• Title/Summary/Keyword: channel 2

Search Result 8,681, Processing Time 0.029 seconds

Identification of Three Types of Voltage Dependent $Ca^{2+}$-Channels in Mouse Follicular Oocytes

  • Bae, In-Ha;Yoon, Sook-Young;Yoon, Yong-Dal;Kim, Moon-Kyoo;Kim, Hae-Kwon
    • Animal cells and systems
    • /
    • v.3 no.1
    • /
    • pp.53-58
    • /
    • 1999
  • The immunocytochemical method was used to identify the existence of voltage-dependent $Ca^{2+}$-channels in mouse follicular oocytes. Three types of voltage-dependent $Ca^{2+}$-channels were shown to exist in the follicular oocytes for the first time, the P/Q-type $Ca^{2+}$-channel, the N-type $Ca^{2+}$-channel, and the L-type $Ca^{2+}$-channel. Among proven $Ca^{2+}$-channels distributions of the P/Q-type $Ca^{2+}$-channel and L-type $Ca^{2+}$-channel showed localized staining (clustered pattern) on the oolemma. The distribution of the P/Q-type $Ca^{2+}$-channel showed all localized staining, and the range of localized staining was from 1 to 8 in staining intensity. As the staining intensity increased from 1 to 8, the number of localized staining decreased. The L-type $Ca^{2+}$-channel are homogeneously stained (29.4%-54.2%), while some of them (around 28.7%-44.1%) showed localized staining on the oolemma. However, the rest of them showed no staining at all (17.1%- 26.5%). On the contrary, the N-type $Ca^{2+}$-channel showed mostly homogeneous staining, while nonstaining oocytes were around 33.8%. The rest showed localized staining (10%). However, staining intensity was much weaker than those of the P/Q-type and L-type $Ca^{2+}$-channel. In fact, the N-type $Ca^{2+}$-channel has been known to exist only in neurons (from ectoderm origin), but it is unknown how the N-type $Ca^{2+}$-channel exists in the follicular oocytes (from mesoderm origin). Further studies are needed to examine the expression of $Ca^{2+}$-channels during the developmental stages of the oocytes.

  • PDF

Effects of $Cl^-$ Channel Blockers on the Cardiac ATP-sensitive $K^+$ Channel

  • Kwak, Yong-Geun
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.3 no.3
    • /
    • pp.305-313
    • /
    • 1999
  • To explore whether $Cl^-$ channel blockers interact with the ATP-sensitive $K^+\;(K_{ATP})$ channel, I have examined the effect of two common $Cl^-$ channel blockers on the $K_{ATP}$ channel activity in isolated rat ventricular myocytes using patch clamp techniques. In inside-out patches, 4,4'-diisothio-cyanatostilbene- 2,2'-disulfonic acid (DIDS) and niflumic acid applied to bath solution inhibited the $K_{ATP}$ channel activity in a concentration-dependent manner with $IC_{50}$ of 0.24 and 927 ${\mu}M,$ respectively. The inhibitory action of DIDS was irreversible whereas that of niflumic acid was reversible. Furthermore, DIDS-induced block was not recovered despite exposure to ATP (1 mM). In cell-attached and inside-out patches, DIDS blocked the pinacidil- or 2,4-dinitrophenol (DNP)-induced $K_{ATP}$ channel openings. In contrast, niflumic acid did not block the pinacidil-induced $K_{ATP}$ channel openings in inside-out patches, but inhibited it in cell-attached patches. DIDS and niflumic acid produced additional block in the presence of ATP and did not affect current-voltage relationship and channel kinetics. All these results indicate that DIDS among $Cl^-$ channel blockers specifically blocks the cardiac $K_{ATP}$ channel.

  • PDF

A Study on the Channel Capacity of Fading Channel (페이딩 통신로의 통신 용량에 관한 연구)

  • 고봉진;황인수;조성준
    • The Journal of Korean Institute of Communications and Information Sciences
    • /
    • v.18 no.8
    • /
    • pp.1136-1145
    • /
    • 1993
  • The channel capacities of various lading channels are calculated and compared with that of Gaussian noise channel to find out the decrements of channel capacity according to each fading environment. As a result, it is confirmed that the channel capacities in Rician and m-distribution fading channels approach to that of Gaussian noise channel as direct-to-indirect power ratio in Rician fading channel and fading index m in m-distribution fading channel increases respectively. And the difference between two channel capacities of Gaussian noise channel and each fading channel which is dependent on carrier-to-noise power ratio (CNR) is found. Also the improvement of channel capacity of Rayleigh fading channel by introducing two-branch diversities is obtained. For diversity reception, predetection maximal-ratio and postdetection selective combining techniques are adopted. The results show that the improvement of channel capacity by predetection maximal-ratio combining diversity is superior to the postdetection selective combining diversitiy regardless of correlation coefficient between two diversity branches in Raylelgh fading channel. The best improvement is achieved when two branches are noncorrelative in both two diversify techniques and as correlation coefficient of two diversity branches is smaller, the improvement of channel capacity is greater.

  • PDF

Multichannel Quantum Defect Study of the Perturber's Effect on the Overlapping Resonances in Rydberg Series for the Systems Involving 2 Closed and Many Open Channels

  • Lee, Chun-Woo
    • Bulletin of the Korean Chemical Society
    • /
    • v.31 no.6
    • /
    • pp.1669-1680
    • /
    • 2010
  • The phase-shifted version of the multichannel quantum-defect theory (MQDT) was reformulated by disentangling the interloper spectrum from the perturbed dense Rydberg series for a systems involving 2 closed and more than 1 open channel. The theory was applied successfully to Martins and Zimmermann's photoionization spectra of the Rydberg series Cu I $3d^9\;4s(^1D_2)\;nd^2G_{9/2}$ perturbed by the interloper, $3d^9\;4p^2\;^4F_{9/2}$, for which Cohen's 4 channel QDT had failed. The zero surface graphic of the perturbed Fano's asymmetry parameter q of the autoionization spectrum of dense Rydberg series by the interloper was determined by only two parameters for this system. It was used as a map to trace the transformation route of the 3 channel autoionization spectra to the 4 channel spectra when the channel coupling of the closed channels with a newly added open channel was turned on progressively.

Numerical study of dividing open-channel flows at bifurcation channel using TELEMAC-2D (TELEMAC-2D모형을 이용한 개수로 분류흐름에 대한 수치모의 연구)

  • Jung, Dae Jin;Jang, Chang-Lae;Jung, Kwansue
    • Journal of Korea Water Resources Association
    • /
    • v.49 no.7
    • /
    • pp.635-644
    • /
    • 2016
  • This study investigates variation of flow characteristics due to variation of branch channel width and discharge ratio at bifurcation channel using 2D numerical model. The calculated result considering secondary flow is more accurate and stable than without considering one. The diversion flow rate ($Q_3/Q_1$) is reduced by flow stagnation effect according to the interaction of the secondary flow and flow separation zone in branch channel. The less upstream inflow or the lower upstream velocity, the bigger variation of diversion flow rate by changing branch channel width. At uniform downstream boundary condition, the rate of change in Froude number of downstream of main channel($Fr_2$)-diversion flow rate ($Q_3/Q_1$) relations is similar about -2.4843~-2.6675 when branch channel width ratio (b/B) is decreased. At uniform diversion flow rate ($Q_3/Q_1$) condition, the width of recirculation zone in branch channel is decreased when branch channel width ratio (b/B) is decreased. The less upstream inflow in the case of increasing branch channel width or the narrower branch channel width in the case of increasing upstream inflow, the bigger reduction ratio of recirculation zone width. At uniform inflow discharge ($Q_1$) condition, diversion flow rate, the width and length of recirculation zone in branch channel are decreased when branch channel width ratio (b/B) is decreased.

Interference Coordination for Device-to-Device (D2D) under Multi-channel of Cellular Networks

  • Zulkifli, Aunee Azrina;Huynh, Thong;Kuroda, Kaori;Hasegawa, Mikio
    • Journal of Multimedia Information System
    • /
    • v.3 no.4
    • /
    • pp.135-140
    • /
    • 2016
  • To improve the throughput of Device-to-Device (D2D) communication, we focus on the scenario where D2D pair can reuse multi-channel of cellular communication. However, as sharing same channel with cellular communication can cause interference between D2D communication and cellular communication, a proper interference management is needed. In this paper, we propose interference-based channel allocation to select the channels to be used by D2D communication and a solution from game theory perspective to optimize the D2D communication throughput under multi-channel as well as guarantee the interference from it to cellular network. The simulation results verify the stability of the proposed method.

A Study on Hydraulic Characteristics of the Curved Channel in the Downstream of Dam (댐 하류 만곡부 하천에 대한 수리학적 특성 연구)

  • Choi, Han-Kyu;Beak, Hyo-Seon;Lee, Kye-Yu
    • Journal of Industrial Technology
    • /
    • v.25 no.A
    • /
    • pp.3-14
    • /
    • 2005
  • In order to accurately analyze the detailed hydraulic characteristics of the curved channel in the downstream of dam with the hydraulic structures such as bridge piers, RMA2 model which is one of two-dimensional models is applied to ChunCheon dam downstream curved channel. A series of hydraulic model tests are carried out for comparison studies. HEC-RAS model is also applied to the same site. There are no errors when velocities and water levels resulted from HEC-RAS model RMA2 model are compared with those of hydraulic model test on the straight channel. But, it is found that results of RMA2 model have a better agreement with those of hydraulic model test than those of HEC-RAS model on the curved channel with bridge piers. Additionally, RMA2 model can be predicted the eddy phenomena around bridge piers of the curved channel.

  • PDF

Two-Bit/Cell NFGM Devices for High-Density NOR Flash Memory

  • Lee, Jong-Ho
    • JSTS:Journal of Semiconductor Technology and Science
    • /
    • v.8 no.1
    • /
    • pp.11-20
    • /
    • 2008
  • The structure of 2-bit/cell flash memory device was characterized for sub-50 nm non-volatile memory (NVM) technology. The memory cell has spacer-type storage nodes on both sidewalls in a recessed channel region, and is erased (or programmed) by using band-to-band tunneling hot-hole injection (or channel hot-electron injection). It was shown that counter channel doping near the bottom of the recessed channel is very important and can improve the $V_{th}$ margin for 2-bit/cell operation by ${\sim}2.5$ times. By controlling doping profiles of the channel doping and the counter channel doping in the recessed channel region, we could obtain the $V_{th}$ margin more than ${\sim}1.5V$. For a bit-programmed cell, reasonable bit-erasing characteristics were shown with the bias and stress pulse time condition for 2-bit/cell operation. The length effect of the spacer-type storage node is also characterized. Device which has the charge storage length of 40 nm shown better ${\Delta}V_{th}$ and $V_{th}$ margin for 2-bit/cell than those of the device with the length of 84 nm at a fixed recess depth of 100 nm. It was shown that peak of trapped charge density was observed near ${\sim}10nm$ below the source/drain junction.

Analysis on Thermal Effects of Process Channel Geometry for Microchannel Fischer-Tropsch Reactor Using Computational Fluid Dynamics (전산유체역학을 이용한 Fischer-Tropsch 마이크로채널 반응기 반응채널구조에 따른 열적 효과 분석)

  • Lee, Yongkyu;Jung, Ikhwan;Na, Jonggeol;Park, Seongho;Kshetrimayum, Krishnadash S.;Han, Chonghun
    • Korean Chemical Engineering Research
    • /
    • v.53 no.6
    • /
    • pp.818-823
    • /
    • 2015
  • In this study, FT reaction in a microchannel was simulated using computational fluid dynamics(CFD), and sensitivity analyses conducted to see effects of channel geometry variables, namely, process channel width, height, gap between process channel and cooling channel, and gap between process channels on the channel temperature profile. Microchannel reactor considered in the study is composed of five reaction channels with height and width ranging from 0.5 mm to 5.0 mm. Cooling surfaces is assumed to be in isothermal condition to account for the heat exchange between the surface and process channels. A gas mixture of $H_2$ and CO($H_2/CO$ molar ratio = 2) is used as a reactant and operating conditions are the following: GHSV(gas hourly space velocity) = $10000h^{-1}$, pressure = 20 bar, and temperature = 483 K. From the simulation study, it was confirmed that heat removal in an FT microchannel reactor is affected channel geometry variables. Of the channel geometry variables considered, channel height and width have significant effect on the channel temperature profile. However, gap between cooling surface and process channel, and gap between process channels have little effect. Maximum temperature in the reaction channel was found to be proportional to channel height, and not affected by the width over a particular channel width size. Therefore, microchannels with smaller channel height(about less than 2 mm) and bigger channel width (about more than 4 mm), can be attractive design for better heat removal and higher production.

Channel-fill Deposits of Gravel-bed Stream, Southeastern Eumsung Basin (Cretaceous), Korea

  • Ryang, Woo-Hun
    • Journal of the Korean earth science society
    • /
    • v.27 no.7
    • /
    • pp.757-767
    • /
    • 2006
  • Alluvial-plain deposits in the southeastern part of the Eumsung Basin (Cretaceous) are characterized by coarse-grained channel fills encased in purple siltstone beds. It represents distinct channel geometry, infill organization, and variations in facies distribution. The directions of paleocurrent, sedimentary facies changes, and channel-fill geometry can be used to reconstruct a channel network in the alluvial system developed along the southeastern margin of the basin. The channel-fill facies represent downstream changes: 1) down-sizing and well-sorting in clast and martix of channel fills and 2) internal organization of scour fill or gravel lag and overlying cross-stratified, planar-stratified beds. These findings suggest multiple stages of channel-filling processes according to flooding and subsequent stream flows. In the small-scale pull-apart Eumsung Basin (${\sim}7{\times}33km^2$ in area), vertical-stacked alluvial architecture of the coarse-grained channel fills encased in purple siltstone is expected to result from episodic channel shifting under a rapidly subsiding setting.