitous molecular chaperone protein, which plays an important role in regulating maturation and stabilization of many oncogenic proteins. Due to its potential to simultaneously disable multiple signaling pathways, Hsp90 represents great promise as a therapeutic target of cancer. In this study, we synthesized flavokawain analogues and evaluated their biological activities against drug-resistant cancer cells. The study indicated that compound 1i impaired the growth of gefitinib-resistant non-small cell lung cancer (H1975), down-regulated the expression of Hsp90 client proteins including EGFR, Her2, Met, Akt and Cdk4, and upregulated the expression of Hsp70. The result strongly suggested that compound 1i inhibited the proliferation of cancer cells through Hsp90 inhibition. Overall, compound 1i could serve as a potential lead compound to overcome the drug resistance in cancer chemotherapy.

• Bulletin of the Korean Chemical Society
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• v.20 no.3
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• pp.281-284
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• 1999

Two La1.82Ca1.18Cu2O6+δ (2126) compounds exhibited different properties depending upon how they were synthesized. The compound prepared under high oxygen pressure showed superconductivity. But the compound prepared under low oxygen pressure did not exhibit superconductivity, and showed a metal-insulator transition. Our study on these compounds shows that a small amount of additional oxygen intercalated into the superconducting phase plays an important role for superconductivity. The Fermi surface of non-superconducting 2126 compound possesses nesting phenomena, which is the reason for the M-1 transition. On the other hand, the superconducting 2126 compound does not show Fermi surface nesting. This is because the additional oxygen removes some electrons from Cu d-orbitals, thereby bradking the Fermi surface nesting.

• Applied Chemistry for Engineering
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• v.5 no.6
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• pp.943-948
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• 1994

The properties of uncured rubber compound and swelling behavior of cured rubber compound with carbon black(N33O grade) increment. Bound Rubber content(BRC) increased according to carbon black increment and ${\alpha}_f$, behavior of uncured rubber compound filled with carbon black, was 1.46. Carbon black added to rubber compound showed behavior of spherical particle by bound rubber. The $C_1$ values of cured rubber compounds, which measured by the stress-strain method of Mooney-Rivlin, increased with carbon black increment.

• Journal of the Korean Chemical Society
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• v.14 no.3
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• pp.207-212
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• 1970

A large variety of weed killers, insecticides, and bactericiedes on the market today are of almost infinite variety, but their pharmacological effects are different from each other according to the objects to cope with. Therefore, it is hoped that some chemical substance which serves as weed killer, an insecticide, and a bactericede at a same time, should be synthesized, in order to save expense and labor. I anticipated that the desire would be met by introducing to a molecule the radical which has the three effects. Here, I made an attempt of introducing $Cl_2$ gas to aniline considering the following respects: 1. Introduction velocity of $Cl_2$ gas under the varied temeratures and velocities of $Cl_2$ gas 2. The effect of reaction period under the condition which gives the most satisfactory yield. 3. The actions of catalysts, $SbCl_3$, $FeCl_3$, and $MoCl_5$, and their proportions when a mixture of the three catalysts is used in producing 2,6-dichloro-aniline. After consideration of above phenomena, the maximum production rate of 79.5% of 2.6-compound was obtained. With the compound I synthesized 2.6-dichloro-4-nitroaniline-mercuric acetate. Investigations of the effects of the compound as weed killer, an insecticide, and a bactericide showed that the compound, 2,6-dichloro-4-Nitro Aniline mercuric acetate has a satisfactory herbi-insecti-bactericidal effect.