• 한국통신학회논문지
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• 제28권5A호
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• pp.294-304
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• 2003

셀룰러 CDMA 시스템에서 보다 효과적인 소프트웨어 다운로드가 되기 위해, 영역 기반 세션수락제어 기법이 제안된다. 제안 방식에서 기지국은 단말이 셀의 기지국 근처에 위치할 때만 세션 시작을 허용한다. 단말의 위치가 셀의 기지국 근처이면 소프트웨어 다운로드 요구를 허용하고, 셀의 경계에 위치한 경우는, 셀의 근처로 올 때까지 기다려서, 소프트웨어 다운로드를 시도하도록 함으로서, 소프트웨어 다운로드 중 셀간 핸드오프가 일어나는 빈도를 줄여, 핸드오프 세션의 강제절단확률을 줄이는 방식이다. 세션지속시간의 분포함수로서 지수분포와 Pareto 분포를 고려하여 핸드오프 빈도, 평균 채널점유시간, 세션 블록킹 확률, 핸드오프 세션의 강제 절단 확률 관점에서 성능을 분석하였다. 성능분석 결과 단말 이동속도, 세션 요구 허용 지역의 크기, 핸드오프 전용 채널 수 등의 트래픽 특성에 따라 다르지만, 분석을 위해 가정한 파라미터 값을 기준으로, 기존 방식에 비해 30 ～ 250% 정도의 핸드오프 빈도를 줄일 수 있게 된다. 또한 신규세션의 블록킹 확률은 5 ~ 20% 정도 줄이지만, 핸드오프세션의 강제절단률은 35% ~ 220%까지 줄일 수 있게 됨을 알 수 있다.

• 대한수의학회지
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• 제34권1호
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• pp.37-47
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• 1994

The effects of the novel compound GS-386 on the calcium current were investigated in rabbit atrial myocytes. The calcium current was recorded during various depolarizations of 200 ms duration from a holding potential of -40 mV using the whole cell patch clamp technique. The calcium current was activated from -30 mV, reached maximum amplitude at +10 mV and almost disappeared at +50 mV. Superfusion of GS-386 led to a reduction of the calcium current amplitude dose-dependently and $ED_{50}$ was $2.5{\times}10^{-7}M$. But the dependence of the calcium current on the membrane potential was not altered by GS-386. The inactivation of the calcium currents showed single exponential curves in both before and after application of GS-386. The inactivation time constants before and after application of GS-386 were almost the same(35 ms and 32.5 ms). The steady-state inactivation curve of the calcium current was not shifted by GS-386. The calcium currents both before and after application of GS-386 recovered completely in 1 sec and the recovery time constants were about 200 ms in both cases. From the above results it is concluded that the novel compound GS-386 has calcium antagonistic property decreasing the calcium current.

• The Korean Journal of Physiology
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• 제26권2호
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• pp.113-122
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• 1992

It is well known that chromaffin cells of adrenal medulla secrete catecholamine in response to sympathetic nerve activation and the influx of $Ca^{2+}$ through the voltage dependent $Ca^{2+}$ channels (VDCC) in the cell membrane do a major role in this secretory process. In this study, we explored the effect of divalent cations on VDCC of rat chromaffin cells. Rat (Sprague-Dawley rat, 150-250 gm) chromaffin cells were isolated and cultured. Standard giga seal, whole cell recording techniques were employed to study $Ca^{2+}$ current with external and internal solutions that could effectively isolate VDCC currents $(NMG\;in\;external\;and\;TEA\;and\;Cs^{2+}\;in\;internal\;solution)$. The voltage dependence and the inactivation time course of VDCC in our cells were identical to those of bovine chromaffin cells. A persistent inward current was first activated by depolarizing step pulse from the holding potential (H.P.) of -80 mV to -40 mV, increased to maximum amplitude at around +10 mV, and became smaller with progressively higher depolarizing pulses to reverse at around +60 mV. The inactivation time constant $(\tau)$, fitted from the long duration test potential (2 sec) was $1295.2{\pm}126.8$ msec $(n=20,\;1\;day\;of\;culture,\;mean\;{\pm}S.E.M.)$ and the kinetic parameters were not altered along the culture duration. Nicardipine $(10\;{\mu}M)$ blocked the current almost completely. Among treated divalent cations such as $Cd^{2+},\;Co^{2+},\;Ni^{2+},\;Zn^{2+}\;and\;,Mn^{2+},\;Cd^{2+}$ was the most potent blocker on VDCC. When the depolarizing step pulse from -80 mV to 10 mV was applied, the equilibrium dissociation constant $(K_d)$ of $Cd^{2+}\;was\;39\;{\mu}M,\;K_d\;of\;Co^{2+}\;was\;100\;{\mu}M\;and\;K_d\;of\;Ni^{2+}];was];780{\mu}M.$ The principal findings of this study are as follows. First, the majority of $Ca^{2+}$ channels in rat chromaffin cells are well classified to L-type $Ca^{2+}$ channel in the view of kinetics and pharmacology. Second, all divalent cations tested could block the $Ca^{2+}$ current and the most potent blocker among the tested was $Cd^{2+}$.

• Transactions on Electrical and Electronic Materials
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• 제7권1호
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• pp.1-6
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• 2006

Hot carrier degradation and roll off characteristics of threshold voltage ($V_{t1}$) on NMOSFETs as I/O transistor are studied as a function of Lightly Doped Drain (LDD) structures. Pocket dose and the combination of Phosphorus (P) and Arsenic (As) dose are applied to control $V_{t1}$ roll off down to the $10\%$ gate length margin. It was seen that the relationship between $V_{t1}$ roll off characteristic and substrate current depends on P dopant dose. For the first time, we found that the n-p-n transistor triggering voltage ($V_{t1}$) depends on drain current, and both $I_{t2}$ and snapback holding voltage ($V_{sp}$) depend on the substrate current by characterization with a transmission line pulse generator. Also it was found that the improved lifetime for hot carrier stress could be obtained by controlling the P dose as loosing the $V_{t1}$ roll off margin. This study suggests that the trade-off characteristic between gate length margin and channel hot carrier (CHC) lifetime in NMOSFETs should be determined by considering Electrostatic Discharge (ESD) characteristic.

• The Korean Journal of Physiology and Pharmacology
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• 제1권6호
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• pp.741-748
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• 1997

In the present study, we have investigated the effect of metabolic inhibition on the inward rectifier K current ($I_{K1}$). Using whole cell patch clamp technique we applied voltage ramp from +80 mV to -140 mV at a holding potential of -30 mV and recorded the whole cell current in single ventricular myocytes isolated from the rabbit heart. The current-voltage relationship showed N-shape (a large inward current and little outward current with a negative slope) which is a characteristic of $I_{K1}$. Application of 0.2 mM dinitrophenol (DNP, an uncoupler of oxidative phosphorylation as a tool for chemical hypoxia) to the bathing solution with the pipette solution containing 5 mM ATP, produced a gradual increase of outward current followed by a gradual decrease of inward current with little change in the reversal potential (-80 mV). The increase of outward current was reversed by glibenclamide ($10\;{\mu}M$), suggesting that it is caused by the activation of $K_{ATP}$. When DNP and glibenclamide were applied at the same time or glibenclamide was pretreated, DNP produced same degree of reduction in the magnitude of the inward current. These results show that metabolic inhibition induces not only the increase of $K_{ATP}$ channel but also the decrease of $I_{K1}$. Perfusing the cell with ATP-free pipette solution induced the changes very similar to those observed using DNP. Long exposure of DNP (30 min) or ATP-free pipette solution produced a marked decrease of both inward and outward current with a significant change in the reversal potential. Above results suggest that the decrease of $I_{K1}$ may contribute to the depolarisation of membrane potential during metabolic inhibition.

• 한국멀티미디어학회논문지
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• 제8권4호
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• pp.502-508
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• 2005

본 논문에서는 VOD 비디오 서버의 제한된 네트워크-입출력 대역폭을 효율적으로 사용하기 위해 탐욕 패칭과 점진 패칭의 장점을 취하여 VOD 시스템의 성능을 향상시킬 수 있는 동적 혼성 패칭 방법을 제안한다. 제안하는 방법은 요청 도착 간격이 패칭 윈도우의 크기보다 작은 비디오 요청은 점진 패칭을 사용하며 나머지 비디오 요청은 탐욕 패칭을 사용한다. 더욱이 제안한 패칭 기법은 탐욕 패칭을 개선시키기 위해 최근의 특정 패칭 멀티캐스트를 정규 멀티캐스트로 확장한다. 그 결과 새로운 요청을 위한 패칭 멀티캐스트 데이터가 비디오의 시작부터 스큐 지점까지로 되어 디스패치된 채널의 사용 시간이 대폭 감소된다. 시뮬레이션 결과는 제안한 기법이 점진 패칭보다 이탈율과 평균 서비스 지연시간에 있어서 우수함을 보여준다.

• 무역상무연구
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• 제13권
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• pp.1013-1032
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• 2000

At present, the scale of Electronic Commerce through internet has been rapidly increasing due to the development of information & communication technology, and aggregated to 2.4 billion dollar in America last year (1998). The market scale of worldwide electronic commerce is also presumed to be about 130 billion dollar in 2000, and to occupy more than 20% of the whole world trade in world 2020. Since the right of trademark, despite of being effective only in registered nations on the principle of territorialism, is unified on the cyber space of internet without domestic barrier or local limitation which make it easier to conduct the distribution of information rapidly through the address-internet domain name, those are very important that the systematic dispute-solving plan on problems such as decision of its Act and international jurisdiction to be established, in an effort to prevent the newly emerging dispute instances such as trademark infringement and improper competitiveness. In addition, it is natural that on the threshold of the electronic commerce age which formed with an unified area without the worldwide specific regulation, each country including us makes haste with the enactment of "electronic commerce Act" aiming at coming into force in 1999, in keeping with getting through "non-tariff law on electronic commerce" by U. S. parliament on May, 1998. In view of the properties of electronic commerce transactions through internet, there are the large curtailment of distributive channel, surmounting of restrictions on transaction area, space and time and the easy feedback with consumer and the cheap-required capital, from which the problems may arise - registration of trademark, the trademark infringement of domain name and the protection of prestigious trademark. Therefore, it is necessary to take the counter-measure, with a view of reviewing the infringement of trademark and domain name and the instances of each national precedent and to preventing the disputes. The improvement of the persistent system should be needed to propel the harmonious protection of those holding trademark right's credit and demanders' expectant profit by way of the righteous use of trademark.

• The Korean Journal of Physiology and Pharmacology
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• 제24권5호
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• pp.433-440
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• 2020

The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) is the first relay site for the orofacial nociceptive inputs via the thin myelinated Aδ and unmyelinated C primary afferent fibers. Borneol, one of the valuable time-honored herbal ingredients in traditional Chinese medicine, is a popular treatment for anxiety, anesthesia, and antinociception. However, to date, little is known as to how borneol acts on the SG neurons of the Vc. To close this gap, the whole-cell patch-clamp technique was applied to elucidate the antinociceptive mechanism responding for the actions of borneol on the SG neurons of the Vc in mice. In the voltage-clamp mode, holding at -60 mV, the borneol-induced non-desensitizing inward currents were not affected by tetrodotoxin, a voltage-gated Na⁺ channel blocker, 6-cyano-7-nitro-quinoxaline-2,3-dione, a non-N-methyl-ᴅ-aspartate (NMDA) glutamate receptor antagonist and DL-2-amino-5-phosphonopentanoic acid, an NMDA receptor antagonist. However, borneol-induced inward currents were partially decreased in the presence of picrotoxin, a γ-aminobutyric acid (GABA)_A receptor antagonist, or strychnine, a glycine receptor antagonist, and was almost suppressed in the presence of picrotoxin and strychnine. Though borneol did not show any effect on the glycine-induced inward currents, borneol enhanced GABA-mediated responses. Beside, borneol enhanced the GABA-induced hyperpolarization under the current-clamp mode. Altogether, we suggest that borneol contributes in part toward mediating the inhibitory GABA and glycine transmission on the SG neurons of the Vc and may serve as an herbal therapeutic for orofacial pain ailments.

• The Korean Journal of Physiology
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• 제28권2호
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• pp.215-224
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• 1994

The presence of a calcium current $(i_{Ca^{2+}})$ passed via a specific channel was examined in the unfertilized hamster egg using the whole-cell voltage clamp technique. Pure inward current was isolated using a $Ca^{2+}-rich$ pipette solution containing 10 mM TEA. This current was independent of external $Na^+$ and was highly sensitive to the $Ca^{2+}$ concentration in the bathing solution, indicating that the inward current is carried by $Ca^{2+}$. The maximal amplitude was $-4.12{\pm}0.58nA\;(n=12)$ with 10mM $Ca^{2+}$ at -3OmV from a holding potential of -8OmV. This current reached its maximum within 20ms beyond -3OmV and decayed rapidly with an inactivation time constant $({\tau})$ of 15ms. Activation and inactivation of this $i_{Ca^{2+}}$ was steeply dependent on the membrane potential. The $i_{Ca^{2+}}$ began to activate at the lower voltage of -55 mV and reached its peak at -35 mV, being completely inactivated at potentials more positive than -40 mV. These result suggest that $i_{Ca^{2+}}$ in hamster eggs passes through channels with electrical properties similar to low voltage-activated T-type channels. Other results from the present study support this suggestion; First, the inhibitory effect of $Ni^{2+}\;(IC_{50}=13.7\;{\mu}M)$ was more potent than $Cd^{2+}\;(IC_{50}=123\;{\mu}M)$. Second, $Ba^{2+}$ conductance was equal to or below that of $Ca^{2+}$. Third, $i_{Ca^{2+}}$ in hamster eggs was relatively insensitive to nifedipine $(IC_{50}=96.6\;{\mu}M)$, known to be a specific t-type blocker. The physiological role of $i_{Ca^{2+}}$ in the unfertilized hamster eggs remains unclear. Analysis from steady-state inactivation activation curves reveals that only a small amount of this current will pass in the voltage range $(-70{\sim}-30\;mV)$ which partially overlaps with the resting membrane potential. This current has the property that it can be easily activated by a weak depolarization, thus it may trigger a certain kind of a intracellular event following fertilization which may cause oscillations in the membrane potential.

• 지능정보연구
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• 제18권2호
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• pp.85-105
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• 2012

온라인 소셜네트워크의 확산으로 인해 사용자들은 특정제품과 서비스에 대한 자신의 생각과 경험을 보다 손쉽게 공유 할 수 있게 되었으며 이러한 환경변화는 기업의 사업성과에 영향을 미칠 수 있는 소비자 구전효과의 영향을 심화시킬 것으로 예상된다. 본 연구의 목적은 영화산업에서의 온라인 소셜네트워크의 구전효과 발생에 대한 기여도를 또 다른 온라인 매체인 인터넷 포탈과의 비교를 통해 검증하는데 있다. 이를 위해 2011년 2월부터 6월 사이에 국내 개봉된 영화 및 이들 영화와 관련된 트위터 메시지 그리고 네이버 무비상의 리뷰를 수집 분석하였다. 분석결과 온라인 소셜네트워크(트위터)와 인터넷 포털 모두에서 영화의 흥행과 관련한 구전효과가 존재하고 있음을 발견하였다. 또한 영화의 인기도에 따라 온라인 소셜케트워크와 인터넷 포털의 구전효과 발생에 대한 영향도가 다르게 나타나는 점도 발견하였다. 인기영화(블록 버스터 영화)의 경우 개봉이전에는 온라인 소셜네트워크에 의한 구전효과가 유의하게 발생하였으며 개봉 이후에는 온라인 소셜네트워크와 인터넷 포털에 의한 구전효과가 유의하게 발생함을 알 수 있었다. 비 인기영화의 경우 개봉이전에만 온라인 소셜네트워크와 인터넷 포털에 의한 구전효과가 유의하게 발생함을 발견하였다. 본 연구의 결과는 영화와 같은 문화상품과 관련한 구전효과 발생에 있어 온라인 소셜네트워크의 영향에 관한 학문적 지식을 증대시키고 실무적으로 기업이 제품 및 서비스에 대한 브랜드가치 재고를 위해 온라인 소셜네트워크를 어떻게 전략적으로 활용할 수 있는가에 방향을 제시 할 것이라 기대된다.